SK14099A3 - Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives - Google Patents

Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives Download PDF

Info

Publication number
SK14099A3
SK14099A3 SK140-99A SK14099A SK14099A3 SK 14099 A3 SK14099 A3 SK 14099A3 SK 14099 A SK14099 A SK 14099A SK 14099 A3 SK14099 A3 SK 14099A3
Authority
SK
Slovakia
Prior art keywords
alkyl
carbon atoms
methyl
pharmaceutically acceptable
formula
Prior art date
Application number
SK140-99A
Other languages
English (en)
Slovak (sk)
Inventor
Liang Chen Yuphyng
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SK14099A3 publication Critical patent/SK14099A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
SK140-99A 1996-08-06 1997-07-23 Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives SK14099A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2345396P 1996-08-06 1996-08-06
PCT/IB1997/000918 WO1998005661A1 (fr) 1996-08-06 1997-07-23 Derives 6,6- ou 6,7-bicycliques contenant pyrido ou pyrimido substitues

Publications (1)

Publication Number Publication Date
SK14099A3 true SK14099A3 (en) 2000-05-16

Family

ID=21815208

Family Applications (1)

Application Number Title Priority Date Filing Date
SK140-99A SK14099A3 (en) 1996-08-06 1997-07-23 Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives

Country Status (41)

