ES8500242A1 - Procedimiento para la preparacion de derivados de imidazol - Google Patents

Procedimiento para la preparacion de derivados de imidazol

Info

Publication number
ES8500242A1
ES8500242A1 ES529175A ES529175A ES8500242A1 ES 8500242 A1 ES8500242 A1 ES 8500242A1 ES 529175 A ES529175 A ES 529175A ES 529175 A ES529175 A ES 529175A ES 8500242 A1 ES8500242 A1 ES 8500242A1
Authority
ES
Spain
Prior art keywords
imidazole derivatives
compounds
preparation
medicines containing
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529175A
Other languages
English (en)
Other versions
ES529175A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES529175A0 publication Critical patent/ES529175A0/es
Publication of ES8500242A1 publication Critical patent/ES8500242A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IMIDAZOL, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS ORGANICOS O INORGANICOS FISIOLOGICAMENTE COMPATIBLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN ACIDO SULFONICO DE FORMULA GENERAL (III), EN PRESENCIA DE UN AGENTE SUBSTRACTOR DE AGUA.DE APLICACION EN EL TRATAMIENTO DE INSUFICIENCIAS CARDIACAS DE DIFERENTES GENESIS.
ES529175A 1982-07-01 1984-01-26 Procedimiento para la preparacion de derivados de imidazol Expired ES8500242A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823224512 DE3224512A1 (de) 1982-07-01 1982-07-01 Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES529175A0 ES529175A0 (es) 1984-10-01
ES8500242A1 true ES8500242A1 (es) 1984-10-01

Family

ID=6167285

Family Applications (3)

Application Number Title Priority Date Filing Date
ES523709A Granted ES523709A0 (es) 1982-07-01 1983-06-30 Procedimiento para la preparacion de derivados de imidazol.
ES529174A Expired ES8500241A1 (es) 1982-07-01 1984-01-26 Procedimiento para la preparacion de derivados de imidazol
ES529175A Expired ES8500242A1 (es) 1982-07-01 1984-01-26 Procedimiento para la preparacion de derivados de imidazol

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES523709A Granted ES523709A0 (es) 1982-07-01 1983-06-30 Procedimiento para la preparacion de derivados de imidazol.
ES529174A Expired ES8500241A1 (es) 1982-07-01 1984-01-26 Procedimiento para la preparacion de derivados de imidazol

Country Status (23)

Country Link
US (2) US4582837A (es)
EP (1) EP0098448A3 (es)
JP (1) JPS5927875A (es)
KR (1) KR840005432A (es)
AU (1) AU1642883A (es)
CS (1) CS254319B2 (es)
DD (1) DD210271A5 (es)
DE (1) DE3224512A1 (es)
DK (1) DK301383A (es)
ES (3) ES523709A0 (es)
FI (1) FI832022L (es)
GB (1) GB2122995B (es)
GR (1) GR78598B (es)
HU (1) HU192152B (es)
IL (1) IL69111A0 (es)
NO (1) NO832356L (es)
NZ (1) NZ204766A (es)
PH (1) PH20810A (es)
PL (2) PL142880B1 (es)
PT (1) PT76968B (es)
SU (2) SU1316559A3 (es)
YU (1) YU143283A (es)
ZA (1) ZA834777B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
GR850426B (es) * 1984-02-24 1985-06-18 Lilly Co Eli
GR851085B (es) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
NZ217755A (en) * 1985-10-09 1989-08-29 Chemie Linz Ag 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and pharmaceutical compositions
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5466704A (en) * 1991-02-26 1995-11-14 E. R. Squibb & Sons, Inc. N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
FR2677020B1 (fr) * 1991-05-31 1993-08-27 Cird Galderma Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
US6867200B1 (en) 1998-12-18 2005-03-15 Axys Pharmaceuticals, Inc. (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
DE10015866A1 (de) * 2000-03-30 2001-10-11 Bayer Ag Aryl- und Heteroarylsulfonate
JP2004503553A (ja) * 2000-06-14 2004-02-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ６，５−縮合二環式複素環
WO2002072090A1 (en) * 2001-03-12 2002-09-19 Avanir Pharmaceuticals Benzimidazole compounds for modulating ige and inhibiting cellular proliferation
JP4416111B2 (ja) * 2002-02-14 2010-02-17 塩野義製薬株式会社 ２，３−ジアミノピリジン誘導体の製造方法
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
WO2004024655A2 (en) 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
JP2007501618A (ja) * 2003-08-08 2007-02-01 アバニール・ファーマシューティカルズ タンパク質輸送の選択的薬理学的阻害、および関連した、ヒト疾患を治療する方法
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
CN101248074A (zh) * 2005-07-01 2008-08-20 日本化学医药株式会社 黄嘌呤氧化酶抑制剂
BRPI0616994A2 (pt) * 2005-08-15 2011-07-05 Irm Llc compostos e composições como miméticos de tpo
TW200831472A (en) * 2006-11-30 2008-08-01 Wyeth Corp Process for the synthesis of monosulfated derivatives of substituted benzoxazoles
US7816540B2 (en) * 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151630A2 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
LT3083627T (lt) 2013-12-19 2018-12-27 Novartis Ag [1,2,4]triazolo[1,5-a]pirimidino dariniai kaip protozoano proteasomos inhibitoriai, skirti parazitinių ligų tokių kaip leišmaniozė, gydymui
AR099677A1 (es) * 2014-03-07 2016-08-10 Sumitomo Chemical Co Compuesto heterocíclico fusionado y su uso para el control de plagas
JP2019503342A (ja) * 2015-11-16 2019-02-07 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305339C3 (de) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Also Published As

Publication number Publication date
GR78598B (es) 1984-09-27
YU143283A (en) 1986-06-30
ES8500056A1 (es) 1984-10-01
SU1316559A3 (ru) 1987-06-07
ES523709A0 (es) 1984-10-01
KR840005432A (ko) 1984-11-12
PH20810A (en) 1987-04-24
ES529175A0 (es) 1984-10-01
JPS5927875A (ja) 1984-02-14
ES529174A0 (es) 1984-10-01
FI832022L (fi) 1984-01-02
NO832356L (no) 1984-01-02
GB2122995B (en) 1986-02-12
PL142880B1 (en) 1987-12-31
GB8317732D0 (en) 1983-08-03
DK301383A (da) 1984-01-02
PT76968A (de) 1983-07-01
FI832022A0 (fi) 1983-06-06
SU1179924A3 (ru) 1985-09-15
US4582837A (en) 1986-04-15
IL69111A0 (en) 1983-10-31
DE3224512A1 (de) 1984-01-05
PL242770A1 (en) 1986-10-21
CS254319B2 (en) 1988-01-15
ES8500241A1 (es) 1984-10-01
NZ204766A (en) 1986-09-10
PT76968B (de) 1986-04-09
DD210271A5 (de) 1984-06-06
EP0098448A3 (de) 1985-04-03
AU1642883A (en) 1984-01-05
HU192152B (en) 1987-05-28
PL144589B1 (en) 1988-06-30
EP0098448A2 (de) 1984-01-18
GB2122995A (en) 1984-01-25
DK301383D0 (da) 1983-06-30
ZA834777B (en) 1985-03-27
US4696931A (en) 1987-09-29

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