TNSN99095A1 - 4 - phenylpiperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents
4 - phenylpiperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenantInfo
- Publication number
- TNSN99095A1 TNSN99095A1 TNTNSN99095A TNSN99095A TNSN99095A1 TN SN99095 A1 TNSN99095 A1 TN SN99095A1 TN TNSN99095 A TNTNSN99095 A TN TNSN99095A TN SN99095 A TNSN99095 A TN SN99095A TN SN99095 A1 TNSN99095 A1 TN SN99095A1
- Authority
- TN
- Tunisia
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- phenylpiperidines
- new
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010048768 Dermatosis Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSES NOUVEAUX DE FORMULE GENERALE (I) : DANS LAQUELLE R1, R2, R3, W, Y1, Y2 ET X REPRESENTENT DIVERS RADICAUX, n EST EGAL A 0,1 OU 2 ET Y EST EGAL A 0 OU 1. ELLE CONCERNE EGALEMENT DES PROCEDES POUR LEUR PREPARATION ET DES INTERMEDIAIRES UTILISES A CETTE FIN, AINSI QUE DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT DE DERMATOSES PRURIGINEUSES CHEZ LES ANIMAUX ET L'HOMME.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9810671.9A GB9810671D0 (en) | 1998-05-18 | 1998-05-18 | Anti-pruritic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN99095A1 true TNSN99095A1 (fr) | 2005-11-10 |
Family
ID=10832267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN99095A TNSN99095A1 (fr) | 1998-05-18 | 1999-05-17 | 4 - phenylpiperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant |
Country Status (18)
Country | Link |
---|---|
US (1) | US6610711B2 (fr) |
EP (1) | EP1077940B1 (fr) |
JP (1) | JP2002515486A (fr) |
AP (1) | AP9901535A0 (fr) |
AT (1) | ATE271038T1 (fr) |
AU (1) | AU3531299A (fr) |
BR (1) | BR9910609A (fr) |
CA (1) | CA2332538C (fr) |
DE (1) | DE69918687T2 (fr) |
DK (1) | DK1077940T3 (fr) |
ES (1) | ES2230846T3 (fr) |
GB (1) | GB9810671D0 (fr) |
GT (1) | GT199900067A (fr) |
MA (1) | MA26630A1 (fr) |
PT (1) | PT1077940E (fr) |
TN (1) | TNSN99095A1 (fr) |
WO (1) | WO1999059971A1 (fr) |
ZA (1) | ZA993364B (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912417D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912416D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
US6727264B1 (en) | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
KR20040027870A (ko) * | 2001-07-05 | 2004-04-01 | 시냅틱 파마세틱칼 코포레이션 | Mch 선택적인 안타고니스트로서의 치환 아닐린 피페리딘 |
PT1440059E (pt) * | 2001-10-22 | 2008-05-16 | Pfizer Prod Inc | Derivados do 3-azabiciclo(3.1.0)hexano como antagonistas de receptores opióides |
AU2002360403A1 (en) * | 2001-11-19 | 2003-06-10 | Elan Pharmaceuticals, Inc. | (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of Alzheimer's disease |
ES2201908B1 (es) * | 2002-05-29 | 2005-02-16 | Laboratorios Del Dr. Esteve, S.A. | Pienso suplementado con ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea. |
EP1615894A2 (fr) * | 2003-04-14 | 2006-01-18 | Pfizer Products Inc. | Derives de 3-azabicyclo 3.2.1]octane |
FR2872416B1 (fr) * | 2004-07-01 | 2006-09-22 | Oreal | Utilisation de derives de piperidine pour lutter contre les rides |
EP1848270B1 (fr) | 2005-02-17 | 2014-05-21 | Abbott Laboratories | Administration par voie transmuqueuse de compositions medicamenteuses pour le traitement et la prevention de troubles chez les animaux |
CA2632030A1 (fr) * | 2005-12-15 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Composes qui modulent le recepteur cb2 |
MY145633A (en) * | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
EP2081905B1 (fr) * | 2006-07-28 | 2012-09-12 | Boehringer Ingelheim International GmbH | Composés sulfonyles modulant le récepteur cb2 |
JP5030114B2 (ja) * | 2006-09-25 | 2012-09-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体をモジュレートする化合物 |
TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
EP2195313B1 (fr) * | 2007-08-27 | 2014-04-02 | Theravance, Inc. | Composés d'hétéroarylalkyl-8-azabicyclo[3.2.1]octane comme antagonistes des récepteurs opioïdes mu |
EP2185553B1 (fr) * | 2007-08-27 | 2012-06-27 | Theravance, Inc. | Composés d'amidoalkyle-8-azabicyclo[3.2.1]octane en tant qu'antagonistes du récepteur opioïde mu |
TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物 |
ATE502939T1 (de) * | 2007-08-27 | 2011-04-15 | Theravance Inc | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten |
JP5492092B2 (ja) * | 2007-11-07 | 2014-05-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節する化合物 |
CA2730037A1 (fr) * | 2008-07-10 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Composes sulfones qui modulent le recepteur cb2 |
CA2737639A1 (fr) | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Composes modulant selectivement le recepteur cb2 |
US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
US8383615B2 (en) | 2009-06-16 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Azetidine 2-carboxamide derivatives which modulate the CB2 receptor |
US8383651B2 (en) * | 2009-09-22 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
US9315454B2 (en) | 2010-01-15 | 2016-04-19 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
WO2011109324A1 (fr) | 2010-03-05 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Composés tétrazoles qui modulent sélectivement le récepteur cb2 |
US8846936B2 (en) | 2010-07-22 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the CB2 receptor |
EP2803668A1 (fr) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Nouveau (cyano-dimethyl-methyl)-isoxazoles et - [1,3,4] thiadiazoles |
CN106278914B (zh) * | 2016-08-19 | 2018-04-13 | 四川福思达生物技术开发有限责任公司 | 一种增产胺的合成工艺 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
DE3851081T2 (de) | 1987-04-16 | 1995-02-16 | Lilly Co Eli | Piperidine als Opioid-Antagoniste. |
US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
CZ284993B6 (cs) | 1991-03-29 | 1999-04-14 | Eli Lilly And Company | Derivát piperidinu |
GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
CA2288172A1 (fr) * | 1997-04-18 | 1998-10-29 | Smithkline Beecham P.L.C. | Aryl bicyclique ou noyau heterocyclique bicyclique contenant des composes presentant une activite antagoniste combinee contre les recepteurs 5ht1a, 5ht1b et 5ht1d |
-
1998
- 1998-05-18 GB GBGB9810671.9A patent/GB9810671D0/en not_active Ceased
-
1999
- 1999-05-13 AP APAP/P/1999/001535A patent/AP9901535A0/en unknown
- 1999-05-14 GT GT199900067A patent/GT199900067A/es unknown
- 1999-05-17 JP JP2000549590A patent/JP2002515486A/ja active Pending
- 1999-05-17 ZA ZA9903364A patent/ZA993364B/xx unknown
- 1999-05-17 AT AT99917038T patent/ATE271038T1/de not_active IP Right Cessation
- 1999-05-17 DK DK99917038T patent/DK1077940T3/da active
- 1999-05-17 WO PCT/IB1999/000886 patent/WO1999059971A1/fr active IP Right Grant
- 1999-05-17 ES ES99917038T patent/ES2230846T3/es not_active Expired - Lifetime
- 1999-05-17 US US09/646,255 patent/US6610711B2/en not_active Expired - Fee Related
- 1999-05-17 PT PT99917038T patent/PT1077940E/pt unknown
- 1999-05-17 DE DE69918687T patent/DE69918687T2/de not_active Expired - Fee Related
- 1999-05-17 TN TNTNSN99095A patent/TNSN99095A1/fr unknown
- 1999-05-17 AU AU35312/99A patent/AU3531299A/en not_active Abandoned
- 1999-05-17 MA MA25582A patent/MA26630A1/fr unknown
- 1999-05-17 BR BR9910609-4A patent/BR9910609A/pt not_active IP Right Cessation
- 1999-05-17 EP EP99917038A patent/EP1077940B1/fr not_active Expired - Lifetime
- 1999-05-17 CA CA002332538A patent/CA2332538C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69918687D1 (de) | 2004-08-19 |
GT199900067A (es) | 2000-11-04 |
ATE271038T1 (de) | 2004-07-15 |
WO1999059971A1 (fr) | 1999-11-25 |
GB9810671D0 (en) | 1998-07-15 |
DK1077940T3 (da) | 2004-11-01 |
PT1077940E (pt) | 2004-10-29 |
JP2002515486A (ja) | 2002-05-28 |
AP9901535A0 (en) | 1999-06-30 |
ES2230846T3 (es) | 2005-05-01 |
US6610711B2 (en) | 2003-08-26 |
EP1077940B1 (fr) | 2004-07-14 |
MA26630A1 (fr) | 2004-12-20 |
CA2332538C (fr) | 2005-08-02 |
AU3531299A (en) | 1999-12-06 |
EP1077940A1 (fr) | 2001-02-28 |
CA2332538A1 (fr) | 1999-11-25 |
ZA993364B (en) | 2000-12-01 |
DE69918687T2 (de) | 2005-07-28 |
BR9910609A (pt) | 2001-01-09 |
US20030078282A1 (en) | 2003-04-24 |
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