SK8712000A3 - Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors - Google Patents
Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors Download PDFInfo
- Publication number
- SK8712000A3 SK8712000A3 SK871-2000A SK8712000A SK8712000A3 SK 8712000 A3 SK8712000 A3 SK 8712000A3 SK 8712000 A SK8712000 A SK 8712000A SK 8712000 A3 SK8712000 A3 SK 8712000A3
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- acetylamino
- ethyl
- methyl
- pharmaceutically acceptable
- Prior art date
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- 0 CCOC(C(*C)(*C)C(C1)C(*)CC1=O)=O Chemical compound CCOC(C(*C)(*C)C(C1)C(*)CC1=O)=O 0.000 description 8
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6995697P | 1997-12-17 | 1997-12-17 | |
US8525298P | 1998-05-13 | 1998-05-13 | |
PCT/US1998/026871 WO1999033781A1 (fr) | 1997-12-17 | 1998-12-17 | Composes des cyclopentane et cyclopentene convenant comme inhibiteurs de neuraminidase |
Publications (1)
Publication Number | Publication Date |
---|---|
SK8712000A3 true SK8712000A3 (en) | 2000-11-07 |
Family
ID=26750600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK871-2000A SK8712000A3 (en) | 1997-12-17 | 1998-12-17 | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
Country Status (28)
Country | Link |
---|---|
US (1) | US6562861B1 (fr) |
EP (1) | EP1040094B9 (fr) |
JP (3) | JP4102022B2 (fr) |
KR (1) | KR20010024743A (fr) |
CN (1) | CN1282316A (fr) |
AR (1) | AR016162A1 (fr) |
AT (1) | ATE425955T1 (fr) |
AU (1) | AU2200199A (fr) |
BE (1) | BE2018C032I2 (fr) |
BR (1) | BR9813480A (fr) |
CA (1) | CA2315262C (fr) |
CY (2) | CY1109153T1 (fr) |
DE (1) | DE69840674D1 (fr) |
DK (1) | DK1040094T3 (fr) |
ES (1) | ES2324746T3 (fr) |
FR (1) | FR18C1037I2 (fr) |
HU (1) | HUP0100142A3 (fr) |
IL (1) | IL136812A0 (fr) |
LT (1) | LTC1040094I2 (fr) |
NL (1) | NL300952I2 (fr) |
NO (1) | NO20003084L (fr) |
PL (1) | PL196674B1 (fr) |
PT (1) | PT1040094E (fr) |
RO (1) | RO121815B1 (fr) |
SI (1) | SI1040094T1 (fr) |
SK (1) | SK8712000A3 (fr) |
WO (1) | WO1999033781A1 (fr) |
ZA (1) | ZA9811595B (fr) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ412898A3 (cs) | 1996-06-14 | 1999-08-11 | Biocryst Pharmaceuticals, Inc. | Substituované cyklopentanové sloučeniny, použitelné jako inhibitory neuraminidázy |
AR016162A1 (es) * | 1997-12-17 | 2001-06-20 | Biocryst Pharm Inc | Compuestos ciclopentano y ciclopenteno sustituidos que son de utilidad como inhibidores de la neuraminidasa y composicion que los contiene. |
US6455571B1 (en) * | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
JP2002521312A (ja) * | 1998-04-23 | 2002-07-16 | アボット・ラボラトリーズ | ノイラミニダーゼの阻害剤 |
US6518305B1 (en) * | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
AU1520300A (en) | 1998-11-05 | 2000-05-29 | Biocryst Pharmaceuticals, Inc. | New cyclopentane and cyclopentene compounds and use for detecting influenza virus |
US6762316B1 (en) * | 1999-06-28 | 2004-07-13 | Biocryst Pharmaceuticals, Inc. | Preparation of substituted cyclopentane and cyclopentene compounds and certain intermediates |
BR0011767A (pt) * | 1999-06-28 | 2002-04-23 | Biocryst Pharm Inc | ésteres de (-) -(1s,4r) n protegido 4-amino-2-ciclopenteno-1-carboxilato e respectivos processos de preparação |
IL147244A0 (en) * | 1999-06-28 | 2002-08-14 | Biocryst Pharm Inc | Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof |
WO2001000558A1 (fr) * | 1999-06-28 | 2001-01-04 | Biocryst Pharmaceuticals, Inc. | Preparation de composes de cyclopentane et cyclopentene substitues et de certains intermediaires |
US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
US6627396B1 (en) | 1999-10-28 | 2003-09-30 | The Regents Of The University Of California | Influenza sensor |
WO2001062242A1 (fr) * | 2000-02-24 | 2001-08-30 | Biocryst Pharmaceuticals, Inc. | Promedicaments de composes cyclopentane et cyclopentene substitues utiles comme inhibiteurs de neuraminidase |
JP2003525291A (ja) * | 2000-03-01 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 2,4−二置換チアゾリル誘導体 |
WO2001080892A1 (fr) * | 2000-04-25 | 2001-11-01 | Sankyo Company, Limited | Substances preventives de la grippe |
GB0015324D0 (en) * | 2000-06-22 | 2000-08-16 | Biota Scient Management | Medicaments |
AUPR001000A0 (en) | 2000-09-08 | 2000-10-05 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
WO2002032885A1 (fr) * | 2000-10-18 | 2002-04-25 | Kuraray Co., Ltd. | Preparation d'esters d'acide amino-2-aza-1-oxybicyclo[3.3.0]oct-2-ene-6-carboxylique 4-n substitues et preparation de leurs produits intermediaires |
WO2002092555A1 (fr) * | 2001-05-11 | 2002-11-21 | Sankyo Company, Limited | Derives d'acides sialiques |
WO2006066074A2 (fr) | 2004-12-16 | 2006-06-22 | The Regents Of The University Of California | Medicaments destines au poumon |
WO2007087056A2 (fr) * | 2006-01-13 | 2007-08-02 | Scolr Pharma, Inc. | Derive de peramivir pour administration orale |
US20070203241A1 (en) | 2006-02-13 | 2007-08-30 | Babu Yarlagadda S | Antiviral treatments |
EA025483B1 (ru) * | 2006-02-13 | 2016-12-30 | Байокрист Фармасьютикалз, Инк. | Внутривенный способ лечения сезонного гриппа |
US20070244193A1 (en) * | 2006-04-12 | 2007-10-18 | Babu Yarlagadda S | Intramuscular antiviral treatments |
JP2009533428A (ja) * | 2006-04-12 | 2009-09-17 | バイオクライスト ファーマシューティカルズ, インコーポレイテッド | 筋肉内抗ウイルス処置 |
CN100432047C (zh) * | 2006-07-03 | 2008-11-12 | 华南农业大学 | 一种抗流感及禽流感病毒药物帕拉米韦的合成方法 |
AU2008208865B2 (en) | 2007-01-23 | 2013-01-24 | Therapicon Srl | Antiviral compounds |
US20080194801A1 (en) * | 2007-02-14 | 2008-08-14 | Swanson Basil I | Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses |
CA2695193C (fr) | 2007-08-02 | 2018-07-17 | Ian Armitage | Procede pour la synthese d'inhibiteurs de l'enzyme d'activation e1 |
CN101367750B (zh) | 2007-08-14 | 2012-05-23 | 中国人民解放军军事医学科学院毒物药物研究所 | (1s,2s,3s,4r)-3-[(1s)-1-乙酰氨-2-乙基-丁基]-4-胍基-2-羟基-环戊基-1-羧酸水合物及其医药用途 |
AU2014200052B2 (en) * | 2007-11-05 | 2016-01-07 | Ala Wai Pharma, Inc. | Formulations for enhanced bioavailability of orally administered polar agents |
CN103536923A (zh) * | 2007-11-05 | 2014-01-29 | 阿拉维制药公司 | 用于口服给药极性药剂的提高生物利用度的制剂 |
CN101538228B (zh) * | 2008-03-21 | 2012-05-30 | 北京普世康医药技术有限公司 | 抗流感和禽流感病毒药物化合物帕拉米韦的合成方法 |
CN101486664B (zh) * | 2008-12-31 | 2013-09-04 | 北京大学深圳研究生院 | 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物 |
CN102459169B (zh) | 2009-05-15 | 2014-12-31 | 莱德克斯制药有限公司 | 氧化还原药物衍生物 |
IT1396620B1 (it) | 2009-11-25 | 2012-12-14 | Therapicon Srl | Analoghi chimerici |
IN2012CN10271A (fr) | 2010-05-27 | 2015-04-10 | Reddy’S Lab Ltd Dr | |
CN102584637B (zh) * | 2011-01-17 | 2014-07-09 | 天津药物研究院 | 帕拉米韦水合物晶体、制备方法、药用组合物及其用途 |
CN102603577A (zh) * | 2011-01-19 | 2012-07-25 | 董慧珍 | 一种抗流感和禽流感药物的衍生物及其用途 |
CN102757365B (zh) * | 2011-04-29 | 2013-10-30 | 上海泓博智源医药技术有限公司 | 一种制备帕拉米韦关键中间体的方法 |
WO2012145932A1 (fr) * | 2011-04-29 | 2012-11-01 | Pharmaresources (Shanghai) Co., Ltd. | Nouveau procédé pour la préparation du péramivir et de ses intermédiaires |
CN102964267B (zh) * | 2011-09-01 | 2015-06-10 | 中山大学 | 一种具有流感病毒神经氨酸酶抑制活性的环己烯化合物及其制备方法以及其应用 |
CN102863359B (zh) * | 2012-05-16 | 2014-05-07 | 常州制药厂有限公司 | 一种抗流感药物的合成方法 |
CN102702033A (zh) * | 2012-06-11 | 2012-10-03 | 天津泰普药品科技发展有限公司 | 无定型帕拉米韦及其制备方法与药物组合物 |
AU2013340559B2 (en) | 2012-10-29 | 2018-03-15 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
PT2970346T (pt) | 2013-03-15 | 2018-11-09 | Univ California | Diésteres de fosfonato nucleosídico acíclico |
CA2911424C (fr) * | 2013-05-14 | 2021-11-30 | Biocryst Pharmaceuticals, Inc. | Derives pyrrolopyrimidines d'imino-ribose anti-grippe |
CN105294589B (zh) * | 2014-06-18 | 2017-06-30 | 朱靖华 | 一种抗病毒药物及其制备方法 |
BR112017005111B1 (pt) | 2014-09-15 | 2023-02-14 | The Regents Of The University Of California | Compostos análogos de nucleotídeo acíclico, composição farmacêutica contendo tais compostos, e usos da composição no tratamento de uma infecção por papilomavírus |
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1998
- 1998-12-17 AR ARP980106457A patent/AR016162A1/es not_active Application Discontinuation
- 1998-12-17 SI SI9830919T patent/SI1040094T1/sl unknown
- 1998-12-17 KR KR1020007006646A patent/KR20010024743A/ko not_active Application Discontinuation
- 1998-12-17 PL PL341431A patent/PL196674B1/pl unknown
- 1998-12-17 RO ROA200000635A patent/RO121815B1/ro unknown
- 1998-12-17 HU HU0100142A patent/HUP0100142A3/hu unknown
- 1998-12-17 WO PCT/US1998/026871 patent/WO1999033781A1/fr not_active Application Discontinuation
- 1998-12-17 ZA ZA9811595A patent/ZA9811595B/xx unknown
- 1998-12-17 US US09/555,131 patent/US6562861B1/en not_active Expired - Lifetime
- 1998-12-17 DE DE69840674T patent/DE69840674D1/de not_active Expired - Lifetime
- 1998-12-17 PT PT98966003T patent/PT1040094E/pt unknown
- 1998-12-17 BR BR9813480-9A patent/BR9813480A/pt not_active IP Right Cessation
- 1998-12-17 AT AT98966003T patent/ATE425955T1/de active
- 1998-12-17 AU AU22001/99A patent/AU2200199A/en not_active Abandoned
- 1998-12-17 JP JP2000526468A patent/JP4102022B2/ja not_active Expired - Lifetime
- 1998-12-17 IL IL13681298A patent/IL136812A0/xx unknown
- 1998-12-17 SK SK871-2000A patent/SK8712000A3/sk unknown
- 1998-12-17 DK DK98966003T patent/DK1040094T3/da active
- 1998-12-17 CN CN98812351A patent/CN1282316A/zh active Pending
- 1998-12-17 CA CA002315262A patent/CA2315262C/fr not_active Expired - Lifetime
- 1998-12-17 EP EP98966003.0A patent/EP1040094B9/fr not_active Expired - Lifetime
- 1998-12-17 ES ES98966003T patent/ES2324746T3/es not_active Expired - Lifetime
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2000
- 2000-06-15 NO NO20003084A patent/NO20003084L/no not_active Application Discontinuation
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2008
- 2008-02-05 JP JP2008025550A patent/JP5118502B2/ja not_active Expired - Lifetime
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2009
- 2009-06-16 CY CY20091100635T patent/CY1109153T1/el unknown
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- 2011-08-12 JP JP2011177226A patent/JP5709688B2/ja not_active Expired - Lifetime
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2018
- 2018-08-30 CY CY2018023C patent/CY2018023I1/el unknown
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- 2018-09-05 FR FR18C1037C patent/FR18C1037I2/fr active Active
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