SK285703B6 - 2-Aryl-8-oxodihydropurínový derivát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahoma medziprodukt na jeho prípravu - Google Patents
2-Aryl-8-oxodihydropurínový derivát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahoma medziprodukt na jeho prípravu Download PDFInfo
- Publication number
- SK285703B6 SK285703B6 SK797-2000A SK7972000A SK285703B6 SK 285703 B6 SK285703 B6 SK 285703B6 SK 7972000 A SK7972000 A SK 7972000A SK 285703 B6 SK285703 B6 SK 285703B6
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- alkyl
- formula
- phenyl
- compound
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- 238000000034 method Methods 0.000 title claims description 43
- 230000008569 process Effects 0.000 title claims description 15
- 239000000543 intermediate Substances 0.000 title abstract description 8
- 239000000203 mixture Substances 0.000 title description 80
- 239000002253 acid Substances 0.000 claims abstract description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 31
- 208000019901 Anxiety disease Diseases 0.000 claims abstract description 14
- 230000036506 anxiety Effects 0.000 claims abstract description 11
- 238000011282 treatment Methods 0.000 claims abstract description 11
- 201000010099 disease Diseases 0.000 claims abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 10
- 208000027520 Somatoform disease Diseases 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 220
- 125000000217 alkyl group Chemical group 0.000 claims description 147
- -1 hydroxy, amino Chemical group 0.000 claims description 85
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 56
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 54
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 53
- 238000002360 preparation method Methods 0.000 claims description 51
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 47
- 125000003545 alkoxy group Chemical group 0.000 claims description 43
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 239000001257 hydrogen Substances 0.000 claims description 39
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 39
- 125000005843 halogen group Chemical group 0.000 claims description 37
- 125000003282 alkyl amino group Chemical group 0.000 claims description 35
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 35
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 34
- 229910052736 halogen Inorganic materials 0.000 claims description 30
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 27
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 24
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 22
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 150000002367 halogens Chemical class 0.000 claims description 21
- 125000001072 heteroaryl group Chemical group 0.000 claims description 19
- 125000003342 alkenyl group Chemical group 0.000 claims description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 17
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 15
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 14
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 125000002619 bicyclic group Chemical group 0.000 claims description 9
- 125000002950 monocyclic group Chemical group 0.000 claims description 9
- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 7
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 7
- 229910052721 tungsten Inorganic materials 0.000 claims description 7
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000004434 sulfur atom Chemical group 0.000 claims description 6
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 5
- 125000002541 furyl group Chemical group 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 5
