SI2155663T1 - SUBSTITUTED 2- (2- (PHENYL) ETHYLAMINO) ALKANAMIDIC DERIVATIVES AND THEIR USE AS SODIUM AND / OR CALCIUM CHANNEL MODULATORS - Google Patents

SUBSTITUTED 2- (2- (PHENYL) ETHYLAMINO) ALKANAMIDIC DERIVATIVES AND THEIR USE AS SODIUM AND / OR CALCIUM CHANNEL MODULATORS Download PDF

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Publication number
SI2155663T1
SI2155663T1 SI200831914T SI200831914T SI2155663T1 SI 2155663 T1 SI2155663 T1 SI 2155663T1 SI 200831914 T SI200831914 T SI 200831914T SI 200831914 T SI200831914 T SI 200831914T SI 2155663 T1 SI2155663 T1 SI 2155663T1
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Slovenia
Prior art keywords
ethylamino
alkyl
dimethylacetamide
disorder
butoxyphenyl
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SI200831914T
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English (en)
Slovenian (sl)
Inventor
Piero Melloni
Alessandra Restivo
Emanuela Izzo
Simona Francisconi
Elena Colombo
Cibele Sabido-David
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Newron Pharmaceuticals S.P.A.
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Publication of SI2155663T1 publication Critical patent/SI2155663T1/en

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SI200831914T 2007-06-15 2008-05-14 SUBSTITUTED 2- (2- (PHENYL) ETHYLAMINO) ALKANAMIDIC DERIVATIVES AND THEIR USE AS SODIUM AND / OR CALCIUM CHANNEL MODULATORS SI2155663T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07011766 2007-06-15
PCT/EP2008/003848 WO2008151702A1 (en) 2007-06-15 2008-05-14 Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
EP08749449.8A EP2155663B1 (en) 2007-06-15 2008-05-14 Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives and their use as sodium and/or calcium channel modulators

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SI2155663T1 true SI2155663T1 (en) 2018-03-30

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US (8) US8519000B2 (enExample)
EP (1) EP2155663B1 (enExample)
JP (1) JP5440496B2 (enExample)
KR (1) KR101545124B1 (enExample)
CN (1) CN101687773B (enExample)
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AU (1) AU2008261325B2 (enExample)
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CY (1) CY1119787T1 (enExample)
DK (1) DK2155663T3 (enExample)
EA (1) EA018195B1 (enExample)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070276046A1 (en) * 2003-08-25 2007-11-29 Patricia Salvati Alpha-Aminoamide Derivatives Useful as Anti-Inflammatory Agents
JP5213265B2 (ja) * 2009-10-08 2013-06-19 花王株式会社 Ｌｏｘ−１発現調節剤の評価又は選択方法
CN103781759B (zh) * 2011-06-27 2016-01-13 纽朗制药有限公司 氟化的芳基烷基氨基甲酰胺衍生物
CN103804341B (zh) * 2012-11-13 2018-04-10 中国人民解放军军事医学科学院毒物药物研究所 酰胺衍生物及其医药用途
CN104761531B (zh) * 2014-01-03 2017-12-01 中国人民解放军军事医学科学院毒物药物研究所 镇痛活性化合物及其医药用途
RU2746188C2 (ru) * 2015-11-12 2021-04-08 Афаски, Инк. Ингибиторы ионного канала, фармацевтические составы и применение
CN106316824B (zh) * 2016-08-18 2018-10-19 广州康瑞泰药业有限公司 一种合成2-氟环丙烷甲酸的新方法
WO2019205147A1 (zh) * 2018-04-28 2019-10-31 上海璃道医药科技有限公司 包含苯并含氧脂肪环结构的氨基乙酰胺类化合物及其用途
US20210162380A1 (en) * 2018-08-30 2021-06-03 Sabic Global Technologies B.V. Aromatization catalyst with improved isomerization, process of making and using thereof
EP3725769A1 (en) * 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives
EP3725768A1 (en) 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives
HRP20260447T1 (hr) 2023-04-28 2026-05-08 Newron Pharmaceuticals S.P.A. Kristalni oblici evenamida

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB586645A (en) * 1944-07-19 1947-03-26 Burroughs Wellcome Co Improvements relating to the synthesis of amino acid derivatives and salts thereof
GB1254332A (en) * 1969-02-27 1971-11-17 Science Union & Cie Amino acids and their derivatives and processes for preparing them
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5051403A (en) 1989-11-22 1991-09-24 Neurex Corporation Method of treating ischemia-related neuronal damage
EP0625162B1 (en) 1991-12-30 1998-05-13 Neurex Corporation Methods of producing analgesia and enhancing opiate analgesia
GB9500691D0 (en) 1995-01-13 1995-03-08 Smithkline Beecham Plc Compounds
GB9515412D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
GB9518572D0 (en) 1995-09-12 1995-11-15 Smithkline Beecham Plc Compounds
US5845454A (en) * 1996-04-23 1998-12-08 Malizia; John T. Drop ceiling hanging system
WO1998035957A1 (en) 1997-02-14 1998-08-20 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists
US6117841A (en) 1997-05-30 2000-09-12 Warner-Lambert Company Substituted peptidylamine calcium channel blockers
DE19740110A1 (de) 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
WO1999055688A1 (en) 1998-04-27 1999-11-04 Warner-Lambert Company Substituted diarylalkyl amides as calcium channel antagonists
US6011035A (en) 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
AU4329499A (en) 1998-07-30 2000-02-21 Warner-Lambert Company Reduced dipeptide analogues as calcium channel antagonists
US6472530B1 (en) 1999-09-22 2002-10-29 Ortho-Mcneil Pharmaceutical, Inc. Benzo-fused dithiepino[6,5-b]pyridines, and related compositions and methods
EP1265903B1 (en) 2000-03-23 2004-05-12 Ortho-Mcneil Pharmaceutical, Inc. Thiepino[3,2-b]dihydropyridines and related compositions and methods
JP2003529589A (ja) 2000-03-31 2003-10-07 ユーロ−セルティック エス． ア． アミノピリジンならびにこれらの鎮痙薬およびナトリウムチャンネル遮断薬としての使用
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
SE0102858D0 (sv) 2001-08-27 2001-08-27 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
CN1274306C (zh) 2001-09-03 2006-09-13 纽朗制药有限公司 包含加巴喷丁或其类似物和α－氨基酰胺的药物组合物及其止痛应用
JP2005514412A (ja) 2001-12-27 2005-05-19 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 中枢神経系疾患を処置するために有用なアロイルピロールヘテロアリールおよびメタノール類
EP1438956A1 (en) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
WO2004087125A1 (en) * 2003-04-02 2004-10-14 Ionix Pharmaceuticals Limited Amino acid derivatives as inhibitors of mammalian sodium channels
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
US20070276046A1 (en) * 2003-08-25 2007-11-29 Patricia Salvati Alpha-Aminoamide Derivatives Useful as Anti-Inflammatory Agents
EP1557166A1 (en) 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
RS51411B (sr) 2004-09-10 2011-02-28 Newron Pharmaceuticals S.P.A. Upotreba (r)-(halobenziloksi) benzilamino-propanamida kao selektivnih modulatora natrijumovih i/ili kalcijumovih kanala
IN266803B (enExample) * 2005-12-22 2015-06-03 Newron Pharm Spa
EP1870097A1 (en) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders

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