SK287597B6 - Heterocyklické zlúčeniny, ich príprava a použitie ako liečiva, najmä ako antibakteriálne činidlá - Google Patents
Heterocyklické zlúčeniny, ich príprava a použitie ako liečiva, najmä ako antibakteriálne činidlá Download PDFInfo
- Publication number
- SK287597B6 SK287597B6 SK105-2003A SK1052003A SK287597B6 SK 287597 B6 SK287597 B6 SK 287597B6 SK 1052003 A SK1052003 A SK 1052003A SK 287597 B6 SK287597 B6 SK 287597B6
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- radical
- dichloromethane
- reaction medium
- reduced pressure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0010121A FR2812635B1 (fr) | 2000-08-01 | 2000-08-01 | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| PCT/FR2001/002418 WO2002010172A1 (fr) | 2000-08-01 | 2001-07-24 | Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK1052003A3 SK1052003A3 (en) | 2003-11-04 |
| SK287597B6 true SK287597B6 (sk) | 2011-03-04 |
Family
ID=8853181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK105-2003A SK287597B6 (sk) | 2000-08-01 | 2001-07-24 | Heterocyklické zlúčeniny, ich príprava a použitie ako liečiva, najmä ako antibakteriálne činidlá |
Country Status (42)
| Country | Link |
|---|---|
| US (5) | US7112592B2 (de) |
| EP (1) | EP1307457B1 (de) |
| JP (2) | JP4515704B2 (de) |
| KR (1) | KR100632906B1 (de) |
| CN (1) | CN1289500C (de) |
| AP (1) | AP1614A (de) |
| AR (1) | AR031716A1 (de) |
| AT (1) | ATE263768T1 (de) |
| AU (2) | AU2001279905B2 (de) |
| BG (1) | BG66094B1 (de) |
| BR (1) | BRPI0112986B8 (de) |
| CA (1) | CA2417475C (de) |
| CR (1) | CR6895A (de) |
| CZ (1) | CZ294956B6 (de) |
| DE (1) | DE60102702T2 (de) |
| DK (1) | DK1307457T3 (de) |
| DZ (1) | DZ3397A1 (de) |
| EA (1) | EA004920B1 (de) |
| EC (1) | ECSP034460A (de) |
| EE (1) | EE05183B1 (de) |
| ES (1) | ES2220793T3 (de) |
| FR (1) | FR2812635B1 (de) |
| HK (1) | HK1060356A1 (de) |
| HR (1) | HRP20030034B1 (de) |
| HU (1) | HU226889B1 (de) |
| IL (2) | IL154187A0 (de) |
| MA (1) | MA26938A1 (de) |
| ME (2) | MEP17108A (de) |
| MX (1) | MXPA03000881A (de) |
| NO (1) | NO324940B1 (de) |
| NZ (1) | NZ523707A (de) |
| OA (1) | OA12347A (de) |
| PL (2) | PL216028B1 (de) |
| PT (1) | PT1307457E (de) |
| RS (1) | RS50214B (de) |
| SI (1) | SI1307457T1 (de) |
| SK (1) | SK287597B6 (de) |
| TR (1) | TR200400859T4 (de) |
| TW (1) | TWI292401B (de) |
| UA (1) | UA73791C2 (de) |
| WO (1) | WO2002010172A1 (de) |
| ZA (1) | ZA200300676B (de) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| FR2844273B1 (fr) * | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
| US7439253B2 (en) | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
| FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
| CA2629570C (en) | 2005-12-07 | 2012-11-27 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| WO2008008502A1 (en) | 2006-07-13 | 2008-01-17 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
| JP5539717B2 (ja) * | 2006-07-14 | 2014-07-02 | 塩野義製薬株式会社 | オキシム化合物およびその使用 |
| US20100009957A1 (en) * | 2006-09-27 | 2010-01-14 | Blizzard Timothy A | Novel inhibitors of beta-lactamase |
| EP2078027A1 (de) * | 2006-10-23 | 2009-07-15 | Irm Llc | Cathepsin-proteasehemmer |
| US20100056497A1 (en) | 2007-01-31 | 2010-03-04 | Dainippon Sumitomo Pharma Co., Ltd | Amide derivative |
| FR2914923B1 (fr) * | 2007-04-12 | 2013-06-14 | Novexel | Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens. |
| ES2422603T3 (es) * | 2007-05-31 | 2013-09-12 | Shionogi & Co | Compuestos oxiimino y el uso de estos |
| FR2921060B1 (fr) * | 2007-09-14 | 2012-06-15 | Novexel | Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires |
| MY162532A (en) * | 2008-01-18 | 2017-06-15 | Merck Sharp & Dohme | Beta-lactamase inhibitors |
| US8518934B2 (en) | 2008-06-11 | 2013-08-27 | Shonogi & Co., Ltd. | Oxycarbamoyl compounds and the use thereof |
| EP2921559A1 (de) | 2008-06-19 | 2015-09-23 | Astra Zeneca Holding France | Verwendung von (1r,2s,5r)-1,6-diazabicyclo[3.2.1]oktan-2-carboxamid, 7-oxo-6-(sulfooxy)-, mononatriumsalz als diagnostisches reagens zum nachweis von serin-beta-lactamasen |
| FR2936798B1 (fr) * | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| FR2937034B1 (fr) | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
| US20120053350A1 (en) * | 2009-04-30 | 2012-03-01 | Ian Mangion | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| CA2765527A1 (en) | 2009-06-24 | 2010-12-29 | Satoshi Suetsugu | N-substituted-cyclic amino derivative |
| FR2951171A1 (fr) * | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| US8772490B2 (en) * | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| TWI599355B (zh) * | 2010-12-22 | 2017-09-21 | 明治製菓藥業股份有限公司 | 光學活性二氮雜二環辛烷衍生物及其製造法 |
| AU2012270051B2 (en) * | 2011-06-17 | 2016-12-22 | Pfizer Anti-Infectives Ab | Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof |
| BR112013028813B1 (pt) * | 2011-08-27 | 2020-10-20 | Wockhardt Limited | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e composições farmacêuticas que os compreendem |
| CN103649088B (zh) * | 2011-08-30 | 2016-05-11 | 沃克哈特有限公司 | 1, 6- 二氮杂双环[3, 2, 1]辛- 7- 酮衍生物及其在治疗细菌感染中的用途 |
| ES2640520T3 (es) * | 2011-09-13 | 2017-11-03 | Wockhardt Limited | Compuestos que contienen nitrógeno y su uso |
| US8969567B2 (en) | 2011-09-13 | 2015-03-03 | Wockhardt Ltd. | Nitrogen containing compounds and their use |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| KR20150003777A (ko) | 2012-03-30 | 2015-01-09 | 큐비스트 파마슈티컬즈 인코포레이티드 | 이속사졸 β-락타마제 억제제 |
| US8916709B2 (en) | 2012-03-30 | 2014-12-23 | Cubist Pharmaceuticals, Inc. | 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors |
| US8933233B2 (en) | 2012-03-30 | 2015-01-13 | Cubist Pharmaceuticals, Inc. | 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors |
| US8969570B2 (en) | 2012-03-30 | 2015-03-03 | Cubist Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| AR090539A1 (es) * | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| MX366948B (es) * | 2012-05-30 | 2019-07-30 | Meiji Seika Pharma Co Ltd | Nuevo inhibidor de beta-lactamasa y proceso para prepararlo. |
| WO2014033560A1 (en) * | 2012-08-25 | 2014-03-06 | Wockhardt Limited | 1,6- diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections |
| WO2014069351A1 (ja) | 2012-11-01 | 2014-05-08 | 株式会社カネカ | 光学活性二環式ウレア化合物の製造方法 |
| UA111925C2 (uk) | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
| IN2015DN02381A (de) | 2013-02-19 | 2015-09-04 | Api Corp | |
