SK285317B6 - Molekula kruhovej DNA s podmienečným začiatkom replikácie, spôsob jej prípravy a jej použitie v génovej terapii - Google Patents
Molekula kruhovej DNA s podmienečným začiatkom replikácie, spôsob jej prípravy a jej použitie v génovej terapii Download PDFInfo
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- SK285317B6 SK285317B6 SK347-98A SK34798A SK285317B6 SK 285317 B6 SK285317 B6 SK 285317B6 SK 34798 A SK34798 A SK 34798A SK 285317 B6 SK285317 B6 SK 285317B6
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- dna molecule
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- C12N1/20—Bacteria; Culture media therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR9510825A FR2738842B1 (fr) | 1995-09-15 | 1995-09-15 | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
PCT/FR1996/001414 WO1997010343A1 (fr) | 1995-09-15 | 1996-09-13 | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
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SK34798A3 SK34798A3 (en) | 1998-11-04 |
SK285317B6 true SK285317B6 (sk) | 2006-10-05 |
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SK347-98A SK285317B6 (sk) | 1995-09-15 | 1996-09-13 | Molekula kruhovej DNA s podmienečným začiatkom replikácie, spôsob jej prípravy a jej použitie v génovej terapii |
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US (3) | US6977174B2 (ko) |
EP (3) | EP0850310B1 (ko) |
JP (3) | JP3818665B2 (ko) |
KR (1) | KR100522369B1 (ko) |
AT (3) | ATE284966T1 (ko) |
BR (1) | BRPI9610511B8 (ko) |
CA (1) | CA2229307C (ko) |
CZ (1) | CZ294525B6 (ko) |
DE (3) | DE69636878T2 (ko) |
DK (3) | DK0850310T3 (ko) |
ES (3) | ES2281721T3 (ko) |
FR (1) | FR2738842B1 (ko) |
HU (1) | HU224400B1 (ko) |
IL (4) | IL123641A0 (ko) |
NO (1) | NO323975B1 (ko) |
PT (3) | PT850310E (ko) |
SK (1) | SK285317B6 (ko) |
TW (1) | TWI231826B (ko) |
WO (1) | WO1997010343A1 (ko) |
ZA (1) | ZA967640B (ko) |
Families Citing this family (32)
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US7038026B2 (en) * | 2000-05-26 | 2006-05-02 | Centelion | Purification of a triple heli formation with an immobilized oligonucleotide |
FR2738842B1 (fr) * | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
US7279313B2 (en) * | 1995-09-15 | 2007-10-09 | Centelion | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy |
US6821759B1 (en) | 1997-06-23 | 2004-11-23 | The Rockefeller University | Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof |
US6156574A (en) | 1997-06-23 | 2000-12-05 | The Rockefeller University | Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof |
CZ299473B6 (cs) | 1997-06-30 | 2008-08-06 | Rhone-Poulenc Rorer S. A. | Nukleová kyselina a elektrické pole jako sdruženýprodukt pro prenos nukleové kyseliny do bunek prícne pruhovaného svalstva |
US6022716A (en) | 1998-04-10 | 2000-02-08 | Genset Sa | High throughput DNA sequencing vector |
WO2000075299A1 (en) * | 1999-06-07 | 2000-12-14 | Cell Genesys, Inc. | Hybrid yeast-bacteria cloning system and uses thereof |
AU6229800A (en) * | 1999-07-20 | 2001-02-05 | Rockefeller University, The | Conditional homologous recombination of large genomic vector inserts |
FR2821855B1 (fr) † | 2001-03-09 | 2004-04-02 | Cayla | Genes synthetiques et plasmides bacteriens depourvus de cpg |
FR2822476B1 (fr) * | 2001-03-23 | 2004-04-02 | Aventis Pharma Sa | Procedes de purification et de detection de sequences cibles d'adn double brin par interaction triple helice |
AU2002325346A1 (en) | 2001-07-05 | 2003-01-21 | Aventis Pharma S.A. | Method of administration of a gene of interest to the heart and vasculature |
US6989261B2 (en) * | 2001-12-20 | 2006-01-24 | Eli Lilly And Company | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
US7049121B2 (en) | 2001-12-20 | 2006-05-23 | Applied Molecular Evolution | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
FI116068B (fi) | 2003-09-15 | 2005-09-15 | Fit Biotech Oyj Plc | Uusi selektiojärjestelmä, siinä käyttökelpoinen vektori, bakteerisolukantoja sekä menetelmä solujen valikoimiseksi |
JP4581851B2 (ja) * | 2004-07-27 | 2010-11-17 | セイコーエプソン株式会社 | 電気光学装置の駆動回路及び駆動方法、電気光学装置並びに電子機器 |
CA2608636C (en) * | 2005-05-17 | 2015-02-10 | Frank Koentgen | Sequential cloning system |
US8716021B2 (en) * | 2005-09-07 | 2014-05-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of replicators to prevent gene silencing |
EP2386564B1 (en) * | 2005-10-01 | 2014-07-16 | Charles Stout | Regulatable fusion promoters |
GB0606190D0 (en) | 2006-03-28 | 2006-05-10 | Isis Innovation | Construct |
CN102124102B (zh) * | 2008-07-18 | 2013-12-18 | 麦克赛特股份有限公司 | 优化电穿孔的方法 |
EP2221066A1 (en) | 2009-02-18 | 2010-08-25 | Sanofi-Aventis | Use of VgII3 activity modulator for the modulation of adipogenesis |
EP2547768B1 (en) | 2010-03-17 | 2015-12-30 | Association Institut de Myologie | Modified u7 snrnas for treatment of neuromuscular diseases |
US9403880B2 (en) | 2010-11-26 | 2016-08-02 | Institut Pasteur | Identification of a human gyrovirus and applications |
WO2013083753A2 (en) | 2011-12-07 | 2013-06-13 | Institut Pasteur | Identification of a swine parecho-like virus and applications |
WO2014035457A1 (en) | 2012-08-29 | 2014-03-06 | Nature Technology Corporation | Dna plasmids with improved expression |
WO2014077863A1 (en) | 2012-11-19 | 2014-05-22 | Nature Technology Corporation | Replicative minicircle vectors with improved expression |
WO2014153205A1 (en) * | 2013-03-14 | 2014-09-25 | Epeius Biotechnologies Corporation | Thymidine kinase diagnostic assay for gene therapy applications |
WO2019057774A1 (en) | 2017-09-19 | 2019-03-28 | Deutsches Krebsforschungszentrum | NON-INTEGRATING DNA VECTORS FOR THE GENETIC MODIFICATION OF CELLS |
EP3456821B2 (en) | 2017-09-19 | 2024-01-24 | Deutsches Krebsforschungszentrum | Non-integrating dna vectors for the genetic modification of cells |
SG11202009009UA (en) | 2018-03-21 | 2020-10-29 | Nature Tech Corporation | Viral and non-viral nanoplasmid vectors with improved production |
WO2023241567A1 (zh) * | 2022-06-13 | 2023-12-21 | 南京金斯瑞生物科技有限公司 | 一种可提高无筛选标签质粒制备效率的野生型-突变体π蛋白切换表达系统 |
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US4654307A (en) * | 1983-02-17 | 1987-03-31 | The Research Foundation Of State University Of New York | Novel bacteria containing a plasmid having a tRNA code |
US4761367A (en) * | 1984-11-07 | 1988-08-02 | The University Of North Carolina At Chapel Hill | Vectors suitable for detection of eukaryotic DNA regulatory sequences |
US5859208A (en) * | 1988-07-06 | 1999-01-12 | Fiddes; John C. | Human basic fibroblast growth factor analog |
US5198343A (en) * | 1986-08-05 | 1993-03-30 | Transgene, S.A. | Method for expressing a heterologous protein in a dapD- mutant of E. coli and the strain obtained |
US5591632A (en) * | 1987-03-02 | 1997-01-07 | Beth Israel Hospital | Recombinant BCG |
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EP0485701A1 (en) * | 1990-09-28 | 1992-05-20 | American Cyanamid Company | Insertion of DNA by modified transposons |
TW201794B (ko) * | 1991-05-03 | 1993-03-11 | American Cyanamid Co | |
US5714323A (en) * | 1991-08-30 | 1998-02-03 | The University Of Medecine And Dentistry Of New Jersey | Over expression of single-stranded molecules |
US5444149A (en) * | 1992-05-11 | 1995-08-22 | Duke University | Methods and compositions useful in the recognition, binding and expression of ribonucleic acids involved in cell growth, neoplasia and immunoregulation |
US5434065A (en) * | 1993-05-06 | 1995-07-18 | President And Fellows Of Harvard College | In vivo selection of microbial virulence genes |
WO1995005452A2 (en) * | 1993-08-12 | 1995-02-23 | Cytotherapeutics, Inc. | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
US5679647A (en) * | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
US5700657A (en) * | 1993-12-13 | 1997-12-23 | Genzyme Corporation | Vectors and vector systems including genes encoding tumor suppressor proteins and producer cells transformed thereby |
IL109558A (en) * | 1994-05-04 | 2004-08-31 | Yissum Res Dev Co | DNA structures Derived from the SV40 virus that include DNA sequences External |
AU2946695A (en) * | 1994-07-08 | 1996-02-09 | Schering Corporation | Method for identifying nucleic acids encoding c-fos promoter activating proteins |
DE4428402A1 (de) * | 1994-08-11 | 1996-02-15 | Boehringer Mannheim Gmbh | Gentherapeutisches Verfahren unter Verwendung von DNA-Vektoren ohne Selektionsmarker-Gen |
US5792647A (en) * | 1995-02-13 | 1998-08-11 | The Johns Hopkins University | Bacterial catabolism of chitin |
US6254874B1 (en) * | 1995-04-13 | 2001-07-03 | President And Fellows Of Harvard College | Attenuated auxotrophic microorganisms having a combination of non-attenuating mutations and method for making same |
US5763270A (en) * | 1995-06-07 | 1998-06-09 | Genemedicine, Inc. | Plasmid for delivery of nucleic acids to cells and methods of use |
US7279313B2 (en) * | 1995-09-15 | 2007-10-09 | Centelion | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy |
US7364894B2 (en) * | 1995-09-15 | 2008-04-29 | Centelion | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy |
FR2738842B1 (fr) * | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
US5851808A (en) * | 1997-02-28 | 1998-12-22 | Baylor College Of Medicine | Rapid subcloning using site-specific recombination |
US5874259A (en) * | 1997-11-21 | 1999-02-23 | Wisconsin Alumni Research Foundation | Conditionally amplifiable BAC vector |
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- 1996-09-13 DE DE69636878T patent/DE69636878T2/de not_active Expired - Lifetime
- 1996-09-13 EP EP96931124A patent/EP0850310B1/fr not_active Expired - Lifetime
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1998
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2005
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2006
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2007
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2008
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Effective date: 20150913 |