- 125000003386 piperidinyl group Chemical group 0.000 claims description 5
- 125000006239 protecting group Chemical group 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- 125000001544 thienyl group Chemical group 0.000 claims description 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 4
- AVQSOJBJNQGERD-UHFFFAOYSA-N 2-(7-methyl-8-oxo-2-phenylpurin-9-yl)-n,n-dipropylacetamide Chemical compound N=1C=C2N(C)C(=O)N(CC(=O)N(CCC)CCC)C2=NC=1C1=CC=CC=C1 AVQSOJBJNQGERD-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims description 4
- 125000003277 amino group Chemical group 0.000 claims description 4
- 239000004202 carbamide Substances 0.000 claims description 4
- RWRIWBAIICGTTQ-UHFFFAOYSA-N difluoromethane Chemical compound FCF RWRIWBAIICGTTQ-UHFFFAOYSA-N 0.000 claims description 4
- 125000006277 halobenzyl group Chemical group 0.000 claims description 4
- 125000005059 halophenyl group Chemical group 0.000 claims description 4
- NBMBIEOUVBHEBM-UHFFFAOYSA-N n-benzyl-n-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide Chemical compound C12=NC(C=3C=CC=CC=3)=NC=C2N(C)C(=O)N1CC(=O)N(CC)CC1=CC=CC=C1 NBMBIEOUVBHEBM-UHFFFAOYSA-N 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 3
- XBSQMRBRINIYEM-UHFFFAOYSA-N 2-(7-ethyl-8-oxo-2-phenylpurin-9-yl)-n,n-dipropylacetamide Chemical compound N=1C=C2N(CC)C(=O)N(CC(=O)N(CCC)CCC)C2=NC=1C1=CC=CC=C1 XBSQMRBRINIYEM-UHFFFAOYSA-N 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 3
- WCGVYRVCYAXRLS-UHFFFAOYSA-N n-benzyl-2-[2-(4-chlorophenyl)-7-methyl-8-oxopurin-9-yl]-n-ethylacetamide Chemical compound C12=NC(C=3C=CC(Cl)=CC=3)=NC=C2N(C)C(=O)N1CC(=O)N(CC)CC1=CC=CC=C1 WCGVYRVCYAXRLS-UHFFFAOYSA-N 0.000 claims description 3
- JUSYVZKYVPSLJP-UHFFFAOYSA-N n-benzyl-2-[2-(4-chlorophenyl)-7-methyl-8-oxopurin-9-yl]-n-methylacetamide Chemical compound C12=NC(C=3C=CC(Cl)=CC=3)=NC=C2N(C)C(=O)N1CC(=O)N(C)CC1=CC=CC=C1 JUSYVZKYVPSLJP-UHFFFAOYSA-N 0.000 claims description 3
- OAAFHIRSRJZNIF-UHFFFAOYSA-N n-benzyl-n-methyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide Chemical compound C12=NC(C=3C=CC=CC=3)=NC=C2N(C)C(=O)N1CC(=O)N(C)CC1=CC=CC=C1 OAAFHIRSRJZNIF-UHFFFAOYSA-N 0.000 claims description 3
- 125000004193 piperazinyl group Chemical group 0.000 claims description 3
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 3
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 claims description 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims description 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims description 2
- YRJXASBDTLXBQA-UHFFFAOYSA-N n-ethyl-2-[2-(4-fluorophenyl)-9-methyl-8-oxopurin-7-yl]-n-phenylacetamide Chemical compound C=1C=CC=CC=1N(CC)C(=O)CN(C(N(C)C1=N2)=O)C1=CN=C2C1=CC=C(F)C=C1 YRJXASBDTLXBQA-UHFFFAOYSA-N 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 238000010511 deprotection reaction Methods 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
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- 239000000047 product Substances 0.000 description 14
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- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 13
- 239000003480 eluent Substances 0.000 description 12
- PGNWLLVXMHCSJK-UHFFFAOYSA-N n-(2-hydroxyethyl)-2-(9-methyl-8-oxo-2-phenylpurin-7-yl)-n-phenylacetamide Chemical compound O=C1N(C)C2=NC(C=3C=CC=CC=3)=NC=C2N1CC(=O)N(CCO)C1=CC=CC=C1 PGNWLLVXMHCSJK-UHFFFAOYSA-N 0.000 description 12
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- 239000011593 sulfur Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- GRGCWBWNLSTIEN-UHFFFAOYSA-N trifluoromethanesulfonyl chloride Chemical compound FC(F)(F)S(Cl)(=O)=O GRGCWBWNLSTIEN-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35000097 | 1997-12-03 | ||
| PCT/JP1998/005320 WO1999028320A1 (fr) | 1997-12-03 | 1998-11-26 | Derives de 2-aryl-8-oxodihydropurine, procede de production de ces derives, compositions medicales contenant ces derives, et intermediaires de ces derives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK7972000A3 SK7972000A3 (en) | 2001-03-12 |
| SK285703B6 true SK285703B6 (sk) | 2007-06-07 |
Family
ID=18407561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK797-2000A SK285703B6 (sk) | 1997-12-03 | 1998-11-26 | 2-Aryl-8-oxodihydropurínový derivát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahoma medziprodukt na jeho prípravu |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6372740B1 (fr) |
| EP (1) | EP1036794B1 (fr) |
| JP (1) | JP3815966B2 (fr) |
| KR (1) | KR100494347B1 (fr) |
| CN (1) | CN1146566C (fr) |
| AR (1) | AR017796A1 (fr) |
| AT (1) | ATE248169T1 (fr) |
| AU (1) | AU744014B2 (fr) |
| BR (1) | BR9815140A (fr) |
| CA (1) | CA2312885C (fr) |
| DE (1) | DE69817611T2 (fr) |
| DK (1) | DK1036794T3 (fr) |
| ES (1) | ES2205574T3 (fr) |
| HK (1) | HK1028769A1 (fr) |
| HU (1) | HUP0004422A3 (fr) |
| ID (1) | ID24929A (fr) |
| IL (1) | IL135920A0 (fr) |
| NO (1) | NO20002835L (fr) |
| NZ (1) | NZ504457A (fr) |
| PL (1) | PL191489B1 (fr) |
| PT (1) | PT1036794E (fr) |
| RU (1) | RU2223272C2 (fr) |
| SK (1) | SK285703B6 (fr) |
| TR (1) | TR200001600T2 (fr) |
| TW (1) | TW502034B (fr) |
| WO (1) | WO1999028320A1 (fr) |
| ZA (1) | ZA9810490B (fr) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003146987A (ja) * | 1999-05-31 | 2003-05-21 | Dainippon Pharmaceut Co Ltd | ２−アリールプリン−９−アセトアミド誘導体 |
| GB9913932D0 (en) | 1999-06-15 | 1999-08-18 | Pfizer Ltd | Purine derivatives |
| CN1399632A (zh) * | 1999-09-27 | 2003-02-26 | 小野药品工业株式会社 | 嘧啶衍生物、其制备方法和含有该化合物作为有效成分的药物 |
| WO2002010167A1 (fr) * | 2000-07-31 | 2002-02-07 | Dainippon Pharmaceutical Co., Ltd. | Medicaments contre la demence contenant des derives de 2-aryl-8-oxodihydropurine comme ingredient actif |
| CA2554566A1 (fr) * | 2003-08-05 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Composes de pyramidine condenses utilises comme inhibiteurs de canaux ioniques potentiel-dependants |
| CA2554774A1 (fr) * | 2004-02-23 | 2005-09-01 | Dainippon Sumitomo Pharma Co., Ltd. | Nouveau compose heterocyclique |
| WO2005115399A2 (fr) * | 2004-04-16 | 2005-12-08 | Neurogen Corporation | Imidazopyrazines, imidazopyridines, et imidazopyrimidines utilisees comme ligands du recepteur crf1 |
| FR2870239B1 (fr) | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique. |
| US7884109B2 (en) * | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
| NZ562468A (en) * | 2005-04-05 | 2009-10-30 | Pharmacopeia Inc | Purine and imidazopyridine derivatives for immunosuppression |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US20070225304A1 (en) * | 2005-09-06 | 2007-09-27 | Pharmacopeia Drug Discovery, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
| US7989459B2 (en) * | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
| US20090281075A1 (en) * | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
| US7951803B2 (en) * | 2006-03-09 | 2011-05-31 | Pharmacopeia, Llc | 8-heteroarylpurine MNK2 inhibitors for treating metabolic disorders |
| AR063142A1 (es) * | 2006-10-04 | 2008-12-30 | Pharmacopeia Inc | Derivados de 2-(bencimidazolil) purina y purinonas 6-sustituidas utiles como inmunosupresores,y composiciones farmaceuticas que los contienen. |
| US7902187B2 (en) * | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| WO2008043019A1 (fr) * | 2006-10-04 | 2008-04-10 | Pharmacopeia, Inc | Dérivés de 2-(benzimidazolyl) purine substitués en position 8 pour immunosuppression |
| RU2478635C2 (ru) | 2006-10-19 | 2013-04-10 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Гетероарильные соединения, содержащие их композиции и способы лечения с применением этих соединений |
| US20080119496A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
| JP2009007273A (ja) * | 2007-06-27 | 2009-01-15 | Ajinomoto Co Inc | ジアミノピリミジン化合物の製造方法 |
| US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| US8473571B2 (en) | 2009-01-08 | 2013-06-25 | Microsoft Corporation | Synchronizing presentation states between multiple applications |
| CN102656172B (zh) * | 2009-09-09 | 2016-03-23 | 大日本住友制药株式会社 | 8-氧代二氢嘌呤衍生物 |
| EP2493472B1 (fr) | 2009-10-26 | 2016-12-07 | Signal Pharmaceuticals, LLC | Procédés de synthèse et de purification de composés hétéroaryles |
| JP2014076947A (ja) * | 2011-02-03 | 2014-05-01 | Dainippon Sumitomo Pharma Co Ltd | ２−オキシ置換８−オキソジヒドロプリン誘導体 |
| WO2012168697A1 (fr) | 2011-06-06 | 2012-12-13 | Imperial Innovations Limited | Procédés de prédiction de l'affinité de liaison à tspo d'agents d'imagerie |
| CN107157990B (zh) | 2011-10-19 | 2020-01-07 | 西格诺药品有限公司 | 利用tor激酶抑制剂治疗癌症 |
| UA114496C2 (uk) | 2011-12-02 | 2017-06-26 | Сігнал Фармасьютікалз, Елелсі | ФАРМАЦЕВТИЧНІ КОМПОЗИЦІЇ 7-(6-(2-ГІДРОКСИПРОПАН-2-ІЛ)ПІРИДИН-3-ІЛ)-1-((ТРАНС)-4-МЕТОКСИЦИКЛОГЕКСИЛ)-3,4-ДИГІДРОПІРАЗИНО[2,3-b]ПІРАЗИН-2(1H)-ОНУ, ЇХ ТВЕРДІ ФОРМИ І СПОСОБИ ЇХ ЗАСТОСУВАННЯ |
| EA028462B1 (ru) | 2012-02-24 | 2017-11-30 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способы лечения немелкоклеточного рака легких на поздних стадиях c применением комбинированного лечения с ингибитором киназы tor |
| CN102675315B (zh) * | 2012-02-28 | 2015-04-01 | 中国人民解放军第四军医大学 | 含取代苯烷基的嘌呤类化合物和制备方法及应用 |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| BR112015016997A2 (pt) | 2013-01-16 | 2017-07-11 | Signal Pharm Llc | composto, composição farmacêutica e método para o tratamento ou prevenção de câncer de mama |
| US9937169B2 (en) | 2013-04-17 | 2018-04-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy |
| CA2908353C (fr) | 2013-04-17 | 2021-11-02 | Signal Pharmaceuticals, Llc | Traitement du cancer par des dihydropyrazino-pyrazines |
| JP6382948B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ，エルエルシー | 癌を治療するためのｔｏｒキナーゼ阻害剤及びシチジン類似体を含む組合せ療法 |
| TW201527300A (zh) | 2013-04-17 | 2015-07-16 | Signal Pharm Llc | 關於１－乙基－７－（２－甲基－６－（１Ｈ－１，２，４－三唑－３－基）吡啶－３－基）－３，４－二氫吡并［２，３－ｂ］吡－２（１Ｈ）－酮之醫藥調配物、方法、固態型式及使用方法 |
| BR112015026297B1 (pt) | 2013-04-17 | 2022-08-23 | Signal Pharmaceuticals, Llc | Uso de um inibidor da quinase tor e quinazolinona 5-substituída, composição farmacêutica que os compreende, e kit |
| US9358232B2 (en) | 2013-04-17 | 2016-06-07 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
| WO2014172426A1 (fr) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Traitement du cancer par des dihydropyrazino-pyrazines |
| CN113831345A (zh) | 2013-05-29 | 2021-12-24 | 西格诺药品有限公司 | 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 |
| EP3131551A4 (fr) | 2014-04-16 | 2017-09-20 | Signal Pharmaceuticals, LLC | Formes solides comprenant 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one, et co-formateur, compositions et procédés d'utilisation de ces dernières |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| WO2015160882A1 (fr) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Formes solides comprenant de la 7-(6- (2-hydroxypropan-2-yl) pyridin-3-yl)-1-(trans)-4-méthoxycyclohexyl)-3, 4-dihydropyrazino[2,3-b] pyrazin-2(1h)-one, et un co-formeur, leurs compositions et leurs procédés d'utilisation |
