AR024746A1 - Androgenos oralmente activos. - Google Patents

Androgenos oralmente activos.

Info

Publication number
AR024746A1
AR024746A1 ARP000103625A ARP000103625A AR024746A1 AR 024746 A1 AR024746 A1 AR 024746A1 AR P000103625 A ARP000103625 A AR P000103625A AR P000103625 A ARP000103625 A AR P000103625A AR 024746 A1 AR024746 A1 AR 024746A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
oralally
active androgens
acyl
Prior art date
Application number
ARP000103625A
Other languages
English (en)
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of AR024746A1 publication Critical patent/AR024746A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nuevos androgenos oralmente activos son derivados de delta14-nandrolona 7alfa-sustituidos. Los compuestos satisfacen la formula general 1 donde R1 es O,(H, H), (H, OR), NOR, siendo R hidrogeno, (C1-6)alquilo o (C1-.6)acilo; R2 se selecciona delgrupo consistente en (C2-4)alquilo, (C2-4)alquenilo o(C2-4)alquinilo, cada uno opcionalmente sustituido por halogeno; o R2 es ciclopropilo o ciclopropenilo, cada uno opcionalmente sustituido por (C1-2)alquilo ohalogeno; R3 es hidrogeno,(C1-2)alquilo o e tenilo; R4 es (C1-2) alquilo; R5 es hidrogeno o (C1-15)acilo; y las líneas de puntos indican enlaces opcionales.
ARP000103625A 1999-07-16 2000-07-14 Androgenos oralmente activos. AR024746A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202348 1999-07-16

Publications (1)

Publication Number Publication Date
AR024746A1 true AR024746A1 (es) 2002-10-23

Family

ID=8240463

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000103625A AR024746A1 (es) 1999-07-16 2000-07-14 Androgenos oralmente activos.

Country Status (28)

Country Link
US (3) US6313108B1 (es)
EP (1) EP1203011B1 (es)
JP (1) JP2003505394A (es)
KR (1) KR20020092890A (es)
CN (1) CN1360589A (es)
AR (1) AR024746A1 (es)
AT (1) ATE257159T1 (es)
AU (1) AU770412B2 (es)
BR (1) BR0012489A (es)
CA (1) CA2379223A1 (es)
CO (1) CO5200765A1 (es)
CZ (1) CZ2002192A3 (es)
DE (1) DE60007530T2 (es)
ES (1) ES2213596T3 (es)
HK (1) HK1043797A1 (es)
HU (1) HUP0201952A3 (es)
IL (1) IL147332A0 (es)
MX (1) MXPA02000601A (es)
NO (1) NO20020222L (es)
NZ (1) NZ516525A (es)
PE (1) PE20010330A1 (es)
PL (1) PL353007A1 (es)
RU (1) RU2002103883A (es)
SK (1) SK712002A3 (es)
TR (1) TR200200076T2 (es)
TW (1) TW548277B (es)
WO (1) WO2001005806A1 (es)
ZA (1) ZA200200106B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE246703T1 (de) * 1999-04-06 2003-08-15 Akzo Nobel Nv Oral wirksame 7-alpha-alkyl androgene
JP4845320B2 (ja) * 2000-03-31 2011-12-28 アメリカ合衆国 （７α，１１β）−ジメチル−１７β−ヒドロキシ−４−エストレン−３−オンの４−Ｎ−ブチルシクロヘキサン酸エステル及びウンデカン酸エステルの製造方法及びそれらの医学用途
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
AU8201601A (en) * 2000-07-28 2002-02-13 Akzo Nobel Nv 16alpha-methyl or ethyl substituted estrogens
EP1379253B1 (en) * 2001-03-30 2006-03-29 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods of making and pharmaceutical formulations comprising 7alpha,11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-one and 17 esters thereof
US20050090476A1 (en) * 2002-01-21 2005-04-28 Arnoldus Maria Van Buggenum Patrick Process for the preparation of 7alpha-methylsteroids
GB0304927D0 (en) * 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
EP2350111A1 (en) * 2008-10-15 2011-08-03 Synthon B.V. Processes and intermediates for the production of fulvestrant
EA025511B1 (ru) * 2011-06-01 2016-12-30 Эстетра С.П.Р.Л. Способ получения промежуточных соединений эстетрола
CN107266514A (zh) 2011-06-01 2017-10-20 埃斯特拉私人有限责任公司 用于产生雌四醇中间体的方法
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US8987484B2 (en) * 2011-10-07 2015-03-24 Estetra S.P.R.L. Process for the production of estetrol
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
DK3310345T3 (da) 2015-06-18 2021-05-25 Estetra Sprl Orodispersibel tablet indeholdende estetrol
UA123098C2 (uk) 2015-06-18 2021-02-17 Естетра Спрл Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент
EP3310346B1 (en) 2015-06-18 2021-03-24 Estetra SPRL Orodispersible tablet containing estetrol
EA035687B1 (ru) 2015-06-18 2020-07-27 Эстетра Спрл Диспергируемая в полости рта единица дозирования, содержащая эстетрольный компонент
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
US20210003596A1 (en) * 2017-02-23 2021-01-07 Siemens Healthcare Diagnostics Inc. Chemiluminescent androstenedione conjugates
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA712312B (en) * 1970-04-28 1972-01-26 Ochsner Med Found Alton 4,14-estradiene compounds

Also Published As

Publication number Publication date
SK712002A3 (en) 2002-06-04
WO2001005806A1 (en) 2001-01-25
NO20020222L (no) 2002-01-25
US6780854B2 (en) 2004-08-24
TW548277B (en) 2003-08-21
IL147332A0 (en) 2002-08-14
AU6562900A (en) 2001-02-05
HUP0201952A2 (en) 2002-10-28
ES2213596T3 (es) 2004-09-01
RU2002103883A (ru) 2004-02-27
ATE257159T1 (de) 2004-01-15
MXPA02000601A (es) 2002-07-30
DE60007530D1 (de) 2004-02-05
US20020022609A1 (en) 2002-02-21
NZ516525A (en) 2003-06-30
US6313108B1 (en) 2001-11-06
NO20020222D0 (no) 2002-01-15
EP1203011B1 (en) 2004-01-02
PE20010330A1 (es) 2001-03-22
BR0012489A (pt) 2002-04-02
HK1043797A1 (zh) 2002-09-27
ZA200200106B (en) 2003-06-25
CO5200765A1 (es) 2002-09-27
EP1203011A1 (en) 2002-05-08
DE60007530T2 (de) 2004-12-23
CZ2002192A3 (cs) 2002-06-12
KR20020092890A (ko) 2002-12-12
HUP0201952A3 (en) 2003-10-28
US6541465B2 (en) 2003-04-01
AU770412B2 (en) 2004-02-19
CA2379223A1 (en) 2001-01-25
JP2003505394A (ja) 2003-02-12
US20030087886A1 (en) 2003-05-08
TR200200076T2 (tr) 2002-04-22
PL353007A1 (en) 2003-09-22
CN1360589A (zh) 2002-07-24

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