ATE156482T1 - 1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungen - Google Patents
1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungenInfo
- Publication number
- ATE156482T1 ATE156482T1 AT95901779T AT95901779T ATE156482T1 AT E156482 T1 ATE156482 T1 AT E156482T1 AT 95901779 T AT95901779 T AT 95901779T AT 95901779 T AT95901779 T AT 95901779T AT E156482 T1 ATE156482 T1 AT E156482T1
- Authority
- AT
- Austria
- Prior art keywords
- methyl
- triphenyl
- inflammatory
- hydrido
- trifluoromethyl
- Prior art date
Links
- GAAAZLAWPPVHHL-UHFFFAOYSA-N 1,4,5-triphenylpyrazole Chemical class C1=NN(C=2C=CC=CC=2)C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 GAAAZLAWPPVHHL-UHFFFAOYSA-N 0.000 title abstract 2
- 206010061218 Inflammation Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 230000004054 inflammatory process Effects 0.000 title abstract 2
- -1 hydrido, methyl Chemical group 0.000 abstract 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 2
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000006343 heptafluoro propyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/161,004 US5401765A (en) | 1993-11-30 | 1993-11-30 | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE156482T1 true ATE156482T1 (de) | 1997-08-15 |
Family
ID=22579400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95901779T ATE156482T1 (de) | 1993-11-30 | 1994-11-14 | 1,4,5-triphenyl-pyrazolverbindungen zur behandlumg von entzündungen und entzündungsverwandten störungen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5401765A (de) |
| EP (1) | EP0731794B1 (de) |
| JP (1) | JPH09505829A (de) |
| AT (1) | ATE156482T1 (de) |
| AU (1) | AU1088795A (de) |
| CA (1) | CA2177573A1 (de) |
| DE (1) | DE69404860T2 (de) |
| DK (1) | DK0731794T3 (de) |
| ES (1) | ES2105874T3 (de) |
| GR (1) | GR3024939T3 (de) |
| WO (1) | WO1995015317A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908852A (en) * | 1994-11-14 | 1999-06-01 | G. D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
| US5643933A (en) * | 1995-06-02 | 1997-07-01 | G. D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| CA2223154A1 (en) * | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US5756529A (en) * | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| BR9708574A (pt) | 1996-04-12 | 1999-08-03 | Searle & Co | Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2 |
| US6677364B2 (en) * | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US5677318A (en) * | 1996-07-11 | 1997-10-14 | Merck Frosst Canada, Inc. | Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents |
| US6174330B1 (en) * | 1997-08-01 | 2001-01-16 | Schneider (Usa) Inc | Bioabsorbable marker having radiopaque constituents |
| CA2327185A1 (en) * | 1998-04-08 | 1999-10-14 | Abbott Laboratories | Pyrazole inhibitors of cytokine production |
| US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| EP1206474B1 (de) * | 1999-08-27 | 2004-05-26 | Abbott Laboratories | Als cox-hemmer verwendbare sulfonylphenylpyrazol-verbindungen |
| EP1104759B1 (de) | 1999-12-03 | 2003-10-22 | Pfizer Products Inc. | Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| ES2200787T3 (es) | 1999-12-03 | 2004-03-16 | Pfizer Products Inc. | Derivados de acetileno como agentes antiinflamatorios/analgesicos. |
| AP2002002532A0 (en) | 1999-12-03 | 2002-06-30 | Pfizer Prod Inc | Heterocyclo-alkylsulfonyl pyrazole derivatives as ant-inflammatory/analgesic agents. |
| EP1104760B1 (de) | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| CO5261556A1 (es) * | 1999-12-08 | 2003-03-31 | Pharmacia Corp | Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico |
| JP2003531202A (ja) * | 2000-04-25 | 2003-10-21 | ファルマシア・コーポレーション | ３，４−ジ（カルボシクリルまたはヘテロシクリル）チオフェンの位置選択的合成 |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| CA2414674A1 (en) * | 2000-07-13 | 2002-01-24 | Pharmacia Corporation | Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| MY137736A (en) | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
| US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
| US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| DE60204823T2 (de) | 2001-07-05 | 2005-12-29 | Pfizer Products Inc., Groton | Heterocyclo-alkylsulfonyl Pyrazole als entzündungshemmende/analgetische Mittel |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| BR0212611A (pt) | 2001-09-19 | 2004-08-17 | Pharmacia Corp | Compostos de pirazolila substituìdos para o tratamento da inflamação |
| GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
| WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
| US7329401B2 (en) * | 2002-04-15 | 2008-02-12 | The Regents Of The University Of California | Cyclooxygenase-2 selective agents useful as imaging probes and related methods |
| WO2004002420A2 (en) | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
| ATE342722T1 (de) | 2003-05-07 | 2006-11-15 | Osteologix As | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
| US20060079566A1 (en) * | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
| SI1696907T1 (sl) * | 2003-10-03 | 2013-12-31 | The Ohio State University Research Foundation | Inhibitorji signaliziranja PDK-1/AKT |
| EP2114461A2 (de) * | 2007-01-19 | 2009-11-11 | Mallinckrodt Inc. | Diagnostische und therapeutische cyclooxygenase-2-bindende liganden |
| US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
| US20120108823A1 (en) | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
| EP3886854A4 (de) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrol- und pyrazolverbindungen und verfahren zu deren verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1373212A (en) * | 1970-12-07 | 1974-11-06 | Wyeth John & Brother Ltd | Pyrazole compounds |
| US3984431A (en) * | 1972-03-15 | 1976-10-05 | Claude Gueremy | Derivatives of pyrazole-5-acetic acid |
| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
-
1993
- 1993-11-30 US US08/161,004 patent/US5401765A/en not_active Expired - Fee Related
-
1994
- 1994-11-14 DE DE69404860T patent/DE69404860T2/de not_active Expired - Fee Related
- 1994-11-14 JP JP7515612A patent/JPH09505829A/ja not_active Ceased
- 1994-11-14 US US08/648,118 patent/US5639777A/en not_active Expired - Fee Related
- 1994-11-14 CA CA002177573A patent/CA2177573A1/en not_active Abandoned
- 1994-11-14 WO PCT/US1994/012721 patent/WO1995015317A1/en not_active Ceased
- 1994-11-14 AU AU10887/95A patent/AU1088795A/en not_active Abandoned
- 1994-11-14 AT AT95901779T patent/ATE156482T1/de not_active IP Right Cessation
- 1994-11-14 ES ES95901779T patent/ES2105874T3/es not_active Expired - Lifetime
- 1994-11-14 EP EP95901779A patent/EP0731794B1/de not_active Expired - Lifetime
- 1994-11-14 DK DK95901779.9T patent/DK0731794T3/da active
-
1997
- 1997-10-03 GR GR970402580T patent/GR3024939T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995015317A1 (en) | 1995-06-08 |
| EP0731794B1 (de) | 1997-08-06 |
| DK0731794T3 (da) | 1998-03-09 |
| CA2177573A1 (en) | 1995-06-08 |
| AU1088795A (en) | 1995-06-19 |
| US5401765A (en) | 1995-03-28 |
| DE69404860D1 (de) | 1997-09-11 |
| GR3024939T3 (en) | 1998-01-30 |
| EP0731794A1 (de) | 1996-09-18 |
| JPH09505829A (ja) | 1997-06-10 |
| ES2105874T3 (es) | 1997-10-16 |
| DE69404860T2 (de) | 1998-01-02 |
| US5639777A (en) | 1997-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |