SK56699A3 - Novel heterocyclically substituted benzamides and their use - Google Patents

Novel heterocyclically substituted benzamides and their use Download PDF

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Publication number
SK56699A3
SK56699A3 SK566-99A SK56699A SK56699A3 SK 56699 A3 SK56699 A3 SK 56699A3 SK 56699 A SK56699 A SK 56699A SK 56699 A3 SK56699 A3 SK 56699A3
Authority
SK
Slovakia
Prior art keywords
alkyl
formula
phenyl
hydrogen
medicament
Prior art date
Application number
SK566-99A
Other languages
English (en)
Slovak (sk)
Inventor
Wilfried Lubisch
Achim Moller
Hans-Jorg Treiber
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of SK56699A3 publication Critical patent/SK56699A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK566-99A 1996-12-09 1997-11-28 Novel heterocyclically substituted benzamides and their use SK56699A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19650975A DE19650975A1 (de) 1996-12-09 1996-12-09 Neue heterocyclisch substituierte Benzamide und deren Anwendung
PCT/EP1997/006653 WO1998025899A1 (fr) 1996-12-09 1997-11-28 Nouveaux benzamides substitues de maniere heterocyclique et leur utilisation pour lutter contre des maladies

Publications (1)

Publication Number Publication Date
SK56699A3 true SK56699A3 (en) 1999-10-08

Family

ID=7814035

Family Applications (1)

Application Number Title Priority Date Filing Date
SK566-99A SK56699A3 (en) 1996-12-09 1997-11-28 Novel heterocyclically substituted benzamides and their use

Country Status (24)

Country Link
US (2) US6172072B1 (fr)
EP (1) EP0946509A1 (fr)
JP (1) JP2001505889A (fr)
KR (1) KR20000057445A (fr)
CN (1) CN1239949A (fr)
AR (1) AR010339A1 (fr)
AU (1) AU742732B2 (fr)
BG (1) BG63388B1 (fr)
BR (1) BR9713884A (fr)
CA (1) CA2273988A1 (fr)
CO (1) CO4910161A1 (fr)
CZ (1) CZ292391B6 (fr)
DE (1) DE19650975A1 (fr)
HR (1) HRP970671A2 (fr)
HU (1) HUP0000496A3 (fr)
ID (1) ID22490A (fr)
IL (1) IL129358A0 (fr)
NO (1) NO992770L (fr)
NZ (1) NZ335066A (fr)
SK (1) SK56699A3 (fr)
TR (1) TR199901282T2 (fr)
TW (1) TW420666B (fr)
WO (1) WO1998025899A1 (fr)
ZA (1) ZA9710979B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1080083A1 (fr) * 1998-04-20 2001-03-07 Basf Aktiengesellschaft Nouveaux amides heterocycliquement substitues a action de proteases de cysteine
CZ20021548A3 (cs) * 1999-11-05 2002-10-16 Societe De Conseils De Recherches Et D'application Nové heterocyklické sloučeniny a jejich pouľití jako léků
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
GB0031302D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Napthalene derivatives
KR100962972B1 (ko) 2002-07-26 2010-06-09 주식회사유한양행 1-페닐피페리딘-3-온 유도체 및 그의 제조방법
ATE443043T1 (de) 2002-11-12 2009-10-15 Merck & Co Inc Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
CA2536313A1 (fr) * 2003-08-22 2005-03-03 Takeda Pharmaceutical Company Limited Derive de pyrimidine fusionne et utilisation associee
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
EP2803667A1 (fr) * 2003-12-22 2014-11-19 Ajinomoto Co., Inc. Dérivés de phenylalanine
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
US20070010537A1 (en) * 2004-08-20 2007-01-11 Kazumasa Hamamura Fused pyramidine derivative and use thereof
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7834023B2 (en) * 2006-09-20 2010-11-16 Portola Pharmaceuticals, Inc. Substituted dihydroquinazolines as platelet ADP receptor inhibitors
BRPI0721298A2 (pt) 2006-12-29 2014-03-25 Abbott Gmbh & Co Kg Composto de carboxamida e seus usos como inibidores de calpaína
US8093265B2 (en) 2007-03-09 2012-01-10 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
TWI453019B (zh) 2007-12-28 2014-09-21 Abbvie Deutschland 甲醯胺化合物
TWI519530B (zh) 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US8598211B2 (en) 2009-12-22 2013-12-03 Abbvie Inc. Carboxamide compounds and their use as calpain inhibitors IV
US9051304B2 (en) 2009-12-22 2015-06-09 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
CN102939126B (zh) 2010-04-30 2015-09-16 雅培心脏血管系统股份有限公司 呈现迅速膨胀和收缩的改进型球囊导管
CA2819087A1 (fr) 2010-12-09 2012-06-14 AbbVie Deutschland GmbH & Co. KG Composes de carboxamide et leur utilisation comme inhibiteurs v de la calpaine
JP2015512427A (ja) 2012-04-03 2015-04-27 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー カルボキサミド化合物およびそれのカルパイン阻害薬ｖとしての使用
EP3426674A4 (fr) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. Composés céto-amides cycliques utilisés en tant que modulateurs de la calpaïne, et leurs procédés de production et d'utilisation
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
SG10201912574WA (en) 2016-09-28 2020-02-27 Blade Therapeutics Inc Calpain modulators and therapeutic uses thereof
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8524663D0 (en) * 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives
DE3717828A1 (de) * 1987-05-27 1988-12-15 Hoechst Ag Siliziumhaltige benzoesaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz
DE4000204A1 (de) 1990-01-05 1991-07-11 Steag Ag Vorrichtung zum dosierten austragen von schuettfaehigem feststoff
EP0473551A1 (fr) * 1990-08-31 1992-03-04 Ciba-Geigy Ag Dérivés de 3-arylaracile, procédé pour leur préparation et herbicides les contenant
CA2097815C (fr) 1990-12-28 2001-04-17 Fumio Suzuki Derive de la quinoline
AU667463B2 (en) 1990-12-28 1996-03-28 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
CA2071621C (fr) * 1991-06-19 1996-08-06 Ahihiko Hosoda Derives d'aldehyde
AU4544993A (en) 1992-06-24 1994-01-24 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity
US5541290A (en) 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds

Also Published As

Publication number Publication date
CA2273988A1 (fr) 1998-06-18
TR199901282T2 (xx) 1999-10-21
HUP0000496A3 (en) 2002-11-28
US6436949B1 (en) 2002-08-20
DE19650975A1 (de) 1998-06-10
AU742732B2 (en) 2002-01-10
US6172072B1 (en) 2001-01-09
IL129358A0 (en) 2000-02-17
CZ292391B6 (cs) 2003-09-17
TW420666B (en) 2001-02-01
ZA9710979B (en) 1999-06-18
WO1998025899A1 (fr) 1998-06-18
JP2001505889A (ja) 2001-05-08
ID22490A (id) 1999-10-21
BG63388B1 (bg) 2001-12-29
CO4910161A1 (es) 2000-04-24
HUP0000496A2 (hu) 2000-09-28
CN1239949A (zh) 1999-12-29
CZ174399A3 (cs) 1999-08-11
AU5558098A (en) 1998-07-03
AR010339A1 (es) 2000-06-07
NO992770D0 (no) 1999-06-08
EP0946509A1 (fr) 1999-10-06
BR9713884A (pt) 2000-02-29
HRP970671A2 (en) 1998-10-31
NO992770L (no) 1999-06-08
BG103399A (en) 2000-01-31
NZ335066A (en) 2000-03-27
KR20000057445A (ko) 2000-09-15

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