| JP2017514806A (ja) | 2014-04-16 | 2017-06-08 | シグナル ファーマシューティカルズ，エルエルシー | Ｔｏｒキナーゼ阻害剤組み合わせ療法を使用して癌を治療する方法 |
| AU2015289929A1 (en) | 2014-07-14 | 2017-03-02 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| SG11201804098TA (en) | 2015-11-20 | 2018-06-28 | Forma Therapeutics Inc | Purinones as ubiquitin-specific protease 1 inhibitors |
| JP7282045B2 (ja) | 2017-06-22 | 2023-05-26 | セルジーン コーポレイション | Ｂ型肝炎ウイルス感染を特徴とする肝細胞癌の治療 |
| EP3752505B1 (fr) | 2018-02-12 | 2023-01-11 | F. Hoffmann-La Roche AG | Nouveaux composés et dérivés de sulfone pour le traitement et la prophylaxie d'une infection virale |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2525595A1 (fr) | 1982-04-27 | 1983-10-28 | Pharmuka Lab | Nouveaux derives d'arene et d'heteroarenecarboxamides et leur utilisation comme medicaments |
| FR2582514B1 (fr) | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| DK273689A (da) | 1988-06-06 | 1989-12-07 | Sanofi Sa | 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler |
| FR2632639B1 (fr) | 1988-06-09 | 1990-10-05 | Sanofi Sa | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent |
| US6083953A (en) | 1994-07-28 | 2000-07-04 | Syntex (U.S.A.) Inc. | 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative |
| IL117659A (en) | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
| US6028076A (en) | 1996-07-03 | 2000-02-22 | Japan Energy Corporation | Purine derivative |
| NZ335823A (en) * | 1997-04-22 | 2001-06-29 | Neurocrine Biosciences Inc | Thiophenopyridines, preparation as CRF receptor antagonists |
| JP3814125B2 (ja) * | 1999-06-02 | 2006-08-23 | 大日本住友製薬株式会社 | ２−アリール−８−オキソジヒドロプリン誘導体からなる医薬 |
-
1998
- 1998-11-17 ZA ZA9810490A patent/ZA9810490B/xx unknown
- 1998-11-25 TW TW087119571A patent/TW502034B/zh not_active IP Right Cessation
- 1998-11-26 DK DK98955937T patent/DK1036794T3/da active
- 1998-11-26 KR KR10-2000-7005968A patent/KR100494347B1/ko not_active IP Right Cessation
- 1998-11-26 JP JP2000523212A patent/JP3815966B2/ja not_active Expired - Fee Related
- 1998-11-26 TR TR2000/01600T patent/TR200001600T2/xx unknown
- 1998-11-26 BR BR9815140-1A patent/BR9815140A/pt not_active Application Discontinuation
- 1998-11-26 NZ NZ504457A patent/NZ504457A/en unknown
- 1998-11-26 AT AT98955937T patent/ATE248169T1/de not_active IP Right Cessation
- 1998-11-26 HU HU0004422A patent/HUP0004422A3/hu unknown
- 1998-11-26 RU RU2000117278/04A patent/RU2223272C2/ru not_active IP Right Cessation
- 1998-11-26 PL PL340925A patent/PL191489B1/pl unknown
- 1998-11-26 WO PCT/JP1998/005320 patent/WO1999028320A1/fr active IP Right Grant
- 1998-11-26 ES ES98955937T patent/ES2205574T3/es not_active Expired - Lifetime
- 1998-11-26 CA CA002312885A patent/CA2312885C/fr not_active Expired - Fee Related
- 1998-11-26 PT PT98955937T patent/PT1036794E/pt unknown
- 1998-11-26 AU AU12604/99A patent/AU744014B2/en not_active Ceased
- 1998-11-26 SK SK797-2000A patent/SK285703B6/sk unknown
- 1998-11-26 DE DE69817611T patent/DE69817611T2/de not_active Expired - Fee Related
- 1998-11-26 EP EP98955937A patent/EP1036794B1/fr not_active Expired - Lifetime
- 1998-11-26 ID IDW20000990A patent/ID24929A/id unknown
- 1998-11-26 IL IL13592098A patent/IL135920A0/xx not_active IP Right Cessation
- 1998-11-26 CN CNB988134519A patent/CN1146566C/zh not_active Expired - Fee Related
- 1998-11-26 US US09/555,490 patent/US6372740B1/en not_active Expired - Fee Related
- 1998-12-03 AR ARP980106147A patent/AR017796A1/es active IP Right Grant
-
2000
- 2000-06-02 NO NO20002835A patent/NO20002835L/no unknown
- 2000-12-15 HK HK00108107A patent/HK1028769A1/xx not_active IP Right Cessation
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