Country Link
US (1) US6492520B1 (fr)
EP (1) EP0920429B1 (fr)
JP (1) JP3345021B2 (fr)
KR (1) KR20000029843A (fr)
CN (1) CN1093130C (fr)
AP (1) AP1096A (fr)
AR (1) AR008829A1 (fr)
AT (1) ATE232863T1 (fr)
AU (1) AU709203B2 (fr)
BG (1) BG103143A (fr)
BR (1) BR9710808A (fr)
CA (1) CA2262692C (fr)
CO (1) CO4900060A1 (fr)
CZ (1) CZ292806B6 (fr)
DE (1) DE69719193T2 (fr)
DK (1) DK0920429T3 (fr)
DZ (1) DZ2289A1 (fr)
EA (1) EA003188B1 (fr)
ES (1) ES2191183T3 (fr)
GT (1) GT199700089A (fr)
HK (1) HK1021734A1 (fr)
HR (1) HRP970432B1 (fr)
ID (1) ID17980A (fr)
IL (1) IL128188A0 (fr)
IS (1) IS4948A (fr)
MA (1) MA24296A1 (fr)
NO (1) NO313293B1 (fr)
NZ (1) NZ333727A (fr)
OA (1) OA10970A (fr)
PA (1) PA8435201A1 (fr)
PE (1) PE97098A1 (fr)
PL (1) PL331602A1 (fr)
SA (1) SA97180334A (fr)
SK (1) SK14099A3 (fr)
TN (1) TNSN97135A1 (fr)
TR (1) TR199900228T2 (fr)
TW (1) TW550265B (fr)
UY (1) UY24655A1 (fr)
WO (1) WO1998005661A1 (fr)
YU (1) YU5399A (fr)
ZA (1) ZA976954B (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
WO2000027850A2 (fr) 1998-11-12 2000-05-18 Neurocrine Biosciences, Inc. Antagonistes de recepteurs du crf et methodes associees
EP1129091B1 (fr) 1998-11-12 2002-10-02 Neurocrine Biosciences, Inc. Antagonistes de recepteurs du crf et methodes associees
US6432989B1 (en) * 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
IL139197A0 (en) * 1999-10-29 2001-11-25 Pfizer Prod Inc Use of corticotropin releasing factor antagonists and related compositions
CA2398956A1 (fr) * 2000-02-14 2001-08-16 Japan Tobacco Inc. Composition pharmaceutique pour la prophylaxie ou le traitement du stress post-operatoire
AU2001234180A1 (en) * 2000-02-25 2001-09-03 Japan Tobacco Inc. Benzamide derivative and use thereof
MY141144A (en) * 2000-03-02 2010-03-15 Smithkline Beecham Corp 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
GB0011964D0 (en) 2000-05-18 2000-07-05 Suyal N Thick glass films with controlled refractive indices and their applications
CZ20031125A3 (cs) 2000-10-23 2003-10-15 Smithkline Beecham Corporation Nové sloučeniny
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
CN1578781A (zh) 2001-09-26 2005-02-09 拜尔药品公司 用作抗糖尿病药物的1,8-萘啶衍生物
PL373339A1 (en) * 2002-04-19 2005-08-22 Smithkline Beecham Corporation Novel compounds
FR2846657B1 (fr) * 2002-11-05 2004-12-24 Servier Lab Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2338545T3 (es) 2002-12-20 2010-05-10 Pfizer Products Inc. Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
US7109337B2 (en) 2002-12-20 2006-09-19 Pfizer Inc Pyrimidine derivatives for the treatment of abnormal cell growth
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
WO2006074147A2 (fr) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Composes et utilisation therapeutique associee
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
WO2005003100A2 (fr) 2003-07-03 2005-01-13 Myriad Genetics, Inc. Composes et leur utilisation therapeutique
WO2005020910A2 (fr) * 2003-08-27 2005-03-10 Pharmacia Corporation Compositions comprenant un inhibiteur selectif de la cyclooxygenase-2 et un antagoniste du facteur de liberation de la corticotropine pour le traitement de troubles ou de lesions du systeme nerveux central d'origine ischemique
EP1732541A4 (fr) * 2004-04-07 2008-03-05 Takeda Pharmaceutical Composes cycliques
MXPA06013165A (es) 2004-05-14 2007-02-13 Pfizer Prod Inc Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
WO2005111024A1 (fr) 2004-05-14 2005-11-24 Pfizer Products Inc. Derives de pyrimidine destines au traitement de croissance cellulaire anormale
WO2005111022A1 (fr) 2004-05-14 2005-11-24 Pfizer Products Inc. Derives pyrimidiques pour le traitement de la croissance de cellules anormales
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP1868612A4 (fr) * 2005-03-25 2010-03-24 Glaxo Group Ltd Nouveaux composes
PE20100737A1 (es) * 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
PE20100741A1 (es) * 2005-03-25 2010-11-25 Glaxo Group Ltd COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38
US7479558B2 (en) * 2005-03-25 2009-01-20 Glaxo Group Limited Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives
JP5042215B2 (ja) 2005-05-26 2012-10-03 ニューロン システムズ, インコーポレイテッド 網膜疾患を処置するための組成物および方法
RU2467007C2 (ru) 2005-12-21 2012-11-20 Эбботт Лэборетриз Производные [1,8]нафтиридина, полезные в качестве ингибиторов репликации вируса hcv
WO2007081517A2 (fr) 2005-12-21 2007-07-19 Abbott Laboratories Composes anti-viraux
KR20080080395A (ko) 2005-12-21 2008-09-03 아보트 러보러터리즈 항바이러스 화합물
EP2345652A1 (fr) 2005-12-21 2011-07-20 Abbott Laboratories Composées antivirales
US8236950B2 (en) 2006-12-20 2012-08-07 Abbott Laboratories Anti-viral compounds
EP2364314B1 (fr) 2008-12-09 2014-03-12 Gilead Sciences, Inc. Modulateurs de récepteurs de type toll (tlr)
WO2010096426A2 (fr) * 2009-02-20 2010-08-26 Emory University Composés, compositions, procédés de synthèse et procédés de traitement
NO2477987T3 (fr) 2009-09-14 2018-06-09
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
ME03300B (fr) 2012-06-13 2019-07-20 Incyte Holdings Corp Composés tricycliques substitués servant d'inhibiteurs des fgfr
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
EP3143025B1 (fr) * 2014-05-15 2019-10-09 F. Hoffmann-La Roche AG Composés destinés à traiter l'amyotrophie spinale
US10882868B2 (en) 2014-05-15 2021-01-05 Hoffmann-La Roche Inc. Compounds for treating spinal muscular atrophy
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
JP2017526730A (ja) 2014-09-16 2017-09-14 ギリアード サイエンシーズ, インコーポレイテッド Toll様受容体モジュレーターの固体形態
CN107074860B (zh) 2014-09-16 2022-07-15 吉利德科学公司 制备toll样受体调节剂的方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (fr) 2015-02-20 2016-08-25 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
EA038045B1 (ru) 2015-02-20 2021-06-28 Инсайт Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
WO2017003724A1 (fr) 2015-07-01 2017-01-05 Crinetics Pharmaceuticals, Inc. Modulateurs de somatostatine et leurs utilisations
EP3337486B1 (fr) 2015-08-21 2024-04-03 Aldeyra Therapeutics, Inc. Composés deutérés et leurs utilisations
MD3413892T2 (ro) 2016-02-12 2022-06-30 Cytokinetics Inc Derivați de tetrahidroizochinolină
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11028068B2 (en) 2017-07-25 2021-06-08 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
EP3694500A4 (fr) * 2017-10-10 2021-06-30 Aldeyra Therapeutics, Inc. Traitement de troubles inflammatoires
EA202092649A1 (ru) 2018-05-04 2021-06-21 Инсайт Корпорейшн Соли ингибитора fgfr
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
JP2021533154A (ja) 2018-08-06 2021-12-02 アルデイラ セラピューティクス, インコーポレイテッド 多形化合物およびその使用
CN115869258A (zh) 2018-09-25 2023-03-31 奥尔德拉医疗公司 用于治疗干眼病的调配物
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2020198064A1 (fr) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Formulations ophtalmiques et leurs utilisations
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
IL291901A (en) 2019-10-14 2022-06-01 Incyte Corp Bicyclyl heterocycles as fgr suppressors
WO2021076728A1 (fr) 2019-10-16 2021-04-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
WO2021113479A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
AR126102A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605642A (en) 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5063245A (en) 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
DK0674641T3 (da) * 1992-12-17 1999-09-27 Pfizer Pyrrolopyrimidiner som CRF-antagonister
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
CN1056611C (zh) * 1994-06-16 2000-09-20 美国辉瑞有限公司 吡唑并吡啶和吡咯并吡啶,其用途和用于制备它们的中间体
JP2898887B2 (ja) * 1994-08-31 1999-06-02 沖電気工業株式会社 Icカードの読み取り装置
EP0729758A3 (fr) * 1995-03-02 1997-10-29 Pfizer Pyrazolopyrimidines et pyrrolopyrimidines pour traiter les troubles neuronaux et autres maladies
AU716993B2 (en) * 1995-05-12 2000-03-16 Neurogen Corporation Novel deazapurine derivatives; a new class of CRF1 specific ligands
US6403599B1 (en) * 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
DK0778277T3 (da) * 1995-12-08 2003-10-27 Pfizer Substituerede heterocycliske derivater som CRF antagonister
WO1997029109A1 (fr) 1996-02-07 1997-08-14 Janssen Pharmaceutica N.V. Pyrazolopyrimidines en tant qu'antagonistes du recepteur de crf
TW477787B (en) 1996-08-27 2002-03-01 Pfizer Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same

