SK281571B6 - Prostriedok na trvalé uvoľňovanie ľudského rastového hormónu - Google Patents
Prostriedok na trvalé uvoľňovanie ľudského rastového hormónu Download PDFInfo
- Publication number
- SK281571B6 SK281571B6 SK1671-97A SK167197A SK281571B6 SK 281571 B6 SK281571 B6 SK 281571B6 SK 167197 A SK167197 A SK 167197A SK 281571 B6 SK281571 B6 SK 281571B6
- Authority
- SK
- Slovakia
- Prior art keywords
- hgh
- polymer
- metal cation
- composition
- poly
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title claims abstract description 237
- 108010000521 Human Growth Hormone Proteins 0.000 title claims abstract description 237
- 239000000854 Human Growth Hormone Substances 0.000 title claims abstract description 234
- 239000000203 mixture Substances 0.000 title claims abstract description 78
- 238000013268 sustained release Methods 0.000 title claims abstract description 47
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 47
- 229910052751 metal Inorganic materials 0.000 claims abstract description 58
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- 150000001768 cations Chemical class 0.000 claims abstract description 56
- 239000002245 particle Substances 0.000 claims abstract description 43
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- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 41
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 21
- 239000011667 zinc carbonate Substances 0.000 claims description 21
- 235000004416 zinc carbonate Nutrition 0.000 claims description 21
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- 239000011701 zinc Substances 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 5
- -1 poly (alkylene oxalate Chemical compound 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
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- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
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- 238000001990 intravenous administration Methods 0.000 description 2
- 230000000366 juvenile effect Effects 0.000 description 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
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- 235000009434 Actinidia chinensis Nutrition 0.000 description 1
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical class OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 1
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
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- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- IHBMMJGTJFPEQY-UHFFFAOYSA-N sulfanylidene(sulfanylidenestibanylsulfanyl)stibane Chemical compound S=[Sb]S[Sb]=S IHBMMJGTJFPEQY-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
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- 238000005303 weighing Methods 0.000 description 1
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/473,544 US5654010A (en) | 1992-12-02 | 1995-06-07 | Composition for sustained release of human growth hormone |
| US08/477,725 US5667808A (en) | 1992-12-02 | 1995-06-07 | Composition for sustained release of human growth hormone |
| PCT/US1996/008086 WO1996040072A2 (en) | 1995-06-07 | 1996-06-03 | Composition for sustained release of human growth hormone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK167197A3 SK167197A3 (en) | 1998-06-03 |
| SK281571B6 true SK281571B6 (sk) | 2001-05-10 |
Family
ID=27044171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1671-97A SK281571B6 (sk) | 1995-06-07 | 1996-06-03 | Prostriedok na trvalé uvoľňovanie ľudského rastového hormónu |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0831787B1 (es) |
| JP (1) | JPH11506740A (es) |
| CN (1) | CN1102854C (es) |
| AT (1) | ATE204468T1 (es) |
| AU (1) | AU708756B2 (es) |
| BR (1) | BR9608542A (es) |
| CA (1) | CA2223436A1 (es) |
| CZ (1) | CZ288147B6 (es) |
| DE (1) | DE69614685T2 (es) |
| DK (1) | DK0831787T3 (es) |
| ES (1) | ES2161366T3 (es) |
| HK (1) | HK1009089A1 (es) |
| HU (1) | HUP9900870A3 (es) |
| IL (1) | IL122385A (es) |
| MX (1) | MX9709698A (es) |
| NO (1) | NO316104B1 (es) |
| NZ (1) | NZ310644A (es) |
| PL (1) | PL184531B1 (es) |
| PT (1) | PT831787E (es) |
| RU (1) | RU2161502C2 (es) |
| SK (1) | SK281571B6 (es) |
| WO (1) | WO1996040072A2 (es) |
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| US5656297A (en) * | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| DK0674506T3 (da) * | 1992-12-02 | 2001-01-08 | Alkermes Inc | Væksthormonholdige mikrosfærer med styret frigivelse |
| ES2151079T3 (es) * | 1994-09-09 | 2000-12-16 | Takeda Chemical Industries Ltd | Preparacion de liberacion sostenida que contiene una sal metalica de un peptido. |
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1996
- 1996-06-03 AU AU61469/96A patent/AU708756B2/en not_active Ceased
- 1996-06-03 RU RU97119935/14A patent/RU2161502C2/ru not_active IP Right Cessation
- 1996-06-03 NZ NZ310644A patent/NZ310644A/xx unknown
- 1996-06-03 WO PCT/US1996/008086 patent/WO1996040072A2/en not_active Application Discontinuation
- 1996-06-03 JP JP9500870A patent/JPH11506740A/ja active Pending
- 1996-06-03 CN CN96194614A patent/CN1102854C/zh not_active Expired - Fee Related
- 1996-06-03 IL IL12238596A patent/IL122385A/xx not_active IP Right Cessation
- 1996-06-03 BR BR9608542-8A patent/BR9608542A/pt not_active Application Discontinuation
- 1996-06-03 DK DK96919016T patent/DK0831787T3/da active
- 1996-06-03 PT PT96919016T patent/PT831787E/pt unknown
- 1996-06-03 CZ CZ19973907A patent/CZ288147B6/cs not_active IP Right Cessation
- 1996-06-03 HU HU9900870A patent/HUP9900870A3/hu unknown
- 1996-06-03 DE DE69614685T patent/DE69614685T2/de not_active Expired - Fee Related
- 1996-06-03 SK SK1671-97A patent/SK281571B6/sk unknown
- 1996-06-03 ES ES96919016T patent/ES2161366T3/es not_active Expired - Lifetime
- 1996-06-03 PL PL96323832A patent/PL184531B1/pl not_active IP Right Cessation
- 1996-06-03 AT AT96919016T patent/ATE204468T1/de not_active IP Right Cessation
- 1996-06-03 EP EP96919016A patent/EP0831787B1/en not_active Expired - Lifetime
- 1996-06-03 CA CA002223436A patent/CA2223436A1/en not_active Abandoned
-
1997
- 1997-12-05 NO NO19975708A patent/NO316104B1/no unknown
- 1997-12-05 MX MX9709698A patent/MX9709698A/es not_active IP Right Cessation
-
1998
- 1998-08-19 HK HK98110029A patent/HK1009089A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2161502C2 (ru) | 2001-01-10 |
| MX9709698A (es) | 1998-07-31 |
| WO1996040072A3 (en) | 1997-01-23 |
| CA2223436A1 (en) | 1996-12-19 |
| CN1187120A (zh) | 1998-07-08 |
| NO975708D0 (no) | 1997-12-05 |
| IL122385A0 (en) | 1998-06-15 |
| HUP9900870A3 (en) | 2001-04-28 |
| ES2161366T3 (es) | 2001-12-01 |
| DK0831787T3 (da) | 2001-12-17 |
| NO316104B1 (no) | 2003-12-15 |
| DE69614685D1 (de) | 2001-09-27 |
| PL323832A1 (en) | 1998-04-27 |
| EP0831787A2 (en) | 1998-04-01 |
| PT831787E (pt) | 2002-02-28 |
| CZ390797A3 (cs) | 1998-07-15 |
| IL122385A (en) | 2001-01-11 |
| AU6146996A (en) | 1996-12-30 |
| CZ288147B6 (en) | 2001-05-16 |
| HK1009089A1 (en) | 1999-09-10 |
| JPH11506740A (ja) | 1999-06-15 |
| WO1996040072A2 (en) | 1996-12-19 |
| NO975708L (no) | 1998-02-05 |
| ATE204468T1 (de) | 2001-09-15 |
| PL184531B1 (pl) | 2002-11-29 |
| EP0831787B1 (en) | 2001-08-22 |
| DE69614685T2 (de) | 2002-06-27 |
| SK167197A3 (en) | 1998-06-03 |
| BR9608542A (pt) | 1999-11-30 |
| HUP9900870A2 (hu) | 1999-09-28 |
| AU708756B2 (en) | 1999-08-12 |
| CN1102854C (zh) | 2003-03-12 |
| NZ310644A (en) | 1999-08-30 |
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