SK287145B6 - Farmaceutická kompozícia obsahujúca kryštalický 11-(4-(2-(2- hydroxyetoxy)etyl)-1-piperazinyl)dibenzo[b,f][1,4]tiazepín, spôsob čistenia tohto tiazepínu, spôsob prípravy kryštalického 11-(4-(2-(2-hydroxyetoxy)etyl)-1- piperazinyl)dibenzo[b,f][1,4]tiazepínu a jeho použitie - Google Patents

Farmaceutická kompozícia obsahujúca kryštalický 11-(4-(2-(2- hydroxyetoxy)etyl)-1-piperazinyl)dibenzo[b,f][1,4]tiazepín, spôsob čistenia tohto tiazepínu, spôsob prípravy kryštalického 11-(4-(2-(2-hydroxyetoxy)etyl)-1- piperazinyl)dibenzo[b,f][1,4]tiazepínu a jeho použitie Download PDF

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Publication number
SK287145B6
SK287145B6 SK130-2000A SK1302000A SK287145B6 SK 287145 B6 SK287145 B6 SK 287145B6 SK 1302000 A SK1302000 A SK 1302000A SK 287145 B6 SK287145 B6 SK 287145B6
Authority
SK
Slovakia
Prior art keywords
thiazepine
ethyl
hydroxyethoxy
dibenzo
piperazinyl
Prior art date
Application number
SK130-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK1302000A3 (en
Inventor
Evan William Snape
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of SK1302000A3 publication Critical patent/SK1302000A3/sk
Publication of SK287145B6 publication Critical patent/SK287145B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Liquid Crystal Substances (AREA)
SK130-2000A 1997-08-01 1998-07-28 Farmaceutická kompozícia obsahujúca kryštalický 11-(4-(2-(2- hydroxyetoxy)etyl)-1-piperazinyl)dibenzo[b,f][1,4]tiazepín, spôsob čistenia tohto tiazepínu, spôsob prípravy kryštalického 11-(4-(2-(2-hydroxyetoxy)etyl)-1- piperazinyl)dibenzo[b,f][1,4]tiazepínu a jeho použitie SK287145B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9716161.6A GB9716161D0 (en) 1997-08-01 1997-08-01 Process
PCT/GB1998/002260 WO1999006381A1 (en) 1997-08-01 1998-07-28 A crystalline dibenzothiazepine derivative and its use as an antipsychotic agent

Publications (2)

Publication Number Publication Date
SK1302000A3 SK1302000A3 (en) 2000-06-12
SK287145B6 true SK287145B6 (sk) 2010-01-07

Family

ID=10816746

Family Applications (1)

Application Number Title Priority Date Filing Date
SK130-2000A SK287145B6 (sk) 1997-08-01 1998-07-28 Farmaceutická kompozícia obsahujúca kryštalický 11-(4-(2-(2- hydroxyetoxy)etyl)-1-piperazinyl)dibenzo[b,f][1,4]tiazepín, spôsob čistenia tohto tiazepínu, spôsob prípravy kryštalického 11-(4-(2-(2-hydroxyetoxy)etyl)-1- piperazinyl)dibenzo[b,f][1,4]tiazepínu a jeho použitie

Country Status (32)

Country Link
US (2) US6372734B1 (bg)
EP (2) EP1000043B1 (bg)
JP (2) JP2001512109A (bg)
KR (1) KR20010022241A (bg)
CN (1) CN1125058C (bg)
AT (2) ATE496037T1 (bg)
AU (1) AU739255B2 (bg)
BG (1) BG64796B1 (bg)
BR (1) BR9811061A (bg)
CA (1) CA2295792C (bg)
CY (2) CY2200162T2 (bg)
CZ (1) CZ299225B6 (bg)
DE (4) DE69842104D1 (bg)
EE (1) EE04550B1 (bg)
ES (2) ES2296575T3 (bg)
GB (2) GB9716161D0 (bg)
HK (2) HK1029992A1 (bg)
HU (1) HU228620B1 (bg)
ID (1) ID24219A (bg)
IL (1) IL133618A (bg)
MY (1) MY120999A (bg)
NO (1) NO20000484L (bg)
NZ (1) NZ501914A (bg)
PL (1) PL338384A1 (bg)
PT (2) PT1589008E (bg)
RU (1) RU2224754C2 (bg)
SI (2) SI1589008T1 (bg)
SK (1) SK287145B6 (bg)
TR (1) TR200000848T2 (bg)
TW (1) TW533207B (bg)
WO (1) WO1999006381A1 (bg)
ZA (1) ZA986904B (bg)

Families Citing this family (30)

