AR033503A1 - Un derivado de 3-metileno esteroide, una composicion farmaceutica que lo comprende, y uso de un derivado de 3-metileno esteroide - Google Patents
Un derivado de 3-metileno esteroide, una composicion farmaceutica que lo comprende, y uso de un derivado de 3-metileno esteroideInfo
- Publication number
- AR033503A1 AR033503A1 ARP000106246A ARP000106246A AR033503A1 AR 033503 A1 AR033503 A1 AR 033503A1 AR P000106246 A ARP000106246 A AR P000106246A AR P000106246 A ARP000106246 A AR P000106246A AR 033503 A1 AR033503 A1 AR 033503A1
- Authority
- AR
- Argentina
- Prior art keywords
- methylene
- derivative
- 7alfa
- methyl
- steroid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un derivado de 3-metileno esteroide que tiene la formula general (1) donde R1 es H o junto con R3 forma un beta-epoxido, o bien R1 está ausente si hay un doble enlace 5-10 o 4-5; R2 es (C1-5)alquilo o CF3; R3 es betaH, betaCH3 o junto con R1 forma un Beta epoxido, o bien R3 está ausente si hay un doble enlace 5-10; R4 es H, alquilo inferior; Y es [H, H],[OH, H] = O, [OH, alquilo inferior], [OH,(C2-5)-alquenilo], [OH, (C2-5)alquinilo] o (C1-6)alquilideno, donde dicho alquilo, alquenilo, alquinilo y alquilideno está opcionalmente halogenado; o =NOR5, donde R5 es H, alquilo inferior; las líneas de punto representan un doble enlace opcional; o profármacos del mismo, con la salvedad de que el derivado de 3-metileno esteroide no es ninguno de la lista (7alfa, 17 beta)-7alfa-metil-3-metilen-4-estren-17-ol, (7alfa-17alfa)-7-metil-3-metilen-19-norpregn-4-en17-ol, (7alfa-17alfa)-7-metil-3-metilen-19,21-dinorpregn-4-en-17-ol, (7alfa)-17-ceto-7-metil-3-metilen-4-estreno, (7alfa, 17alfa)-7-metil-3-metilen-19-norpregn-4-en-20-in-17-ol, 17beta-hidroxi-7alfa-metil-3-metilen-17alfa-propen-2-il-4-estreno, y 17beta-hidroxi-7alfa-metil-3-metilen-17alfa-buten-2-il-4-estreno. Una composicion farmacéutica que comprende el derivado de 3-metileno esteroide; y uso de un derivado de 3-metileno. El derivado de 3-metileno esteroide es util como medicamento, especialmente para el tratamiento de la profilaxis de enfermedades artríticas y/o enfermedades autoinmunes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99204000 | 1999-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033503A1 true AR033503A1 (es) | 2003-12-26 |
Family
ID=8240918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000106246A AR033503A1 (es) | 1999-11-29 | 2000-11-28 | Un derivado de 3-metileno esteroide, una composicion farmaceutica que lo comprende, y uso de un derivado de 3-metileno esteroide |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6579864B1 (es) |
| EP (1) | EP1240179B1 (es) |
| JP (1) | JP2003517472A (es) |
| KR (1) | KR100720326B1 (es) |
| CN (1) | CN1254479C (es) |
| AR (1) | AR033503A1 (es) |
| AT (1) | ATE319732T1 (es) |
| AU (1) | AU778773B2 (es) |
| BR (1) | BR0015950A (es) |
| CA (1) | CA2391096A1 (es) |
| CO (1) | CO5251432A1 (es) |
| CY (1) | CY1106088T1 (es) |
| CZ (1) | CZ20021837A3 (es) |
| DE (1) | DE60026608T2 (es) |
| DK (1) | DK1240179T3 (es) |
| ES (1) | ES2259624T3 (es) |
| HK (1) | HK1047595B (es) |
| HU (1) | HUP0203596A3 (es) |
| IL (2) | IL149412A0 (es) |
| MX (1) | MXPA02005334A (es) |
| NO (1) | NO323136B1 (es) |
| NZ (1) | NZ518756A (es) |
| PE (1) | PE20010980A1 (es) |
| PL (1) | PL355968A1 (es) |
| PT (1) | PT1240179E (es) |
| RU (1) | RU2248358C2 (es) |
| SK (1) | SK285398B6 (es) |
| TW (1) | TWI265167B (es) |
| WO (1) | WO2001040253A2 (es) |
| ZA (1) | ZA200203455B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI265167B (en) * | 1999-11-29 | 2006-11-01 | Akzo Nobel Nv | 3-methylene steroid derivatives |
