ATE319732T1 - 3-methylen steroid derivate zur behandlung von autoimmunerkrankungen - Google Patents

3-methylen steroid derivate zur behandlung von autoimmunerkrankungen

Info

Publication number
ATE319732T1
ATE319732T1 AT00988758T AT00988758T ATE319732T1 AT E319732 T1 ATE319732 T1 AT E319732T1 AT 00988758 T AT00988758 T AT 00988758T AT 00988758 T AT00988758 T AT 00988758T AT E319732 T1 ATE319732 T1 AT E319732T1
Authority
AT
Austria
Prior art keywords
treatment
autoimmune diseases
steroid derivatives
methylene steroid
methylene
Prior art date
Application number
AT00988758T
Other languages
English (en)
Inventor
Ralf Plate
Wilhelmina Maria Bagchus
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE319732T1 publication Critical patent/ATE319732T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051Estrane derivatives
    • C07J1/0066Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051Estrane derivatives
    • C07J1/0081Substituted in position 17 alfa and 17 beta
    • C07J1/0088Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096Alkynyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00988758T 1999-11-29 2000-11-23 3-methylen steroid derivate zur behandlung von autoimmunerkrankungen ATE319732T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99204000 1999-11-29

Publications (1)

Publication Number Publication Date
ATE319732T1 true ATE319732T1 (de) 2006-03-15

Family

ID=8240918

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00988758T ATE319732T1 (de) 1999-11-29 2000-11-23 3-methylen steroid derivate zur behandlung von autoimmunerkrankungen

Country Status (30)

Country Link
US (2) US6579864B1 (de)
EP (1) EP1240179B1 (de)
JP (1) JP2003517472A (de)
KR (1) KR100720326B1 (de)
CN (1) CN1254479C (de)
AR (1) AR033503A1 (de)
AT (1) ATE319732T1 (de)
AU (1) AU778773B2 (de)
BR (1) BR0015950A (de)
CA (1) CA2391096A1 (de)
CO (1) CO5251432A1 (de)
CY (1) CY1106088T1 (de)
CZ (1) CZ20021837A3 (de)
DE (1) DE60026608T2 (de)
DK (1) DK1240179T3 (de)
ES (1) ES2259624T3 (de)
HK (1) HK1047595B (de)
HU (1) HUP0203596A3 (de)
IL (2) IL149412A0 (de)
MX (1) MXPA02005334A (de)
NO (1) NO323136B1 (de)
NZ (1) NZ518756A (de)
PE (1) PE20010980A1 (de)
PL (1) PL355968A1 (de)
PT (1) PT1240179E (de)
RU (1) RU2248358C2 (de)
SK (1) SK285398B6 (de)
TW (1) TWI265167B (de)
WO (1) WO2001040253A2 (de)
ZA (1) ZA200203455B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
WO2005117968A2 (en) 2004-04-14 2005-12-15 Genentech, Inc. Compositions and methods comprising an egfl7 antagonist for modulating vascular development

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1085035A (en) * 1913-05-01 1914-01-20 George H Greimann Ditch-digging machine.
US1171221A (en) * 1915-12-13 1916-02-08 Charles Ephriam Marion Combination-tool.
US3213117A (en) * 1963-07-03 1965-10-19 Syntex Corp Process for preparation of delta1(10)-5alpha-estren-17beta-ol-2-one and derivatives thereof
NL299654A (de) * 1963-10-23
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
DE3560449D1 (en) 1984-03-29 1987-09-17 Ciba Geigy Ag Substituted 1-propanoles, process for their production, chloroformic-acid esters ad their use
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids
IE63051B1 (en) 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives

Also Published As

Publication number Publication date
SK285398B6 (sk) 2007-01-04
IL149412A (en) 2007-07-24
CN1254479C (zh) 2006-05-03
PL355968A1 (en) 2004-05-31
NO20022521D0 (no) 2002-05-28
SK7272002A3 (en) 2002-09-10
EP1240179A2 (de) 2002-09-18
CO5251432A1 (es) 2003-02-28
WO2001040253A3 (en) 2002-05-02
HK1047595B (zh) 2006-05-04
CA2391096A1 (en) 2001-06-07
MXPA02005334A (es) 2003-04-10
NZ518756A (en) 2004-05-28
TWI265167B (en) 2006-11-01
CZ20021837A3 (cs) 2002-08-14
CN1402734A (zh) 2003-03-12
RU2248358C2 (ru) 2005-03-20
PT1240179E (pt) 2006-05-31
US6579864B1 (en) 2003-06-17
KR100720326B1 (ko) 2007-05-22
IL149412A0 (en) 2002-11-10
DE60026608D1 (de) 2006-05-04
WO2001040253A2 (en) 2001-06-07
DK1240179T3 (da) 2006-07-03
KR20030024656A (ko) 2003-03-26
NO20022521L (no) 2002-05-28
AU2508701A (en) 2001-06-12
AR033503A1 (es) 2003-12-26
CY1106088T1 (el) 2011-06-08
EP1240179B1 (de) 2006-03-08
HUP0203596A3 (en) 2003-12-29
ES2259624T3 (es) 2006-10-16
HK1047595A1 (en) 2003-02-28
HUP0203596A2 (hu) 2003-02-28
AU778773B2 (en) 2004-12-23
ZA200203455B (en) 2004-04-28
PE20010980A1 (es) 2001-10-02
BR0015950A (pt) 2002-11-12
DE60026608T2 (de) 2006-12-28
JP2003517472A (ja) 2003-05-27
US20040043972A1 (en) 2004-03-04
NO323136B1 (no) 2007-01-08

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