ZA834777B - Imidazole derivatives,processes for their preparation,and pharmaceutical compositions thereof - Google Patents

Imidazole derivatives,processes for their preparation,and pharmaceutical compositions thereof

Info

Publication number
ZA834777B
ZA834777B ZA834777A ZA834777A ZA834777B ZA 834777 B ZA834777 B ZA 834777B ZA 834777 A ZA834777 A ZA 834777A ZA 834777 A ZA834777 A ZA 834777A ZA 834777 B ZA834777 B ZA 834777B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
pharmaceutical compositions
imidazole derivatives
imidazole
Prior art date
Application number
ZA834777A
Other languages
English (en)
Inventor
Norbert Hauel
Volkhard Austel
Joachim Heider
Manfred Reiffen
Willi Diederen
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of ZA834777B publication Critical patent/ZA834777B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA834777A 1982-07-01 1983-06-30 Imidazole derivatives,processes for their preparation,and pharmaceutical compositions thereof ZA834777B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823224512 DE3224512A1 (de) 1982-07-01 1982-07-01 Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ZA834777B true ZA834777B (en) 1985-03-27

Family

ID=6167285

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA834777A ZA834777B (en) 1982-07-01 1983-06-30 Imidazole derivatives,processes for their preparation,and pharmaceutical compositions thereof

Country Status (23)

Country Link
US (2) US4582837A (xx)
EP (1) EP0098448A3 (xx)
JP (1) JPS5927875A (xx)
KR (1) KR840005432A (xx)
AU (1) AU1642883A (xx)
CS (1) CS254319B2 (xx)
DD (1) DD210271A5 (xx)
DE (1) DE3224512A1 (xx)
DK (1) DK301383A (xx)
ES (3) ES523709A0 (xx)
FI (1) FI832022L (xx)
GB (1) GB2122995B (xx)
GR (1) GR78598B (xx)
HU (1) HU192152B (xx)
IL (1) IL69111A0 (xx)
NO (1) NO832356L (xx)
NZ (1) NZ204766A (xx)
PH (1) PH20810A (xx)
PL (2) PL142880B1 (xx)
PT (1) PT76968B (xx)
SU (2) SU1316559A3 (xx)
YU (1) YU143283A (xx)
ZA (1) ZA834777B (xx)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
GR850426B (xx) * 1984-02-24 1985-06-18 Lilly Co Eli
PL147842B1 (en) * 1984-05-12 1989-08-31 Method of obtaining novel pyroisobenzimidazoles
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4720501A (en) * 1985-10-09 1988-01-19 Chemi Linz Aktiengesellschaft 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and salts thereof useful in the treatment of myocardial insufficiency
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5466704A (en) * 1991-02-26 1995-11-14 E. R. Squibb & Sons, Inc. N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
FR2677020B1 (fr) * 1991-05-31 1993-08-27 Cird Galderma Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
EA200100675A1 (ru) 1998-12-18 2001-12-24 Аксис Фармасьютикалз, Инк. Ингибиторы протеазы
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
DE10015866A1 (de) * 2000-03-30 2001-10-11 Bayer Ag Aryl- und Heteroarylsulfonate
MXPA02010763A (es) * 2000-06-14 2003-03-10 Warner Lambert Co Heterociclicos biciclos-6,5 fusionados.
ATE369853T1 (de) 2001-03-12 2007-09-15 Avanir Pharmaceuticals Benzimidazolderivate zur ige-modulierung und zellproliferationshemmung
WO2003068745A1 (fr) * 2002-02-14 2003-08-21 Shionogi & Co., Ltd. Procédé de production de dérivés de 2,3-diaminopyridine
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
TWI276631B (en) * 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
JP2007501618A (ja) * 2003-08-08 2007-02-01 アバニール・ファーマシューティカルズ タンパク質輸送の選択的薬理学的阻害、および関連した、ヒト疾患を治療する方法
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1911760A4 (en) * 2005-07-01 2010-06-02 Nippon Chemiphar Co xanthine oxidase inhibitor
CA2618634A1 (en) * 2005-08-15 2007-02-22 Irm Llc Compounds and compositions as tpo mimetics
US20080139820A1 (en) * 2006-11-30 2008-06-12 Wyeth Process for the Synthesis of Monosulfated Derivatives of Substituted Benzoxazoles
US7816540B2 (en) * 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
US9233961B2 (en) 2013-03-15 2016-01-12 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
MX368072B (es) 2013-12-19 2019-09-18 Novartis Ag Derivados de [1,2,4]-triazolo-[1,5-a]-pirimidina como inhibidores del proteasoma de protozoarios para el tratamiento de enfermedades parasitarias tales como leishmaniasis.
AR099677A1 (es) * 2014-03-07 2016-08-10 Sumitomo Chemical Co Compuesto heterocíclico fusionado y su uso para el control de plagas
US10730872B2 (en) * 2015-11-16 2020-08-04 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing sustitutents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305339C3 (de) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
DE3273461D1 (en) * 1981-08-19 1986-10-30 Merck Patent Gmbh 2-arylimidazopyridines
ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Also Published As

Publication number Publication date
GB2122995B (en) 1986-02-12
ES8500241A1 (es) 1984-10-01
FI832022A0 (fi) 1983-06-06
HU192152B (en) 1987-05-28
ES8500056A1 (es) 1984-10-01
GR78598B (xx) 1984-09-27
GB8317732D0 (en) 1983-08-03
US4582837A (en) 1986-04-15
US4696931A (en) 1987-09-29
PT76968B (de) 1986-04-09
ES8500242A1 (es) 1984-10-01
PL242770A1 (en) 1986-10-21
NO832356L (no) 1984-01-02
NZ204766A (en) 1986-09-10
PH20810A (en) 1987-04-24
SU1316559A3 (ru) 1987-06-07
DK301383D0 (da) 1983-06-30
EP0098448A3 (de) 1985-04-03
EP0098448A2 (de) 1984-01-18
PL144589B1 (en) 1988-06-30
DK301383A (da) 1984-01-02
FI832022L (fi) 1984-01-02
ES523709A0 (es) 1984-10-01
JPS5927875A (ja) 1984-02-14
SU1179924A3 (ru) 1985-09-15
ES529174A0 (es) 1984-10-01
CS254319B2 (en) 1988-01-15
GB2122995A (en) 1984-01-25
PL142880B1 (en) 1987-12-31
AU1642883A (en) 1984-01-05
IL69111A0 (en) 1983-10-31
DD210271A5 (de) 1984-06-06
KR840005432A (ko) 1984-11-12
YU143283A (en) 1986-06-30
DE3224512A1 (de) 1984-01-05
ES529175A0 (es) 1984-10-01
PT76968A (de) 1983-07-01

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