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EP2000141A1 (en) * 2002-03-20 2008-12-10 Teva Pharmaceutical Industries Ltd. Methods for preparing crystalline quetiapine hemifumarate
US7071331B2 (en) 2003-02-22 2006-07-04 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
US7238686B2 (en) * 2003-03-03 2007-07-03 Hetero Drugs Limited Polymorphs of quetiapine fumarate
EP1611138A1 (en) 2003-04-07 2006-01-04 Hetero Drugs Limited A novel crystalline form of dorzolamide hydrochloride
ES2223294B2 (es) 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
US20060081361A1 (en) * 2004-09-13 2006-04-20 Gabbey Lawrence W Oil cooler with integral filter
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
JP2008502707A (ja) 2005-04-14 2008-01-31 テバ ファーマシューティカル インダストリーズ リミティド クエチアピンフマレートの調製方法
US20070072840A1 (en) * 2005-05-30 2007-03-29 Pandya Bhargav Polymorphic forms of quetiapine
EP1928849A1 (en) 2005-09-30 2008-06-11 Fermion Oy New crystallization process of quetiapine hemifumarate
EP1948628A1 (en) * 2005-10-28 2008-07-30 Fermion Oy Quetiapine hemifumarate purification by crystallization
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
CN101360502B (zh) * 2005-11-18 2012-03-14 阿斯利康公司 结晶形式
US20090215744A1 (en) * 2005-11-18 2009-08-27 Astrazeneca Ab Solid Formulations
CN101360503A (zh) * 2005-11-18 2009-02-04 阿斯利康公司 液体制剂
JP2009516705A (ja) * 2005-11-18 2009-04-23 アストラゼネカ・アクチエボラーグ 塩の形態
CZ300451B6 (cs) * 2006-07-03 2009-05-20 Farmak, A. S. Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení
WO2008066620A2 (en) * 2006-10-20 2008-06-05 Concert Pharmaceuticals Inc. Dibenzothiazepine derivatives
ATE480227T1 (de) 2007-02-14 2010-09-15 Lesvi Laboratorios Sl Pharmazeutische zusammensetzungen mit quetiapinfumarat
EP2144892A2 (en) * 2007-03-29 2010-01-20 Teva Pharmaceutical Industries Ltd. Improved process for preparing quetiapine fumarate
WO2009004480A2 (en) * 2007-05-07 2009-01-08 Actavis Group Ptc Ehf Quetiapine salts and their polymorphs
US20090082334A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched quetiapine
EP2229364B1 (en) * 2007-12-05 2015-02-25 Janssen Pharmaceutica, N.V. Dibenzoazepine and dibenzooxazepine trpa1 agonists
SI2262486T1 (sl) 2008-08-01 2013-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Sestavek kvetiapina
US20100069356A1 (en) * 2008-09-17 2010-03-18 Auspex Pharmaceuticals, Inc. Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors
US20120071649A1 (en) 2009-03-04 2012-03-22 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
WO2013024072A1 (en) 2011-08-12 2013-02-21 Qiagen Gmbh Method for isolating nucleic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787249A (fr) 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
GB8705574D0 (en) * 1987-03-10 1987-04-15 Ici Plc Preparation of thiazepine compound

Also Published As

Publication number Publication date
AU8549898A (en) 1999-02-22
ZA986904B (en) 1999-02-01
EP1589008B1 (en) 2011-01-19
TR200000848T2 (tr) 2000-08-21
HU228620B1 (en) 2013-04-29
ES2296575T1 (es) 2008-05-01
EE200000062A (et) 2000-10-16
SI1000043T1 (sl) 2010-01-29
JP2001512109A (ja) 2001-08-21
BG64796B1 (bg) 2006-04-28
DE69841216D1 (de) 2009-11-19
NO20000484L (no) 2000-03-16
GB9814882D0 (en) 1998-09-09
CZ2000341A3 (cs) 2000-05-17
AU739255B2 (en) 2001-10-04
ID24219A (id) 2000-07-13
CN1125058C (zh) 2003-10-22
CA2295792A1 (en) 1999-02-11
BR9811061A (pt) 2000-09-19
TW533207B (en) 2003-05-21
DE98936529T1 (de) 2008-11-20
DE69842104D1 (de) 2011-03-03
EP1000043A1 (en) 2000-05-17
HUP0002663A3 (en) 2001-10-29
JP2009102345A (ja) 2009-05-14
IL133618A (en) 2004-02-08
IL133618A0 (en) 2001-04-30
EP1589008A1 (en) 2005-10-26
ES2296575T3 (es) 2010-02-05
ATE444959T1 (de) 2009-10-15
US6372734B1 (en) 2002-04-16
KR20010022241A (ko) 2001-03-15
CY2200162T2 (el) 2010-07-28
ES2296568T3 (es) 2011-05-06
CY2200161T2 (el) 2010-07-28
HK1029992A1 (en) 2001-04-20
EE04550B1 (et) 2005-10-17
ES2296568T1 (es) 2008-05-01
SK1302000A3 (en) 2000-06-12
PT1000043E (pt) 2009-11-30
PL338384A1 (en) 2000-10-23
CZ299225B6 (cs) 2008-05-21
NZ501914A (en) 2001-09-28
RU2224754C2 (ru) 2004-02-27
HUP0002663A2 (hu) 2001-09-28
CN1265101A (zh) 2000-08-30
HK1081962A1 (en) 2006-05-26
ATE496037T1 (de) 2011-02-15
EP1000043B1 (en) 2009-10-07
DE05011169T1 (de) 2008-11-06
NO20000484D0 (no) 2000-01-31
CA2295792C (en) 2007-04-17
GB9716161D0 (en) 1997-10-08
WO1999006381A1 (en) 1999-02-11
US20020147186A1 (en) 2002-10-10
MY120999A (en) 2005-12-30
BG104176A (bg) 2000-08-31
SI1589008T1 (sl) 2011-04-29
PT1589008E (pt) 2011-03-23

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Legal Events

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20160728