MXPA02009082A - Conjugados de acido poliglutamico-camptotecina y metodos de preparacion. - Google Patents
Conjugados de acido poliglutamico-camptotecina y metodos de preparacion.Info
- Publication number
- MXPA02009082A MXPA02009082A MXPA02009082A MXPA02009082A MXPA02009082A MX PA02009082 A MXPA02009082 A MX PA02009082A MX PA02009082 A MXPA02009082 A MX PA02009082A MX PA02009082 A MXPA02009082 A MX PA02009082A MX PA02009082 A MXPA02009082 A MX PA02009082A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- methods
- polyglutamic acid
- camptothecin conjugates
- camptothecin
- Prior art date
Links
- 229940127093 camptothecin Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19042900P | 2000-03-17 | 2000-03-17 | |
| PCT/US2001/008553 WO2001070275A2 (en) | 2000-03-17 | 2001-03-19 | Polyglutamic acid-camptothecin conjugates and methods of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02009082A true MXPA02009082A (es) | 2003-12-11 |
Family
ID=22701317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02009082A MXPA02009082A (es) | 2000-03-17 | 2001-03-19 | Conjugados de acido poliglutamico-camptotecina y metodos de preparacion. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020016285A1 (es) |
| EP (1) | EP1267939A2 (es) |
| JP (1) | JP2003527443A (es) |
| KR (1) | KR20020082888A (es) |
| CN (1) | CN1429121A (es) |
| AU (1) | AU2001247513A1 (es) |
| BR (1) | BR0109272A (es) |
| CA (1) | CA2402643A1 (es) |
| CZ (1) | CZ20023330A3 (es) |
| HU (1) | HUP0204562A2 (es) |
| IL (1) | IL151685A0 (es) |
| MX (1) | MXPA02009082A (es) |
| NO (1) | NO20024421L (es) |
| PL (1) | PL358335A1 (es) |
| RU (1) | RU2002128610A (es) |
| SI (1) | SI21172A (es) |
| SK (1) | SK14822002A3 (es) |
| TR (1) | TR200202194T2 (es) |
| WO (1) | WO2001070275A2 (es) |
| ZA (1) | ZA200207423B (es) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| US20030054977A1 (en) * | 1999-10-12 | 2003-03-20 | Cell Therapeutics, Inc. | Manufacture of polyglutamate-therapeutic agent conjugates |
| SG147286A1 (en) * | 1999-10-12 | 2008-11-28 | Cell Therapeutics Inc | Manufacture of polyglumate-therapeutic agent conjugates |
| US20020077290A1 (en) * | 2000-03-17 | 2002-06-20 | Rama Bhatt | Polyglutamic acid-camptothecin conjugates and methods of preparation |
| US6629995B1 (en) * | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| EP2105136A3 (en) * | 2002-05-17 | 2010-01-27 | Celgene Corporation | Pharmaceutical compositions for treating cancer |
| USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| KR101057102B1 (ko) | 2002-10-31 | 2011-08-16 | 니폰 가야꾸 가부시끼가이샤 | 캄프토테신의 고분자량 유도체 |
| US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
| US8796436B2 (en) | 2003-04-17 | 2014-08-05 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
| EP1620544B1 (en) * | 2003-04-17 | 2018-09-19 | Alnylam Pharmaceuticals Inc. | MODIFIED iRNA AGENTS |
| US8017762B2 (en) * | 2003-04-17 | 2011-09-13 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
| US7851615B2 (en) * | 2003-04-17 | 2010-12-14 | Alnylam Pharmaceuticals, Inc. | Lipophilic conjugated iRNA agents |
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US20070207149A1 (en) | 2004-04-27 | 2007-09-06 | Wellstat Biologics Corporation | Cancer treatment using viruses and camptothecins |
| US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
| WO2006020719A2 (en) | 2004-08-11 | 2006-02-23 | Arqule, Inc. | Aminoacid conjugates of beta - lapachone for tumor targeting |
| EP1792927B1 (en) * | 2004-09-22 | 2013-03-06 | Nippon Kayaku Kabushiki Kaisha | Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient |
| ATE540698T1 (de) | 2005-07-14 | 2012-01-15 | Wellstat Biologics Corp | Krebsbehandlung mit viren, fluoropyrimidinen und camptothecinen |
| ITPD20050242A1 (it) * | 2005-08-03 | 2007-02-04 | Fidia Farmaceutici | Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico |
| RU2472812C2 (ru) * | 2005-12-05 | 2013-01-20 | НИТТО ДЕНКО КОРПОРЭЙШН (Джэпэн/Джэпэн) | Конъюгаты полиглутамат-аминокислота и способы |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
| JP5313867B2 (ja) | 2006-03-30 | 2013-10-09 | ドライス ファーマシューティカルズ，インコーポレイティド | カンプトテシン−細胞透過性ペプチド複合体及びそれを含む医薬組成物 |
| WO2007135910A1 (ja) | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | ポドフィロトキシン類の高分子結合体 |
| CL2007002218A1 (es) | 2006-08-03 | 2008-03-14 | Celgene Corp Soc Organizada Ba | Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa. |
| US20090239782A1 (en) * | 2006-10-03 | 2009-09-24 | Masaharu Nakamura | High-molecular weight conjugate of resorcinol derivatives |
| JP5503872B2 (ja) | 2006-11-06 | 2014-05-28 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| WO2008056654A1 (en) * | 2006-11-08 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
| US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
| CN101605539B (zh) * | 2007-02-09 | 2013-01-02 | 安佐制药股份有限公司 | 用7-乙基-10-羟基喜树碱的多臂聚合缀合物治疗抵抗性或顽固性癌症 |
| US20080253969A1 (en) * | 2007-04-10 | 2008-10-16 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
| TWI401081B (zh) | 2007-04-30 | 2013-07-11 | Arqule Inc | 苯醌化合物的羥基磺酸鹽及其用途 |
| ES2430380T3 (es) | 2007-05-09 | 2013-11-20 | Nitto Denko Corporation | Composiciones que incluyen un compuesto hidrófobo y un conjugado de poliaminoácido |
| WO2008141110A2 (en) * | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
| EP2155254B1 (en) * | 2007-05-09 | 2012-11-28 | Nitto Denko Corporation | Polymers conjugated with platinum drugs |
| US8703878B2 (en) | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| KR20100122510A (ko) * | 2008-03-06 | 2010-11-22 | 닛토덴코 가부시키가이샤 | 중합체 파클리탁셀 접합체 및 암 치료 방법 |
| US8920788B2 (en) | 2008-03-18 | 2014-12-30 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of physiologically active substances |
| US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
| JP2011162569A (ja) * | 2008-05-23 | 2011-08-25 | Nano Career Kk | カンプトテシン高分子誘導体及びその用途 |
| US20100056555A1 (en) * | 2008-08-29 | 2010-03-04 | Enzon Pharmaceuticals, Inc. | Method of treating ras associated cancer |
| KR20110074583A (ko) * | 2008-10-15 | 2011-06-30 | 닛토덴코 가부시키가이샤 | 폴리글루타메이트 접합체의 제조 방법 |
| WO2010048018A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| US8808749B2 (en) | 2009-05-15 | 2014-08-19 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of bioactive substance having hydroxy group |
| CA2782410A1 (en) * | 2009-12-16 | 2011-06-23 | Nitto Denko Corporation | Controlled synthesis of polyglutamic acid |
| US20110224148A1 (en) * | 2010-03-11 | 2011-09-15 | Nitto Denko Corporation | Carbohydrate-polyamino acid-drug conjugates |
| CN103221054A (zh) | 2010-11-17 | 2013-07-24 | 日本化药株式会社 | 新的胞苷类代谢拮抗剂的高分子衍生物 |
| CN102649810A (zh) * | 2011-05-19 | 2012-08-29 | 东北林业大学 | 喜树碱衍生物、其制备方法和用途 |
| PT2754682T (pt) | 2011-09-11 | 2017-08-29 | Nippon Kayaku Kk | Método para o fabrico de copolímero de bloco |
| EP2911701A4 (en) * | 2012-10-23 | 2016-06-08 | Univ Johns Hopkins | Novel self-assembling drug amphiphiles and methods for synthesis and application |
| HRP20230265T1 (hr) | 2014-08-22 | 2023-04-14 | Celgene Corporation | Postupci liječenja multiplog mijeloma imunomodulatornim spojevima u kombinaciji s protutijelima |
| SI3313818T1 (sl) | 2015-06-26 | 2024-03-29 | Celgene Corporation | Postopki zdravljenja Kaposijevega sarkoma ali s KSHV povzročenega limfoma, z uporabo imunomodulatornih spojin in uporabe biomarkerjev |
| CN106267227A (zh) * | 2016-08-12 | 2017-01-04 | 北京蓝贝望生物医药科技股份有限公司 | 抗肿瘤药物 |
| WO2018064683A1 (en) * | 2016-09-30 | 2018-04-05 | If7Cure, Inc | Process for the manufacture of a tumor-vasculature targeting antitumor agent |
| CN106831853B (zh) * | 2017-02-15 | 2019-02-22 | 浙江海正药业股份有限公司 | 7-乙基-10-o-叔丁基二苯基硅基喜树碱-20-o-甘氨酸盐酸盐的制备工艺 |
| CN108727581A (zh) * | 2017-04-18 | 2018-11-02 | 华东师范大学 | 以苯硼酸酯为连接单元的两亲性喜树碱高分子前药及其制备方法和应用 |
| JP2021095424A (ja) * | 2018-03-28 | 2021-06-24 | 持田製薬株式会社 | 抗癌剤結合アルギン酸誘導体 |
| EP4069707A4 (en) * | 2019-12-04 | 2023-12-06 | Dantari, Inc. | PROCESSES AND COMPOSITIONS FOR THE SYNTHESIS OF THERAPEUTIC NANOPARTICLES |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| KR100561788B1 (ko) * | 1996-03-12 | 2006-09-20 | 피지-티엑스엘 컴파니,엘.피. | 수용성파클리탁셀전구약물을포함하는조성물및이러한조성물을포함하는이식가능한의료장치 |
-
2001
- 2001-03-19 KR KR1020027012206A patent/KR20020082888A/ko not_active Application Discontinuation
- 2001-03-19 CN CN01809441A patent/CN1429121A/zh active Pending
- 2001-03-19 SK SK1482-2002A patent/SK14822002A3/sk unknown
- 2001-03-19 CZ CZ20023330A patent/CZ20023330A3/cs unknown
- 2001-03-19 CA CA002402643A patent/CA2402643A1/en not_active Abandoned
- 2001-03-19 MX MXPA02009082A patent/MXPA02009082A/es unknown
- 2001-03-19 AU AU2001247513A patent/AU2001247513A1/en not_active Abandoned
- 2001-03-19 HU HU0204562A patent/HUP0204562A2/hu unknown
- 2001-03-19 TR TR2002/02194T patent/TR200202194T2/xx unknown
- 2001-03-19 US US09/810,345 patent/US20020016285A1/en not_active Abandoned
- 2001-03-19 JP JP2001568471A patent/JP2003527443A/ja not_active Withdrawn
- 2001-03-19 BR BR0109272-3A patent/BR0109272A/pt active Pending
- 2001-03-19 PL PL01358335A patent/PL358335A1/xx not_active Application Discontinuation
- 2001-03-19 WO PCT/US2001/008553 patent/WO2001070275A2/en not_active Application Discontinuation
- 2001-03-19 SI SI200120021A patent/SI21172A/sl not_active IP Right Cessation
- 2001-03-19 EP EP01920466A patent/EP1267939A2/en not_active Withdrawn
- 2001-03-19 IL IL15168501A patent/IL151685A0/xx unknown
- 2001-03-19 RU RU2002128610/15A patent/RU2002128610A/ru unknown
-
2002
- 2002-09-16 NO NO20024421A patent/NO20024421L/no not_active Application Discontinuation
- 2002-09-16 ZA ZA200207423A patent/ZA200207423B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002128610A (ru) | 2004-03-27 |
| CZ20023330A3 (cs) | 2003-02-12 |
| KR20020082888A (ko) | 2002-10-31 |
| TR200202194T2 (tr) | 2003-01-21 |
| BR0109272A (pt) | 2004-06-29 |
| IL151685A0 (en) | 2003-04-10 |
| EP1267939A2 (en) | 2003-01-02 |
| ZA200207423B (en) | 2003-12-17 |
| CN1429121A (zh) | 2003-07-09 |
| NO20024421L (no) | 2002-11-15 |
| US20020016285A1 (en) | 2002-02-07 |
| SI21172A (sl) | 2003-10-31 |
| SK14822002A3 (sk) | 2003-05-02 |
| PL358335A1 (en) | 2004-08-09 |
| CA2402643A1 (en) | 2001-09-27 |
| NO20024421D0 (no) | 2002-09-16 |
| WO2001070275A2 (en) | 2001-09-27 |
| AU2001247513A1 (en) | 2001-10-03 |
| JP2003527443A (ja) | 2003-09-16 |
| HUP0204562A2 (hu) | 2003-04-28 |
| WO2001070275A3 (en) | 2002-01-03 |
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