SK542003A3 - Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use - Google Patents

Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use Download PDF

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Publication number
SK542003A3
SK542003A3 SK54-2003A SK542003A SK542003A3 SK 542003 A3 SK542003 A3 SK 542003A3 SK 542003 A SK542003 A SK 542003A SK 542003 A3 SK542003 A3 SK 542003A3
Authority
SK
Slovakia
Prior art keywords
compound
vegf
group
pharmaceutical compositions
receptor
Prior art date
Application number
SK54-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Gerhard Siemeister
Martin Haberey
Karl-Heinz Thierauch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00250194A external-priority patent/EP1166798A1/de
Priority claimed from EP00250214A external-priority patent/EP1166799A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of SK542003A3 publication Critical patent/SK542003A3/sk

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK54-2003A 2000-06-23 2001-06-20 Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use SK542003A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00250194A EP1166798A1 (de) 2000-06-23 2000-06-23 Zusammensetzungen die interferieren mit VEGF/VEGF und Angiopoietin/Tie Rezeptor-Funktionen
EP00250214A EP1166799A1 (de) 2000-06-28 2000-06-28 Zusammensetzungen die interferieren mit VEGF/VEGF und Angiopoietin/Tie Rezeptor-Funktionen
PCT/EP2001/006976 WO2001097850A2 (en) 2000-06-23 2001-06-20 Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii)

Publications (1)

Publication Number Publication Date
SK542003A3 true SK542003A3 (en) 2003-09-11

Family

ID=26072945

Family Applications (1)

Application Number Title Priority Date Filing Date
SK54-2003A SK542003A3 (en) 2000-06-23 2001-06-20 Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use

Country Status (29)

Country Link
US (2) US20030055006A1 (de)
EP (2) EP1292335B1 (de)
JP (1) JP2003535910A (de)
KR (2) KR20080068151A (de)
CN (1) CN1479629A (de)
AT (1) ATE363291T1 (de)
AU (1) AU784231B2 (de)
BG (1) BG107396A (de)
BR (1) BR0111861A (de)
CA (1) CA2411236A1 (de)
CY (1) CY1107717T1 (de)
CZ (1) CZ2003187A3 (de)
DE (1) DE60128685T2 (de)
DK (1) DK1292335T3 (de)
EE (1) EE200200706A (de)
ES (1) ES2287152T3 (de)
HR (1) HRP20030041A2 (de)
HU (1) HUP0302779A3 (de)
IL (1) IL152794A0 (de)
ME (1) MEP13708A (de)
MX (1) MXPA02011897A (de)
NO (1) NO20026152L (de)
NZ (1) NZ536196A (de)
PL (1) PL359653A1 (de)
PT (1) PT1292335E (de)
RS (1) RS50249B (de)
RU (1) RU2292221C2 (de)
SK (1) SK542003A3 (de)
WO (1) WO2001097850A2 (de)

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Also Published As

Publication number Publication date
CN1479629A (zh) 2004-03-03
CY1107717T1 (el) 2013-04-18
PT1292335E (pt) 2007-08-13
RS50249B (sr) 2009-07-15
WO2001097850A2 (en) 2001-12-27
PL359653A1 (en) 2004-08-23
US20040147449A1 (en) 2004-07-29
DK1292335T3 (da) 2007-09-17
MEP13708A (en) 2010-06-10
EE200200706A (et) 2004-06-15
NO20026152L (no) 2003-02-21
EP1292335B1 (de) 2007-05-30
KR20080068151A (ko) 2008-07-22
HRP20030041A2 (en) 2005-02-28
RU2292221C2 (ru) 2007-01-27
JP2003535910A (ja) 2003-12-02
EP1586333A2 (de) 2005-10-19
WO2001097850A3 (en) 2002-12-12
MXPA02011897A (es) 2003-04-22
BG107396A (bg) 2003-07-31
KR20030036238A (ko) 2003-05-09
BR0111861A (pt) 2003-12-23
IL152794A0 (en) 2003-06-24
US20030055006A1 (en) 2003-03-20
EP1292335A2 (de) 2003-03-19
AU8576601A (en) 2002-01-02
AU784231B2 (en) 2006-02-23
CA2411236A1 (en) 2001-12-27
DE60128685T2 (de) 2009-03-05
YU97202A (sh) 2006-01-16
DE60128685D1 (de) 2007-07-12
ATE363291T1 (de) 2007-06-15
NZ536196A (en) 2006-12-22
ES2287152T3 (es) 2007-12-16
NO20026152D0 (no) 2002-12-20
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HUP0302779A2 (hu) 2003-12-29
CZ2003187A3 (cs) 2003-06-18

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