Also Published As

Publication number Publication date
CZ292806B6 (cs) 2003-12-17
CA2262692C (fr) 2002-06-11
AP1096A (en) 2002-08-26
AU709203B2 (en) 1999-08-26
PE97098A1 (es) 1999-01-12
DE69719193D1 (de) 2003-03-27
DK0920429T3 (da) 2003-05-12
GT199700089A (es) 1999-01-26
HRP970432B1 (en) 2002-10-31
UY24655A1 (es) 2000-09-29
YU5399A (sh) 2002-03-18
CN1227552A (zh) 1999-09-01
EP0920429A1 (fr) 1999-06-09
NO990544L (no) 1999-03-31
ZA976954B (en) 1999-02-05
DZ2289A1 (fr) 2002-12-25
AU3356397A (en) 1998-02-25
JP2000501116A (ja) 2000-02-02
IS4948A (is) 1999-01-19
KR20000029843A (ko) 2000-05-25
ES2191183T3 (es) 2003-09-01
ID17980A (id) 1998-02-12
TR199900228T2 (xx) 1999-03-22
EA199900083A1 (ru) 1999-08-26
CO4900060A1 (es) 2000-03-27
BR9710808A (pt) 1999-08-17
TW550265B (en) 2003-09-01
NO313293B1 (no) 2002-09-09
TNSN97135A1 (fr) 2005-03-15
JP3345021B2 (ja) 2002-11-18
US6492520B1 (en) 2002-12-10
WO1998005661A1 (fr) 1998-02-12
HK1021734A1 (en) 2000-06-30
EA003188B1 (ru) 2003-02-27
NO990544D0 (no) 1999-02-05
MA24296A1 (fr) 1998-04-01
ATE232863T1 (de) 2003-03-15
OA10970A (en) 2001-11-05
NZ333727A (en) 2000-09-29
CN1093130C (zh) 2002-10-23
EP0920429B1 (fr) 2003-02-19
BG103143A (en) 1999-09-30
DE69719193T2 (de) 2003-09-25
IL128188A0 (en) 1999-11-30
AR008829A1 (es) 2000-02-23
SA97180334A (ar) 2005-12-03
HRP970432A2 (en) 1998-08-31
AP9701052A0 (en) 1997-10-31
CA2262692A1 (fr) 1998-02-12
CZ41199A3 (cs) 2000-01-12
PA8435201A1 (es) 1999-12-27
PL331602A1 (en) 1999-08-02

Similar Documents

Publication Publication Date Title
SK14099A3 (en) Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
AU726771B2 (en) Substituted 6,6-hetero-bicyclic derivatives
JP3621706B2 (ja) 置換された6,5―ヘテロ―二環式誘導体
JP3457490B2 (ja) 置換されたヘテロ環誘導体
EP0765327B1 (fr) Pyrazolo et pyrrolopyridines
MXPA96006203A (en) Heterociclic derivatives sustitui
US20030114671A1 (en) Substituted6,6-hetero-bicyclicderivatives
US6992188B1 (en) Substituted heterocyclic derivatives
MXPA99001309A (en) Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives