TR200000848T2 - Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması. - Google Patents

Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması.

Info

Publication number
TR200000848T2
TR200000848T2 TR2000/00848T TR200000848T TR200000848T2 TR 200000848 T2 TR200000848 T2 TR 200000848T2 TR 2000/00848 T TR2000/00848 T TR 2000/00848T TR 200000848 T TR200000848 T TR 200000848T TR 200000848 T2 TR200000848 T2 TR 200000848T2
Authority
TR
Turkey
Prior art keywords
crystalline
ethyl
thiazepine
dibenzo
hydroxyethoxy
Prior art date
Application number
TR2000/00848T
Other languages
English (en)
Inventor
William Snape Evan
Original Assignee
Zeneca Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Limited filed Critical Zeneca Limited
Publication of TR200000848T2 publication Critical patent/TR200000848T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

Kristalin 11-(4-[2-(2-hidroksietoksi) etil]-1- piperazinil)-dibenzo[b,f] [1,4] tiazepin (I), etil esetat, izobütil asetat, metil izo-bütilketon ya da tert-bütil eter gibi aromatik olmayan bir çözgenden hareketle tercihen sudan arik bir ortamda 11-(4-[2-(2-hidroksietoksi) etil]-1- piperazinil)-dibenzo[b,f] [1,4] tiazepini kristallestirmek suretiyle hazirlanabilir. Elde edilen kristalin maddeyi fumarat gibi farmasötik açidan geçerli bir tuza dönüstürmek mümkündür. Kristalin 11-(4-[2-(2-hidroksietoksi) etil]-1- piperazinil)-dibenzo[b,f] [1,4] tiazepin psikozlari tedavi etmek için kullanilabilir.
TR2000/00848T 1997-08-01 1998-07-28 Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması. TR200000848T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9716161.6A GB9716161D0 (en) 1997-08-01 1997-08-01 Process

Publications (1)

Publication Number Publication Date
TR200000848T2 true TR200000848T2 (tr) 2000-08-21

Family

ID=10816746

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00848T TR200000848T2 (tr) 1997-08-01 1998-07-28 Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması.

Country Status (32)

Country Link
US (2) US6372734B1 (tr)
EP (2) EP1000043B1 (tr)
JP (2) JP2001512109A (tr)
KR (1) KR20010022241A (tr)
CN (1) CN1125058C (tr)
AT (2) ATE444959T1 (tr)
AU (1) AU739255B2 (tr)
BG (1) BG64796B1 (tr)
BR (1) BR9811061A (tr)
CA (1) CA2295792C (tr)
CY (2) CY2200162T2 (tr)
CZ (1) CZ299225B6 (tr)
DE (4) DE69841216D1 (tr)
EE (1) EE04550B1 (tr)
ES (2) ES2296568T3 (tr)
GB (2) GB9716161D0 (tr)
HK (2) HK1029992A1 (tr)
HU (1) HU228620B1 (tr)
ID (1) ID24219A (tr)
IL (1) IL133618A (tr)
MY (1) MY120999A (tr)
NO (1) NO20000484L (tr)
NZ (1) NZ501914A (tr)
PL (1) PL338384A1 (tr)
PT (2) PT1589008E (tr)
RU (1) RU2224754C2 (tr)
SI (2) SI1589008T1 (tr)
SK (1) SK287145B6 (tr)
TR (1) TR200000848T2 (tr)
TW (1) TW533207B (tr)
WO (1) WO1999006381A1 (tr)
ZA (1) ZA986904B (tr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL164155A0 (en) * 2002-03-20 2005-12-18 Teva Pharma Crystalline forms of quetiapine hemifumarate
EP1495008A1 (en) * 2003-02-22 2005-01-12 Teva Pharmaceutical Industries Limited Synthesis of quetiapine and pharmaceutically acceptable salts thereof
AU2003216705A1 (en) * 2003-03-03 2004-09-28 Hetero Drugs Limited Novel polymorphs of quetiapine fumarate
US7053115B2 (en) * 2003-04-07 2006-05-30 Hetero Drugs Limited Crystalline form of dorzolamide hydrochloride
ES2223294B2 (es) 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
US20060081361A1 (en) * 2004-09-13 2006-04-20 Gabbey Lawrence W Oil cooler with integral filter
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
WO2006113425A1 (en) * 2005-04-14 2006-10-26 Teva Pharmaceutical Industries Ltd. Process for preparing quetiapine fumarate
US20070072840A1 (en) * 2005-05-30 2007-03-29 Pandya Bhargav Polymorphic forms of quetiapine
EP1928849A1 (en) * 2005-09-30 2008-06-11 Fermion Oy New crystallization process of quetiapine hemifumarate
US8044039B2 (en) 2005-10-28 2011-10-25 Fermion Oy Quetiapine hemifumarate purification by crystallization
WO2007062337A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Crystalline forms
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
CN101360725B (zh) * 2005-11-18 2011-09-21 阿斯利康公司 固体制剂
WO2007062336A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Salt forms
US20090069292A1 (en) * 2005-11-18 2009-03-12 Astrazeneca Ab Liquid Formulations
CZ300451B6 (cs) * 2006-07-03 2009-05-20 Farmak, A. S. Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení
WO2008066620A2 (en) * 2006-10-20 2008-06-05 Concert Pharmaceuticals Inc. Dibenzothiazepine derivatives
ATE480227T1 (de) 2007-02-14 2010-09-15 Lesvi Laboratorios Sl Pharmazeutische zusammensetzungen mit quetiapinfumarat
EP2144892A2 (en) * 2007-03-29 2010-01-20 Teva Pharmaceutical Industries Ltd. Improved process for preparing quetiapine fumarate
WO2009004480A2 (en) * 2007-05-07 2009-01-08 Actavis Group Ptc Ehf Quetiapine salts and their polymorphs
US20090082334A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched quetiapine
KR101598558B1 (ko) * 2007-12-05 2016-02-29 얀센 파마슈티카 엔.브이. 디벤조아제핀 및 디벤조옥사제핀 ｔｒｐａ1 효능제
DK2262486T3 (da) 2008-08-01 2013-03-25 Krka Tovarna Zdravil D D Novo Mesto Quetiapin sammensætning
US20100069356A1 (en) * 2008-09-17 2010-03-18 Auspex Pharmaceuticals, Inc. Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors
EP2403841A1 (en) 2009-03-04 2012-01-11 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
US9695465B2 (en) 2011-08-12 2017-07-04 Qiagen Gmbh Method for isolating nucleic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787249A (fr) 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
GB8705574D0 (en) * 1987-03-10 1987-04-15 Ici Plc Preparation of thiazepine compound

Also Published As

Publication number Publication date
HUP0002663A3 (en) 2001-10-29
AU739255B2 (en) 2001-10-04
JP2001512109A (ja) 2001-08-21
ID24219A (id) 2000-07-13
PT1000043E (pt) 2009-11-30
AU8549898A (en) 1999-02-22
ES2296575T3 (es) 2010-02-05
CY2200162T2 (el) 2010-07-28
RU2224754C2 (ru) 2004-02-27
SK1302000A3 (en) 2000-06-12
IL133618A (en) 2004-02-08
IL133618A0 (en) 2001-04-30
GB9814882D0 (en) 1998-09-09
PT1589008E (pt) 2011-03-23
ZA986904B (en) 1999-02-01
ES2296568T3 (es) 2011-05-06
CA2295792A1 (en) 1999-02-11
US6372734B1 (en) 2002-04-16
MY120999A (en) 2005-12-30
BG104176A (en) 2000-08-31
HU228620B1 (en) 2013-04-29
NZ501914A (en) 2001-09-28
TW533207B (en) 2003-05-21
PL338384A1 (en) 2000-10-23
BG64796B1 (bg) 2006-04-28
ATE444959T1 (de) 2009-10-15
DE69841216D1 (de) 2009-11-19
ATE496037T1 (de) 2011-02-15
GB9716161D0 (en) 1997-10-08
KR20010022241A (ko) 2001-03-15
HUP0002663A2 (hu) 2001-09-28
EE200000062A (et) 2000-10-16
HK1029992A1 (en) 2001-04-20
ES2296575T1 (es) 2008-05-01
DE69842104D1 (de) 2011-03-03
BR9811061A (pt) 2000-09-19
SI1000043T1 (sl) 2010-01-29
EE04550B1 (et) 2005-10-17
NO20000484D0 (no) 2000-01-31
CN1125058C (zh) 2003-10-22
DE98936529T1 (de) 2008-11-20
US20020147186A1 (en) 2002-10-10
SI1589008T1 (sl) 2011-04-29
JP2009102345A (ja) 2009-05-14
EP1000043A1 (en) 2000-05-17
CZ299225B6 (cs) 2008-05-21
ES2296568T1 (es) 2008-05-01
CN1265101A (zh) 2000-08-30
EP1000043B1 (en) 2009-10-07
CY2200161T2 (el) 2010-07-28
EP1589008A1 (en) 2005-10-26
CA2295792C (en) 2007-04-17
EP1589008B1 (en) 2011-01-19
SK287145B6 (sk) 2010-01-07
WO1999006381A1 (en) 1999-02-11
DE05011169T1 (de) 2008-11-06
NO20000484L (no) 2000-03-16
HK1081962A1 (en) 2006-05-26
CZ2000341A3 (cs) 2000-05-17

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