CO5160345A1 - Nuevos androgenos oralmente activos derivados de 7 alfa- metil-19-nortestosterona - Google Patents

Nuevos androgenos oralmente activos derivados de 7 alfa- metil-19-nortestosterona

Info

Publication number
CO5160345A1
CO5160345A1 CO00025244A CO00025244A CO5160345A1 CO 5160345 A1 CO5160345 A1 CO 5160345A1 CO 00025244 A CO00025244 A CO 00025244A CO 00025244 A CO00025244 A CO 00025244A CO 5160345 A1 CO5160345 A1 CO 5160345A1
Authority
CO
Colombia
Prior art keywords
oralally
nortestosterona
metil
alfa
new
Prior art date
Application number
CO00025244A
Other languages
English (en)
Inventor
Van Der Louw Jaap
Dirk Leysen
Roberta Buma Bursi
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5160345A1 publication Critical patent/CO5160345A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters

Abstract

Un compuesto CARACTERIZADO porque tiene la fórmula estructural:<EMI FILE="00025244_1" ID="1" IMF=JPEG >donde R1 es O, (H,H), (H,OR), NOR, siendo R hidrógeno, (C1-6)-alquilo o (C1-6)acilo;R2 es (C2-3)alquilo, isopropilo, (C2-3)1-alquenilo, isopropenilo, 1,2-propadienilo o (C2-3)1-alquinilo, cada uno opcionalmente sustituido por halógeno; o R2 es ciclopropilo o ciclopropenilo, cada uno opcionalmente sustituido por (C1-2)alquilo o halógeno;R3 es hidrógeno, (C1-2)alquilo o etenilo;R4 es (C1-2)alquilo;R5 es hidrógeno o (C1-15)acilo;y las líneas de puntos indican enlaces opcionales;con la salvedad de que el compuesto no es (7a, 17ß)-7-etil-17-hidroxiestr-4-en-3-ona (7a-etil-19-nortestosterona) o un éster carboxílico de la misma, y no es (7a-17ß)-17-(acetil-oxi)-7-propilestr-4-en-3-ona (acetato de 7a-propil-19-nortestosterona).
CO00025244A 1999-04-06 2000-04-06 Nuevos androgenos oralmente activos derivados de 7 alfa- metil-19-nortestosterona CO5160345A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201070 1999-04-06

Publications (1)

Publication Number Publication Date
CO5160345A1 true CO5160345A1 (es) 2002-05-30

Family

ID=8240066

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00025244A CO5160345A1 (es) 1999-04-06 2000-04-06 Nuevos androgenos oralmente activos derivados de 7 alfa- metil-19-nortestosterona

Country Status (10)

Country Link
US (2) US6756366B1 (es)
EP (1) EP1212345B1 (es)
JP (1) JP2002541153A (es)
AT (1) ATE246703T1 (es)
AU (1) AU5209600A (es)
CO (1) CO5160345A1 (es)
DE (1) DE60004377T2 (es)
ES (1) ES2204613T3 (es)
PE (1) PE20010029A1 (es)
WO (1) WO2000059920A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756366B1 (en) * 1999-04-06 2004-06-29 Akzo Nobel N.V. Orally active androgens
DE10104327A1 (de) 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
IL162770A0 (en) * 2002-01-21 2005-11-20 Akzo Nobel Nv Process for the preparation methylsteroids of 7
GB0304927D0 (en) * 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
MX2010011063A (es) 2008-04-09 2010-11-22 Pherin Pharm Inc Tratamiento esteroidal para sofocos.
AU2011343615A1 (en) * 2010-12-15 2013-05-09 Harbor Biosciences, Inc. Methods and compounds for preparing 3alpha-oxygen substituted steroids

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755689A (fr) * 1969-09-03 1971-03-03 Upjohn Co Procede de fabrication de nouvelles 7 beta-alkyl-19- nortestosterones
US5342834A (en) * 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
US6037339A (en) * 1993-02-08 2000-03-14 Akzo Nobel N.V. C-11 substituted steroids for treating menopausal complaints
ES2134313T3 (es) * 1993-03-05 1999-10-01 Akzo Nobel Nv Utilizacion de derivados de pregnano para el tratamiento de tumores.
IL113816A (en) * 1994-06-08 1998-12-06 Akzo Nobel Nv Pharmaceutical preparations containing desogestral, their preparation and use
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
CN1119998C (zh) * 1995-06-22 2003-09-03 阿克佐诺贝尔公司 去氧孕烯的压制干颗粒片
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
US5998639A (en) * 1995-11-06 1999-12-07 Akzo Nobel, N.V. Sulfatation of estrogen mixtures
IL119468A (en) * 1995-11-06 2000-02-29 Akzo Nobel Nv Method of isomerisation of equilin or derivatives thereof
CA2200423C (en) * 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
US6506390B2 (en) * 1996-06-25 2003-01-14 Akzo Nobel Progestogen-anti-progestogen regimens
TW403736B (en) * 1997-02-21 2000-09-01 Akzo Nobel Nv Steroid compounds having contraceptive and anti-osteoporosis activity
CN1260802A (zh) * 1997-05-16 2000-07-19 阿克佐诺贝尔公司 20－芳烷基－5α－孕甾烷衍生物
PL337188A1 (en) * 1997-06-04 2000-08-14 Akzo Nobel Nv Derivatives of 17beta - allyloxy (thio) alkyl - androstane for modulation of meiosis
PT927556E (pt) * 1997-09-23 2000-12-29 Akzo Nobel Nv Unidades de dosagem de esteroides com um revestimento para selagem destes
US6080773A (en) * 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
RU2215540C2 (ru) * 1997-11-14 2003-11-10 Акцо Нобель Н.В. Схемы приема гестаген-антигестагена
EP1042353B1 (en) * 1997-12-18 2002-07-17 Akzo Nobel N.V. 17beta-aryl (arylmethyl) oxy(thio)alkyl -androstane derivatives
RU2198873C2 (ru) * 1998-02-26 2003-02-20 Акцо Нобель Н.В. Производные азетидина и пирролидина
ID27260A (id) * 1998-06-19 2001-03-22 Akzo Nobel Nv Turunan testosteron
DE69903346T2 (de) * 1998-12-11 2003-01-30 Akzo Nobel Nv 22s-hydroxycholesta-8,14-dien derivate mit meiose regulierende aktivität
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
DE60000978T2 (de) * 1999-03-09 2003-07-17 Akzo Nobel Nv 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose
US6756366B1 (en) * 1999-04-06 2004-06-29 Akzo Nobel N.V. Orally active androgens
TW548277B (en) * 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
CA2382489C (en) * 1999-09-06 2008-03-11 Akzo Nobel N.V. Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
ATE317396T1 (de) * 1999-12-02 2006-02-15 Akzo Nobel Nv 14,15-beta-methylen substituierte androgene
DE60130748T2 (de) * 2000-03-27 2008-07-17 N.V. Organon Nicht-steroidale tetracyclische verbindungen für östrogen-verwandte behandlungen
CZ2003514A3 (cs) * 2000-08-23 2003-10-15 Akzo Nobel N. V. Fluorenové deriváty a jejich analogy

Also Published As

Publication number Publication date
EP1212345B1 (en) 2003-08-06
US20040209853A1 (en) 2004-10-21
US6756366B1 (en) 2004-06-29
DE60004377D1 (de) 2003-09-11
WO2000059920A2 (en) 2000-10-12
ATE246703T1 (de) 2003-08-15
JP2002541153A (ja) 2002-12-03
EP1212345A2 (en) 2002-06-12
ES2204613T3 (es) 2004-05-01
AU5209600A (en) 2000-10-23
PE20010029A1 (es) 2001-01-26
DE60004377T2 (de) 2004-06-09
WO2000059920A3 (en) 2001-02-15

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