SK287582B6 - 2-(Substituovaná amino)benztiazolsulfonamidová zlúčenina, spôsob jej prípravy, použitie a farmaceutická zmes s jej obsahom - Google Patents

2-(Substituovaná amino)benztiazolsulfonamidová zlúčenina, spôsob jej prípravy, použitie a farmaceutická zmes s jej obsahom Download PDF

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Publication number
SK287582B6
SK287582B6 SK1102-2003A SK11022003A SK287582B6 SK 287582 B6 SK287582 B6 SK 287582B6 SK 11022003 A SK11022003 A SK 11022003A SK 287582 B6 SK287582 B6 SK 287582B6
Authority
SK
Slovakia
Prior art keywords
alkyl
het
aryl
alkanediyl
cycloalkyl
Prior art date
Application number
SK1102-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK11022003A3 (sk
Inventor
Dominique Louis Nestor Ghislain Surleraux
Piet Tom Bert Paul Wigerinck
Daniel Getman
Wim Gaston Verschueren
Sandrine Vendeville
Bethune Marie-Pierre De
Kerpel Jan Octaaf Antoon De
Samuel Leo Christiaan Moors
Kock Herman Augustinus De
Marieke Christiane Johanna Voets
Original Assignee
Tibotec Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharmaceuticals Ltd. filed Critical Tibotec Pharmaceuticals Ltd.
Publication of SK11022003A3 publication Critical patent/SK11022003A3/sk
Publication of SK287582B6 publication Critical patent/SK287582B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1102-2003A 2001-02-14 2002-02-14 2-(Substituovaná amino)benztiazolsulfonamidová zlúčenina, spôsob jej prípravy, použitie a farmaceutická zmes s jej obsahom SK287582B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01200529 2001-02-14
US28775801P 2001-05-02 2001-05-02
PCT/EP2002/001788 WO2002083657A2 (en) 2001-02-14 2002-02-14 Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number Publication Date
SK11022003A3 SK11022003A3 (sk) 2004-07-07
SK287582B6 true SK287582B6 (sk) 2011-03-04

Family

ID=26076833

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1102-2003A SK287582B6 (sk) 2001-02-14 2002-02-14 2-(Substituovaná amino)benztiazolsulfonamidová zlúčenina, spôsob jej prípravy, použitie a farmaceutická zmes s jej obsahom

Country Status (30)

Country Link
US (1) US7659404B2 (cs)
EP (1) EP1370543B1 (cs)
JP (1) JP4530612B2 (cs)
KR (1) KR100870184B1 (cs)
CN (2) CN101230067B (cs)
AP (1) AP1504A (cs)
AT (1) ATE343567T1 (cs)
AU (1) AU2002302363B2 (cs)
BG (1) BG66301B1 (cs)
BR (1) BR0207862A (cs)
CA (1) CA2438304C (cs)
CY (1) CY1108073T1 (cs)
CZ (1) CZ304273B6 (cs)
DE (1) DE60215623T2 (cs)
DK (1) DK1370543T3 (cs)
EA (1) EA006096B1 (cs)
EE (1) EE05385B1 (cs)
ES (1) ES2275866T3 (cs)
HR (1) HRP20030735B1 (cs)
HU (1) HU229224B1 (cs)
IL (2) IL157171A0 (cs)
MX (1) MXPA03007236A (cs)
NO (1) NO326174B1 (cs)
NZ (1) NZ527391A (cs)
PL (1) PL213327B1 (cs)
PT (1) PT1370543E (cs)
SI (1) SI1370543T1 (cs)
SK (1) SK287582B6 (cs)
WO (1) WO2002083657A2 (cs)
ZA (1) ZA200306086B (cs)

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NZ516259A (en) 1999-05-28 2004-02-27 Virco N New mutational profiles in HIV-1 reverse transcriptase correlated with phenotypic drug resistance
RU2318213C2 (ru) 2000-10-20 2008-02-27 Вирко Бвба Новые мутационные профили обратной транскриптазы вич-1, коррелирующие с фенотипической резистентностью к лекарственным средствам
ES2275866T3 (es) 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.
EP1472536A4 (en) 2002-01-07 2007-02-14 Sequoia Pharmaceuticals VERSATILE INHIBITORS
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
DE60327768D1 (de) 2002-07-01 2009-07-09 Tibotec Pharm Ltd Mutationsprofile bei mit phänotypischer medikamentenresistenz korrelierter hiv-1-protease
ATE397669T1 (de) 2002-07-01 2008-06-15 Tibotec Pharm Ltd Mit phänotypischer medikamentenresistenz korrelierte mutationsprofile in hiv-1-reverse- transkriptase
EA008594B1 (ru) * 2002-08-02 2007-06-29 Тиботек Фармасьютикалз Лтд. 2-аминобензотиазолсульфонамидные ингибиторы протеазы вич широкого спектра действия
CN101445493A (zh) * 2002-08-02 2009-06-03 泰博特克药品有限公司 广谱2-氨基-苯并噻唑磺酰胺类hiv蛋白酶抑制剂
MXPA06003575A (es) * 2003-09-30 2006-06-05 Tibotec Pharm Ltd Metodos para la preparacion de compuestos de benzoxazol sulfonamida e intermediarios de los mismos.
DE10360835A1 (de) * 2003-12-23 2005-07-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel
CA2566340C (en) * 2004-05-07 2014-05-06 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
MX2007010378A (es) 2005-02-25 2007-09-25 Tibotec Pharm Ltd Sintesis del precursor inhibidor de la proteasa.
AR053845A1 (es) 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
JO3090B1 (ar) * 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
US9024038B2 (en) 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
RU2014115227A (ru) 2012-04-20 2015-10-27 Джилид Сайэнс, Инк. Производные бензотиазол-6-ил уксусной кислоты и их примение для лечения вич-инфекции
CN104000824B (zh) * 2014-05-28 2016-07-06 中山大学 苯并五元杂环类化合物在制备抗hiv-1病毒药物中的应用
US11439608B2 (en) 2017-09-25 2022-09-13 Qun Lu Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease
CN116354903B (zh) * 2021-12-28 2025-09-09 南京药石科技股份有限公司 一种6-苯并噻唑磺酰氯的制备方法
WO2024206093A1 (en) * 2023-03-24 2024-10-03 Purdue Research Foundation Hiv-1p rotease inhibitors and uses thereof

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ES2275866T3 (es) 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.

Also Published As

Publication number Publication date
HUP0303257A2 (hu) 2004-01-28
HK1061233A1 (en) 2004-09-10
WO2002083657A3 (en) 2003-02-13
CA2438304A1 (en) 2002-10-24
BG66301B1 (bg) 2013-03-29
NZ527391A (en) 2005-04-29
PL213327B1 (pl) 2013-02-28
CA2438304C (en) 2011-04-12
US20040116485A1 (en) 2004-06-17
MXPA03007236A (es) 2003-12-04
ES2275866T3 (es) 2007-06-16
AP1504A (en) 2005-12-10
SK11022003A3 (sk) 2004-07-07
DE60215623T2 (de) 2007-08-30
EA200300891A1 (ru) 2004-02-26
CN101230067A (zh) 2008-07-30
CN101230067B (zh) 2011-06-15
JP2004518767A (ja) 2004-06-24
NO20033584L (no) 2003-10-14
BG108143A (en) 2004-07-30
PT1370543E (pt) 2007-02-28
PL363778A1 (en) 2004-11-29
KR100870184B1 (ko) 2008-11-24
IL157171A0 (en) 2004-02-08
EP1370543A2 (en) 2003-12-17
WO2002083657A2 (en) 2002-10-24
CY1108073T1 (el) 2014-02-12
EE05385B1 (et) 2011-02-15
DE60215623D1 (de) 2006-12-07
CZ304273B6 (cs) 2014-02-12
IL157171A (en) 2012-10-31
EE200300381A (et) 2003-12-15
DK1370543T3 (da) 2007-02-19
BR0207862A (pt) 2004-06-22
NO326174B1 (no) 2008-10-13
EP1370543B1 (en) 2006-10-25
US7659404B2 (en) 2010-02-09
CN1525962A (zh) 2004-09-01
ATE343567T1 (de) 2006-11-15
CZ20032415A3 (cs) 2004-04-14
HU229224B1 (en) 2013-09-30
HRP20030735B1 (en) 2012-02-29
SI1370543T1 (sl) 2007-04-30
HRP20030735A2 (en) 2005-08-31
JP4530612B2 (ja) 2010-08-25
CN100369904C (zh) 2008-02-20
AU2002302363B2 (en) 2008-05-01
EA006096B1 (ru) 2005-08-25
ZA200306086B (en) 2005-01-26
KR20030077017A (ko) 2003-09-29
AP2003002856A0 (en) 2003-09-30
NO20033584D0 (no) 2003-08-13

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20160214