SK10772002A3 - Pyridopyrimidinónové deriváty na liečbu neurodegeneratívnych ochorení - Google Patents
Pyridopyrimidinónové deriváty na liečbu neurodegeneratívnych ochorení Download PDFInfo
- Publication number
- SK10772002A3 SK10772002A3 SK1077-2002A SK10772002A SK10772002A3 SK 10772002 A3 SK10772002 A3 SK 10772002A3 SK 10772002 A SK10772002 A SK 10772002A SK 10772002 A3 SK10772002 A3 SK 10772002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- pyrimidin
- pyrido
- phenylamino
- ethyl
- propyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17840000P | 2000-01-27 | 2000-01-27 | |
PCT/US2000/032572 WO2001055148A1 (en) | 2000-01-27 | 2000-11-30 | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease |
Publications (1)
Publication Number | Publication Date |
---|---|
SK10772002A3 true SK10772002A3 (sk) | 2004-01-08 |
Family
ID=22652409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1077-2002A SK10772002A3 (sk) | 2000-01-27 | 2000-11-30 | Pyridopyrimidinónové deriváty na liečbu neurodegeneratívnych ochorení |
Country Status (22)
Country | Link |
---|---|
US (1) | US20040224958A1 (es) |
EP (1) | EP1255755A1 (es) |
JP (1) | JP2003523358A (es) |
KR (1) | KR20020070520A (es) |
CN (1) | CN1433417A (es) |
AR (1) | AR029437A1 (es) |
AU (1) | AU1808601A (es) |
BR (1) | BR0017075A (es) |
CA (1) | CA2394525A1 (es) |
CO (1) | CO5280216A1 (es) |
CZ (1) | CZ20022521A3 (es) |
GT (1) | GT200100005A (es) |
HN (1) | HN2001000012A (es) |
HU (1) | HUP0203803A3 (es) |
IL (1) | IL150742A0 (es) |
PA (1) | PA8510801A1 (es) |
PE (1) | PE20011228A1 (es) |
PL (1) | PL357634A1 (es) |
SK (1) | SK10772002A3 (es) |
SV (1) | SV2002000287A (es) |
TN (1) | TNSN01018A1 (es) |
WO (1) | WO2001055148A1 (es) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
EP2404603A1 (en) | 2000-10-23 | 2012-01-11 | Glaxosmithkline LLC | Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds for the treatment of CSBP/p38 kinase mediated diseases |
CN1503797A (zh) * | 2001-02-26 | 2004-06-09 | 田边制药株式会社 | 吡啶并嘧啶或二氮杂萘衍生物 |
ES2278016T3 (es) | 2001-04-09 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r). |
US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
JP2005500294A (ja) | 2001-06-19 | 2005-01-06 | ブリストル−マイヤーズ スクイブ カンパニー | ホスホジエステラーゼ7に対するピリミジン阻害剤 |
PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
ATE407678T1 (de) | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
WO2003032994A2 (de) | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren |
PL220952B1 (pl) | 2002-01-22 | 2016-01-29 | Warner Lambert Co | 2-(Pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-ony |
ATE370952T1 (de) * | 2002-04-19 | 2007-09-15 | Smithkline Beecham Corp | Neue verbindungen |
WO2004043367A2 (en) | 2002-11-06 | 2004-05-27 | Bristol-Myers Squibb Company | Fused heterocyclic compounds and use thereof |
CN1717396A (zh) * | 2002-11-28 | 2006-01-04 | 舍林股份公司 | Chk-、Pdk-和Akt-抑制嘧啶,其制备及作为药物的用途 |
US7157455B2 (en) * | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
AU2004235907B2 (en) | 2003-05-05 | 2007-08-30 | F. Hoffmann La-Roche Ag | Fused pyrimidine derivatives with CRF activity |
DE602004005238T2 (de) | 2003-11-13 | 2007-11-08 | F. Hoffmann-La Roche Ag | Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one |
JP4989233B2 (ja) * | 2004-02-14 | 2012-08-01 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
WO2005082903A1 (en) * | 2004-02-18 | 2005-09-09 | Warner-Lambert Company Llc | 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
JP2008510770A (ja) * | 2004-08-26 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Plk阻害剤としての新規プテリジノン |
JP5111113B2 (ja) * | 2004-12-13 | 2012-12-26 | サネシス ファーマシューティカルズ, インコーポレイテッド | Rafキナーゼ阻害剤として有用なピリドピリミジノン、ジヒドロピリミドピリミジノンおよびプテリジノン |
US7479558B2 (en) * | 2005-03-25 | 2009-01-20 | Glaxo Group Limited | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives |
US20090137550A1 (en) * | 2005-03-25 | 2009-05-28 | Glaxo Group Limited | Novel Compounds |
PE20100737A1 (es) | 2005-03-25 | 2010-11-27 | Glaxo Group Ltd | Nuevos compuestos |
AR053450A1 (es) * | 2005-03-25 | 2007-05-09 | Glaxo Group Ltd | Derivados de 3,4-dihidro-pirimido(4,5-d)pirimidin-2-(1h)-ona 1,5,7 trisustituidos como inhibidores de la quinasa p38 |
EP2322523B1 (en) | 2005-10-07 | 2019-01-02 | Exelixis, Inc. | Process for the preparation of Pyridopyrimidinone Inhibitors of PI3Kalpha |
EA201200669A1 (ru) | 2005-10-07 | 2012-11-30 | Экселиксис, Инк. | ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα |
MEP8009A (en) | 2006-09-15 | 2011-12-20 | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors | |
CA2719868A1 (en) * | 2008-04-29 | 2009-11-05 | F. Hoffmann-La Roche Ag | Pyrimidinyl pyridone inhibitors of jnk. |
US8101622B2 (en) | 2008-09-30 | 2012-01-24 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of PI3Kα and mTOR |
CA2734037A1 (en) * | 2008-10-22 | 2010-04-29 | F. Hoffmann-La Roche Ag | Pyrimidinyl pyridone inhibitors of jnk |
US20130059824A1 (en) * | 2009-11-23 | 2013-03-07 | Afraxis, Inc. | Methods for treating mild cognitive impairment |
CA2784749C (en) | 2009-12-18 | 2017-12-12 | E. Premkumar Reddy | Substituted pyrido[2,3-d]pyrimidin-7(8h)-ones and therapeutic uses thereof |
TW201139436A (en) | 2010-02-09 | 2011-11-16 | Exelixis Inc | Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors |
EP2580214A4 (en) * | 2010-06-09 | 2013-12-04 | Afraxis Holdings Inc | 8- (SULFONYLARYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS |
EP2580213A4 (en) * | 2010-06-09 | 2013-12-25 | Afraxis Holdings Inc | 8- (HETEROARYLMETHYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS |
WO2011156780A2 (en) * | 2010-06-10 | 2011-12-15 | Afraxis, Inc. | 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
WO2011156786A2 (en) * | 2010-06-10 | 2011-12-15 | Afraxis, Inc. | 6-(ethynyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
WO2011156775A2 (en) * | 2010-06-10 | 2011-12-15 | Afraxis, Inc. | 8-(2'-heterocycyl)pyrido[2.3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
PT2600719E (pt) * | 2010-08-05 | 2014-12-22 | Univ Temple | 8 ¿ alquilo -2 - substituído 7 ¿ oxo ¿ 7,8 ¿ diidropirido [2,3 ¿ d] pirimidina ¿ 6 ¿ carbonitrilos e seus usos |
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BR112014023460B1 (pt) * | 2012-03-22 | 2020-09-01 | Oscotec, Inc | Composto, formulação farmacêutica, uso de um composto |
CN103930425B (zh) * | 2012-05-14 | 2016-04-27 | 华东理工大学 | 蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用 |
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US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
WO2014151682A1 (en) | 2013-03-14 | 2014-09-25 | Icahn School Of Medicine At Mount Sinai | Pyrimidine compounds as kinase inhibitors |
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MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
CN108699055B (zh) * | 2015-12-13 | 2020-10-23 | 杭州英创医药科技有限公司 | 用作抗癌药物的杂环化合物 |
US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
ES2876411T3 (es) * | 2016-08-15 | 2021-11-12 | Pfizer | Inhibidores de piridopirimdinona CDK2/4/6 |
JP6545747B2 (ja) * | 2017-05-09 | 2019-07-17 | 山田化学工業株式会社 | 色素化合物 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
EA036060B1 (ru) * | 2017-07-17 | 2020-09-21 | Пфайзер Инк. | Пиридопиримидиноновые ингибиторы cdk2/4/6 |
WO2019213544A2 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
ES2929406T3 (es) * | 2018-05-21 | 2022-11-29 | Nerviano Medical Sciences Srl | Compuestos de piridonas heterocondensadas y su uso como inhibidores de IDH |
US20210261547A1 (en) * | 2018-06-27 | 2021-08-26 | Tufts Medical Center, Inc. | Pyridopyrimidine compounds and methods of their use |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
CA3137869A1 (en) * | 2019-05-16 | 2020-11-19 | Gregory Cuny | Protein kinase inhibitors and uses thereof for the treatment of diseases and conditions |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
KR20220099970A (ko) | 2019-10-11 | 2022-07-14 | 인사이트 코포레이션 | Cdk2 억제제로서의 이환식 아민 |
JOP20220083A1 (ar) | 2019-10-14 | 2023-01-30 | Incyte Corp | حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
EP4065578A1 (en) | 2019-11-26 | 2022-10-05 | Theravance Biopharma R&D IP, LLC | Fused pyrimidine pyridinone compounds as jak inhibitors |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
EP4118082A4 (en) * | 2020-03-13 | 2024-05-01 | Prosenestar LLC | PYRIDO[2,3-D PYRIMIDIN-7(8H)-ONE AS CDK INHIBITORS |
CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為fgfr抑制劑之三環雜環 |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
US6498163B1 (en) * | 1997-02-05 | 2002-12-24 | Warner-Lambert Company | Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
WO1998033798A2 (en) * | 1997-02-05 | 1998-08-06 | Warner Lambert Company | Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation |
-
2000
- 2000-11-30 US US10/181,866 patent/US20040224958A1/en not_active Abandoned
- 2000-11-30 CA CA002394525A patent/CA2394525A1/en not_active Abandoned
- 2000-11-30 SK SK1077-2002A patent/SK10772002A3/sk not_active Application Discontinuation
- 2000-11-30 WO PCT/US2000/032572 patent/WO2001055148A1/en not_active Application Discontinuation
- 2000-11-30 PL PL00357634A patent/PL357634A1/xx not_active Application Discontinuation
- 2000-11-30 CZ CZ20022521A patent/CZ20022521A3/cs unknown
- 2000-11-30 AU AU18086/01A patent/AU1808601A/en not_active Abandoned
- 2000-11-30 EP EP00980883A patent/EP1255755A1/en not_active Withdrawn
- 2000-11-30 HU HU0203803A patent/HUP0203803A3/hu unknown
- 2000-11-30 BR BR0017075-5A patent/BR0017075A/pt not_active IP Right Cessation
- 2000-11-30 KR KR1020027009631A patent/KR20020070520A/ko not_active Application Discontinuation
- 2000-11-30 CN CN00818672A patent/CN1433417A/zh active Pending
- 2000-11-30 JP JP2001561007A patent/JP2003523358A/ja active Pending
- 2000-11-30 IL IL15074200A patent/IL150742A0/xx unknown
-
2001
- 2001-01-08 GT GT200100005A patent/GT200100005A/es unknown
- 2001-01-22 SV SV2001000287A patent/SV2002000287A/es not_active Application Discontinuation
- 2001-01-24 HN HN2001000012A patent/HN2001000012A/es unknown
- 2001-01-24 PA PA20018510801A patent/PA8510801A1/es unknown
- 2001-01-25 AR ARP010100308A patent/AR029437A1/es unknown
- 2001-01-25 CO CO01005602A patent/CO5280216A1/es not_active Application Discontinuation
- 2001-01-25 PE PE2001000082A patent/PE20011228A1/es not_active Application Discontinuation
- 2001-01-26 TN TNTNSN01018A patent/TNSN01018A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU1808601A (en) | 2001-08-07 |
CZ20022521A3 (cs) | 2003-02-12 |
EP1255755A1 (en) | 2002-11-13 |
CN1433417A (zh) | 2003-07-30 |
PA8510801A1 (es) | 2002-12-11 |
HN2001000012A (es) | 2001-07-09 |
US20040224958A1 (en) | 2004-11-11 |
CA2394525A1 (en) | 2001-08-02 |
AR029437A1 (es) | 2003-06-25 |
KR20020070520A (ko) | 2002-09-09 |
WO2001055148A1 (en) | 2001-08-02 |
BR0017075A (pt) | 2002-11-05 |
JP2003523358A (ja) | 2003-08-05 |
PE20011228A1 (es) | 2002-01-18 |
PL357634A1 (en) | 2004-07-26 |
HUP0203803A3 (en) | 2004-09-28 |
SV2002000287A (es) | 2002-01-08 |
HUP0203803A2 (hu) | 2003-02-28 |
GT200100005A (es) | 2002-02-05 |
TNSN01018A1 (en) | 2005-11-10 |
IL150742A0 (en) | 2003-02-12 |
CO5280216A1 (es) | 2003-05-30 |
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