SK283224B6 - Použitie derivátov 7-(2-oxa-5,8-diazabicyklo[4.3.0] non-8-yl)- chinolónkarboxylovej a -naftyridónkarboxylovej kyseliny na výrobu liečiv na terapiu infekcií spôsobených Helicobacter pylori a ním asociovaných gastroduodenálnych ochorení a zlúčenina tohto typu - Google Patents

Použitie derivátov 7-(2-oxa-5,8-diazabicyklo[4.3.0] non-8-yl)- chinolónkarboxylovej a -naftyridónkarboxylovej kyseliny na výrobu liečiv na terapiu infekcií spôsobených Helicobacter pylori a ním asociovaných gastroduodenálnych ochorení a zlúčenina tohto typu Download PDF

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Publication number
SK283224B6
SK283224B6 SK1496-2000A SK14962000A SK283224B6 SK 283224 B6 SK283224 B6 SK 283224B6 SK 14962000 A SK14962000 A SK 14962000A SK 283224 B6 SK283224 B6 SK 283224B6
Authority
SK
Slovakia
Prior art keywords
group
diazabicyclo
oxa
methyl
oxo
Prior art date
Application number
SK1496-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK14962000A3 (sk
Inventor
Michael Matzke
Uwe Petersen
Thomas Jaetsch
Stephan Bartel
Thomas Schenke
Thomas Himmler
Bernd Baasner
Hans-Otto Werling
Klaus Schaller
Harald Labischinski
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of SK14962000A3 publication Critical patent/SK14962000A3/sk
Publication of SK283224B6 publication Critical patent/SK283224B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK1496-2000A 1996-12-16 1997-12-04 Použitie derivátov 7-(2-oxa-5,8-diazabicyklo[4.3.0] non-8-yl)- chinolónkarboxylovej a -naftyridónkarboxylovej kyseliny na výrobu liečiv na terapiu infekcií spôsobených Helicobacter pylori a ním asociovaných gastroduodenálnych ochorení a zlúčenina tohto typu SK283224B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19652239A DE19652239A1 (de) 1996-12-16 1996-12-16 Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
PCT/EP1997/006781 WO1998026779A1 (de) 1996-12-16 1997-12-04 Verwendung von 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen

Publications (2)

Publication Number Publication Date
SK14962000A3 SK14962000A3 (sk) 2003-01-09
SK283224B6 true SK283224B6 (sk) 2003-03-04

Family

ID=7814837

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1496-2000A SK283224B6 (sk) 1996-12-16 1997-12-04 Použitie derivátov 7-(2-oxa-5,8-diazabicyklo[4.3.0] non-8-yl)- chinolónkarboxylovej a -naftyridónkarboxylovej kyseliny na výrobu liečiv na terapiu infekcií spôsobených Helicobacter pylori a ním asociovaných gastroduodenálnych ochorení a zlúčenina tohto typu
SK795-99A SK283223B6 (sk) 1996-12-16 1997-12-04 Kyselina 8-kyano-1-cyklopropyl-6-fluór-7-(2-oxa-5,8- diazabicyklo[4.3.0]non-8-yl)-1,4-dihydro-4-oxo-3- chinolínkarboxylová, jej použitie a liečivá túto zlúčeninu obsahujúce

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK795-99A SK283223B6 (sk) 1996-12-16 1997-12-04 Kyselina 8-kyano-1-cyklopropyl-6-fluór-7-(2-oxa-5,8- diazabicyklo[4.3.0]non-8-yl)-1,4-dihydro-4-oxo-3- chinolínkarboxylová, jej použitie a liečivá túto zlúčeninu obsahujúce

Country Status (28)

Country Link
US (2) US6133260A (cs)
EP (1) EP0946176B1 (cs)
JP (3) JP3463939B2 (cs)
KR (1) KR100536153B1 (cs)
CN (1) CN100335054C (cs)
AT (1) ATE214929T1 (cs)
AU (1) AU717751B2 (cs)
BG (1) BG64615B1 (cs)
BR (1) BR9714032A (cs)
CA (1) CA2274894C (cs)
CZ (2) CZ297363B6 (cs)
DE (2) DE19652239A1 (cs)
DK (1) DK0946176T3 (cs)
EA (1) EA002477B1 (cs)
EE (1) EE04090B1 (cs)
ES (1) ES2175519T3 (cs)
HK (1) HK1025517A1 (cs)
HU (1) HU226523B1 (cs)
IL (1) IL130311A (cs)
NO (1) NO325617B1 (cs)
NZ (2) NZ336228A (cs)
PL (1) PL191193B1 (cs)
PT (1) PT946176E (cs)
RS (1) RS49684B (cs)
SK (2) SK283224B6 (cs)
TR (1) TR199901754T2 (cs)
UA (1) UA57055C2 (cs)
WO (1) WO1998026779A1 (cs)

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Also Published As

Publication number Publication date
BG64615B1 (bg) 2005-09-30
SK283223B6 (sk) 2003-03-04
NO992903L (no) 1999-06-14
CZ216899A3 (cs) 2000-02-16
BR9714032A (pt) 2000-05-09
ES2175519T3 (es) 2002-11-16
NZ336228A (en) 2000-12-22
CZ297364B6 (cs) 2006-11-15
NZ506162A (en) 2001-06-29
YU27499A (sh) 2002-10-18
RS49684B (sr) 2007-11-15
DE19652239A1 (de) 1998-06-18
CN1245428A (zh) 2000-02-23
SK14962000A3 (sk) 2003-01-09
EE04090B1 (et) 2003-08-15
KR100536153B1 (ko) 2005-12-14
CA2274894A1 (en) 1998-06-25
EA002477B1 (ru) 2002-06-27
DK0946176T3 (da) 2002-06-10
CA2274894C (en) 2009-04-07
PL191193B1 (pl) 2006-03-31
JP2000514825A (ja) 2000-11-07
PT946176E (pt) 2002-08-30
HU226523B1 (en) 2009-03-30
KR20000069483A (ko) 2000-11-25
EE9900248A (et) 1999-12-15
EP0946176B1 (de) 2002-03-27
CN100335054C (zh) 2007-09-05
HUP0000450A2 (hu) 2000-10-28
JP2000351781A (ja) 2000-12-19
IL130311A (en) 2004-01-04
HK1025517A1 (en) 2000-11-17
ATE214929T1 (de) 2002-04-15
JP5112395B2 (ja) 2013-01-09
JP2009235106A (ja) 2009-10-15
EP0946176A1 (de) 1999-10-06
JP4463380B2 (ja) 2010-05-19
NO325617B1 (no) 2008-06-30
UA57055C2 (uk) 2003-06-16
AU717751B2 (en) 2000-03-30
EA199900526A1 (ru) 2000-08-28
TR199901754T2 (xx) 1999-09-21
SK79599A3 (en) 2001-01-18
DE59706808D1 (de) 2002-05-02
WO1998026779A1 (de) 1998-06-25
PL333928A1 (en) 2000-01-31
NO992903D0 (no) 1999-06-14
JP3463939B2 (ja) 2003-11-05
US6432948B1 (en) 2002-08-13
AU5854198A (en) 1998-07-15
HUP0000450A3 (en) 2001-02-28
IL130311A0 (en) 2000-06-01
BG103474A (en) 2000-01-31
US6133260A (en) 2000-10-17
CZ297363B6 (cs) 2006-11-15

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