EP3518954A4 - Process for the manufacture of a tumor-vasculature targeting antitumor agent - Google Patents
Process for the manufacture of a tumor-vasculature targeting antitumor agent Download PDFInfo
- Publication number
- EP3518954A4 EP3518954A4 EP17857627.8A EP17857627A EP3518954A4 EP 3518954 A4 EP3518954 A4 EP 3518954A4 EP 17857627 A EP17857627 A EP 17857627A EP 3518954 A4 EP3518954 A4 EP 3518954A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- tumor
- manufacture
- antitumor agent
- vasculature targeting
- targeting antitumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402127P | 2016-09-30 | 2016-09-30 | |
| PCT/US2017/054801 WO2018064683A1 (en) | 2016-09-30 | 2017-10-02 | Process for the manufacture of a tumor-vasculature targeting antitumor agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3518954A1 EP3518954A1 (en) | 2019-08-07 |
| EP3518954A4 true EP3518954A4 (en) | 2020-05-27 |
Family
ID=61760273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17857627.8A Withdrawn EP3518954A4 (en) | 2016-09-30 | 2017-10-02 | Process for the manufacture of a tumor-vasculature targeting antitumor agent |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200030452A1 (en) |
| EP (1) | EP3518954A4 (en) |
| JP (1) | JP2019532104A (en) |
| CN (1) | CN110177566A (en) |
| CA (1) | CA3038912A1 (en) |
| WO (1) | WO2018064683A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112334158B (en) * | 2018-06-20 | 2023-10-13 | 国立大学法人弘前大学 | Aggregated boron 10 agents for boron neutron capture therapy capable of selectively or locally targeting tumor tissue in a short time |
| WO2022035843A1 (en) * | 2020-08-12 | 2022-02-17 | Nanomedicine Innovation Center, Llc | Topoisomerase inhibitors |
| CA3193485A1 (en) | 2020-09-28 | 2022-03-31 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Peptidic conjugates of sn38 useful in the treatment of cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020082888A (en) * | 2000-03-17 | 2002-10-31 | 쎌세러퓨틱스,인코포레이티드 | Polyglutamic acid-camptothecin conjugates and methods of preparation |
| JP5313867B2 (en) * | 2006-03-30 | 2013-10-09 | ドライス ファーマシューティカルズ，インコーポレイティド | Camptothecin-cell penetrating peptide complex and pharmaceutical composition containing the same |
| WO2011079304A1 (en) * | 2009-12-23 | 2011-06-30 | Sanford-Burnham Medical Research Institute | Methods and compositions related to annexin 1-binding compounds |
-
2017
- 2017-10-02 WO PCT/US2017/054801 patent/WO2018064683A1/en unknown
- 2017-10-02 EP EP17857627.8A patent/EP3518954A4/en not_active Withdrawn
- 2017-10-02 CN CN201780066081.7A patent/CN110177566A/en active Pending
- 2017-10-02 US US16/337,627 patent/US20200030452A1/en not_active Abandoned
- 2017-10-02 JP JP2019538576A patent/JP2019532104A/en active Pending
- 2017-10-02 CA CA3038912A patent/CA3038912A1/en not_active Abandoned
Non-Patent Citations (5)
| Title |
|---|
| F. MEYER-LOSIC ET AL: "DTS-108, A Novel Peptidic Prodrug of SN38: In vivo Efficacy and Toxicokinetic Studies", CLINICAL CANCER RESEARCH, vol. 14, no. 7, 1 April 2008 (2008-04-01), US, pages 2145 - 2153, XP055685092, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-07-4580 * |
| MICHIKO F FUKUDA ET AL: "Carbohydrate mimetic peptides as research reagent and therapeutic", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), vol. 35, no. 10, 1 January 2012 (2012-01-01), JP, pages 1626 - 1632, XP055665398, ISSN: 0918-6158, DOI: 10.1248/bpb.b12-00395 * |
| S. HATAKEYAMA ET AL: "Supporting Information - Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 49, 23 November 2011 (2011-11-23), US, pages 19587 - 19592, XP055685086, ISSN: 0027-8424, DOI: 10.1073/pnas.1105057108 * |
| S. HATAKEYAMA ET AL: "Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 49, 6 December 2011 (2011-12-06), pages 19587 - 19592, XP055040103, ISSN: 0027-8424, DOI: 10.1073/pnas.1105057108 * |
| See also references of WO2018064683A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200030452A1 (en) | 2020-01-30 |
| CN110177566A (en) | 2019-08-27 |
| CA3038912A1 (en) | 2018-04-05 |
| WO2018064683A1 (en) | 2018-04-05 |
| JP2019532104A (en) | 2019-11-07 |
| EP3518954A1 (en) | 2019-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20190404 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| AX | Request for extension of the european patent |
Extension state: BA ME |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20200424 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 7/06 20060101ALI20200420BHEP Ipc: A61P 35/00 20060101ALI20200420BHEP Ipc: A61K 38/08 20190101ALI20200420BHEP Ipc: A61K 47/64 20170101AFI20200420BHEP |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40012792 Country of ref document: HK |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
| 18W | Application withdrawn |
Effective date: 20201218 |