| WO2005117968A2 (en) | 2004-04-14 | 2005-12-15 | Genentech, Inc. | Compositions and methods comprising an egfl7 antagonist for modulating vascular development |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1085035A (en) * | 1913-05-01 | 1914-01-20 | George H Greimann | Ditch-digging machine. |
| US1171221A (en) * | 1915-12-13 | 1916-02-08 | Charles Ephriam Marion | Combination-tool. |
| US3213117A (en) * | 1963-07-03 | 1965-10-19 | Syntex Corp | Process for preparation of delta1(10)-5alpha-estren-17beta-ol-2-one and derivatives thereof |
| BE654772A (es) * | 1963-10-23 | |||
| US4701450A (en) * | 1984-03-21 | 1987-10-20 | Akzo N.V. | Steroids for use as immunomodulators |
| EP0157739B1 (de) | 1984-03-29 | 1987-08-12 | Ciba-Geigy Ag | Substituierte 1-Propanole, Verfahren zu deren Herstellung, Chlorameisensäureester und deren Verwendung |
| GB8513723D0 (en) * | 1985-05-31 | 1985-07-03 | Erba Farmitalia | 11-beta substituted steroids |
| IE63051B1 (en) * | 1989-03-18 | 1995-03-22 | Akzo Nv | Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one |
| TWI265167B (en) * | 1999-11-29 | 2006-11-01 | Akzo Nobel Nv | 3-methylene steroid derivatives |
-
2000
- 2000-11-14 TW TW089124108A patent/TWI265167B/zh not_active IP Right Cessation
- 2000-11-23 CN CNB008163561A patent/CN1254479C/zh not_active Expired - Fee Related
- 2000-11-23 IL IL14941200A patent/IL149412A0/xx active IP Right Grant
- 2000-11-23 MX MXPA02005334A patent/MXPA02005334A/es active IP Right Grant
- 2000-11-23 CA CA002391096A patent/CA2391096A1/en not_active Abandoned
- 2000-11-23 US US10/148,247 patent/US6579864B1/en not_active Expired - Fee Related
- 2000-11-23 NZ NZ518756A patent/NZ518756A/en unknown
- 2000-11-23 AU AU25087/01A patent/AU778773B2/en not_active Ceased
- 2000-11-23 DE DE60026608T patent/DE60026608T2/de not_active Expired - Fee Related
- 2000-11-23 RU RU2002117297/04A patent/RU2248358C2/ru not_active IP Right Cessation
- 2000-11-23 DK DK00988758T patent/DK1240179T3/da active
- 2000-11-23 PT PT00988758T patent/PT1240179E/pt unknown
- 2000-11-23 KR KR1020027006843A patent/KR100720326B1/ko not_active IP Right Cessation
- 2000-11-23 AT AT00988758T patent/ATE319732T1/de not_active IP Right Cessation
- 2000-11-23 SK SK727-2002A patent/SK285398B6/sk unknown
- 2000-11-23 WO PCT/EP2000/011787 patent/WO2001040253A2/en active IP Right Grant
- 2000-11-23 ES ES00988758T patent/ES2259624T3/es not_active Expired - Lifetime
- 2000-11-23 BR BR0015950-6A patent/BR0015950A/pt not_active Application Discontinuation
- 2000-11-23 HU HU0203596A patent/HUP0203596A3/hu unknown
- 2000-11-23 EP EP00988758A patent/EP1240179B1/en not_active Expired - Lifetime
- 2000-11-23 PL PL00355968A patent/PL355968A1/xx not_active Application Discontinuation
- 2000-11-23 CZ CZ20021837A patent/CZ20021837A3/cs unknown
- 2000-11-23 JP JP2001541008A patent/JP2003517472A/ja active Pending
- 2000-11-28 AR ARP000106246A patent/AR033503A1/es unknown
- 2000-11-28 CO CO00090980A patent/CO5251432A1/es not_active Application Discontinuation
- 2000-11-29 PE PE2000001274A patent/PE20010980A1/es not_active Application Discontinuation
-
2002
- 2002-04-30 IL IL149412A patent/IL149412A/en not_active IP Right Cessation
- 2002-04-30 ZA ZA200203455A patent/ZA200203455B/xx unknown
- 2002-05-28 NO NO20022521A patent/NO323136B1/no unknown
- 2002-12-18 HK HK02109166.7A patent/HK1047595B/zh not_active IP Right Cessation
-
2003
- 2003-04-28 US US10/424,399 patent/US20040043972A1/en not_active Abandoned
-
2006
- 2006-05-16 CY CY20061100629T patent/CY1106088T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |