DE69918687D1 - 4-phenylpiperidine zur behandlung von prutitischen hauterkrankungen - Google Patents
4-phenylpiperidine zur behandlung von prutitischen hauterkrankungenInfo
- Publication number
- DE69918687D1 DE69918687D1 DE69918687T DE69918687T DE69918687D1 DE 69918687 D1 DE69918687 D1 DE 69918687D1 DE 69918687 T DE69918687 T DE 69918687T DE 69918687 T DE69918687 T DE 69918687T DE 69918687 D1 DE69918687 D1 DE 69918687D1
- Authority
- DE
- Germany
- Prior art keywords
- prutitic
- phenylpiperidine
- treatment
- skin diseases
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- UTBULQCHEUWJNV-UHFFFAOYSA-N 4-phenylpiperidine Chemical compound C1CNCCC1C1=CC=CC=C1 UTBULQCHEUWJNV-UHFFFAOYSA-N 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9810671.9A GB9810671D0 (en) | 1998-05-18 | 1998-05-18 | Anti-pruritic agents |
| GB9810671 | 1998-05-18 | ||
| PCT/IB1999/000886 WO1999059971A1 (en) | 1998-05-18 | 1999-05-17 | Novel 4-phenylpiperidines for the treatment of pruritic dermatoses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69918687D1 true DE69918687D1 (de) | 2004-08-19 |
| DE69918687T2 DE69918687T2 (de) | 2005-07-28 |
Family
ID=10832267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69918687T Expired - Fee Related DE69918687T2 (de) | 1998-05-18 | 1999-05-17 | 4-Phenylpiperidine zur Behandlung von pruritischen Hauterkrankungen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6610711B2 (de) |
| EP (1) | EP1077940B1 (de) |
| JP (1) | JP2002515486A (de) |
| AP (1) | AP9901535A0 (de) |
| AT (1) | ATE271038T1 (de) |
| AU (1) | AU3531299A (de) |
| BR (1) | BR9910609A (de) |
| CA (1) | CA2332538C (de) |
| DE (1) | DE69918687T2 (de) |
| DK (1) | DK1077940T3 (de) |
| ES (1) | ES2230846T3 (de) |
| GB (1) | GB9810671D0 (de) |
| GT (1) | GT199900067A (de) |
| MA (1) | MA26630A1 (de) |
| PT (1) | PT1077940E (de) |
| TN (1) | TNSN99095A1 (de) |
| WO (1) | WO1999059971A1 (de) |
| ZA (1) | ZA993364B (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9912416D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| MXPA03011886A (es) * | 2001-07-05 | 2005-03-07 | Lundbeck & Co As H | Piperidinias anilinicas sustituidas como antagonistas selectivos de mch. |
| US6727264B1 (en) | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| AU2002329557B2 (en) * | 2001-10-22 | 2008-07-31 | Pfizer Products Inc. | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
| US7338965B2 (en) * | 2001-11-19 | 2008-03-04 | Pharmacia & Upjohn Company | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines |
| ES2201908B1 (es) * | 2002-05-29 | 2005-02-16 | Laboratorios Del Dr. Esteve, S.A. | Pienso suplementado con ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea. |
| CA2522323C (en) * | 2003-04-14 | 2009-09-15 | Pfizer Products Inc. | 3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands |
| FR2872416B1 (fr) * | 2004-07-01 | 2006-09-22 | Oreal | Utilisation de derives de piperidine pour lutter contre les rides |
| US8097614B2 (en) * | 2005-02-17 | 2012-01-17 | Velcera Pharmaceuticals, Inc. | Transmucosal administration of meloxicam compositions for treating and preventing disorders in non-human domesticated animals |
| CA2632030A1 (en) * | 2005-12-15 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| US7935715B2 (en) * | 2006-07-28 | 2011-05-03 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| CA2664310A1 (en) * | 2006-09-25 | 2008-04-03 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| EP2185553B1 (de) * | 2007-08-27 | 2012-06-27 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]oktan-verbindungen als mu-opioid-rezeptorantagonisten |
| US7691878B2 (en) * | 2007-08-27 | 2010-04-06 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| US7947710B2 (en) * | 2007-08-27 | 2011-05-24 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| EP2217565B1 (de) * | 2007-11-07 | 2013-05-22 | Boehringer Ingelheim International GmbH | Cb2 rezeptor-modulierende verbindungen |
