ATE303357T1 - Amid-derivate - Google Patents
Amid-derivateInfo
- Publication number
- ATE303357T1 ATE303357T1 AT00909500T AT00909500T ATE303357T1 AT E303357 T1 ATE303357 T1 AT E303357T1 AT 00909500 T AT00909500 T AT 00909500T AT 00909500 T AT00909500 T AT 00909500T AT E303357 T1 ATE303357 T1 AT E303357T1
- Authority
- AT
- Austria
- Prior art keywords
- halogeno
- aryl
- group
- amide derivatives
- arylamino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9906277.0A GB9906277D0 (en) | 1999-03-17 | 1999-03-17 | Amide derivatives |
GB0002472A GB0002472D0 (en) | 2000-02-03 | 2000-02-03 | Amide derivatives |
PCT/GB2000/000914 WO2000055120A1 (en) | 1999-03-17 | 2000-03-13 | Amide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE303357T1 true ATE303357T1 (de) | 2005-09-15 |
Family
ID=26243557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00909500T ATE303357T1 (de) | 1999-03-17 | 2000-03-13 | Amid-derivate |
Country Status (23)
Country | Link |
---|---|
US (2) | US6548514B1 (de) |
EP (1) | EP1163212B1 (de) |
JP (1) | JP2002539187A (de) |
KR (1) | KR20010110668A (de) |
CN (1) | CN100352804C (de) |
AT (1) | ATE303357T1 (de) |
AU (1) | AU761291B2 (de) |
BR (1) | BR0009041A (de) |
CA (1) | CA2361819A1 (de) |
CZ (1) | CZ20013276A3 (de) |
DE (1) | DE60022328T2 (de) |
DK (1) | DK1163212T3 (de) |
ES (1) | ES2246830T3 (de) |
HK (1) | HK1041875A1 (de) |
HU (1) | HUP0105136A3 (de) |
IL (1) | IL145277A0 (de) |
NO (1) | NO20014488L (de) |
NZ (1) | NZ513726A (de) |
PL (1) | PL350448A1 (de) |
RU (1) | RU2284187C2 (de) |
SK (1) | SK13132001A3 (de) |
TR (1) | TR200102568T2 (de) |
WO (1) | WO2000055120A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
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US7772432B2 (en) | 1991-09-19 | 2010-08-10 | Astrazeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
DK1017378T3 (da) | 1997-09-23 | 2003-03-17 | Astrazeneca Ab | Amidderivater til behandling af sygdomme medieret af cytokiner |
ID26236A (id) | 1998-05-15 | 2000-12-07 | Astrazeneca Ab | Turunan benzamida untuk pengobatan penyakit yang diperantarai oleh sitokina |
US6465455B1 (en) | 1998-05-15 | 2002-10-15 | Astrazeneca Ab | Benzamide derivatives for the treatment of diseases mediated by cytokines |
EP1102750A1 (de) | 1998-08-04 | 2001-05-30 | AstraZeneca AB | Amid-derivate verwendbar als inhibitoren der cytokinproduktion |
DE69912823T2 (de) | 1998-09-25 | 2004-09-23 | Astrazeneca Ab | Benzamid-derivate und ihre verwendung als cytokine inhibitoren |
IL145357A0 (en) | 1999-03-17 | 2002-06-30 | Astrazeneca Ab | Amide derivatives |
GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
US6943161B2 (en) | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
KR100407640B1 (ko) * | 2000-12-19 | 2003-12-01 | 주식회사 태평양 | 신규한 디페닐 아미드 유도체, 그의 제조방법 및 이를포함하는 약학 및 화장료 조성물 |
JP2002338537A (ja) * | 2001-05-16 | 2002-11-27 | Mitsubishi Pharma Corp | アミド化合物およびその医薬用途 |
AU2002350172A1 (en) * | 2001-12-07 | 2003-06-23 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
DE60310730T2 (de) | 2002-07-09 | 2007-05-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
ES2397389T3 (es) * | 2003-07-30 | 2013-03-06 | Xenon Pharmaceuticals Inc. | Derivados de piridilo y su uso como agentes terapéuticos |
JP4895811B2 (ja) * | 2003-09-11 | 2012-03-14 | ケミア,インコーポレイテッド | サイトカイン阻害剤 |
GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
IN240644B (de) | 2004-01-28 | 2010-05-28 | Mitsui Chemicals Inc | |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
DE102005023834A1 (de) * | 2004-11-20 | 2006-05-24 | Bayer Healthcare Ag | Substituierte[(Phenylethanoyl)amino]benzamide |
TW200635899A (en) * | 2004-12-22 | 2006-10-16 | Astrazeneca Ab | Chemical compounds |
DE602005013819D1 (de) * | 2004-12-22 | 2009-05-20 | Astrazeneca Ab | Pyridincarbonsäureamidderivate zur verwendung als antikrebsmittel |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
DE602006016430D1 (de) * | 2005-05-03 | 2010-10-07 | Ranbaxy Lab Ltd | Phosphodiesteraseinhibitoren auf azolbasis |
MX295245B (es) | 2005-06-21 | 2012-01-26 | Mitsui Chemicals Inc | Derivado de amida e insecticida que contiene el mismo. |
WO2006137395A1 (ja) * | 2005-06-23 | 2006-12-28 | Mitsui Chemicals, Inc. | アミド誘導体、該化合物を含有する殺虫剤およびその使用方法 |
DE602006000082T2 (de) * | 2005-07-07 | 2008-05-15 | Rohm And Haas Co. | Faser mit antimikrobiell wirksamer Zusammensetzung |
JP4580836B2 (ja) * | 2005-07-25 | 2010-11-17 | 三井化学アグロ株式会社 | 殺虫殺菌組成物 |
CN101208009B (zh) * | 2005-07-27 | 2011-05-25 | 三井化学株式会社 | 有害生物防除组合物 |
US7754717B2 (en) * | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
AU2007240568A1 (en) * | 2006-04-21 | 2007-11-01 | Amgen Inc. | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use |
CA2656507C (en) * | 2006-07-17 | 2012-03-20 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
AU2007293065B2 (en) * | 2006-09-05 | 2011-08-18 | Amgen Inc. | Phthalazine, AZA- and diaza-phthalazine compounds and methods of use |
EP2069287A1 (de) | 2006-09-11 | 2009-06-17 | Syngeta Participations AG | Insektizidverbindungen |
CA2665195C (en) * | 2006-10-11 | 2011-08-09 | Amgen Inc. | Imidazo- and triazolo-pyridine compounds and methods of use thereof |
US7935696B2 (en) | 2006-10-27 | 2011-05-03 | Bristol-Myers Squibb Company | Heterocyclic amide compounds useful as kinase inhibitors |
US8022085B2 (en) | 2007-05-07 | 2011-09-20 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof |
EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
WO2009038784A1 (en) * | 2007-09-21 | 2009-03-26 | Amgen Inc. | Triazole fused heteroaryl compounds as p38 kinase inhibitors |
WO2010025202A1 (en) | 2008-08-29 | 2010-03-04 | Amgen Inc. | PYRIDO[3,2-d]PYRIDAZINE-2(1H)-ONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF |
EP2334674B1 (de) | 2008-08-29 | 2012-06-06 | Amgen, Inc | Pyridazinopyridinonverbindungen zur Behandlung von durch Proteinkinase vermittelten Krankheiten |
WO2010042649A2 (en) | 2008-10-10 | 2010-04-15 | Amgen Inc. | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF |
WO2010042646A1 (en) | 2008-10-10 | 2010-04-15 | Amgen Inc. | Aza- and diaza-phthalazine compounds as p38 map kinase modulators and methods of use thereof |
GB0902648D0 (en) * | 2009-02-17 | 2009-04-01 | Argenta Discovery Ltd | Pharmaceutical compounds and compositions |
US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
JP2016521259A (ja) | 2013-03-20 | 2016-07-21 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換N−ビフェニル−3−アセチルアミノ−ベンズアミドおよびN−[3−(アセチルアミノ)フェニル]−ビフェニル−カルボキサミドならびにWntシグナル伝達経路の阻害剤としてのそれらの使用 |
MX2015013348A (es) | 2013-03-20 | 2016-01-20 | Bayer Pharma AG | Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos. |
ME03398B (de) * | 2013-12-17 | 2020-01-20 | Lilly Co Eli | Dimethylbenzoesäureverbindungen |
CN106458983A (zh) * | 2014-03-20 | 2017-02-22 | 拜耳制药股份公司 | 新型化合物 |
EP3119787A1 (de) * | 2014-03-20 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Inhibitoren der wnt-signalwege |
US9688637B2 (en) | 2014-08-21 | 2017-06-27 | Northwestern Universtiy | 3-amidobenzamides and uses thereof for increasing cellular levels of A3G and other A3 family members |
CA2976971A1 (en) | 2015-02-20 | 2016-08-25 | Bayer Pharma Aktiengesellschaft | 3-carbamoylphenyl-4-carboxamide and isophtalamide derivatives as inhibitors of the wnt signalling pathway |
WO2016131810A1 (en) | 2015-02-20 | 2016-08-25 | Bayer Pharma Aktiengesellschaft | N-phenyl-(morpholin-4-yl or piperazinyl)acetamide derivatives and their use as inhibitors of the wnt signalling pathways |
US20180044306A1 (en) | 2015-02-20 | 2018-02-15 | Bayer Pharma Aktiengesellschaft | 1,3,4-thiadiazol-2-yl-benzamide derivatives as inhibitors of the wnt signalling pathway |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
EP3757102A1 (de) | 2016-03-17 | 2020-12-30 | F. Hoffmann-La Roche AG | 5-ethyl-4-methyl-pyrazole-3-carboxamid-derivat mit wirkung als taar agonist |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
Family Cites Families (19)
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DE522788C (de) * | 1928-11-01 | 1931-04-15 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Carbonsaeurearyliden der Benzolreihe |
NL129433C (de) * | 1963-09-21 | |||
GB9413975D0 (en) * | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
CA2020887A1 (en) * | 1989-07-28 | 1991-01-29 | Michael Klaus | Aromatic carboxylic amides |
GB9816837D0 (en) * | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
GB9307956D0 (en) * | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体拮抗剤 |
KR100284382B1 (ko) * | 1995-08-22 | 2001-03-02 | 미즈노 마사루 | 아미드화합물 및 그의 용도 |
JPH09124571A (ja) * | 1995-11-01 | 1997-05-13 | Japan Tobacco Inc | アミド化合物及びその用途 |
GB9623833D0 (en) * | 1996-11-16 | 1997-01-08 | Zeneca Ltd | Chemical compound |
DK1017378T3 (da) * | 1997-09-23 | 2003-03-17 | Astrazeneca Ab | Amidderivater til behandling af sygdomme medieret af cytokiner |
ID26236A (id) | 1998-05-15 | 2000-12-07 | Astrazeneca Ab | Turunan benzamida untuk pengobatan penyakit yang diperantarai oleh sitokina |
US6465455B1 (en) * | 1998-05-15 | 2002-10-15 | Astrazeneca Ab | Benzamide derivatives for the treatment of diseases mediated by cytokines |
EP1102750A1 (de) * | 1998-08-04 | 2001-05-30 | AstraZeneca AB | Amid-derivate verwendbar als inhibitoren der cytokinproduktion |
DE69912823T2 (de) * | 1998-09-25 | 2004-09-23 | Astrazeneca Ab | Benzamid-derivate und ihre verwendung als cytokine inhibitoren |
ATE232205T1 (de) | 1998-10-01 | 2003-02-15 | Astrazeneca Ab | Chinolin- und chinazolin derivate und ihre verwendung als inhibitoren von krankheiten, bei denen cytokine beteiligt wird |
IL145357A0 (en) | 1999-03-17 | 2002-06-30 | Astrazeneca Ab | Amide derivatives |
GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
-
2000
- 2000-03-13 IL IL14527700A patent/IL145277A0/xx unknown
- 2000-03-13 CA CA002361819A patent/CA2361819A1/en not_active Abandoned
- 2000-03-13 KR KR1020017011738A patent/KR20010110668A/ko not_active Application Discontinuation
- 2000-03-13 HU HU0105136A patent/HUP0105136A3/hu unknown
- 2000-03-13 EP EP00909500A patent/EP1163212B1/de not_active Expired - Lifetime
- 2000-03-13 DE DE60022328T patent/DE60022328T2/de not_active Expired - Fee Related
- 2000-03-13 DK DK00909500T patent/DK1163212T3/da active
- 2000-03-13 AT AT00909500T patent/ATE303357T1/de not_active IP Right Cessation
- 2000-03-13 CZ CZ20013276A patent/CZ20013276A3/cs unknown
- 2000-03-13 RU RU2001128067/04A patent/RU2284187C2/ru not_active IP Right Cessation
- 2000-03-13 NZ NZ513726A patent/NZ513726A/en unknown
- 2000-03-13 BR BR0009041-7A patent/BR0009041A/pt not_active IP Right Cessation
- 2000-03-13 WO PCT/GB2000/000914 patent/WO2000055120A1/en active Search and Examination
- 2000-03-13 AU AU31780/00A patent/AU761291B2/en not_active Ceased
- 2000-03-13 CN CNB008051283A patent/CN100352804C/zh not_active Expired - Fee Related
- 2000-03-13 US US09/936,698 patent/US6548514B1/en not_active Expired - Fee Related
- 2000-03-13 JP JP2000605551A patent/JP2002539187A/ja active Pending
- 2000-03-13 TR TR2001/02568T patent/TR200102568T2/xx unknown
- 2000-03-13 SK SK1313-2001A patent/SK13132001A3/sk unknown
- 2000-03-13 PL PL00350448A patent/PL350448A1/xx not_active Application Discontinuation
- 2000-03-13 ES ES00909500T patent/ES2246830T3/es not_active Expired - Lifetime
-
2001
- 2001-09-14 NO NO20014488A patent/NO20014488L/no not_active Application Discontinuation
-
2002
- 2002-05-21 HK HK02103784A patent/HK1041875A1/xx not_active IP Right Cessation
-
2003
- 2003-01-29 US US10/353,127 patent/US6794380B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
BR0009041A (pt) | 2001-12-26 |
EP1163212B1 (de) | 2005-08-31 |
HK1041875A1 (en) | 2002-07-26 |
US6794380B2 (en) | 2004-09-21 |
CN100352804C (zh) | 2007-12-05 |
DE60022328D1 (de) | 2005-10-06 |
CA2361819A1 (en) | 2000-09-21 |
NO20014488L (no) | 2001-11-14 |
PL350448A1 (en) | 2002-12-16 |
HUP0105136A2 (hu) | 2002-04-29 |
SK13132001A3 (sk) | 2002-02-05 |
JP2002539187A (ja) | 2002-11-19 |
IL145277A0 (en) | 2002-06-30 |
DK1163212T3 (da) | 2005-11-14 |
AU3178000A (en) | 2000-10-04 |
NZ513726A (en) | 2001-09-28 |
RU2001128067A (ru) | 2004-01-20 |
US6548514B1 (en) | 2003-04-15 |
HUP0105136A3 (en) | 2002-05-28 |
KR20010110668A (ko) | 2001-12-13 |
RU2284187C2 (ru) | 2006-09-27 |
TR200102568T2 (tr) | 2002-05-21 |
US20030186966A1 (en) | 2003-10-02 |
CZ20013276A3 (cs) | 2001-12-12 |
DE60022328T2 (de) | 2006-06-01 |
CN1344249A (zh) | 2002-04-10 |
EP1163212A1 (de) | 2001-12-19 |
AU761291B2 (en) | 2003-05-29 |
NO20014488D0 (no) | 2001-09-14 |
ES2246830T3 (es) | 2006-03-01 |
WO2000055120A1 (en) | 2000-09-21 |
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