SI9012429B - Novi derivati kromana in tiokromana - Google Patents

Novi derivati kromana in tiokromana Download PDF

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Publication number
SI9012429B
SI9012429B SI9012429A SI9012429A SI9012429B SI 9012429 B SI9012429 B SI 9012429B SI 9012429 A SI9012429 A SI 9012429A SI 9012429 A SI9012429 A SI 9012429A SI 9012429 B SI9012429 B SI 9012429B
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SI
Slovenia
Prior art keywords
alkyl
formula
alkenyl
compound
hydrogen
Prior art date
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SI9012429A
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English (en)
Slovenian (sl)
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SI9012429A (en
Inventor
Lars-Gunnar Larsson
Rolf Noreen
Lucy Anna Renyi
Svante Bertil Ross
Daniel Dungan Sohn
Bjoern Eric Svensson
Seth Olov Thorberg
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Aktiebolaget Astra
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Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of SI9012429A publication Critical patent/SI9012429A/sl
Publication of SI9012429B publication Critical patent/SI9012429B/sl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Threshing Machine Elements (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Harvester Elements (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
SI9012429A 1989-12-22 1990-12-21 Novi derivati kromana in tiokromana SI9012429B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives
YU242990A YU47936B (sh) 1989-12-22 1990-12-21 Derivati hromana i tiohromana i postupak za njihovo dobijanje

Publications (2)

Publication Number Publication Date
SI9012429A SI9012429A (en) 1997-12-31
SI9012429B true SI9012429B (sl) 1998-10-31

Family

ID=20377869

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9012429A SI9012429B (sl) 1989-12-22 1990-12-21 Novi derivati kromana in tiokromana

Country Status (42)

Country Link
EP (1) EP0460169B1 (oth)
JP (1) JP2879972B2 (oth)
KR (1) KR0178991B1 (oth)
CN (1) CN1037438C (oth)
AT (1) ATE138918T1 (oth)
AU (1) AU641204B2 (oth)
CA (1) CA2047237C (oth)
CY (1) CY1991A (oth)
CZ (1) CZ283630B6 (oth)
DE (1) DE69027311T2 (oth)
DK (1) DK0460169T3 (oth)
DZ (1) DZ1469A1 (oth)
EG (1) EG19749A (oth)
ES (1) ES2087993T3 (oth)
FI (1) FI102177B1 (oth)
GR (1) GR3020497T3 (oth)
HK (1) HK55897A (oth)
HR (1) HRP920851B1 (oth)
HU (1) HU211860A9 (oth)
ID (1) ID945B (oth)
IE (1) IE80753B1 (oth)
IL (1) IL96712A (oth)
IS (1) IS1665B (oth)
LT (1) LT3967B (oth)
LV (2) LV10449B (oth)
MX (1) MX23889A (oth)
NO (1) NO180336C (oth)
NZ (1) NZ236407A (oth)
PH (1) PH30797A (oth)
PL (3) PL164592B1 (oth)
PT (1) PT96304B (oth)
RU (1) RU2092483C1 (oth)
SA (1) SA90110186B1 (oth)
SE (1) SE8904361D0 (oth)
SG (1) SG48043A1 (oth)
SI (1) SI9012429B (oth)
SK (1) SK280261B6 (oth)
TW (1) TW221056B (oth)
UA (1) UA34416C2 (oth)
WO (1) WO1991009853A1 (oth)
YU (2) YU47936B (oth)
ZA (1) ZA909708B (oth)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
CA2048846A1 (en) * 1990-08-15 1992-02-16 Craig Steven Hoechstetter Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and aminothiochromanes
ES2153071T3 (es) * 1991-02-08 2001-02-16 Lilly Co Eli 2-amino-1,2,3,4-tetrahidronaftalenos y 3-aminocromanos sustituidos en anillo.
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703377D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
TW555757B (en) * 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
BR0206513A (pt) 2001-01-16 2004-01-06 Astrazeneca Ab Composição, métodos de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de qualquer um dos compostos, composição farmacêutica, e, processo para preparar compostos
IL156595A0 (en) 2001-01-16 2004-01-04 Astrazeneca Ab Therapeutic heterocyclic compounds
MXPA03006261A (es) * 2001-01-16 2003-09-22 Astrazeneca Ab Compuestos terapeuticos de cromano.
RU2193559C1 (ru) * 2001-05-16 2002-11-27 Пермская государственная фармацевтическая академия 2,4-ксилидид и м-фенетидид 2-ацетилиминокумарин-3-карбоновой кислоты, обладающие антикоагулянтной активностью
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
WO2008080120A2 (en) * 2006-12-22 2008-07-03 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
CN116655242A (zh) * 2023-05-10 2023-08-29 东北大学 一系列有机-无机杂化金属卤化物玻璃材料及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR862239B (en) * 1985-09-03 1986-12-31 Ciba Geigy Ag 3-amino-dihydro-(1)-benzopyrans and benzothiopyrans
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
MX23889A (es) 1993-10-01
TW221056B (oth) 1994-02-11
JPH04503682A (ja) 1992-07-02
CZ657890A3 (cs) 1998-02-18
ES2087993T3 (es) 1996-08-01
NZ236407A (en) 1993-08-26
RU2092483C1 (ru) 1997-10-10
DZ1469A1 (fr) 2004-09-13
HRP920851B1 (en) 2000-02-29
PT96304B (pt) 1998-09-30
UA34416C2 (uk) 2001-03-15
FI102177B (fi) 1998-10-30
ZA909708B (en) 1991-08-28
EP0460169B1 (en) 1996-06-05
CA2047237C (en) 2003-02-11
PH30797A (en) 1997-10-17
DE69027311T2 (de) 1996-10-24
HRP920851A2 (en) 1995-10-31
IL96712A (en) 1995-08-31
LT3967B (en) 1996-05-27
PL164609B1 (en) 1994-08-31
PL293065A1 (en) 1992-08-10
ATE138918T1 (de) 1996-06-15
YU242990A (sh) 1993-10-20
NO913273D0 (no) 1991-08-21
LV10449A (lv) 1995-02-20
EP0460169A1 (en) 1991-12-11
SK657890A3 (en) 1999-10-08
SE8904361D0 (sv) 1989-12-22
AU6977091A (en) 1991-07-24
HK55897A (en) 1997-05-09
IS1665B (is) 1997-07-04
ID945B (id) 1996-09-20
YU47923B (sh) 1996-05-20
NO913273L (no) 1991-10-08
LV11894B (en) 1998-05-20
YU47936B (sh) 1996-05-20
IL96712A0 (en) 1991-09-16
GR3020497T3 (en) 1996-10-31
IE80753B1 (en) 1999-01-13
SI9012429A (en) 1997-12-31
PL164608B1 (pl) 1994-08-31
EG19749A (en) 1996-01-31
FI913943A0 (fi) 1991-08-21
FI102177B1 (fi) 1998-10-30
KR0178991B1 (ko) 1999-03-20
SK280261B6 (sk) 1999-10-08
PL293066A1 (en) 1992-08-10
IE904535A1 (en) 1991-07-03
NO180336B (no) 1996-12-23
HU211860A9 (en) 1995-12-28
CN1052669A (zh) 1991-07-03
PL164592B1 (pl) 1994-08-31
KR920701193A (ko) 1992-08-11
CY1991A (en) 1997-09-05
AU641204B2 (en) 1993-09-16
NO180336C (no) 1997-04-02
LV11894A (lv) 1997-12-20
IS3662A7 (is) 1991-06-23
LTIP1730A (en) 1995-08-25
YU72191A (sh) 1995-01-31
JP2879972B2 (ja) 1999-04-05
LV10449B (en) 1995-10-20
WO1991009853A1 (en) 1991-07-11
DE69027311D1 (en) 1996-07-11
DK0460169T3 (da) 1996-09-23
SG48043A1 (en) 1998-04-17
SA90110186B1 (ar) 2001-11-11
CA2047237A1 (en) 1991-06-23
CN1037438C (zh) 1998-02-18
PT96304A (pt) 1991-09-30
CZ283630B6 (cs) 1998-05-13

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