SK51398A3 - Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use - Google Patents
Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use Download PDFInfo
- Publication number
- SK51398A3 SK51398A3 SK513-98A SK51398A SK51398A3 SK 51398 A3 SK51398 A3 SK 51398A3 SK 51398 A SK51398 A SK 51398A SK 51398 A3 SK51398 A3 SK 51398A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ethyl
- amino
- carbonyl
- phenylmethyloxy
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Fodder In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590095P | 1995-10-27 | 1995-10-27 | |
| GBGB9603361.8A GB9603361D0 (en) | 1996-02-16 | 1996-02-16 | Polymorphic forms of a growth hormone secretagogue |
| PCT/US1996/016955 WO1997015574A1 (en) | 1995-10-27 | 1996-10-23 | Polymorphic forms of a growth hormone secretagogue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK51398A3 true SK51398A3 (en) | 1998-12-02 |
Family
ID=26308741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK513-98A SK51398A3 (en) | 1995-10-27 | 1996-10-23 | Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1019402A1 (no) |
| JP (1) | JP3204266B2 (no) |
| KR (1) | KR19990067098A (no) |
| CN (1) | CN1067687C (no) |
| AU (1) | AU707946B2 (no) |
| BG (1) | BG102476A (no) |
| BR (1) | BR9611229A (no) |
| CA (1) | CA2235371A1 (no) |
| CO (1) | CO4770956A1 (no) |
| CZ (1) | CZ128098A3 (no) |
| EA (1) | EA000528B1 (no) |
| EE (1) | EE9800147A (no) |
| HK (1) | HK1017894A1 (no) |
| HU (1) | HUP9902208A3 (no) |
| IS (1) | IS4721A (no) |
| NO (1) | NO310556B1 (no) |
| NZ (1) | NZ321370A (no) |
| PL (1) | PL327511A1 (no) |
| SK (1) | SK51398A3 (no) |
| TR (1) | TR199800726T2 (no) |
| WO (1) | WO1997015574A1 (no) |
| YU (1) | YU56696A (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046333A (en) * | 1996-10-25 | 2000-04-04 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ151495A3 (en) * | 1992-12-11 | 1995-12-13 | Merck & Co Inc | Spiropiperidine derivatives, process of their preparation and a pharmaceutical composition containing thereof |
-
1996
- 1996-10-23 AU AU74686/96A patent/AU707946B2/en not_active Expired
- 1996-10-23 NZ NZ321370A patent/NZ321370A/xx not_active IP Right Cessation
- 1996-10-23 KR KR1019980703038A patent/KR19990067098A/ko not_active Application Discontinuation
- 1996-10-23 EP EP96936869A patent/EP1019402A1/en not_active Withdrawn
- 1996-10-23 CZ CZ981280A patent/CZ128098A3/cs unknown
- 1996-10-23 EA EA199800335A patent/EA000528B1/ru not_active IP Right Cessation
- 1996-10-23 HU HU9902208A patent/HUP9902208A3/hu unknown
- 1996-10-23 TR TR1998/00726T patent/TR199800726T2/xx unknown
- 1996-10-23 CN CN96199328A patent/CN1067687C/zh not_active Expired - Lifetime
- 1996-10-23 PL PL96327511A patent/PL327511A1/xx unknown
- 1996-10-23 BR BR9611229A patent/BR9611229A/pt not_active IP Right Cessation
- 1996-10-23 EE EE9800147A patent/EE9800147A/xx unknown
- 1996-10-23 CA CA002235371A patent/CA2235371A1/en not_active Abandoned
- 1996-10-23 WO PCT/US1996/016955 patent/WO1997015574A1/en not_active Application Discontinuation
- 1996-10-23 SK SK513-98A patent/SK51398A3/sk unknown
- 1996-10-23 JP JP51673797A patent/JP3204266B2/ja not_active Expired - Lifetime
