HUP0000496A2 - Heterociklusos csoporttal szubsztituált benzamidszármazékok és alkalmazásuk betegségek leküzdésére - Google Patents
Heterociklusos csoporttal szubsztituált benzamidszármazékok és alkalmazásuk betegségek leküzdéséreInfo
- Publication number
- HUP0000496A2 HUP0000496A2 HU0000496A HUP0000496A HUP0000496A2 HU P0000496 A2 HUP0000496 A2 HU P0000496A2 HU 0000496 A HU0000496 A HU 0000496A HU P0000496 A HUP0000496 A HU P0000496A HU P0000496 A2 HUP0000496 A2 HU P0000496A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- amino
- ring
- nitro
- carboxyl
- Prior art date
Links
- 150000003936 benzamides Chemical class 0.000 title abstract 2
- 229940054066 benzamide antipsychotics Drugs 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- -1 nitro- Chemical group 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002934 lysing effect Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát heterőciklűsős csőpőrttal szűbsztitűált (I)általánős képletű benzamidszármazékők - ahől R1 hidrőgénatőm, alkil-,alkőxi-, hidrőxicsőpőrt, halőgénatőm, triflűőr-metil-, nitrő-, aminő-,cianő-, karbőxil-, alkőxi-karbőnil-csőpőrt, mőnőszűbsztitűáltsavamid-, szűbsztitűált szűlfőn-aminő- vagy szűlfőncsőpőrt, R2hidrőgénatőm, alkil-, alkőxi-, hidrőxicsőpőrt, halőgénatőm, triflűőr-metil-, nitrő-, aminő-, cianő-, karbőxil-, alkőxi-karbőnil-csőpőrt,mőnőszűbsztitűált savamid-, szűbsztitűált szűlfőn-aminő- vagyszűlfőncsőpőrt, vagy R1 és R2 együttesen adőtt esetben szűbsztitűált -CH=CH-CH=CH- képletű lánc, R3 hidrőgén-, halőgénatőm, alkil-, fenil-,-NHCO-alkil-csőpőrt, nitrő- vagy aminőcsőpőrt, R4 adőtt esetbenszűbsztitűált alkilcsőpőrt, R5 hidrőgénatőm, észter- vagy savamid-csőpőrt X jelentése -NH-CO-, -NH=CH-, etilén-, -CH=CH-, -SO2-,metilén-, őxő- és -CH2-CO- csőpőrt, n = 0, 1 vagy 2, és m = értéke 0,1 és 2 - és taűtőmereik, izőmereik, valamint sóik és ezeket tartalmazógyógyszerkészítmények képezik. Az (I) általánős képletű vegyületek acisztein prőteázők inhibitőrai. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19650975A DE19650975A1 (de) | 1996-12-09 | 1996-12-09 | Neue heterocyclisch substituierte Benzamide und deren Anwendung |
| PCT/EP1997/006653 WO1998025899A1 (de) | 1996-12-09 | 1997-11-28 | Neue heterocyclisch substituierte benzamide und deren anwendung bei der bekämpfung von krankheiten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000496A2 true HUP0000496A2 (hu) | 2000-09-28 |
| HUP0000496A3 HUP0000496A3 (en) | 2002-11-28 |
Family
ID=7814035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000496A HUP0000496A3 (en) | 1996-12-09 | 1997-11-28 | Heterocyclically substituted benzamides and their use in fighting diseases |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6172072B1 (hu) |
| EP (1) | EP0946509A1 (hu) |
| JP (1) | JP2001505889A (hu) |
| KR (1) | KR20000057445A (hu) |
| CN (1) | CN1239949A (hu) |
| AR (1) | AR010339A1 (hu) |
| AU (1) | AU742732B2 (hu) |
| BG (1) | BG63388B1 (hu) |
| BR (1) | BR9713884A (hu) |
| CA (1) | CA2273988A1 (hu) |
| CO (1) | CO4910161A1 (hu) |
| CZ (1) | CZ292391B6 (hu) |
| DE (1) | DE19650975A1 (hu) |
| HR (1) | HRP970671A2 (hu) |
| HU (1) | HUP0000496A3 (hu) |
| ID (1) | ID22490A (hu) |
| IL (1) | IL129358A0 (hu) |
| NO (1) | NO992770D0 (hu) |
| NZ (1) | NZ335066A (hu) |
| SK (1) | SK56699A3 (hu) |
| TR (1) | TR199901282T2 (hu) |
| TW (1) | TW420666B (hu) |
| WO (1) | WO1998025899A1 (hu) |
| ZA (1) | ZA9710979B (hu) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3818799A (en) * | 1998-04-20 | 1999-11-08 | Basf Aktiengesellschaft | Novel heterocyclically substituted amides with cysteine protease-inhibiting effect |
| FR2800737B1 (fr) * | 1999-11-05 | 2006-06-30 | Sod Conseils Rech Applic | Nouveaux composes heterocycliques et leur application a titre de medicaments |
| PL200167B1 (pl) * | 1999-11-05 | 2008-12-31 | Sod Conseils Rech Applic | Związki heterocykliczne o aktywności hamowania kalpain i/lub pułapkowania ROS, ich zastosowanie i kompozycje farmaceutyczne je zawierające oraz związki pośrednie |
| GB0031302D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
| KR100962972B1 (ko) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
| CA2505098A1 (en) | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| CA2536313A1 (en) * | 2003-08-22 | 2005-03-03 | Takeda Pharmaceutical Company Limited | Fused pyrimidine derivative and use thereof |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| FR2863268B1 (fr) * | 2003-12-09 | 2006-02-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments |
| BRPI0418026A (pt) * | 2003-12-22 | 2007-04-17 | Ajinomoto Kk | derivados de fenilalanina ou sais farmaceuticamente aceitáveis destes, composição farmacêutica, antagonista de alfa4 integrina, e, agente terapêutico ou agente preventivo para doenças |
| GB0416730D0 (en) | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| US20070010537A1 (en) * | 2004-08-20 | 2007-01-11 | Kazumasa Hamamura | Fused pyramidine derivative and use thereof |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US7834023B2 (en) * | 2006-09-20 | 2010-11-16 | Portola Pharmaceuticals, Inc. | Substituted dihydroquinazolines as platelet ADP receptor inhibitors |
| JP5295976B2 (ja) | 2006-12-29 | 2013-09-18 | アボット ゲーエムベーハー ウント カンパニー カーゲー | カルボキサミド化合物およびカルパイン阻害剤としてのこれらの使用 |
| ES2576643T3 (es) | 2007-03-09 | 2016-07-08 | Second Genome, Inc. | Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos |
| TWI453019B (zh) | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
| TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| CN102939126B (zh) | 2010-04-30 | 2015-09-16 | 雅培心脏血管系统股份有限公司 | 呈现迅速膨胀和收缩的改进型球囊导管 |
| WO2012076639A1 (en) | 2010-12-09 | 2012-06-14 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors v |
| RU2014144285A (ru) | 2012-04-03 | 2016-05-27 | Эббви Дойчланд Гмбх Унд Ко. Кг | Карбоксамидные соединения и их применение в качестве ингибиторов кальпаина v |
| EP3426674A4 (en) | 2016-03-09 | 2019-08-14 | Blade Therapeutics, Inc. | CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| CA3038331A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8524663D0 (en) * | 1985-10-07 | 1985-11-13 | Fujisawa Pharmaceutical Co | Quinazoline derivatives |
| DE3717828A1 (de) * | 1987-05-27 | 1988-12-15 | Hoechst Ag | Siliziumhaltige benzoesaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz |
| DE4000204A1 (de) | 1990-01-05 | 1991-07-11 | Steag Ag | Vorrichtung zum dosierten austragen von schuettfaehigem feststoff |
| EP0473551A1 (de) * | 1990-08-31 | 1992-03-04 | Ciba-Geigy Ag | 3-Aryluracil-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Unkrautbekämpfungsmittel |
