DK0785948T3 - Analoger af keratinocyt vækstfaktor - Google Patents

Analoger af keratinocyt vækstfaktor

Info

Publication number
DK0785948T3
DK0785948T3 DK95934793T DK95934793T DK0785948T3 DK 0785948 T3 DK0785948 T3 DK 0785948T3 DK 95934793 T DK95934793 T DK 95934793T DK 95934793 T DK95934793 T DK 95934793T DK 0785948 T3 DK0785948 T3 DK 0785948T3
Authority
DK
Denmark
Prior art keywords
growth factor
analogues
keratinocyte growth
keratinocyte
mammals
Prior art date
Application number
DK95934793T
Other languages
English (en)
Inventor
Charles F Morris
William C Kenney
Bao-Lu Chen
Eric W Hsu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0785948T3 publication Critical patent/DK0785948T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factors [FGF]
DK95934793T 1994-10-13 1995-10-12 Analoger af keratinocyt vækstfaktor DK0785948T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32347594A 1994-10-13 1994-10-13
US32334094A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/IB1995/000971 WO1996011949A2 (en) 1994-10-13 1995-10-12 Analogs of keratinocyte growth factor

Publications (1)

Publication Number Publication Date
DK0785948T3 true DK0785948T3 (da) 2003-08-04

Family

ID=27406268

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95934808T DK0804479T3 (da) 1994-10-13 1995-10-12 Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF
DK95934793T DK0785948T3 (da) 1994-10-13 1995-10-12 Analoger af keratinocyt vækstfaktor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK95934808T DK0804479T3 (da) 1994-10-13 1995-10-12 Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF

Country Status (23)

Country Link
EP (2) EP0804479B1 (da)
JP (2) JP4216329B2 (da)
KR (1) KR100278597B1 (da)
CN (1) CN1168678A (da)
AT (2) ATE342278T1 (da)
AU (1) AU3707795A (da)
BG (2) BG101392A (da)
BR (2) BR9509269A (da)
CA (2) CA2202075C (da)
CZ (3) CZ297328B6 (da)
DE (2) DE69535264T2 (da)
DK (2) DK0804479T3 (da)
EE (2) EE03975B1 (da)
ES (2) ES2273338T3 (da)
FI (2) FI971420A0 (da)
HU (2) HUT78050A (da)
NO (2) NO318761B1 (da)
NZ (2) NZ505502A (da)
PL (2) PL320484A1 (da)
PT (2) PT785948E (da)
SI (2) SI0804479T1 (da)
SK (2) SK284534B6 (da)
WO (2) WO1996011949A2 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218090B (hu) 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
ES2227527T3 (es) 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
PT785949E (pt) * 1994-10-13 2003-09-30 Amgen Inc Metodo para purificar factores de crescimento de queratinocitos
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
WO1996034017A1 (en) * 1995-04-27 1996-10-31 Coöperatie Suiker Unie U.A. Inulin derivatives
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
EP1473366A1 (en) * 1996-10-15 2004-11-03 Amgen Inc. Keratinocyte growth factor-2 products
CA2269077C (en) * 1996-10-15 2004-04-06 Amgen Inc. Keratinocyte growth factor-2 products
BR9812267B1 (pt) 1997-07-14 2013-11-26 Hormônio de crescimento recombinante.
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
EP1041996A4 (en) 1997-12-22 2003-05-14 Human Genome Sciences Inc KERATINOCYTE GROWTH FACTOR-2 FORMULATIONS
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6242666B1 (en) * 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
CN1210400C (zh) * 1999-01-14 2005-07-13 博尔德生物技术公司 制备含游离半胱氨酸残基的蛋白质的方法
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
US20040063634A1 (en) * 2001-01-19 2004-04-01 Carr Francis J. Modified kertinocyte growth factor (kgf) with reduced immunogenicity
AU2007214362B2 (en) * 2001-08-21 2009-11-26 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
WO2003016505A2 (en) * 2001-08-21 2003-02-27 Chiron Corporation Kgf polypeptide compositions
ES2504441T3 (es) 2004-12-15 2014-10-08 Swedish Orphan Biovitrum Ab (Publ) Formulaciones terapéuticas del factor de crecimiento de queratinocitos
CN102242124B (zh) * 2010-05-10 2013-05-22 齐鲁制药有限公司 改造的角化细胞生长因子基因及其在酵母中的表达
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH01137994A (ja) * 1987-08-10 1989-05-30 Shionogi & Co Ltd ｒｅｇ蛋白質
US5145225A (en) * 1988-07-27 1992-09-08 Muller George M Carpet stretcher
HU218090B (hu) * 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 ｂＦＧＦムテインおよびその製造法
KR100390340B1 (ko) * 1993-03-26 2003-09-26 암겐 인코포레이티드 케라티노사이트성장인자산물을함유하는제약학적조성물
ES2227527T3 (es) * 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
US5348563A (en) * 1993-06-29 1994-09-20 Honeywell Inc. Air purifying apparatus
GB9315501D0 (en) * 1993-07-27 1993-09-08 Ici Plc Surfactant compositions
JPH09503751A (ja) * 1993-08-02 1997-04-15 プリズム ファーマシュティカルズ，インコーポレイティド 細胞毒性抱合体の単一起源性製剤

Also Published As

Publication number Publication date
BG63167B1 (bg) 2001-05-31
FI971536A (fi) 1997-06-09
BR9509269A (pt) 1997-12-23
BG101408A (en) 1997-12-30
HUT78058A (hu) 1999-07-28
CA2201940A1 (en) 1996-04-25
EP0804479A1 (en) 1997-11-05
FI120040B (fi) 2009-06-15
SK284534B6 (sk) 2005-06-02
SK45597A3 (en) 1999-02-11
PL319784A1 (en) 1997-08-18
NZ335109A (en) 2000-08-25
CZ297329B6 (cs) 2006-11-15
CZ297328B6 (cs) 2006-11-15
CA2202075A1 (en) 1996-04-25
ES2196082T3 (es) 2003-12-16
HUT78050A (hu) 1999-07-28
AU681546B2 (en) 1997-08-28
JPH10507080A (ja) 1998-07-14
BR9509329A (pt) 1997-10-14
NO318761B1 (no) 2005-05-02
NO971568D0 (no) 1997-04-04
WO1996011949A3 (en) 1996-12-12
ATE237633T1 (de) 2003-05-15
DE69535264T2 (de) 2007-02-01
PL182888B1 (pl) 2002-03-29
FI971536A0 (fi) 1997-04-11
DE69535264D1 (de) 2006-11-23
EE03975B1 (et) 2003-02-17
PT785948E (pt) 2003-09-30
WO1996011950A1 (en) 1996-04-25
SK43197A3 (en) 1999-03-12
EP0785948B1 (en) 2003-04-16
EE9700081A (et) 1997-10-15
PL320484A1 (en) 1997-09-29
CN1168678A (zh) 1997-12-24
WO1996011949A2 (en) 1996-04-25
SI0804479T1 (sl) 2006-12-31
AU3707795A (en) 1996-05-06
CA2202075C (en) 2003-12-09
NO971566D0 (no) 1997-04-04
DE69530403T2 (de) 2003-10-30
JP4216329B2 (ja) 2009-01-28
FI971420A (fi) 1997-04-04
JP4426646B2 (ja) 2010-03-03
NO971568L (no) 1997-06-12
SI0785948T1 (en) 2003-08-31
CZ105097A3 (cs) 1998-10-14
BG101392A (en) 1997-10-31
DK0804479T3 (da) 2007-01-29
FI971420A0 (fi) 1997-04-04
KR100278597B1 (ko) 2001-01-15
CZ98197A3 (cs) 1998-11-11
DE69530403D1 (de) 2003-05-22
EP0785948A1 (en) 1997-07-30
ATE342278T1 (de) 2006-11-15
PT804479E (pt) 2007-02-28
EP0804479B1 (en) 2006-10-11
CA2201940C (en) 2009-05-12
NO971566L (no) 1997-04-14
ES2273338T3 (es) 2007-05-01
EE9700225A (et) 1998-02-16
HU226168B1 (en) 2008-05-28
AU3708395A (en) 1996-05-06
NZ505502A (en) 2005-01-28
JPH10507193A (ja) 1998-07-14

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