PE20010330A1 - Androgenos oralmente activos - Google Patents

Androgenos oralmente activos

Info

Publication number
PE20010330A1
PE20010330A1 PE2000000702A PE0007022000A PE20010330A1 PE 20010330 A1 PE20010330 A1 PE 20010330A1 PE 2000000702 A PE2000000702 A PE 2000000702A PE 0007022000 A PE0007022000 A PE 0007022000A PE 20010330 A1 PE20010330 A1 PE 20010330A1
Authority
PE
Peru
Prior art keywords
alkyl
orally active
hydroxystra
dien
ona
Prior art date
Application number
PE2000000702A
Other languages
English (en)
Inventor
Dirk Leysen
Der Louw Jaap Van
Hubert Jan Josef Loozen
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20010330A1 publication Critical patent/PE20010330A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A 14 NANDROLONA 7O-SUSTITUIDO DERIVADOS DE 19-NORTESTOSTERONA DE FORMULA I, DONDE: R1 ES O, (H,H), (H,OR), NOR; R ES H, ALQUILO C1-C6, ACILO C1-C6; R2 ES ALQUILO C2-C4, ALQUENILO C2-C4, ALQUINILO C2-C4 OPCIONALMENTE SUSTITUIDO CON HALOGENO; R2 ES CICLOPROPILO, CICLOPROPENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C2, HALOGENO; R3 ES H, ALQUILO C1-C2; R4 ES ALQUILO C1-C2; R5 ES H, ACILO C1-C15. UN COMPUESTO PREFERIDO ES (7O,17ß)-7-ETIL-17-HIDROXIESTRA-4,14-DIEN-3-ONA, (7O,17ß)-7-ETENIL-17-HIDROXIESTRA-4,14-DIEN-3-ONA. LOS COMPUESTOS I SON ANDROGENOS UTILES PARA EL TRATAMIENTO DE LA INSUFICIENCIA ANDROGENICA Y COMO ANTICONCEPTIVO MASCULINO
PE2000000702A 1999-07-16 2000-07-14 Androgenos oralmente activos PE20010330A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202348 1999-07-16

Publications (1)

Publication Number Publication Date
PE20010330A1 true PE20010330A1 (es) 2001-03-22

Family

ID=8240463

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000702A PE20010330A1 (es) 1999-07-16 2000-07-14 Androgenos oralmente activos

Country Status (28)

Country Link
US (3) US6313108B1 (es)
EP (1) EP1203011B1 (es)
JP (1) JP2003505394A (es)
KR (1) KR20020092890A (es)
CN (1) CN1360589A (es)
AR (1) AR024746A1 (es)
AT (1) ATE257159T1 (es)
AU (1) AU770412B2 (es)
BR (1) BR0012489A (es)
CA (1) CA2379223A1 (es)
CO (1) CO5200765A1 (es)
CZ (1) CZ2002192A3 (es)
DE (1) DE60007530T2 (es)
ES (1) ES2213596T3 (es)
HK (1) HK1043797A1 (es)
HU (1) HUP0201952A3 (es)
IL (1) IL147332A0 (es)
MX (1) MXPA02000601A (es)
NO (1) NO20020222L (es)
NZ (1) NZ516525A (es)
PE (1) PE20010330A1 (es)
PL (1) PL353007A1 (es)
RU (1) RU2002103883A (es)
SK (1) SK712002A3 (es)
TR (1) TR200200076T2 (es)
TW (1) TW548277B (es)
WO (1) WO2001005806A1 (es)
ZA (1) ZA200200106B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60004377T2 (de) * 1999-04-06 2004-06-09 Akzo Nobel N.V. Oral wirksame 7-alpha-alkyl androgene
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
WO2001074839A2 (en) * 2000-03-31 2001-10-11 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha, 11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use
SK882003A3 (en) * 2000-07-28 2003-07-01 Akzo Nobel Nv 16alpha-substituted steroid compounds, pharmaceutical composition comprising same and their use
DE60210268T2 (de) * 2001-03-30 2006-12-07 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Verfahren zur herstellung von 7alpha,11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-one, dessen 17-ester und pharmazeutische zubereitungen die sie enthalten
MXPA04007049A (es) * 2002-01-21 2004-10-14 Akzo Nobel Nv Proceso para la preparacion de 7a-metilesteroides.
GB0304927D0 (en) * 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
CN102227441A (zh) * 2008-10-15 2011-10-26 斯索恩有限公司 制备氟维司群的方法和中间体
ES2600703T3 (es) * 2011-06-01 2017-02-10 Estetra S.P.R.L. Proceso para la producción de intermediarios de estetrol
EP2714710B1 (en) 2011-06-01 2016-04-06 Estetra S.P.R.L. Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
DK2764008T3 (en) * 2011-10-07 2016-11-07 Estetra Sprl A process for the preparation of estetrol
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
ES2877186T3 (es) 2015-06-18 2021-11-16 Estetra Sprl Comprimido orodispersable que contiene estetrol
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
TN2017000499A1 (en) 2015-06-18 2019-04-12 Mithra Pharmaceuticals S A Orodispersible dosage unit containing an estetrol component
LT3310346T (lt) 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
CN110603059B (zh) * 2017-02-23 2023-06-30 美国西门子医学诊断股份有限公司 化学发光雄烯二酮缀合物
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA712312B (en) * 1970-04-28 1972-01-26 Ochsner Med Found Alton 4,14-estradiene compounds

Also Published As

Publication number Publication date
BR0012489A (pt) 2002-04-02
CO5200765A1 (es) 2002-09-27
RU2002103883A (ru) 2004-02-27
CZ2002192A3 (cs) 2002-06-12
EP1203011A1 (en) 2002-05-08
HK1043797A1 (zh) 2002-09-27
IL147332A0 (en) 2002-08-14
NZ516525A (en) 2003-06-30
WO2001005806A1 (en) 2001-01-25
ATE257159T1 (de) 2004-01-15
US6313108B1 (en) 2001-11-06
AU6562900A (en) 2001-02-05
AU770412B2 (en) 2004-02-19
HUP0201952A3 (en) 2003-10-28
US6541465B2 (en) 2003-04-01
CA2379223A1 (en) 2001-01-25
JP2003505394A (ja) 2003-02-12
ES2213596T3 (es) 2004-09-01
US6780854B2 (en) 2004-08-24
DE60007530T2 (de) 2004-12-23
TW548277B (en) 2003-08-21
AR024746A1 (es) 2002-10-23
KR20020092890A (ko) 2002-12-12
TR200200076T2 (tr) 2002-04-22
HUP0201952A2 (en) 2002-10-28
EP1203011B1 (en) 2004-01-02
US20020022609A1 (en) 2002-02-21
SK712002A3 (en) 2002-06-04
ZA200200106B (en) 2003-06-25
NO20020222L (no) 2002-01-25
CN1360589A (zh) 2002-07-24
US20030087886A1 (en) 2003-05-08
PL353007A1 (en) 2003-09-22
NO20020222D0 (no) 2002-01-15
MXPA02000601A (es) 2002-07-30
DE60007530D1 (de) 2004-02-05

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