SK283793B6 - Spôsob prípravy enantiomérne čistých esterov kyseliny (+)- a (-)-tropovej - Google Patents

Spôsob prípravy enantiomérne čistých esterov kyseliny (+)- a (-)-tropovej Download PDF

Info

Publication number
SK283793B6
SK283793B6 SK1444-97A SK144497A SK283793B6 SK 283793 B6 SK283793 B6 SK 283793B6 SK 144497 A SK144497 A SK 144497A SK 283793 B6 SK283793 B6 SK 283793B6
Authority
SK
Slovakia
Prior art keywords
acid
tropic acid
chloride
tropic
optically active
Prior art date
Application number
SK1444-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK144497A3 (en
Inventor
Rolf Banholzer
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of SK144497A3 publication Critical patent/SK144497A3/sk
Publication of SK283793B6 publication Critical patent/SK283793B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
SK1444-97A 1995-04-28 1996-04-29 Spôsob prípravy enantiomérne čistých esterov kyseliny (+)- a (-)-tropovej SK283793B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19515625A DE19515625C2 (de) 1995-04-28 1995-04-28 Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern
PCT/EP1996/001779 WO1996033996A1 (de) 1995-04-28 1996-04-29 Verfahren zur herstellung von enantiomerenreinen tropasäureestern

Publications (2)

Publication Number Publication Date
SK144497A3 SK144497A3 (en) 1998-03-04
SK283793B6 true SK283793B6 (sk) 2004-01-08

Family

ID=7760581

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1444-97A SK283793B6 (sk) 1995-04-28 1996-04-29 Spôsob prípravy enantiomérne čistých esterov kyseliny (+)- a (-)-tropovej

Country Status (27)

Country Link
US (1) US5952505A (da)
EP (1) EP0822935B1 (da)
JP (1) JP3988056B2 (da)
KR (1) KR100386383B1 (da)
CN (1) CN1050357C (da)
AT (1) ATE208389T1 (da)
AU (1) AU702141B2 (da)
BG (1) BG62209B1 (da)
BR (1) BR9608288A (da)
CZ (1) CZ292579B6 (da)
DE (2) DE19515625C2 (da)
DK (1) DK0822935T3 (da)
EE (1) EE03398B1 (da)
ES (1) ES2167573T3 (da)
HK (1) HK1010878A1 (da)
HU (1) HU228037B1 (da)
MX (1) MX9708211A (da)
NO (1) NO316175B1 (da)
NZ (1) NZ308462A (da)
PL (1) PL183118B1 (da)
PT (1) PT822935E (da)
RO (1) RO118871B1 (da)
RU (1) RU2162850C2 (da)
SK (1) SK283793B6 (da)
TR (1) TR199701266T1 (da)
TW (1) TW413680B (da)
WO (1) WO1996033996A1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2279345A1 (en) 1997-01-31 1998-08-06 Human Genome Sciences, Inc. Tissue factor pathway inhibitor-3
CZ20023537A3 (cs) * 2000-04-27 2003-02-12 Boehringer Ingelheim Pharma Kg Betamimetika, způsob jejich výroby a použití jako farmaceutický prostředek
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
EP1430887A1 (de) * 2000-10-12 2004-06-23 Boehringer Ingelheim Pharma GmbH & Co.KG Tiotropium-haltige Inhalationspulver
US6852728B2 (en) 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
DE10062712A1 (de) * 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
DE10212264A1 (de) * 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
ES2272968T3 (es) * 2002-04-04 2007-05-01 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO.KG Formulaciones en polvo, adecuadas para inhalacion.
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
US8283864B2 (en) * 2010-02-12 2012-10-09 Panasonic Corporation Plasma display panel with protective layer comprising crystal particles of magnesium oxide
US8899463B2 (en) 2010-09-30 2014-12-02 Ethicon Endo-Surgery, Inc. Surgical staple cartridges supporting non-linearly arranged staples and surgical stapling instruments with common staple-forming pockets
CN103387534B (zh) * 2012-05-09 2015-02-18 北大方正集团有限公司 一种拆分托吡卡胺外消旋体的方法
CN104628718A (zh) * 2014-06-11 2015-05-20 苏州景泓生物技术有限公司 一种合成东莨菪碱及其盐的方法
CN115572290A (zh) * 2022-09-06 2023-01-06 河北仁合益康药业有限公司 一种一锅法合成异丙托溴铵的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1289429A (fr) * 1960-03-10 1962-04-06 Lepetit Spa Procédé de préparation des nouveaux esters de la tropine

Also Published As

Publication number Publication date
TW413680B (en) 2000-12-01
NO974967L (no) 1997-10-27
BR9608288A (pt) 1999-06-29
RU2162850C2 (ru) 2001-02-10
CZ292579B6 (cs) 2003-10-15
DE59608148D1 (de) 2001-12-13
HUP9802210A2 (hu) 1999-02-01
NO974967D0 (no) 1997-10-27
AU5812096A (en) 1996-11-18
PL323038A1 (en) 1998-03-02
EE9700262A (et) 1998-06-15
JPH11504027A (ja) 1999-04-06
ATE208389T1 (de) 2001-11-15
DE19515625C2 (de) 1998-02-19
AU702141B2 (en) 1999-02-11
NO316175B1 (no) 2003-12-22
HK1010878A1 (en) 1999-07-02
HU228037B1 (en) 2012-08-28
EE03398B1 (et) 2001-04-16
CN1050357C (zh) 2000-03-15
JP3988056B2 (ja) 2007-10-10
RO118871B1 (ro) 2003-12-30
PL183118B1 (pl) 2002-05-31
MX9708211A (es) 1997-12-31
NZ308462A (en) 1999-01-28
EP0822935A1 (de) 1998-02-11
SK144497A3 (en) 1998-03-04
CZ340597A3 (cs) 1998-01-14
ES2167573T3 (es) 2002-05-16
WO1996033996A1 (de) 1996-10-31
DE19515625A1 (de) 1996-10-31
HUP9802210A3 (en) 2000-03-28
KR19990008072A (ko) 1999-01-25
US5952505A (en) 1999-09-14
EP0822935B1 (de) 2001-11-07
KR100386383B1 (ko) 2003-09-19
BG101948A (en) 1998-05-29
TR199701266T1 (xx) 1998-02-21
DK0822935T3 (da) 2001-12-27
PT822935E (pt) 2002-04-29
BG62209B1 (bg) 1999-05-31
CN1183098A (zh) 1998-05-27

Similar Documents

Publication Publication Date Title
SK283793B6 (sk) Spôsob prípravy enantiomérne čistých esterov kyseliny (+)- a (-)-tropovej
WO2003097622A2 (en) Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof
US4297282A (en) Resolution of mercaptopropionic acids
EP0182279B1 (en) Process for the optical resolution of racemic mixtures of alpha-naphtyl-propionic acids
WO2008096373A2 (en) Process for synthesizing highly pure nateglinide polymorphs
US5399763A (en) Process for preparing optically active 2-aminopropanal
JPH06340595A (ja) 光学的に純粋なアミノアルコールの製造方法
KR101304640B1 (ko) 신규의 로수바스타틴 엔-메틸벤질아민 염 및 그의 제조방법
WO2002068391A1 (en) Process for resolving racemic mixtures of piperidine derivatives
US6743944B1 (en) Process for producing optically active aminoalcohol
EP0179487B1 (en) 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof
US5338868A (en) Process for preparing alpha-amino-phenylacetic acid-trifluoromethane sulfonic acid mixed anhydrides
US20040039206A1 (en) Process for resolving racemic mixtures of piperidine derivatives
CA2219533C (en) Process for preparing enantiomerically pure tropic acid esters
JP3272377B2 (ja) 光学活性なグルタル酸エステル誘導体の光学分割法
IL118660A (en) Process for preparing enantiomerically pure tropic acid esters
EP0784608A1 (en) The manufacture of levobupivacaine and analogues thereof from l-lysine
JPH05339267A (ja) 新規なピリジン誘導体、その製造方法及びその中間体
JPH03200747A (ja) Ｎ−メチル−４−ｔ−ブチルベンジルアミンの製造法
JPH0572381B2 (da)
JPH08143545A (ja) ４−メルカプトピロリジン化合物の製法
WO2009104849A1 (en) Cis-2,6-disubstituted tetrahydropyran derivatives and preparation method thereof

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120429