| CN105164132A (zh) * | 2013-03-08 | 2015-12-16 | 沃克哈特有限公司 | (2s,5r)-6-苄氧基-7-氧代-1,6-二氮杂-双环[3.2.1]辛烷-2-羧酸钠及其制备方法 |
| AU2013380573B2 (en) * | 2013-03-08 | 2016-07-07 | Wockhardt Limited | A process for sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane |
| WO2014152996A1 (en) | 2013-03-14 | 2014-09-25 | Cubist Pharmaceuticals, Inc. | Crystalline form of a beta-lactamase inhibitor |
| CA2911544A1 (en) * | 2013-06-10 | 2014-12-18 | Merck Sharp & Dohme Corp. | Preparation of tert-butyl 4-((1r,2s,5r)-6-(benzyloxy)-7-0x0-1,6-diazabicycl0[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate |
| KR102239725B1 (ko) | 2013-09-24 | 2021-04-12 | 메이지 세이카 파루마 가부시키가이샤 | 디아자비시클로옥탄 유도체의 제조법과 그의 중간체 |
| WO2015051101A1 (en) | 2013-10-02 | 2015-04-09 | Cubist Pharmaceuticals, Inc. | B-lactamase inhibitor picoline salt |
| ES2842225T3 (es) | 2013-10-08 | 2021-07-13 | Meiji Seika Pharma Co Ltd | Cristales de derivado de diazabiciclooctano y método de producción para cristales de derivado de diazabiciclooctano |
| RU2016113755A (ru) | 2013-10-11 | 2017-11-16 | Вокхардт Лимитед | Азотсодержащие соединения и их применение |
| EP3096754B1 (de) | 2014-01-22 | 2018-08-29 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase-hemmer |
| EP3139918B1 (de) | 2014-05-09 | 2019-12-25 | Merck Sharp & Dohme Corp. | Beta-tetrazolyl-propionsäuren als metallo-beta-lactamase-hemmer |
| AU2015350128B2 (en) | 2014-11-17 | 2019-05-16 | Entasis Therapeutics Limited | Combination therapy for treatment of resistant bacterial infections |
| EP3227306B1 (de) | 2014-12-02 | 2020-07-15 | Merck Sharp & Dohme Corp. | Verfahren zur herstellung von tert-butyl-4-((2s,5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxamido)piperidin-1-carboxylaten und analoga davon |
| WO2016088863A1 (ja) | 2014-12-05 | 2016-06-09 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | ジアザビシクロオクタン誘導体の結晶及び安定な凍結乾燥製剤の製造法 |
| US10667737B2 (en) | 2015-03-23 | 2020-06-02 | International Business Machines Corporation | Monitoring a person for indications of a brain injury |
| CA2983674A1 (en) * | 2015-05-07 | 2016-11-10 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP3091018A1 (de) * | 2015-05-07 | 2016-11-09 | Mutabilis | Heterocyclische verbindungen und deren verwendung zur vorbeugung oder behandlung von bakteriellen infektionen |
| WO2016206101A1 (en) | 2015-06-26 | 2016-12-29 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors |
| WO2017002087A1 (en) | 2015-07-02 | 2017-01-05 | Wockhardtlimited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| WO2017002083A1 (en) | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| WO2017002086A1 (en) | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| WO2017002089A1 (en) | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| AU2016307256B2 (en) * | 2015-08-10 | 2020-11-19 | Sandoz Ag | Form C of avibactam sodium |
| WO2017037607A1 (en) | 2015-09-01 | 2017-03-09 | Wockhardt Limited | (aminomethylidene)amino-substituted (2s,5r)-6-(sulfonyl)-7-oxo-1,6-diazabicyclo[3.2.1 ]octane-2-carboxamide derivatives with antibacterial activity |
| KR20170131661A (ko) | 2015-09-16 | 2017-11-29 | 수안주 파마 코포레이션 리미티드 | β-락타메이즈 억제제 및 이의 용도 |
| WO2017057730A1 (ja) | 2015-10-02 | 2017-04-06 | 株式会社エーピーアイ コーポレーション | ヒドロキシ－ｌ－ピペコリン酸の製造方法 |
| US9951072B2 (en) | 2015-10-02 | 2018-04-24 | Legochem Biosciences, Inc. | Compositions and methods for inhibiting beta-lactamase |
| US20180282331A1 (en) | 2015-11-09 | 2018-10-04 | Wockhardt Limited | 7-Oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections (changed by PCT to: 7-OXO -6-(SULFOOXY)- 1,6-DIAZABICYCLO [3.2.1] OCTANE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS |
| CN106749242B (zh) * | 2015-11-23 | 2021-04-02 | 上海医药工业研究院 | 阿维巴坦中间体的制备方法 |
| US10472345B2 (en) | 2016-02-04 | 2019-11-12 | Merck Sharp & Dohme Corp. | Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents |
| CN105753867B (zh) * | 2016-03-24 | 2018-03-27 | 齐鲁制药有限公司 | 一种改进的阿维巴坦钠中间体化合物的制备方法 |
| EP3156400B1 (de) | 2016-05-27 | 2019-05-15 | Valoralia I Más D, SL | Dihydrooxadiazine verbindungen für die behandlung von infektionen und krebs |
| CN106279163A (zh) * | 2016-08-12 | 2017-01-04 | 上海龙翔生物医药开发有限公司 | 一种合成阿维巴坦及其中间体光学异构体的方法 |
| WO2018037124A1 (en) * | 2016-08-26 | 2018-03-01 | Sandoz Ag | Avibactam free acid |
| KR102537340B1 (ko) | 2016-09-16 | 2023-05-26 | 엔타시스 테라퓨틱스 리미티드 | 베타-락타마제 억제제 화합물 |
| JOP20190061A1 (ar) | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| EP3301094A1 (de) * | 2016-09-30 | 2018-04-04 | Mutabilis | Heterocyclische verbindungen und deren verwendung zur vorbeugung oder behandlung von bakteriellen infektionen |
| CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
| TW201831482A (zh) * | 2017-02-06 | 2018-09-01 | 法商木塔比利斯公司 | 新穎雜環化合物及其預防或治療細菌感染之用途 |
| PE20200333A1 (es) | 2017-05-08 | 2020-02-14 | Entasis Therapeutics Inc | Compuestos y metodos para tratar infecciones bacterianas |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| WO2018234962A1 (en) | 2017-06-20 | 2018-12-27 | Wockhardt Limited | PROCESS FOR O-SULFONATION OF 1,6-DIAZABICYCLO [3.2.1] OCTANE COMPOUNDS |
| US11207312B2 (en) | 2017-07-17 | 2021-12-28 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors and methods of use thereof |
| BR112020006594A2 (pt) | 2017-10-02 | 2020-12-15 | Arixa Pharmaceuticals, Inc. | Derivados de aztreonam e usos dos mesmos |
| CN109678856B (zh) * | 2017-10-18 | 2020-09-25 | 新发药业有限公司 | 一种阿维巴坦中间体的制备方法 |
| JP7289836B2 (ja) | 2017-11-23 | 2023-06-12 | エフ． ホフマン－ラ ロシュ アーゲー | プロリンヒドロキシラーゼ、ならびにそれに伴う使用、方法および生成物 |
| CN109956941B (zh) * | 2017-12-25 | 2020-08-04 | 新发药业有限公司 | 一种阿维巴坦的简便制备方法 |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| JP7437847B2 (ja) | 2018-10-01 | 2024-02-26 | アリクサ ファーマシューティカルズ、インコーポレイテッド | レレバクタムの誘導体およびその使用 |
| CN111072660B (zh) * | 2018-10-22 | 2021-05-18 | 新发药业有限公司 | 一种瑞来巴坦的简便制备方法 |
| AU2020237440B2 (en) | 2019-03-12 | 2022-10-20 | Arixa Pharmaceuticals, Inc. | Crystalline form of an avibactam derivative |
| WO2020219258A1 (en) | 2019-04-25 | 2020-10-29 | Arixa Pharmaceuticals, Inc. | Methods of synthesizing aztreonam derivatives |
| CN110078728B (zh) * | 2019-05-23 | 2020-10-23 | 江西富祥药业股份有限公司 | 一种阿维巴坦中间体、制备方法及其应用 |
| WO2021106864A1 (en) * | 2019-11-25 | 2021-06-03 | Eisai R&D Management Co., Ltd. | Process for the preparation of producing pyrazolo[1,5-a] pyrimidine derivatives |
| US11814385B2 (en) | 2021-06-25 | 2023-11-14 | University Of South Florida | Small molecule inhibitors targeting Clostridioides difficile sporulation |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4939678B1 (de) * | 1968-05-06 | 1974-10-28 | ||
| US4024147A (en) * | 1972-06-30 | 1977-05-17 | John Wyeth & Brother Limited | Heterocyclic compounds |
| US4049821A (en) * | 1976-05-12 | 1977-09-20 | A. H. Robins Company, Inc. | Method of treating allergy |
| EP0260057A3 (de) * | 1986-09-02 | 1989-02-01 | The University Of Melbourne | 2-Oxo-4-Karboxypyrimidine |
| JPS63119471A (ja) * | 1986-09-02 | 1988-05-24 | ザ・ユニバーシテイ・オブ・メルボルン | ２−オキソ−４−カルボキシ−ピリミジン |
| BR9408450A (pt) * | 1993-12-29 | 1997-08-05 | Pfizer | Antagonistas da neuroquinina diazabiciclicos |
| TW358097B (en) * | 1996-05-24 | 1999-05-11 | Hoffmann La Roche | Beta-lactams and their process and pharmaceutical compositions |
| HUP0001741A3 (en) * | 1996-08-02 | 2000-11-28 | Smithkline Beecham Plc | Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use |
| CN1523015A (zh) * | 1997-02-10 | 2004-08-25 | �Ʒ� | 2-氨基-6-(2-取代的-4-苯氧基)取代的吡啶类化合物 |
| US6060585A (en) * | 1997-03-04 | 2000-05-09 | Wisconsin Alumni Research Foundation | β-polypeptide foldamers of well-defined secondary structure |
| KR100207096B1 (ko) * | 1997-07-08 | 1999-07-15 | 이명환 | 시사프라이드의 제조 방법 |
| US6384080B1 (en) * | 1998-04-20 | 2002-05-07 | Fujisawa Pharmaceutical Co., Ltd. | Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase |
| GB9817029D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
| FR2784682B1 (fr) * | 1998-10-15 | 2002-12-06 | Hoechst Marion Roussel Inc | Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments |
| US6635657B1 (en) * | 1998-12-23 | 2003-10-21 | Eli Lilly And Company | Aromatic amides |
| JP2002534420A (ja) * | 1999-01-02 | 2002-10-15 | アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規なマロン酸誘導体、その調製方法、その使用およびそれを含有する医薬組成物（Ｘａ因子活性阻害） |
| FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
-
2000
- 2000-08-01 FR FR0010121A patent/FR2812635B1/fr not_active Expired - Lifetime
-
2001
- 2001-07-24 AP APAP/P/2003/002726A patent/AP1614A/en active
- 2001-07-24 CA CA2417475A patent/CA2417475C/en not_active Expired - Lifetime
- 2001-07-24 PT PT01958173T patent/PT1307457E/pt unknown
- 2001-07-24 MX MXPA03000881A patent/MXPA03000881A/es active IP Right Grant
- 2001-07-24 JP JP2002515901A patent/JP4515704B2/ja not_active Expired - Lifetime
- 2001-07-24 BR BRPI0112986A patent/BRPI0112986B8/pt not_active IP Right Cessation
- 2001-07-24 OA OA1200300019A patent/OA12347A/fr unknown
- 2001-07-24 EE EEP200300046A patent/EE05183B1/xx unknown
- 2001-07-24 US US10/343,315 patent/US7112592B2/en active Active
- 2001-07-24 EA EA200300211A patent/EA004920B1/ru active Protection Beyond IP Right Term
- 2001-07-24 ES ES01958173T patent/ES2220793T3/es not_active Expired - Lifetime
- 2001-07-24 UA UA2003021827A patent/UA73791C2/uk unknown
- 2001-07-24 SI SI200130094T patent/SI1307457T1/xx unknown
- 2001-07-24 AU AU2001279905A patent/AU2001279905B2/en active Active
- 2001-07-24 TR TR2004/00859T patent/TR200400859T4/xx unknown
- 2001-07-24 HU HU0302943A patent/HU226889B1/hu unknown
- 2001-07-24 RS YU6303A patent/RS50214B/sr unknown
- 2001-07-24 DK DK01958173T patent/DK1307457T3/da active
- 2001-07-24 SK SK105-2003A patent/SK287597B6/sk not_active IP Right Cessation
- 2001-07-24 IL IL15418701A patent/IL154187A0/xx active IP Right Grant
- 2001-07-24 WO PCT/FR2001/002418 patent/WO2002010172A1/fr not_active Application Discontinuation
- 2001-07-24 AU AU7990501A patent/AU7990501A/xx active Pending
- 2001-07-24 EP EP01958173A patent/EP1307457B1/de not_active Expired - Lifetime
- 2001-07-24 CN CNB018167004A patent/CN1289500C/zh not_active Expired - Lifetime
- 2001-07-24 KR KR1020037001437A patent/KR100632906B1/ko active IP Right Grant
- 2001-07-24 PL PL365162A patent/PL216028B1/pl unknown
- 2001-07-24 NZ NZ523707A patent/NZ523707A/en not_active IP Right Cessation
- 2001-07-24 CZ CZ2003223A patent/CZ294956B6/cs not_active IP Right Cessation
- 2001-07-24 ME MEP-171/08A patent/MEP17108A/xx unknown
- 2001-07-24 ME MEP-2008-171A patent/ME00060B/me unknown
- 2001-07-24 DE DE60102702T patent/DE60102702T2/de not_active Expired - Lifetime
- 2001-07-24 PL PL401469A patent/PL234468B1/pl unknown
- 2001-07-24 DZ DZ013397A patent/DZ3397A1/xx active
- 2001-07-24 AT AT01958173T patent/ATE263768T1/de active
- 2001-07-25 TW TW090118209A patent/TWI292401B/zh not_active IP Right Cessation
- 2001-07-26 AR ARP010103571A patent/AR031716A1/es active IP Right Grant
-
2003
- 2003-01-21 HR HR20030034A patent/HRP20030034B1/xx not_active IP Right Cessation
- 2003-01-23 BG BG107497A patent/BG66094B1/bg unknown
- 2003-01-24 ZA ZA200300676A patent/ZA200300676B/en unknown
- 2003-01-28 MA MA27016A patent/MA26938A1/fr unknown
- 2003-01-29 CR CR6895A patent/CR6895A/es unknown
- 2003-01-29 IL IL154187A patent/IL154187A/en unknown
- 2003-01-30 EC EC2003004460A patent/ECSP034460A/es unknown
- 2003-01-31 NO NO20030494A patent/NO324940B1/no not_active IP Right Cessation
-
2004
- 2004-05-11 HK HK04103300A patent/HK1060356A1/xx not_active IP Right Cessation
-
2005
- 2005-09-14 US US11/226,749 patent/US7638529B2/en not_active Expired - Fee Related
-
2006
- 2006-02-06 US US11/348,047 patent/US7732610B2/en not_active Expired - Lifetime
-
2010
- 2010-03-16 JP JP2010059251A patent/JP2010138206A/ja active Pending
- 2010-04-16 US US12/799,038 patent/US20110021772A1/en not_active Abandoned
-
2011
- 2011-05-10 US US13/068,399 patent/US8178554B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SK287597B6 (sk) | Heterocyklické zlúčeniny, ich príprava a použitie ako liečiva, najmä ako antibakteriálne činidlá | |
| US8148540B2 (en) | Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents | |
| JP4472346B2 (ja) | ベータ−ラクタマーゼの阻害剤として活性である新規な複素環化合物 | |
| BR122015020406B1 (pt) | uso de compostos de formula i como inibidores de beta-lactamases e composições farmaceuticas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Assignment and transfer of rights |
Owner name: NOVEXEL, ROMAINVILLE, FR Free format text: FORMER OWNER: AVENTIS PHARMA S. A., ANTONY CEDEX, FR Effective date: 20100222 |
|
| PC4A | Assignment and transfer of rights |
Owner name: ASTRA ZENECA HOLDING FRANCE, RUEIL MALMAISON, FR Free format text: FORMER OWNER: NOVEXEL, ROMAINVILLE, FR Effective date: 20150108 |
|
| PC4A | Assignment and transfer of rights |
Owner name: PFIZER IRELAND PHARMACEUTICALS, RINGASKIDDY, C, IE Free format text: FORMER OWNER: ASTRA ZENECA HOLDING FRANCE, RUEIL MALMAISON, FR Effective date: 20180117 |
|
| MK4A | Patent expired |
Expiry date: 20210724 |