SK286945B6 - Expresný systém faktora VIII - Google Patents

Expresný systém faktora VIII Download PDF

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Publication number
SK286945B6
SK286945B6 SK792-2001A SK7922001A SK286945B6 SK 286945 B6 SK286945 B6 SK 286945B6 SK 7922001 A SK7922001 A SK 7922001A SK 286945 B6 SK286945 B6 SK 286945B6
Authority
SK
Slovakia
Prior art keywords
leu
ser
protein
factor viii
glu
Prior art date
Application number
SK792-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK7922001A3 (en
Inventor
Myung-Sam Cho
Sham-Yuen Chan
William Kelsey
Helena Yee
Original Assignee
Bayer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of SK7922001A3 publication Critical patent/SK7922001A3/sk
Publication of SK286945B6 publication Critical patent/SK286945B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
SK792-2001A 1998-12-10 1999-12-08 Expresný systém faktora VIII SK286945B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/209,916 US6358703B1 (en) 1998-12-10 1998-12-10 Expression system for factor VIII
PCT/US1999/029169 WO2000034505A1 (en) 1998-12-10 1999-12-08 Expression system for factor viii

Publications (2)

Publication Number Publication Date
SK7922001A3 SK7922001A3 (en) 2002-01-07
SK286945B6 true SK286945B6 (sk) 2009-08-06

Family

ID=22780858

Family Applications (1)

Application Number Title Priority Date Filing Date
SK792-2001A SK286945B6 (sk) 1998-12-10 1999-12-08 Expresný systém faktora VIII

Country Status (26)

Country Link
US (10) US6358703B1 (bg)
EP (1) EP1137797B1 (bg)
JP (1) JP4240818B2 (bg)
KR (1) KR100616028B1 (bg)
AT (1) ATE412765T1 (bg)
AU (1) AU761801B2 (bg)
BG (1) BG65431B1 (bg)
BR (1) BRPI9916069B8 (bg)
CA (1) CA2354845C (bg)
CZ (1) CZ302330B6 (bg)
DE (1) DE69939839D1 (bg)
DK (1) DK1137797T3 (bg)
ES (1) ES2315026T3 (bg)
HU (1) HU228489B1 (bg)
IL (2) IL143353A0 (bg)
NO (1) NO329544B1 (bg)
NZ (1) NZ512234A (bg)
PL (1) PL200676B1 (bg)
PT (1) PT1137797E (bg)
RO (1) RO121604B1 (bg)
RU (1) RU2249041C2 (bg)
SI (1) SI20644B (bg)
SK (1) SK286945B6 (bg)
TR (1) TR200101592T2 (bg)
UA (1) UA77383C2 (bg)
WO (1) WO2000034505A1 (bg)

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US6180108B1 (en) * 1998-12-10 2001-01-30 Bayer Corporation Vectors having terminal repeat sequence of Epstein-Barr virus
US6358703B1 (en) * 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
CN1454257B (zh) * 2000-03-22 2013-01-16 奥克塔金尼有限责任公司 重组凝血因子在人类细胞系中的生产
WO2002103024A2 (en) * 2001-06-14 2002-12-27 The Scripps Research Institute Stabilized proteins with engineered disulfide bonds
BRPI0407882B1 (pt) 2003-02-26 2021-07-27 Nektar Therapeutics Composição compreendendo conjugados de polímero-porção de fator viii e seu método de fabricação
US7709224B2 (en) * 2003-06-03 2010-05-04 Biosante Pharmaceuticals, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US7598083B2 (en) * 2004-10-29 2009-10-06 Centocor, Inc. Chemically defined media compositions
PH12014500352A1 (en) 2004-11-12 2015-07-20 Bayer Healthcare Llc Site-directed modification of fviii
PE20080556A1 (es) 2005-12-20 2008-06-13 Bristol Myers Squibb Co Composicion que comprende una poblacion aislada de moleculas ctla4-ig a partir de un medio de cultivo liquido y metodos para su obtencion
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
PL2574676T3 (pl) 2007-12-27 2017-12-29 Baxalta GmbH Sposoby hodowli komórek
KR101005967B1 (ko) * 2008-04-12 2011-01-05 (주)셀트리온 우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포
EP2304046A4 (en) * 2008-06-25 2011-11-23 Bayer Healthcare Llc FACTOR VIII MUTES WITH REDUCED IMMUNOGENITY
BRPI0917656A2 (pt) 2008-08-21 2017-07-11 Octapharma Ag Fatores viii e ix humanos produzidos de forma recombinante
AU2009289212B2 (en) * 2008-09-03 2015-02-12 Octapharma Ag New protecting compositions for recombinantly produced factor VIII
DK3178835T3 (da) 2009-02-03 2019-06-24 Amunix Pharmaceuticals Inc Forlængede rekombinante polypeptider og sammensætninger omfattende samme
CA2756197A1 (en) * 2009-03-24 2010-09-30 Bayer Healthcare Llc Factor viii variants and methods of use
JP5813641B2 (ja) 2009-08-24 2015-11-17 アムニクス オペレーティング インコーポレイテッド 凝固第ｉｘ因子組成物ならびにそれを製造および使用する方法
US20110150843A1 (en) * 2009-10-30 2011-06-23 National Institute Of Immunology Method for the therapeutic correction of hemophilia a by transplanting bone marrow cells
US20130017997A1 (en) * 2010-08-19 2013-01-17 Amunix Operating Inc. Factor VIII Compositions and Methods of Making and Using Same
EP2707387B1 (en) * 2011-05-13 2019-12-25 Octapharma AG A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii
DK2804623T3 (da) 2012-01-12 2019-11-11 Bioverativ Therapeutics Inc Kimære faktor viii-polypeptider og anvendelser deraf
US10370430B2 (en) 2012-02-15 2019-08-06 Bioverativ Therapeutics Inc. Recombinant factor VIII proteins
ES2771208T3 (es) * 2012-02-15 2020-07-06 Bioverativ Therapeutics Inc Composiciones de factor VIII y métodos de preparación y uso de las mismas
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
PL3091997T3 (pl) 2014-01-10 2023-01-02 Bioverativ Therapeutics Inc. Białka chimeryczne czynnika viii i ich zastosowania
CA2994547A1 (en) 2015-08-03 2017-02-09 Bioverativ Therapeutics Inc. Factor ix fusion proteins and methods of making and using same
IL288790B2 (en) 2016-04-15 2024-01-01 Takeda Pharmaceuticals Co Method and device for delivering a pharmacokinetic drug dosage regimen
WO2018017923A1 (en) 2016-07-22 2018-01-25 Nektar Therapeutics Conjugates of a factor viii moiety having an oxime-containing linkage
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
US20200245667A1 (en) * 2017-09-13 2020-08-06 Evolve Biosystems, Inc. Oligosaccharide compositions and their use during transitional phases of the mammalian gut microbiome
KR20190086269A (ko) * 2018-01-12 2019-07-22 재단법인 목암생명과학연구소 체내 지속형 재조합 당단백질 및 이의 제조방법
CA3099049A1 (en) 2018-05-18 2019-11-21 Bioverativ Therapeutics Inc. Methods of treating hemophilia a
AU2019366942A1 (en) * 2018-10-23 2021-06-10 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor VIII function

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Also Published As

Publication number Publication date
KR20020013481A (ko) 2002-02-20
UA77383C2 (uk) 2006-12-15
BR9916069A (pt) 2001-09-04
WO2000034505A1 (en) 2000-06-15
IL143353A (en) 2010-12-30
HU228489B1 (en) 2013-03-28
HUP0200558A3 (en) 2004-11-29
US20090036358A1 (en) 2009-02-05
RO121604B1 (ro) 2007-12-28
US20020102730A1 (en) 2002-08-01
BG65431B1 (bg) 2008-07-31
SI20644B (sl) 2009-04-30
NO20012718D0 (no) 2001-06-01
EP1137797A4 (en) 2005-06-22
US9249209B2 (en) 2016-02-02
DK1137797T3 (da) 2009-02-23
EP1137797B1 (en) 2008-10-29
US20030077752A1 (en) 2003-04-24
US7459525B2 (en) 2008-12-02
EP1137797A1 (en) 2001-10-04
AU761801B2 (en) 2003-06-12
US20130267468A1 (en) 2013-10-10
CA2354845A1 (en) 2000-06-15
ES2315026T3 (es) 2009-03-16
US9650431B2 (en) 2017-05-16
NZ512234A (en) 2002-12-20
CZ20012024A3 (cs) 2001-10-17
US8945869B2 (en) 2015-02-03
US20170267745A1 (en) 2017-09-21
KR100616028B1 (ko) 2006-08-28
BRPI9916069B8 (pt) 2021-05-25
NO329544B1 (no) 2010-11-08
US6358703B1 (en) 2002-03-19
PT1137797E (pt) 2008-12-26
HUP0200558A2 (en) 2002-06-28
SI20644A (sl) 2002-02-28
PL200676B1 (pl) 2009-01-30
US20130143818A1 (en) 2013-06-06
JP2002531137A (ja) 2002-09-24
BRPI9916069B1 (pt) 2016-08-02
RU2249041C2 (ru) 2005-03-27
ATE412765T1 (de) 2008-11-15
NO20012718L (no) 2001-06-01
US20110144025A1 (en) 2011-06-16
CA2354845C (en) 2008-08-12
JP4240818B2 (ja) 2009-03-18
CZ302330B6 (cs) 2011-03-16
US20020115152A1 (en) 2002-08-22
US8207117B2 (en) 2012-06-26
PL349284A1 (en) 2002-07-15
IL143353A0 (en) 2002-04-21
DE69939839D1 (de) 2008-12-11
SK7922001A3 (en) 2002-01-07
BG105567A (bg) 2002-03-29
TR200101592T2 (tr) 2001-11-21
AU2170100A (en) 2000-06-26
US20160115219A1 (en) 2016-04-28

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Expiry date: 20191208