| DE69113284T2 (de) | 1990-12-28 | 1996-02-22 | Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo | Chinolinderivat. |
| WO1992011850A2 (en) | 1990-12-28 | 1992-07-23 | Cortex Pharmaceuticals, Inc. | Use of calpain inhibitors in the inhibition and treatment of neurodegeneration |
| CA2071621C (en) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
| JPH09500087A (ja) | 1992-06-24 | 1997-01-07 | コーテックス ファーマシューティカルズ インコーポレイテッド | カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法 |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
-
1996
- 1996-12-09 DE DE19650975A patent/DE19650975A1/de not_active Withdrawn
-
1997
- 1997-11-28 CN CN97180437A patent/CN1239949A/zh active Pending
- 1997-11-28 CZ CZ19991743A patent/CZ292391B6/cs not_active IP Right Cessation
- 1997-11-28 WO PCT/EP1997/006653 patent/WO1998025899A1/de active IP Right Grant
- 1997-11-28 IL IL12935897A patent/IL129358A0/xx unknown
- 1997-11-28 KR KR1019990705071A patent/KR20000057445A/ko not_active Application Discontinuation
- 1997-11-28 HU HU0000496A patent/HUP0000496A3/hu unknown
- 1997-11-28 AU AU55580/98A patent/AU742732B2/en not_active Ceased
- 1997-11-28 NZ NZ335066A patent/NZ335066A/xx unknown
- 1997-11-28 CA CA002273988A patent/CA2273988A1/en not_active Abandoned
- 1997-11-28 SK SK566-99A patent/SK56699A3/sk unknown
- 1997-11-28 ID IDW990486D patent/ID22490A/id unknown
- 1997-11-28 JP JP52615598A patent/JP2001505889A/ja active Pending
- 1997-11-28 US US09/308,350 patent/US6172072B1/en not_active Expired - Fee Related
- 1997-11-28 BR BR9713884-3A patent/BR9713884A/pt not_active IP Right Cessation
- 1997-11-28 EP EP97952007A patent/EP0946509A1/de not_active Withdrawn
- 1997-11-28 TR TR1999/01282T patent/TR199901282T2/xx unknown
- 1997-12-08 ZA ZA9710979A patent/ZA9710979B/xx unknown
- 1997-12-08 HR HR19650975.0A patent/HRP970671A2/hr not_active Application Discontinuation
- 1997-12-08 TW TW086118462A patent/TW420666B/zh active
- 1997-12-09 AR ARP970105766A patent/AR010339A1/es not_active Application Discontinuation
- 1997-12-09 CO CO97071820A patent/CO4910161A1/es unknown
-
1999
- 1999-05-12 BG BG103399A patent/BG63388B1/bg unknown
- 1999-06-08 NO NO992770A patent/NO992770D0/no unknown
-
2000
- 2000-09-21 US US09/666,304 patent/US6436949B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CZ292391B6 (cs) | 2003-09-17 |
| HRP970671A2 (en) | 1998-10-31 |
| NO992770L (no) | 1999-06-08 |
| WO1998025899A1 (de) | 1998-06-18 |
| BR9713884A (pt) | 2000-02-29 |
| ZA9710979B (en) | 1999-06-18 |
| BG103399A (en) | 2000-01-31 |
| NO992770D0 (no) | 1999-06-08 |
| SK56699A3 (en) | 1999-10-08 |
| TR199901282T2 (xx) | 1999-10-21 |
| AU742732B2 (en) | 2002-01-10 |
| CO4910161A1 (es) | 2000-04-24 |
| HUP0000496A3 (en) | 2002-11-28 |
| EP0946509A1 (de) | 1999-10-06 |
| BG63388B1 (bg) | 2001-12-29 |
| KR20000057445A (ko) | 2000-09-15 |
| IL129358A0 (en) | 2000-02-17 |
| ID22490A (id) | 1999-10-21 |
| DE19650975A1 (de) | 1998-06-10 |
| CZ174399A3 (cs) | 1999-08-11 |
| CA2273988A1 (en) | 1998-06-18 |
| US6436949B1 (en) | 2002-08-20 |
| AR010339A1 (es) | 2000-06-07 |
| CN1239949A (zh) | 1999-12-29 |
| JP2001505889A (ja) | 2001-05-08 |
| NZ335066A (en) | 2000-03-27 |
| AU5558098A (en) | 1998-07-03 |
| US6172072B1 (en) | 2001-01-09 |
| TW420666B (en) | 2001-02-01 |
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