ES443333A1 - Un procedimiento para la produccion de nuevos derivados tri-ciclicos de dibenzazepina. - Google Patents

Un procedimiento para la produccion de nuevos derivados tri-ciclicos de dibenzazepina.

Info

Publication number
ES443333A1
ES443333A1 ES75443333A ES443333A ES443333A1 ES 443333 A1 ES443333 A1 ES 443333A1 ES 75443333 A ES75443333 A ES 75443333A ES 443333 A ES443333 A ES 443333A ES 443333 A1 ES443333 A1 ES 443333A1
Authority
ES
Spain
Prior art keywords
alkyl
morpholinyl
hydrogen
image
tricyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES75443333A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14169174A external-priority patent/JPS5833875B2/ja
Priority claimed from JP291175A external-priority patent/JPS5939433B2/ja
Priority claimed from JP4989175A external-priority patent/JPS5939435B2/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES443333A1 publication Critical patent/ES443333A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Nuevos compuestos tricíclicos y a su producción y uso. Más especialmente, se refiere a nuevos derivados tríciclicos de dibenzazepina y a su sales no tóxicas y farmacéuticamente aceptables, útiles como antidepresores y a su producción y uso. Los derivados tricíclicos de dibenzazepina proporcionados de acuerdo con esta invención se pueden representar por la siguiente fórmula: **(Fórmula)** donde A es -CH2-CH2-, -CH=CH- o -CH-CH-, X es hidrógeno, halógeno, nitro, trifluormetilo, alquilo C1-C3 o alcoxi C1-C3; R1 y R2, que pueden ser iguales o diferentes, son hidrógeno o alquilo C1-C4 y R3 es hidrógeno, alquilo C1-C4, alquenilo C3-C5, alquinilo C3-C5, cicloalquil(C3-C6)-alquilo(C!-C3), ar-alquilo(C1-C3), polihaloalquilo (C1-C2), alcoxi(C1-C4)-alquilo(C1-C3) o hidroxialquilo(C1-C3) y sus sales no tóxicas y farmacéuticamente aceptables.
ES75443333A 1974-12-09 1975-12-09 Un procedimiento para la produccion de nuevos derivados tri-ciclicos de dibenzazepina. Expired ES443333A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14169174A JPS5833875B2 (ja) 1974-12-09 1974-12-09 シンキナルモルホリンユウドウタイ オヨビ ソノサンフカエンノセイゾウホウ
JP291175A JPS5939433B2 (ja) 1974-12-27 1974-12-27 新規なるモルホリン誘導体及びその酸付加塩の製造法
JP4989175A JPS5939435B2 (ja) 1975-04-23 1975-04-23 新規なるモルホリン誘導体及びその酸付加塩の製造法

Publications (1)

Publication Number Publication Date
ES443333A1 true ES443333A1 (es) 1978-02-01

Family

ID=27275587

Family Applications (1)

Application Number Title Priority Date Filing Date
ES75443333A Expired ES443333A1 (es) 1974-12-09 1975-12-09 Un procedimiento para la produccion de nuevos derivados tri-ciclicos de dibenzazepina.

Country Status (15)

Country Link
US (1) US4017621A (es)
AR (2) AR213082A1 (es)
AT (1) AT348532B (es)
CA (1) CA1064924A (es)
CH (2) CH622792A5 (es)
DE (1) DE2555351A1 (es)
DK (1) DK551175A (es)
ES (1) ES443333A1 (es)
FI (1) FI753414A (es)
FR (1) FR2293936A1 (es)
GB (1) GB1510669A (es)
HU (1) HU170641B (es)
NL (1) NL7514348A (es)
NO (1) NO145074C (es)
SE (1) SE419985B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW248556B (es) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
WO1999047517A1 (en) * 1998-03-17 1999-09-23 Novo Nordisk A/S Novel heterocyclic compounds
US6214816B1 (en) * 1998-03-17 2001-04-10 Novo Nordisk A/S Heterocyclic compounds
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976281A (en) * 1961-03-21 Substituted iminostilbenes
NL110232C (es) * 1958-12-06
CH554342A (de) * 1969-06-20 1974-09-30 Takeda Chemical Industries Ltd Verfahren zur herstellung neuer dibenzazepinderivate.

Also Published As

Publication number Publication date
CH626083A5 (es) 1981-10-30
SE419985B (sv) 1981-09-07
NL7514348A (nl) 1976-06-11
DK551175A (da) 1976-06-10
NO145074C (no) 1982-01-06
SE7513577L (sv) 1976-06-10
AT348532B (de) 1979-02-26
NO754126L (es) 1976-06-10
NO145074B (no) 1981-09-28
FI753414A (es) 1976-06-10
DE2555351A1 (de) 1976-06-10
HU170641B (es) 1977-07-28
CH622792A5 (es) 1981-04-30
AU8734175A (en) 1977-06-16
US4017621A (en) 1977-04-12
ATA931175A (de) 1978-07-15
AR213082A1 (es) 1978-12-15
FR2293936A1 (fr) 1976-07-09
AR212970A1 (es) 1978-11-30
GB1510669A (en) 1978-05-10
CA1064924A (en) 1979-10-23
FR2293936B1 (es) 1978-11-10

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