PE20010980A1 - Derivados de 3-metileno esteroides - Google Patents

Derivados de 3-metileno esteroides

Info

Publication number
PE20010980A1
PE20010980A1 PE2000001274A PE0012742000A PE20010980A1 PE 20010980 A1 PE20010980 A1 PE 20010980A1 PE 2000001274 A PE2000001274 A PE 2000001274A PE 0012742000 A PE0012742000 A PE 0012742000A PE 20010980 A1 PE20010980 A1 PE 20010980A1
Authority
PE
Peru
Prior art keywords
derivatives
methylen
alkyl
methyl
methylene steroids
Prior art date
Application number
PE2000001274A
Other languages
English (en)
Inventor
Ralf Plate
Wilhelmina Maria Bagchus
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20010980A1 publication Critical patent/PE20010980A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE 3-METILENO ESTEROIDES DE FORMULA I, DONDE R1 ES H, JUNTO A R3 FORMA UN ß-EPOXIDO;O ESTA AUSENTE SI EXISTE UN DOBLE ENLACE ENTRE LA POSICION 5-10 O 4-5; R2 ES ALQUILO C1-C5, CF3; R3 ES ßH, ßCH3; R4 Y R5 SON H, ALQUILO; Y ES (H,H); (OH,H); (=O); (OH, ALQUILO); =NOR5, ENTRE OTROS; EXCEPTO LOS COMPUESTOS (7O,17ß)-7O-METIL-3-METILEN-4-ESTREN-17-OL, (7O,17O)-7-METIL-3-METILEN-19-NORPREGN-4-EN-17-OL, ENTRE OTROS; UN COMPUESTO PREFERIDO ES (7O,17O)-7-METIL-3-METILEN-19-NORPREGN-5(10)-EN-20-IN-17-OL. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES ARTRITICAS, AUTOINMUNES
PE2000001274A 1999-11-29 2000-11-29 Derivados de 3-metileno esteroides PE20010980A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99204000 1999-11-29

Publications (1)

Publication Number Publication Date
PE20010980A1 true PE20010980A1 (es) 2001-10-02

Family

ID=8240918

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001274A PE20010980A1 (es) 1999-11-29 2000-11-29 Derivados de 3-metileno esteroides

Country Status (30)

Country Link
US (2) US6579864B1 (es)
EP (1) EP1240179B1 (es)
JP (1) JP2003517472A (es)
KR (1) KR100720326B1 (es)
CN (1) CN1254479C (es)
AR (1) AR033503A1 (es)
AT (1) ATE319732T1 (es)
AU (1) AU778773B2 (es)
BR (1) BR0015950A (es)
CA (1) CA2391096A1 (es)
CO (1) CO5251432A1 (es)
CY (1) CY1106088T1 (es)
CZ (1) CZ20021837A3 (es)
DE (1) DE60026608T2 (es)
DK (1) DK1240179T3 (es)
ES (1) ES2259624T3 (es)
HK (1) HK1047595B (es)
HU (1) HUP0203596A3 (es)
IL (2) IL149412A0 (es)
MX (1) MXPA02005334A (es)
NO (1) NO323136B1 (es)
NZ (1) NZ518756A (es)
PE (1) PE20010980A1 (es)
PL (1) PL355968A1 (es)
PT (1) PT1240179E (es)
RU (1) RU2248358C2 (es)
SK (1) SK285398B6 (es)
TW (1) TWI265167B (es)
WO (1) WO2001040253A2 (es)
ZA (1) ZA200203455B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
WO2005117968A2 (en) 2004-04-14 2005-12-15 Genentech, Inc. Compositions and methods comprising an egfl7 antagonist for modulating vascular development

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1085035A (en) * 1913-05-01 1914-01-20 George H Greimann Ditch-digging machine.
US1171221A (en) * 1915-12-13 1916-02-08 Charles Ephriam Marion Combination-tool.
US3213117A (en) * 1963-07-03 1965-10-19 Syntex Corp Process for preparation of delta1(10)-5alpha-estren-17beta-ol-2-one and derivatives thereof
BE654772A (es) * 1963-10-23
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
EP0157739B1 (de) 1984-03-29 1987-08-12 Ciba-Geigy Ag Substituierte 1-Propanole, Verfahren zu deren Herstellung, Chlorameisensäureester und deren Verwendung
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids
IE63051B1 (en) * 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives

Also Published As

Publication number Publication date
KR100720326B1 (ko) 2007-05-22
SK7272002A3 (en) 2002-09-10
ATE319732T1 (de) 2006-03-15
PT1240179E (pt) 2006-05-31
AU2508701A (en) 2001-06-12
DE60026608T2 (de) 2006-12-28
CO5251432A1 (es) 2003-02-28
JP2003517472A (ja) 2003-05-27
WO2001040253A3 (en) 2002-05-02
EP1240179B1 (en) 2006-03-08
CN1254479C (zh) 2006-05-03
HUP0203596A3 (en) 2003-12-29
DK1240179T3 (da) 2006-07-03
TWI265167B (en) 2006-11-01
US20040043972A1 (en) 2004-03-04
ES2259624T3 (es) 2006-10-16
PL355968A1 (en) 2004-05-31
RU2248358C2 (ru) 2005-03-20
ZA200203455B (en) 2004-04-28
KR20030024656A (ko) 2003-03-26
AU778773B2 (en) 2004-12-23
NO20022521D0 (no) 2002-05-28
SK285398B6 (sk) 2007-01-04
HUP0203596A2 (hu) 2003-02-28
IL149412A (en) 2007-07-24
US6579864B1 (en) 2003-06-17
NO323136B1 (no) 2007-01-08
WO2001040253A2 (en) 2001-06-07
NZ518756A (en) 2004-05-28
IL149412A0 (en) 2002-11-10
CA2391096A1 (en) 2001-06-07
MXPA02005334A (es) 2003-04-10
CN1402734A (zh) 2003-03-12
BR0015950A (pt) 2002-11-12
NO20022521L (no) 2002-05-28
CZ20021837A3 (cs) 2002-08-14
CY1106088T1 (el) 2011-06-08
DE60026608D1 (de) 2006-05-04
HK1047595A1 (en) 2003-02-28
EP1240179A2 (en) 2002-09-18
HK1047595B (zh) 2006-05-04
AR033503A1 (es) 2003-12-26

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed