SK285398B6 - 3-Metylén steroidné deriváty, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

3-Metylén steroidné deriváty, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

Info

Publication number
SK285398B6
SK285398B6 SK727-2002A SK7272002A SK285398B6 SK 285398 B6 SK285398 B6 SK 285398B6 SK 7272002 A SK7272002 A SK 7272002A SK 285398 B6 SK285398 B6 SK 285398B6
Authority
SK
Slovakia
Prior art keywords
methylene
methyl
alkyl
norpregn
double bond
Prior art date
Application number
SK727-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK7272002A3 (en
Inventor
Ralf Plate
Wilhelmina Maria Bagchus
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of SK7272002A3 publication Critical patent/SK7272002A3/sk
Publication of SK285398B6 publication Critical patent/SK285398B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK727-2002A 1999-11-29 2000-11-23 3-Metylén steroidné deriváty, farmaceutický prostriedok s ich obsahom a ich použitie SK285398B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204000 1999-11-29
PCT/EP2000/011787 WO2001040253A2 (en) 1999-11-29 2000-11-23 3-methylene steroid derivative for the treatment of autoimmune diseases

Publications (2)

Publication Number Publication Date
SK7272002A3 SK7272002A3 (en) 2002-09-10
SK285398B6 true SK285398B6 (sk) 2007-01-04

Family

ID=8240918

Family Applications (1)

Application Number Title Priority Date Filing Date
SK727-2002A SK285398B6 (sk) 1999-11-29 2000-11-23 3-Metylén steroidné deriváty, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (30)

Country Link
US (2) US6579864B1 (ru)
EP (1) EP1240179B1 (ru)
JP (1) JP2003517472A (ru)
KR (1) KR100720326B1 (ru)
CN (1) CN1254479C (ru)
AR (1) AR033503A1 (ru)
AT (1) ATE319732T1 (ru)
AU (1) AU778773B2 (ru)
BR (1) BR0015950A (ru)
CA (1) CA2391096A1 (ru)
CO (1) CO5251432A1 (ru)
CY (1) CY1106088T1 (ru)
CZ (1) CZ20021837A3 (ru)
DE (1) DE60026608T2 (ru)
DK (1) DK1240179T3 (ru)
ES (1) ES2259624T3 (ru)
HK (1) HK1047595B (ru)
HU (1) HUP0203596A3 (ru)
IL (2) IL149412A0 (ru)
MX (1) MXPA02005334A (ru)
NO (1) NO323136B1 (ru)
NZ (1) NZ518756A (ru)
PE (1) PE20010980A1 (ru)
PL (1) PL355968A1 (ru)
PT (1) PT1240179E (ru)
RU (1) RU2248358C2 (ru)
SK (1) SK285398B6 (ru)
TW (1) TWI265167B (ru)
WO (1) WO2001040253A2 (ru)
ZA (1) ZA200203455B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
WO2005117968A2 (en) 2004-04-14 2005-12-15 Genentech, Inc. Compositions and methods comprising an egfl7 antagonist for modulating vascular development

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1085035A (en) * 1913-05-01 1914-01-20 George H Greimann Ditch-digging machine.
US1171221A (en) * 1915-12-13 1916-02-08 Charles Ephriam Marion Combination-tool.
US3213117A (en) * 1963-07-03 1965-10-19 Syntex Corp Process for preparation of delta1(10)-5alpha-estren-17beta-ol-2-one and derivatives thereof
NL299654A (ru) * 1963-10-23
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
DE3560449D1 (en) 1984-03-29 1987-09-17 Ciba Geigy Ag Substituted 1-propanoles, process for their production, chloroformic-acid esters ad their use
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids
IE63051B1 (en) 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives

Also Published As

Publication number Publication date
IL149412A (en) 2007-07-24
CN1254479C (zh) 2006-05-03
PL355968A1 (en) 2004-05-31
NO20022521D0 (no) 2002-05-28
ATE319732T1 (de) 2006-03-15
SK7272002A3 (en) 2002-09-10
EP1240179A2 (en) 2002-09-18
CO5251432A1 (es) 2003-02-28
WO2001040253A3 (en) 2002-05-02
HK1047595B (zh) 2006-05-04
CA2391096A1 (en) 2001-06-07
MXPA02005334A (es) 2003-04-10
NZ518756A (en) 2004-05-28
TWI265167B (en) 2006-11-01
CZ20021837A3 (cs) 2002-08-14
CN1402734A (zh) 2003-03-12
RU2248358C2 (ru) 2005-03-20
PT1240179E (pt) 2006-05-31
US6579864B1 (en) 2003-06-17
KR100720326B1 (ko) 2007-05-22
IL149412A0 (en) 2002-11-10
DE60026608D1 (de) 2006-05-04
WO2001040253A2 (en) 2001-06-07
DK1240179T3 (da) 2006-07-03
KR20030024656A (ko) 2003-03-26
NO20022521L (no) 2002-05-28
AU2508701A (en) 2001-06-12
AR033503A1 (es) 2003-12-26
CY1106088T1 (el) 2011-06-08
EP1240179B1 (en) 2006-03-08
HUP0203596A3 (en) 2003-12-29
ES2259624T3 (es) 2006-10-16
HK1047595A1 (en) 2003-02-28
HUP0203596A2 (hu) 2003-02-28
AU778773B2 (en) 2004-12-23
ZA200203455B (en) 2004-04-28
PE20010980A1 (es) 2001-10-02
BR0015950A (pt) 2002-11-12
DE60026608T2 (de) 2006-12-28
JP2003517472A (ja) 2003-05-27
US20040043972A1 (en) 2004-03-04
NO323136B1 (no) 2007-01-08

Similar Documents

Publication Publication Date Title
DE3124780C2 (ru)
KR100577129B1 (ko) 안드로겐 스테로이드 화합물 및 그의 제조 및 이용 방법
JPS6119640B2 (ru)
US4273771A (en) Novel Δ4,9 -gonadiene-21-ol-3,20-diones
JPS6220998B2 (ru)
US4082780A (en) Estradiol derivatives
SK285398B6 (sk) 3-Metylén steroidné deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
SK3282002A3 (en) Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
US7199115B2 (en) 17α-fluorosteroids, pharmaceutical compositions containing 17α-fluorosteroids and a method of making them
JPS6355488B2 (ru)
PL207582B1 (pl) 11ß-fluorowcosteroidy, ich otrzymywanie i zastosowanie oraz preparaty farmaceutyczne je zawierające
GB2127827A (en) Pregnane compounds
US4390530A (en) 3-Deoxy-Δ15 -steroids
JP2004505093A (ja) １６α−メチルまたはエチル置換エストロゲン
WO2004101594A1 (en) New mono-and bismethylene-steroid derivatives and process for their synthesis
JPS6230200B2 (ru)
JPS6249280B2 (ru)
NO860177L (no) 17a-beta-hydroksy-7 alfa-metyl-d-homo-19-norandrost-4,16-dien-3-on- og 17a-beta-hydroksyestere derav, deres fremstilling og anvendelser.
MXPA03001912A (es) 17-metilenesteroides-4-halogenados, metodo para su produccion y composiciones farmaceuticas que contienen estos compuestos.
US3840568A (en) Estratriene derivatives
Coussediere et al. Novel Δ 4, 9-gonadiene-21-ol-3, 20-diones
CA2193610A1 (en) 17 .alpha.-cyanomethylestra-4, 9-dien derivative compounds, processes for making same and pharmaceutical compositions containing same