SK43197A3 - Method of treating diabetes mellitus using kgf - Google Patents

Method of treating diabetes mellitus using kgf Download PDF

Info

Publication number
SK43197A3
SK43197A3 SK431-97A SK43197A SK43197A3 SK 43197 A3 SK43197 A3 SK 43197A3 SK 43197 A SK43197 A SK 43197A SK 43197 A3 SK43197 A3 SK 43197A3
Authority
SK
Slovakia
Prior art keywords
kgf
rats
quot
diabetes
day
Prior art date
Application number
SK431-97A
Other languages
English (en)
Slovak (sk)
Inventor
Sharon L Aukerman
Glenn F Pierce
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SK43197A3 publication Critical patent/SK43197A3/sk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SK431-97A 1994-10-13 1995-10-12 Method of treating diabetes mellitus using kgf SK43197A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32347594A 1994-10-13 1994-10-13
US32334094A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/IB1995/000992 WO1996011950A1 (en) 1994-10-13 1995-10-12 Method of treating diabetes mellitus using kgf

Publications (1)

Publication Number Publication Date
SK43197A3 true SK43197A3 (en) 1999-03-12

Family

ID=27406268

Family Applications (2)

Application Number Title Priority Date Filing Date
SK431-97A SK43197A3 (en) 1994-10-13 1995-10-12 Method of treating diabetes mellitus using kgf
SK455-97A SK284534B6 (sk) 1994-10-13 1995-10-12 Polypeptidový analóg natívneho keratinocytového rastového faktora, spôsob jeho výroby a použitie, farmaceutický prostriedok a kit, nukleová kyselina, vektor a hostiteľská bunka

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK455-97A SK284534B6 (sk) 1994-10-13 1995-10-12 Polypeptidový analóg natívneho keratinocytového rastového faktora, spôsob jeho výroby a použitie, farmaceutický prostriedok a kit, nukleová kyselina, vektor a hostiteľská bunka

Country Status (23)

Country Link
EP (2) EP0785948B1 (da)
JP (2) JP4426646B2 (da)
KR (1) KR100278597B1 (da)
CN (1) CN1168678A (da)
AT (2) ATE237633T1 (da)
AU (1) AU3707795A (da)
BG (2) BG101392A (da)
BR (2) BR9509329A (da)
CA (2) CA2202075C (da)
CZ (3) CZ98197A3 (da)
DE (2) DE69530403T2 (da)
DK (2) DK0785948T3 (da)
EE (2) EE03975B1 (da)
ES (2) ES2273338T3 (da)
FI (2) FI971420A0 (da)
HU (2) HUT78050A (da)
NO (2) NO318761B1 (da)
NZ (2) NZ505502A (da)
PL (2) PL182888B1 (da)
PT (2) PT804479E (da)
SI (2) SI0785948T1 (da)
SK (2) SK43197A3 (da)
WO (2) WO1996011950A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20022681B (en) 1989-01-31 2002-04-25 Aaronson Us Stuart A Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
ES2227527T3 (es) 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
DK0785949T3 (da) * 1994-10-13 2003-08-18 Amgen Inc Fremgangsmåde til oprensning af keratinocytvækstfaktorer
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
AU5410196A (en) * 1995-04-27 1996-11-18 Cooperatie Suiker Unie U.A. Inulin derivatives
EP0935652B1 (en) * 1996-10-15 2004-03-31 Amgen Inc. Keratinocyte growth factor-2 products
SI0935652T1 (en) * 1996-10-15 2004-06-30 Amgen Inc. Keratinocyte growth factor-2 products
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
CA2296770A1 (en) 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
EP1041996A4 (en) 1997-12-22 2003-05-14 Human Genome Sciences Inc KERATINOCYTE GROWTH FACTOR-2 FORMULATIONS
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
BR122013003013B8 (pt) * 1999-01-14 2021-07-06 Bolder Biotechnology Inc proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
EP1360201A1 (en) * 2001-02-06 2003-11-12 MERCK PATENT GmbH Modified keratinocyte growth factor (kgf) with reduced immunogenicity
CA2457781A1 (en) 2001-08-21 2003-02-27 Chiron Corporation Kgf polypeptide compositions
AU2007214362B2 (en) * 2001-08-21 2009-11-26 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
WO2006065861A2 (en) 2004-12-15 2006-06-22 Amgen Inc Therapeutic formulations of keratinocyte growth factor
CN102242124B (zh) * 2010-05-10 2013-05-22 齐鲁制药有限公司 改造的角化细胞生长因子基因及其在酵母中的表达
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH01137994A (ja) * 1987-08-10 1989-05-30 Shionogi & Co Ltd reg蛋白質
WO1990000877A1 (en) * 1988-07-27 1990-02-08 Marjan International Pty Ltd Carpet stretcher
GEP20022681B (en) * 1989-01-31 2002-04-25 Aaronson Us Stuart A Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 bFGFムテインおよびその製造法
KR100390340B1 (ko) * 1993-03-26 2003-09-26 암겐 인코포레이티드 케라티노사이트성장인자산물을함유하는제약학적조성물
ES2227527T3 (es) * 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
US5348563A (en) * 1993-06-29 1994-09-20 Honeywell Inc. Air purifying apparatus
GB9315501D0 (en) * 1993-07-27 1993-09-08 Ici Plc Surfactant compositions
AU7475694A (en) * 1993-08-02 1995-02-28 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates

Also Published As

Publication number Publication date
CZ105097A3 (cs) 1998-10-14
KR100278597B1 (ko) 2001-01-15
AU3707795A (en) 1996-05-06
DK0804479T3 (da) 2007-01-29
SK284534B6 (sk) 2005-06-02
EP0804479A1 (en) 1997-11-05
ATE342278T1 (de) 2006-11-15
WO1996011949A2 (en) 1996-04-25
BG101408A (en) 1997-12-30
HUT78050A (hu) 1999-07-28
JPH10507193A (ja) 1998-07-14
ATE237633T1 (de) 2003-05-15
BR9509269A (pt) 1997-12-23
BG63167B1 (bg) 2001-05-31
ES2273338T3 (es) 2007-05-01
CA2201940C (en) 2009-05-12
JP4426646B2 (ja) 2010-03-03
SK45597A3 (en) 1999-02-11
EP0785948A1 (en) 1997-07-30
FI971420A (fi) 1997-04-04
SI0804479T1 (sl) 2006-12-31
EE03975B1 (et) 2003-02-17
CA2202075C (en) 2003-12-09
DE69530403T2 (de) 2003-10-30
NO971566D0 (no) 1997-04-04
CZ297328B6 (cs) 2006-11-15
NZ335109A (en) 2000-08-25
BR9509329A (pt) 1997-10-14
FI971536A (fi) 1997-06-09
EP0804479B1 (en) 2006-10-11
WO1996011949A3 (en) 1996-12-12
PL182888B1 (pl) 2002-03-29
HU226168B1 (en) 2008-05-28
CZ98197A3 (cs) 1998-11-11
PL319784A1 (en) 1997-08-18
DE69535264T2 (de) 2007-02-01
EE9700081A (et) 1997-10-15
NO971566L (no) 1997-04-14
BG101392A (en) 1997-10-31
NO971568L (no) 1997-06-12
HUT78058A (hu) 1999-07-28
AU681546B2 (en) 1997-08-28
WO1996011950A1 (en) 1996-04-25
FI971536A0 (fi) 1997-04-11
NO971568D0 (no) 1997-04-04
JP4216329B2 (ja) 2009-01-28
PL320484A1 (en) 1997-09-29
DE69535264D1 (de) 2006-11-23
CA2202075A1 (en) 1996-04-25
DK0785948T3 (da) 2003-08-04
PT804479E (pt) 2007-02-28
NO318761B1 (no) 2005-05-02
SI0785948T1 (en) 2003-08-31
JPH10507080A (ja) 1998-07-14
FI971420A0 (fi) 1997-04-04
DE69530403D1 (de) 2003-05-22
NZ505502A (en) 2005-01-28
FI120040B (fi) 2009-06-15
CA2201940A1 (en) 1996-04-25
EP0785948B1 (en) 2003-04-16
EE9700225A (et) 1998-02-16
CZ297329B6 (cs) 2006-11-15
CN1168678A (zh) 1997-12-24
ES2196082T3 (es) 2003-12-16
AU3708395A (en) 1996-05-06
PT785948E (pt) 2003-09-30

Similar Documents

Publication Publication Date Title
SK43197A3 (en) Method of treating diabetes mellitus using kgf
EA011390B1 (ru) Мутантные белки (мутеины) фактора роста фибробластов 21
CN108026153A (zh) 作为选择性肽双重glp-1/胰高血糖素受体激动剂的新毒蜥外泌肽-4衍生物
CN107080835A (zh) 长效生长激素及其生产方法
US5858977A (en) Method of treating diabetes mellitus using KGF
CN109096387A (zh) 聚乙二醇化的oxm变体
JP2003517294A5 (da)
AU2006322656A1 (en) VIP fragments and methods of use
CN102209784B (zh) 骨膜素诱导的胰腺再生
CN104045698B (zh) 一种多肽、多肽衍生物、多肽的可药用盐及药物组合物
CN112680445A (zh) 一种靶向敲减Atf6α基因表达的shRNA、重组载体及其应用
US6815418B2 (en) TGF-α polypeptides, functional fragments and methods of use therefor
CA2272854C (en) Keratinocyte growth factors and their use in combination with glucagon-like peptide derivatives
CN107847546A (zh) 聚乙二醇化的胃泌酸调节素变体
ES2216134T3 (es) Utilizaciones del factor de crecimiento de los queratinocitos 2)(kgf-2).
EP1205551A1 (en) Growth hormone and growth hormone releasing hormone compositions
US6677307B2 (en) TGF-α polypeptides, functional fragments and methods of use therefor
CN113018424B (zh) Cst1在预防和/或治疗肝脏免疫失调疾病中的应用
US20190284252A1 (en) Engineered fgf1 and fgf2 compositions and methods of use thereof
TW202039531A (zh) 用於治療平滑肌功能不良之組成物及方法
EP1210102B1 (en) Tgf-alpha polypeptides, functional fragments and methods of use therefor
AU681546C (en) Method of treating diabetes mellitus using KGF
CN108018311A (zh) 通过基因编辑特异靶向肌肉组织mstn治疗恶病质
WO2012038957A1 (en) Ktpaf50 (prt3) for treating diseases of the pancreas
CA2452540A1 (en) Keratinocyte growth factor-2 products