NO20022521L - 3-metylen steroid derivater - Google Patents

3-metylen steroid derivater

Info

Publication number
NO20022521L
NO20022521L NO20022521A NO20022521A NO20022521L NO 20022521 L NO20022521 L NO 20022521L NO 20022521 A NO20022521 A NO 20022521A NO 20022521 A NO20022521 A NO 20022521A NO 20022521 L NO20022521 L NO 20022521L
Authority
NO
Norway
Prior art keywords
double bond
lower alkyl
alkyl
methylene steroid
steroid derivatives
Prior art date
Application number
NO20022521A
Other languages
English (en)
Other versions
NO20022521D0 (no
NO323136B1 (no
Inventor
Ralf Plate
Wilhelmina Maria Bagchus
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of NO20022521L publication Critical patent/NO20022521L/no
Publication of NO20022521D0 publication Critical patent/NO20022521D0/no
Publication of NO323136B1 publication Critical patent/NO323136B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det er beskrevet et 3-metylen steroidderivat som har den generelle formel 1. hvor Rer H eller sammen med R3 danner et Ø-epoksyd eller Rer fraværende hvis det er en 5-10 eller 4-5 dobbeltbinding; R2 er (CC)alkyl eller CF; R3 er PH, (3CHeller sammen med Rdanner et P-epoksyd eller Rer fraværende hvis det er en 5-10 dobbeltbinding; R4 er H, lavere alkyl; Y er [H, H], [OH, H], =0, [OH, lavere alkyl], [OH, (C-C)alkenyl], [OH, (C-C)alkynyl] eller (C,-C)alkyliden, hvorved nevnte alkyl, alkenyl, alkynyl og alkyliden eventuelt er halogenert; =NOR, hvorved Rer H, lavere alkyl; den stiplede linjen representerer en eventuell dobbeltbinding eller prodrug derav for behandling av artrittiske sykdommer og/eller autoimmune sykdommer.
NO20022521A 1999-11-29 2002-05-28 3-metylen steroid derivater, anvendelse derav og farmasoytisk preparat. NO323136B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204000 1999-11-29
PCT/EP2000/011787 WO2001040253A2 (en) 1999-11-29 2000-11-23 3-methylene steroid derivative for the treatment of autoimmune diseases

Publications (3)

Publication Number Publication Date
NO20022521L true NO20022521L (no) 2002-05-28
NO20022521D0 NO20022521D0 (no) 2002-05-28
NO323136B1 NO323136B1 (no) 2007-01-08

Family

ID=8240918

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022521A NO323136B1 (no) 1999-11-29 2002-05-28 3-metylen steroid derivater, anvendelse derav og farmasoytisk preparat.

Country Status (30)

Country Link
US (2) US6579864B1 (no)
EP (1) EP1240179B1 (no)
JP (1) JP2003517472A (no)
KR (1) KR100720326B1 (no)
CN (1) CN1254479C (no)
AR (1) AR033503A1 (no)
AT (1) ATE319732T1 (no)
AU (1) AU778773B2 (no)
BR (1) BR0015950A (no)
CA (1) CA2391096A1 (no)
CO (1) CO5251432A1 (no)
CY (1) CY1106088T1 (no)
CZ (1) CZ20021837A3 (no)
DE (1) DE60026608T2 (no)
DK (1) DK1240179T3 (no)
ES (1) ES2259624T3 (no)
HK (1) HK1047595B (no)
HU (1) HUP0203596A3 (no)
IL (2) IL149412A0 (no)
MX (1) MXPA02005334A (no)
NO (1) NO323136B1 (no)
NZ (1) NZ518756A (no)
PE (1) PE20010980A1 (no)
PL (1) PL355968A1 (no)
PT (1) PT1240179E (no)
RU (1) RU2248358C2 (no)
SK (1) SK285398B6 (no)
TW (1) TWI265167B (no)
WO (1) WO2001040253A2 (no)
ZA (1) ZA200203455B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
EP1734998A2 (en) 2004-04-14 2006-12-27 Genentech, Inc. Compositions and methods comprising an egfl7 antagonist for modulating vascular development

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1085035A (en) * 1913-05-01 1914-01-20 George H Greimann Ditch-digging machine.
US1171221A (en) * 1915-12-13 1916-02-08 Charles Ephriam Marion Combination-tool.
US3213117A (en) * 1963-07-03 1965-10-19 Syntex Corp Process for preparation of delta1(10)-5alpha-estren-17beta-ol-2-one and derivatives thereof
BE654772A (no) * 1963-10-23
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
DE3560449D1 (en) 1984-03-29 1987-09-17 Ciba Geigy Ag Substituted 1-propanoles, process for their production, chloroformic-acid esters ad their use
GB8513723D0 (en) 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids
IE63051B1 (en) * 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives

Also Published As

Publication number Publication date
AR033503A1 (es) 2003-12-26
AU2508701A (en) 2001-06-12
SK7272002A3 (en) 2002-09-10
HUP0203596A3 (en) 2003-12-29
PL355968A1 (en) 2004-05-31
EP1240179A2 (en) 2002-09-18
PT1240179E (pt) 2006-05-31
US20040043972A1 (en) 2004-03-04
DE60026608D1 (de) 2006-05-04
IL149412A0 (en) 2002-11-10
KR20030024656A (ko) 2003-03-26
SK285398B6 (sk) 2007-01-04
CY1106088T1 (el) 2011-06-08
NZ518756A (en) 2004-05-28
WO2001040253A2 (en) 2001-06-07
BR0015950A (pt) 2002-11-12
HK1047595B (zh) 2006-05-04
TWI265167B (en) 2006-11-01
HK1047595A1 (en) 2003-02-28
WO2001040253A3 (en) 2002-05-02
CN1402734A (zh) 2003-03-12
JP2003517472A (ja) 2003-05-27
US6579864B1 (en) 2003-06-17
NO20022521D0 (no) 2002-05-28
CO5251432A1 (es) 2003-02-28
CA2391096A1 (en) 2001-06-07
PE20010980A1 (es) 2001-10-02
CN1254479C (zh) 2006-05-03
MXPA02005334A (es) 2003-04-10
IL149412A (en) 2007-07-24
KR100720326B1 (ko) 2007-05-22
DE60026608T2 (de) 2006-12-28
HUP0203596A2 (hu) 2003-02-28
DK1240179T3 (da) 2006-07-03
ES2259624T3 (es) 2006-10-16
EP1240179B1 (en) 2006-03-08
CZ20021837A3 (cs) 2002-08-14
AU778773B2 (en) 2004-12-23
NO323136B1 (no) 2007-01-08
ZA200203455B (en) 2004-04-28
RU2248358C2 (ru) 2005-03-20
ATE319732T1 (de) 2006-03-15

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