EE9700262A - Meetod troopahappeestrite puhaste enantiomeeride valmistamiseks - Google Patents

Meetod troopahappeestrite puhaste enantiomeeride valmistamiseks

Info

Publication number
EE9700262A
EE9700262A EE9700262A EE9700262A EE9700262A EE 9700262 A EE9700262 A EE 9700262A EE 9700262 A EE9700262 A EE 9700262A EE 9700262 A EE9700262 A EE 9700262A EE 9700262 A EE9700262 A EE 9700262A
Authority
EE
Estonia
Prior art keywords
pct
preparation
acid esters
pure enantiomers
sec
Prior art date
Application number
EE9700262A
Other languages
English (en)
Other versions
EE03398B1 (et
Inventor
Banholzer Rolf
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of EE9700262A publication Critical patent/EE9700262A/et
Publication of EE03398B1 publication Critical patent/EE03398B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EE9700262A 1995-04-28 1996-04-29 Meetod troopahappeestrite puhaste enantiomeeride valmistamiseks EE03398B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19515625A DE19515625C2 (de) 1995-04-28 1995-04-28 Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern
PCT/EP1996/001779 WO1996033996A1 (de) 1995-04-28 1996-04-29 Verfahren zur herstellung von enantiomerenreinen tropasäureestern

Publications (2)

Publication Number Publication Date
EE9700262A true EE9700262A (et) 1998-06-15
EE03398B1 EE03398B1 (et) 2001-04-16

Family

ID=7760581

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700262A EE03398B1 (et) 1995-04-28 1996-04-29 Meetod troopahappeestrite puhaste enantiomeeride valmistamiseks

Country Status (27)

Country Link
US (1) US5952505A (et)
EP (1) EP0822935B1 (et)
JP (1) JP3988056B2 (et)
KR (1) KR100386383B1 (et)
CN (1) CN1050357C (et)
AT (1) ATE208389T1 (et)
AU (1) AU702141B2 (et)
BG (1) BG62209B1 (et)
BR (1) BR9608288A (et)
CZ (1) CZ292579B6 (et)
DE (2) DE19515625C2 (et)
DK (1) DK0822935T3 (et)
EE (1) EE03398B1 (et)
ES (1) ES2167573T3 (et)
HK (1) HK1010878A1 (et)
HU (1) HU228037B1 (et)
MX (1) MX9708211A (et)
NO (1) NO316175B1 (et)
NZ (1) NZ308462A (et)
PL (1) PL183118B1 (et)
PT (1) PT822935E (et)
RO (1) RO118871B1 (et)
RU (1) RU2162850C2 (et)
SK (1) SK283793B6 (et)
TR (1) TR199701266T1 (et)
TW (1) TW413680B (et)
WO (1) WO1996033996A1 (et)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6042298A (en) 1997-01-31 1998-08-25 Human Genome Sciences, Inc. Tissue factor pathway inhibitor-3
HUP0300832A2 (hu) * 2000-04-27 2003-08-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Új, lassú hatású bétamimetikumok, eljárás előállításukra és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
UA72014C2 (en) * 2000-10-12 2005-01-17 Boehringer Ingelheim Pharma Tiotropium-containing powdery preparations for inhalations intended for treating asthma and chronic obstructive pulmonary disease (variants), method for their production and capsule
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US6852728B2 (en) * 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
DE10062712A1 (de) * 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
DE10212264A1 (de) * 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
BR0308984A (pt) * 2002-04-04 2005-02-09 Boehringer Ingelheim Pharma Formulações em pó adequadas para inalação
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
KR20120023053A (ko) * 2010-02-12 2012-03-12 파나소닉 주식회사 플라즈마 디스플레이 패널의 제조 방법
US9044228B2 (en) 2010-09-30 2015-06-02 Ethicon Endo-Surgery, Inc. Fastener system comprising a plurality of fastener cartridges
CN103387534B (zh) * 2012-05-09 2015-02-18 北大方正集团有限公司 一种拆分托吡卡胺外消旋体的方法
CN104628718A (zh) * 2014-06-11 2015-05-20 苏州景泓生物技术有限公司 一种合成东莨菪碱及其盐的方法
CN115572290A (zh) * 2022-09-06 2023-01-06 河北仁合益康药业有限公司 一种一锅法合成异丙托溴铵的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1289429A (fr) * 1960-03-10 1962-04-06 Lepetit Spa Procédé de préparation des nouveaux esters de la tropine

Also Published As

Publication number Publication date
PT822935E (pt) 2002-04-29
RU2162850C2 (ru) 2001-02-10
WO1996033996A1 (de) 1996-10-31
EE03398B1 (et) 2001-04-16
NO974967D0 (no) 1997-10-27
DE19515625C2 (de) 1998-02-19
AU5812096A (en) 1996-11-18
RO118871B1 (ro) 2003-12-30
KR100386383B1 (ko) 2003-09-19
NZ308462A (en) 1999-01-28
CZ292579B6 (cs) 2003-10-15
US5952505A (en) 1999-09-14
EP0822935A1 (de) 1998-02-11
BG62209B1 (bg) 1999-05-31
HK1010878A1 (en) 1999-07-02
BR9608288A (pt) 1999-06-29
TR199701266T1 (xx) 1998-02-21
PL183118B1 (pl) 2002-05-31
HUP9802210A2 (hu) 1999-02-01
DE19515625A1 (de) 1996-10-31
DK0822935T3 (da) 2001-12-27
JP3988056B2 (ja) 2007-10-10
NO974967L (no) 1997-10-27
PL323038A1 (en) 1998-03-02
SK144497A3 (en) 1998-03-04
HU228037B1 (en) 2012-08-28
BG101948A (en) 1998-05-29
NO316175B1 (no) 2003-12-22
HUP9802210A3 (en) 2000-03-28
SK283793B6 (sk) 2004-01-08
ES2167573T3 (es) 2002-05-16
ATE208389T1 (de) 2001-11-15
TW413680B (en) 2000-12-01
CN1183098A (zh) 1998-05-27
DE59608148D1 (de) 2001-12-13
EP0822935B1 (de) 2001-11-07
KR19990008072A (ko) 1999-01-25
MX9708211A (es) 1997-12-31
AU702141B2 (en) 1999-02-11
CZ340597A3 (cs) 1998-01-14
CN1050357C (zh) 2000-03-15
JPH11504027A (ja) 1999-04-06

Similar Documents

Publication Publication Date Title
EE9700262A (et) Meetod troopahappeestrite puhaste enantiomeeride valmistamiseks
HU9503401D0 (en) Novel 5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole derivatives
WO2001068037A3 (de) Kieselsäureester-mischungen
TR27835A (tr) Sübstitüe edilmis azadiokzasikloalkenler.
HUT77925A (hu) Dihidrobenzofuránok, azokat tartalmazó gyógyászati készítmények és eljárás előállításukra
ATE206130T1 (de) Methylphosphonsäureester, verfahren zu deren herstellung und deren verwendung
DE50113943D1 (de) 4-alkoxy-cyclohexan-1-amino-carbonsäureester und verfahren zu ihrer herstellung
MX9708735A (es) Benzotiazoles y benzoxazoles, composiciones farmaceuticas que contienen estos compuestos y su uso y proceso para prepararlos.
AU2566101A (en) Compounds and methods for the treatment of pain
CA2208032A1 (en) Substituted amidinonaphthyl ester derivative
DK0802920T3 (da) Fusacandin-antisvampemidler
DE69627533D1 (de) Herstellung von einem kristallinen amoxicillinsalz
CA2219533A1 (en) Process for preparing enantiomerically pure tropic acid esters
AU7582396A (en) Synthesis of carboxylic acid derivatives
GB9523924D0 (en) Production of optically active 2-substituted tetrahydropyran-4-ones
AR002139A1 (es) Procedimiento para la preparacion de esteres de acidos tropicos, puros en cuanto a los enantiomeros
NO972290L (no) Fremgangsmåte for fremstilling av optisk aktive forbindelser
HUT53593A (en) Process for producing optically active n-(terc butoxy-carbonyl)-o-benzyl-serine and n-(terc butoxy-carbonyl)-o-benzyl-treonine
ATE286539T1 (de) Verfahren zur herstellung von optisch aktiven 3,3,3- trifluormethyl- 2- alkylpropionsäurederivaten

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20120429