- 1996-10-25 YU YU56696A patent/YU56696A/sh unknown
- 1996-10-25 CO CO96056663A patent/CO4770956A1/es unknown
-
1998
- 1998-04-21 IS IS4721A patent/IS4721A/is unknown
- 1998-04-24 NO NO19981867A patent/NO310556B1/no not_active IP Right Cessation
- 1998-05-21 BG BG102476A patent/BG102476A/xx unknown
-
1999
- 1999-07-12 HK HK99102961A patent/HK1017894A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ128098A3 (cs) | 1998-09-16 |
| EA000528B1 (ru) | 1999-10-28 |
| JP3204266B2 (ja) | 2001-09-04 |
| JPH10512295A (ja) | 1998-11-24 |
| CO4770956A1 (es) | 1999-04-30 |
| EP1019402A1 (en) | 2000-07-19 |
| YU56696A (sh) | 1999-09-27 |
| CN1205703A (zh) | 1999-01-20 |
| NO981867D0 (no) | 1998-04-24 |
| NO310556B1 (no) | 2001-07-23 |
| MX9803351A (es) | 1998-09-30 |
| AU7468696A (en) | 1997-05-15 |
| CN1067687C (zh) | 2001-06-27 |
| WO1997015574A1 (en) | 1997-05-01 |
| EE9800147A (et) | 1998-12-15 |
| KR19990067098A (ko) | 1999-08-16 |
| NZ321370A (en) | 1999-11-29 |
| CA2235371A1 (en) | 1997-05-01 |
| EA199800335A1 (ru) | 1998-12-24 |
| BG102476A (en) | 1999-04-30 |
| BR9611229A (pt) | 1999-05-25 |
| HUP9902208A3 (en) | 2001-05-28 |
| NO981867L (no) | 1998-06-29 |
| AU707946B2 (en) | 1999-07-22 |
| PL327511A1 (en) | 1998-12-21 |
| HK1017894A1 (en) | 1999-12-03 |
| TR199800726T2 (xx) | 1998-08-21 |
| HUP9902208A2 (hu) | 1999-10-28 |
| IS4721A (is) | 1998-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5767124A (en) | Polymorphic forms of a growth hormone secretagogue | |
| DE69332075T2 (de) | Spiropiperidine and ihre Homologen, die die Ausschüttung von Wachstumshormonen stimulieren | |
| TWI221153B (en) | Tartrate salt of a substituted dipeptide | |
| WO1995003289A1 (en) | Benzo-fused lactams promote release of growth hormone | |
| JP4932132B2 (ja) | 成長ホルモン分泌促進薬 | |
| CZ293423B6 (cs) | Heterocyklické dipeptidové sloučeniny, jejich použití a farmaceutické kompozice na jejich bázi a meziprodukty | |
| JPH09502961A (ja) | 成長ホルモンの放出を促進するベンゾ−縮合ラクタム | |
| WO1995034311A1 (en) | Piperazine compounds promote release of growth hormone | |
| WO1996002530A1 (en) | Piperidines and hexahydro-1h-azepines spiro substituted at the 4-position promote release of growth hormone | |
| JPH10506914A (ja) | ４−複素環式ピペリジンは成長ホルモンの放出を促進する | |
| AU2001266066A1 (en) | Growth hormone secretagogues | |
| JP2509147B2 (ja) | 成長ホルモンの放出を亢進させるスピロピペリジン及び同族体 | |
| KR20020015987A (ko) | 성장 호르몬 분비촉진제로서의 신규 아미드 유도체 | |
| GB2297972A (en) | Camphor compounds promote release of growth hormone | |
| JP4679778B2 (ja) | アミドスピロピペリジン類による成長ホルモン放出の促進 | |
| US6211174B1 (en) | Naphtho-fused lactams promote release of growth hormone | |
| SK51398A3 (en) | Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use | |
| MXPA98003351A (en) | ot. POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE | |
| BRPI9611229B1 (pt) | Polymorphic form of the compound of N- [1 (R) - [(1,2-dihydro-1-methanesulfonyl-spiro [3 H -indol-3,4'-piperdin] -1'-yl) carbonyl] -2- - (phenylmethyl oxy) ethyl] -2-amino-2-methylpropanamide and pharmaceutical composition | |
| CZ20003152A3 (cs) | Soli N-methyi-N-((lR)-l-(N-methyl-N-((lR)-l- (methylkarbamoyl)-2-fenylethyl)karbamoyl)-2 (2-naftyl)ethyl)amidu (2E)-5-amino-5-methylhex- 2-enové kyseliny |