SK280134B6 - N-[[4,5-dihydroxy- a 4,5,8-trihydroxy-9,10-dihydro - Google Patents
N-[[4,5-dihydroxy- a 4,5,8-trihydroxy-9,10-dihydro Download PDFInfo
- Publication number
- SK280134B6 SK280134B6 SK947-93A SK94793A SK280134B6 SK 280134 B6 SK280134 B6 SK 280134B6 SK 94793 A SK94793 A SK 94793A SK 280134 B6 SK280134 B6 SK 280134B6
- Authority
- SK
- Slovakia
- Prior art keywords
- compounds according
- dioxo
- dihydroxy
- dihydro
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 6
- 238000000034 method Methods 0.000 title claims abstract description 5
- 238000002360 preparation method Methods 0.000 title claims abstract description 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title claims description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 14
- 150000001413 amino acids Chemical class 0.000 claims abstract description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- NUJIRYCECATQCS-UHFFFAOYSA-N 4,5-dihydroxy-9,10-dioxoanthracene-2-carbonyl chloride Chemical compound O=C1C2=CC(C(Cl)=O)=CC(O)=C2C(=O)C2=C1C=CC=C2O NUJIRYCECATQCS-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004185 ester group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- -1 diacetyl chloride Chemical compound 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004372 methylthioethyl group Chemical group [H]C([H])([H])SC([H])([H])C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000003254 radicals Chemical group 0.000 description 3
- TYNLGDBUJLVSMA-UHFFFAOYSA-N 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid Chemical compound O=C1C2=CC(C(O)=O)=CC(OC(C)=O)=C2C(=O)C2=C1C=CC=C2OC(=O)C TYNLGDBUJLVSMA-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 102000016387 Pancreatic elastase Human genes 0.000 description 2
- 108010067372 Pancreatic elastase Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229960004590 diacerein Drugs 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FJNCXZZQNBKEJT-UHFFFAOYSA-N 8beta-hydroxymarrubiin Natural products O1C(=O)C2(C)CCCC3(C)C2C1CC(C)(O)C3(O)CCC=1C=COC=1 FJNCXZZQNBKEJT-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- HULZXFBQTQXWJX-UHFFFAOYSA-N OC1=CC(=CC=2C(C3=CC=CC(=C3C(C12)=O)O)=O)C(=O)C(C(=O)O)(CC(C)C)N Chemical compound OC1=CC(=CC=2C(C3=CC=CC(=C3C(C12)=O)O)=O)C(=O)C(C(=O)O)(CC(C)C)N HULZXFBQTQXWJX-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- OKDQKPLMQBXTNH-UHFFFAOYSA-N n,n-dimethyl-2h-pyridin-1-amine Chemical compound CN(C)N1CC=CC=C1 OKDQKPLMQBXTNH-UHFFFAOYSA-N 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI910658A IT1244773B (it) | 1991-03-12 | 1991-03-12 | N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari |
| PCT/EP1992/000479 WO1992016496A1 (en) | 1991-03-12 | 1992-03-04 | N-[[4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl]carbonyl]amino acids useful in the therapy of osteoarticular affections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK94793A3 SK94793A3 (en) | 1994-03-09 |
| SK280134B6 true SK280134B6 (sk) | 1999-08-06 |
Family
ID=11359001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK947-93A SK280134B6 (sk) | 1991-03-12 | 1992-03-04 | N-[[4,5-dihydroxy- a 4,5,8-trihydroxy-9,10-dihydro |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5451606A (cs) |
| EP (1) | EP0588797B1 (cs) |
| JP (1) | JP2979054B2 (cs) |
| KR (1) | KR100224330B1 (cs) |
| AT (1) | ATE134363T1 (cs) |
| AU (1) | AU661475B2 (cs) |
| CA (1) | CA2105683C (cs) |
| CZ (1) | CZ282997B6 (cs) |
| DE (1) | DE69208464T2 (cs) |
| DK (1) | DK0588797T3 (cs) |
| ES (1) | ES2084348T3 (cs) |
| FI (1) | FI113167B (cs) |
| GR (1) | GR3019069T3 (cs) |
| HU (1) | HU215436B (cs) |
| IT (1) | IT1244773B (cs) |
| MX (1) | MX9201055A (cs) |
| NO (1) | NO304592B1 (cs) |
| PT (1) | PT100216B (cs) |
| RU (1) | RU2111959C1 (cs) |
| SK (1) | SK280134B6 (cs) |
| WO (1) | WO1992016496A1 (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ245989A (en) * | 1992-02-28 | 1995-02-24 | Lilly Industries Ltd | Anthraquinone derivatives and pharmaceutical compositions |
| GB9417102D0 (en) * | 1994-08-24 | 1994-10-12 | Lilly Industries Ltd | Pharmaceutical compounds |
| IT1276781B1 (it) * | 1995-06-23 | 1997-11-03 | Gentili Ist Spa | Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie |
| GB2398780A (en) * | 2003-02-26 | 2004-09-01 | Arakis Ltd | 1,8-dihydroxyanthraquinone-6-carboxamide derivatives as inhibitors of T-cell proliferation for treatment of autoimmune or inflammatory conditions |
| CN102060809B (zh) * | 2009-05-01 | 2015-05-20 | 常州高新技术产业开发区三维工业技术研究所有限公司 | 一种大黄酸衍生物及其制备和用途 |
| CN102225913B (zh) * | 2011-04-07 | 2013-09-04 | 栗进才 | 大黄酸衍生物以及它们的治疗用途 |
| RU2466134C1 (ru) * | 2011-06-24 | 2012-11-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Иркутский государственный университет" | Способ получения катионных комплексов палладия |
| CN104557603A (zh) * | 2014-12-08 | 2015-04-29 | 石河子大学 | 一种大黄酸类化合物及制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA761627B (en) * | 1976-03-16 | 1978-01-25 | C Friedmann | Improvements in or relating to the treatment of arthritis |
| FR2492372A1 (fr) * | 1980-10-21 | 1982-04-23 | Cird | Dihydroxy-1,8 anthrones-9 substituees en position 10 et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| US4649152A (en) * | 1985-10-01 | 1987-03-10 | Elena Avram | Composition and method for treatment of potassium deficiency |
| US4966918A (en) * | 1989-01-27 | 1990-10-30 | Sloan-Kettering Institute For Cancer Research | Derivatives of chryosphanol |
-
1991
- 1991-03-12 IT ITMI910658A patent/IT1244773B/it active IP Right Grant
-
1992
- 1992-03-04 WO PCT/EP1992/000479 patent/WO1992016496A1/en active IP Right Grant
- 1992-03-04 CZ CS931829A patent/CZ282997B6/cs not_active IP Right Cessation
- 1992-03-04 US US08/117,065 patent/US5451606A/en not_active Expired - Fee Related
- 1992-03-04 AT AT92905647T patent/ATE134363T1/de not_active IP Right Cessation
- 1992-03-04 KR KR1019930702709A patent/KR100224330B1/ko not_active Expired - Fee Related
- 1992-03-04 AU AU13596/92A patent/AU661475B2/en not_active Ceased
- 1992-03-04 SK SK947-93A patent/SK280134B6/sk unknown
- 1992-03-04 HU HU9302510A patent/HU215436B/hu not_active IP Right Cessation
- 1992-03-04 EP EP92905647A patent/EP0588797B1/en not_active Expired - Lifetime
- 1992-03-04 DE DE69208464T patent/DE69208464T2/de not_active Expired - Fee Related
- 1992-03-04 JP JP4505494A patent/JP2979054B2/ja not_active Expired - Fee Related
- 1992-03-04 DK DK92905647.1T patent/DK0588797T3/da active
- 1992-03-04 CA CA002105683A patent/CA2105683C/en not_active Expired - Fee Related
- 1992-03-04 RU RU93057732A patent/RU2111959C1/ru not_active IP Right Cessation
- 1992-03-04 ES ES92905647T patent/ES2084348T3/es not_active Expired - Lifetime
- 1992-03-09 PT PT100216A patent/PT100216B/pt active IP Right Grant
- 1992-03-11 MX MX9201055A patent/MX9201055A/es not_active IP Right Cessation
-
1993
- 1993-09-08 FI FI933925A patent/FI113167B/fi not_active IP Right Cessation
- 1993-09-10 NO NO933241A patent/NO304592B1/no not_active IP Right Cessation
-
1996
- 1996-02-22 GR GR960400457T patent/GR3019069T3/el unknown
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