SI21172A - Konjugati poliglutaminska kislina-kamptotecin in postopki za pripravo - Google Patents
Konjugati poliglutaminska kislina-kamptotecin in postopki za pripravo Download PDFInfo
- Publication number
- SI21172A SI21172A SI200120021A SI200120021A SI21172A SI 21172 A SI21172 A SI 21172A SI 200120021 A SI200120021 A SI 200120021A SI 200120021 A SI200120021 A SI 200120021A SI 21172 A SI21172 A SI 21172A
- Authority
- SI
- Slovenia
- Prior art keywords
- camptothecin
- polyglutamic acid
- cpt
- conjugate
- conjugates
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 229940127093 camptothecin Drugs 0.000 title claims description 256
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- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 194
- 239000000203 mixture Substances 0.000 claims description 116
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 110
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- HAWSQZCWOQZXHI-FQEVSTJZSA-N 10-Hydroxycamptothecin Chemical compound C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-FQEVSTJZSA-N 0.000 claims description 24
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- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims description 6
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- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19042900P | 2000-03-17 | 2000-03-17 | |
| PCT/US2001/008553 WO2001070275A2 (en) | 2000-03-17 | 2001-03-19 | Polyglutamic acid-camptothecin conjugates and methods of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI21172A true SI21172A (sl) | 2003-10-31 |
Family
ID=22701317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200120021A SI21172A (sl) | 2000-03-17 | 2001-03-19 | Konjugati poliglutaminska kislina-kamptotecin in postopki za pripravo |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020016285A1 (no) |
| EP (1) | EP1267939A2 (no) |
| JP (1) | JP2003527443A (no) |
| KR (1) | KR20020082888A (no) |
| CN (1) | CN1429121A (no) |
| AU (1) | AU2001247513A1 (no) |
| BR (1) | BR0109272A (no) |
| CA (1) | CA2402643A1 (no) |
| CZ (1) | CZ20023330A3 (no) |
| HU (1) | HUP0204562A2 (no) |
| IL (1) | IL151685A0 (no) |
| MX (1) | MXPA02009082A (no) |
| NO (1) | NO20024421L (no) |
| PL (1) | PL358335A1 (no) |
| RU (1) | RU2002128610A (no) |
| SI (1) | SI21172A (no) |
| SK (1) | SK14822002A3 (no) |
| TR (1) | TR200202194T2 (no) |
| WO (1) | WO2001070275A2 (no) |
| ZA (1) | ZA200207423B (no) |
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| US20020077290A1 (en) * | 2000-03-17 | 2002-06-20 | Rama Bhatt | Polyglutamic acid-camptothecin conjugates and methods of preparation |
| US6629995B1 (en) * | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
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| CA2752140A1 (en) * | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methods and compositions using 3-(4-amino-1-oxo-1,3-dihydroisoindol-1-yl)-piperidine-2,6-dione for treatment and management of renal cancer |
| USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
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| JP2011162569A (ja) | 2008-05-23 | 2011-08-25 | Nano Career Kk | カンプトテシン高分子誘導体及びその用途 |
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| US20100093935A1 (en) * | 2008-10-15 | 2010-04-15 | Nitto Denko Corporation | Method of preparing polyglutamate conjugates |
| JP2012506380A (ja) * | 2008-10-21 | 2012-03-15 | エンゾン ファーマシューティカルズ，インコーポレーテッド | ７−エチル−１０−ヒドロキシカンプトテシンのマルチアーム型ポリマーコンジュゲートによる神経芽腫の治療 |
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| CN106831853B (zh) * | 2017-02-15 | 2019-02-22 | 浙江海正药业股份有限公司 | 7-乙基-10-o-叔丁基二苯基硅基喜树碱-20-o-甘氨酸盐酸盐的制备工艺 |
| CN108727581A (zh) * | 2017-04-18 | 2018-11-02 | 华东师范大学 | 以苯硼酸酯为连接单元的两亲性喜树碱高分子前药及其制备方法和应用 |
| JP2021095424A (ja) * | 2018-03-28 | 2021-06-24 | 持田製薬株式会社 | 抗癌剤結合アルギン酸誘導体 |
| JP2023506703A (ja) | 2019-12-04 | 2023-02-20 | ダンタリ インコーポレイテッド | 治療用ナノ粒子を合成するための方法及び組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
| PL189698B1 (pl) * | 1996-03-12 | 2005-09-30 | Pg Txl Co | Kompozycja farmaceutyczna zawierająca lek przeciwnowotworowy i jej zastosowania |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
-
2001
- 2001-03-19 TR TR2002/02194T patent/TR200202194T2/xx unknown
- 2001-03-19 WO PCT/US2001/008553 patent/WO2001070275A2/en not_active Application Discontinuation
- 2001-03-19 CZ CZ20023330A patent/CZ20023330A3/cs unknown
- 2001-03-19 KR KR1020027012206A patent/KR20020082888A/ko not_active Application Discontinuation
- 2001-03-19 MX MXPA02009082A patent/MXPA02009082A/es unknown
- 2001-03-19 SK SK1482-2002A patent/SK14822002A3/sk unknown
- 2001-03-19 JP JP2001568471A patent/JP2003527443A/ja not_active Withdrawn
- 2001-03-19 US US09/810,345 patent/US20020016285A1/en not_active Abandoned
- 2001-03-19 HU HU0204562A patent/HUP0204562A2/hu unknown
- 2001-03-19 PL PL01358335A patent/PL358335A1/xx not_active Application Discontinuation
- 2001-03-19 SI SI200120021A patent/SI21172A/sl not_active IP Right Cessation
- 2001-03-19 CN CN01809441A patent/CN1429121A/zh active Pending
- 2001-03-19 RU RU2002128610/15A patent/RU2002128610A/ru unknown
- 2001-03-19 EP EP01920466A patent/EP1267939A2/en not_active Withdrawn
- 2001-03-19 AU AU2001247513A patent/AU2001247513A1/en not_active Abandoned
- 2001-03-19 CA CA002402643A patent/CA2402643A1/en not_active Abandoned
- 2001-03-19 IL IL15168501A patent/IL151685A0/xx unknown
- 2001-03-19 BR BR0109272-3A patent/BR0109272A/pt active Pending
-
2002
- 2002-09-16 ZA ZA200207423A patent/ZA200207423B/en unknown
- 2002-09-16 NO NO20024421A patent/NO20024421L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002128610A (ru) | 2004-03-27 |
| WO2001070275A3 (en) | 2002-01-03 |
| BR0109272A (pt) | 2004-06-29 |
| SK14822002A3 (sk) | 2003-05-02 |
| IL151685A0 (en) | 2003-04-10 |
| TR200202194T2 (tr) | 2003-01-21 |
| NO20024421D0 (no) | 2002-09-16 |
| WO2001070275A2 (en) | 2001-09-27 |
| HUP0204562A2 (hu) | 2003-04-28 |
| CN1429121A (zh) | 2003-07-09 |
| NO20024421L (no) | 2002-11-15 |
| US20020016285A1 (en) | 2002-02-07 |
| AU2001247513A1 (en) | 2001-10-03 |
| MXPA02009082A (es) | 2003-12-11 |
| PL358335A1 (en) | 2004-08-09 |
| KR20020082888A (ko) | 2002-10-31 |
| ZA200207423B (en) | 2003-12-17 |
| CZ20023330A3 (cs) | 2003-02-12 |
| CA2402643A1 (en) | 2001-09-27 |
| EP1267939A2 (en) | 2003-01-02 |
| JP2003527443A (ja) | 2003-09-16 |
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| IF | Valid on the event date | ||
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Effective date: 20051222 |