| US8178568B2 (en) * | 2008-07-10 | 2012-05-15 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the CB2 receptor |
| EP2342200B1 (de) | 2008-09-25 | 2013-01-23 | Boehringer Ingelheim International GmbH | Selektiv den cb2-Rezeptor modulierende Verbindungen |
| US8299103B2 (en) * | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| WO2010147791A1 (en) | 2009-06-16 | 2010-12-23 | Boehringer Ingelheim International Gmbh | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
| WO2011037795A1 (en) * | 2009-09-22 | 2011-03-31 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| EP2523936A1 (de) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Cb2 rezeptor-modulierende verbindungen |
| JP5746228B2 (ja) | 2010-03-05 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を選択的に調節するテトラゾール化合物 |
| US8846936B2 (en) | 2010-07-22 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the CB2 receptor |
| EP2803668A1 (de) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole |
| CN106278914B (zh) * | 2016-08-19 | 2018-04-13 | 四川福思达生物技术开发有限责任公司 | 一种增产胺的合成工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206937A1 (es) | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
| EP0287339B1 (de) * | 1987-04-16 | 1994-08-17 | Eli Lilly And Company | Piperidine als Opioid-Antagoniste |
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| ZA922180B (en) | 1991-03-29 | 1993-09-27 | Lilly Co Eli | Piperidine derivatives |
| GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| EP0975614A1 (de) * | 1997-04-18 | 2000-02-02 | Smithkline Beecham Plc | Ein bicyclisches aryl or einen bicyclischen heterocyclischen ring enthaltende verbindungen mit kombinierter 5ht1a, 5ht1b und 5ht1d rezeptor antagonistischer aktivität |
-
1998
- 1998-05-18 GB GBGB9810671.9A patent/GB9810671D0/en not_active Ceased
-
1999
- 1999-05-13 AP APAP/P/1999/001535A patent/AP9901535A0/en unknown
- 1999-05-14 GT GT199900067A patent/GT199900067A/es unknown
- 1999-05-17 ES ES99917038T patent/ES2230846T3/es not_active Expired - Lifetime
- 1999-05-17 JP JP2000549590A patent/JP2002515486A/ja active Pending
- 1999-05-17 AU AU35312/99A patent/AU3531299A/en not_active Abandoned
- 1999-05-17 MA MA25582A patent/MA26630A1/fr unknown
- 1999-05-17 CA CA002332538A patent/CA2332538C/en not_active Expired - Fee Related
- 1999-05-17 TN TNTNSN99095A patent/TNSN99095A1/fr unknown
- 1999-05-17 BR BR9910609-4A patent/BR9910609A/pt not_active IP Right Cessation
- 1999-05-17 WO PCT/IB1999/000886 patent/WO1999059971A1/en active IP Right Grant
- 1999-05-17 PT PT99917038T patent/PT1077940E/pt unknown
- 1999-05-17 DE DE69918687T patent/DE69918687T2/de not_active Expired - Fee Related
- 1999-05-17 ZA ZA9903364A patent/ZA993364B/xx unknown
- 1999-05-17 US US09/646,255 patent/US6610711B2/en not_active Expired - Fee Related
- 1999-05-17 DK DK99917038T patent/DK1077940T3/da active
- 1999-05-17 EP EP99917038A patent/EP1077940B1/de not_active Expired - Lifetime
- 1999-05-17 AT AT99917038T patent/ATE271038T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69918687T2 (de) | 2005-07-28 |
| US6610711B2 (en) | 2003-08-26 |
| JP2002515486A (ja) | 2002-05-28 |
| GB9810671D0 (en) | 1998-07-15 |
| WO1999059971A1 (en) | 1999-11-25 |
| AP9901535A0 (en) | 1999-06-30 |
| ATE271038T1 (de) | 2004-07-15 |
| US20030078282A1 (en) | 2003-04-24 |
| ES2230846T3 (es) | 2005-05-01 |
| DK1077940T3 (da) | 2004-11-01 |
| TNSN99095A1 (fr) | 2005-11-10 |
| CA2332538A1 (en) | 1999-11-25 |
| PT1077940E (pt) | 2004-10-29 |
| EP1077940B1 (de) | 2004-07-14 |
| BR9910609A (pt) | 2001-01-09 |
| EP1077940A1 (de) | 2001-02-28 |
| GT199900067A (es) | 2000-11-04 |
| ZA993364B (en) | 2000-12-01 |
| CA2332538C (en) | 2005-08-02 |
| MA26630A1 (fr) | 2004-12-20 |
| AU3531299A (en) | 1999-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |