NO20024421D0 - Polyglutaminsyre-camptotecin-konjugater og fremgangsmåte for fremstilling av disse - Google Patents

Polyglutaminsyre-camptotecin-konjugater og fremgangsmåte for fremstilling av disse

Info

Publication number
NO20024421D0
NO20024421D0 NO20024421A NO20024421A NO20024421D0 NO 20024421 D0 NO20024421 D0 NO 20024421D0 NO 20024421 A NO20024421 A NO 20024421A NO 20024421 A NO20024421 A NO 20024421A NO 20024421 D0 NO20024421 D0 NO 20024421D0
Authority
NO
Norway
Prior art keywords
preparation
polyglutamic acid
camptothecin conjugates
camptothecin
conjugates
Prior art date
Application number
NO20024421A
Other languages
English (en)
Other versions
NO20024421L (no
Inventor
Rama Bhatt
Peter De Vries
Peter J Klein
Robert A Lewis
Jack W Singer
John Tulinsky
Original Assignee
Cell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of NO20024421D0 publication Critical patent/NO20024421D0/no
Publication of NO20024421L publication Critical patent/NO20024421L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
NO20024421A 2000-03-17 2002-09-16 Polyglutaminsyre-camptothecin-konjugater og fremgangsmÕte for fremstilling av disse NO20024421L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19042900P 2000-03-17 2000-03-17
PCT/US2001/008553 WO2001070275A2 (en) 2000-03-17 2001-03-19 Polyglutamic acid-camptothecin conjugates and methods of preparation

Publications (2)

Publication Number Publication Date
NO20024421D0 true NO20024421D0 (no) 2002-09-16
NO20024421L NO20024421L (no) 2002-11-15

Family

ID=22701317

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024421A NO20024421L (no) 2000-03-17 2002-09-16 Polyglutaminsyre-camptothecin-konjugater og fremgangsmÕte for fremstilling av disse

Country Status (20)

Country Link
US (1) US20020016285A1 (no)
EP (1) EP1267939A2 (no)
JP (1) JP2003527443A (no)
KR (1) KR20020082888A (no)
CN (1) CN1429121A (no)
AU (1) AU2001247513A1 (no)
BR (1) BR0109272A (no)
CA (1) CA2402643A1 (no)
CZ (1) CZ20023330A3 (no)
HU (1) HUP0204562A2 (no)
IL (1) IL151685A0 (no)
MX (1) MXPA02009082A (no)
NO (1) NO20024421L (no)
PL (1) PL358335A1 (no)
RU (1) RU2002128610A (no)
SI (1) SI21172A (no)
SK (1) SK14822002A3 (no)
TR (1) TR200202194T2 (no)
WO (1) WO2001070275A2 (no)
ZA (1) ZA200207423B (no)

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USRE48890E1 (en) 2002-05-17 2022-01-11 Celgene Corporation Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
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Also Published As

Publication number Publication date
BR0109272A (pt) 2004-06-29
CZ20023330A3 (cs) 2003-02-12
WO2001070275A2 (en) 2001-09-27
MXPA02009082A (es) 2003-12-11
US20020016285A1 (en) 2002-02-07
AU2001247513A1 (en) 2001-10-03
RU2002128610A (ru) 2004-03-27
WO2001070275A3 (en) 2002-01-03
IL151685A0 (en) 2003-04-10
ZA200207423B (en) 2003-12-17
CA2402643A1 (en) 2001-09-27
JP2003527443A (ja) 2003-09-16
TR200202194T2 (tr) 2003-01-21
HUP0204562A2 (hu) 2003-04-28
PL358335A1 (en) 2004-08-09
CN1429121A (zh) 2003-07-09
NO20024421L (no) 2002-11-15
EP1267939A2 (en) 2003-01-02
SI21172A (sl) 2003-10-31
SK14822002A3 (sk) 2003-05-02
KR20020082888A (ko) 2002-10-31

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