SI20208A - INHIBITORJI FAKTORJA Xa Z NEVTRALNO P1 SPECIFIČNO SKUPINO - Google Patents
INHIBITORJI FAKTORJA Xa Z NEVTRALNO P1 SPECIFIČNO SKUPINO Download PDFInfo
- Publication number
- SI20208A SI20208A SI9820043A SI9820043A SI20208A SI 20208 A SI20208 A SI 20208A SI 9820043 A SI9820043 A SI 9820043A SI 9820043 A SI9820043 A SI 9820043A SI 20208 A SI20208 A SI 20208A
- Authority
- SI
- Slovenia
- Prior art keywords
- carboxamide
- phenyl
- methoxyphenyl
- pyrazole
- biphen
- Prior art date
Links
- 0 B**C1=NN(C)C*=C1 Chemical compound B**C1=NN(C)C*=C1 0.000 description 12
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87888597A | 1997-06-19 | 1997-06-19 | |
US7669198P | 1998-02-27 | 1998-02-27 | |
PCT/US1998/012681 WO1998057937A2 (en) | 1997-06-19 | 1998-06-18 | Inhibitors of factor xa with a neutral p1 specificity group |
Publications (1)
Publication Number | Publication Date |
---|---|
SI20208A true SI20208A (sl) | 2000-10-31 |
Family
ID=26758382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9820043A SI20208A (sl) | 1997-06-19 | 1998-06-18 | INHIBITORJI FAKTORJA Xa Z NEVTRALNO P1 SPECIFIČNO SKUPINO |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0991625B1 (ru) |
JP (1) | JP2002507968A (ru) |
KR (1) | KR20010013977A (ru) |
AR (1) | AR015906A1 (ru) |
AT (1) | ATE296805T1 (ru) |
AU (1) | AU8150398A (ru) |
BR (1) | BR9810151A (ru) |
CA (1) | CA2290982A1 (ru) |
DE (1) | DE69830403T2 (ru) |
EA (1) | EA200000048A1 (ru) |
EE (1) | EE9900584A (ru) |
ES (1) | ES2239806T3 (ru) |
HR (1) | HRP980334A2 (ru) |
HU (1) | HUP0003906A2 (ru) |
IL (1) | IL133526A0 (ru) |
LV (1) | LV12516B (ru) |
NO (1) | NO996316L (ru) |
PL (1) | PL337831A1 (ru) |
PT (1) | PT991625E (ru) |
SI (1) | SI20208A (ru) |
SK (1) | SK174699A3 (ru) |
WO (1) | WO1998057937A2 (ru) |
Families Citing this family (104)
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US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
IL136637A0 (en) * | 1997-12-22 | 2001-06-14 | Du Pont Pharm Co | Nitrogen containing heteroaromatics with ortho-substituted pi's as factor xa inhibitors |
WO1999041231A1 (fr) | 1998-02-17 | 1999-08-19 | Ono Pharmaceutical Co., Ltd. | Derives amidino utilises comme ingredients actifs et medicaments les contenant |
EP1064270B1 (en) | 1998-03-27 | 2004-10-06 | Bristol-Myers Squibb Pharma Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
WO2000006550A1 (fr) * | 1998-07-31 | 2000-02-10 | Nippon Soda Co., Ltd. | Composes phenylazole, procede de production desdits composes et medicaments pour le traitement de l'hyperlipidemie |
AU3127900A (en) | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
US6395897B1 (en) | 1999-03-02 | 2002-05-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5 |
ATE241621T1 (de) * | 1999-04-02 | 2003-06-15 | Bristol Myers Squibb Pharma Co | Arylsulfonyle als faktor xa inhibitoren |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
PT1169038E (pt) | 1999-04-15 | 2012-10-26 | Bristol Myers Squibb Co | Inibidores cíclicos da proteína tirosina cinase |
KR20030011268A (ko) | 1999-07-16 | 2003-02-07 | 브리스톨-마이어스 스퀴브 파마 컴퍼니 | Xa 인자 억제제로서의 질소 함유 헤테로바이사이클 |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
WO2001032628A1 (en) * | 1999-11-03 | 2001-05-10 | Bristol-Myers Squibb Pharma Company | Cyano compounds as factor xa inhibitors |
US6407256B1 (en) | 1999-11-03 | 2002-06-18 | Bristol Myers Squibb Co | Cyano-pyrrole, cyano-imidazole, cyano-pyrazole, and cyano-triazole compounds as factor Xa inhibitors |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
CA2409762A1 (en) | 2000-06-23 | 2002-01-03 | Donald J.P. Pinto | Heteroaryl-phenyl substituted factor xa inhibitors |
CN1439008A (zh) * | 2000-06-23 | 2003-08-27 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为因子xa抑制剂的1-(杂芳环基-苯基)-稠合吡唑衍生物 |
US6586418B2 (en) | 2000-06-29 | 2003-07-01 | Bristol-Myers Squibb Company | Thrombin or factor Xa inhibitors |
AU2002231235A1 (en) | 2000-11-07 | 2002-05-21 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
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AR036872A1 (es) | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
TWI325302B (en) | 2001-08-13 | 2010-06-01 | Du Pont | Benzoxazinone compounds |
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KR100866463B1 (ko) | 2001-08-15 | 2008-10-31 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충 방제용 오르토-치환 아릴 아미드 |
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KR101204247B1 (ko) | 2003-07-22 | 2012-11-22 | 아스텍스 테라퓨틱스 리미티드 | 3,4-이치환된 1h-피라졸 화합물 및 그의 시클린 의존성키나제 (cdk) 및 글리코겐 합성효소 키나제-3(gsk-3) 조정제로서 용도 |
CN1826121B (zh) * | 2003-07-23 | 2013-05-29 | 幸讬制药公司 | 苯基与吡啶基衍生物用于制备调控钙离子释放活化钙离子通道的药物的用途 |
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CN104072432B (zh) * | 2014-07-23 | 2015-12-30 | 张远强 | 含苯基取代三唑希夫碱类结构的化合物、其制备方法和用途 |
CN104086501B (zh) * | 2014-07-23 | 2016-02-17 | 张远强 | 一种par-1拮抗剂、其制备方法和用途 |
CN104086502B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 卤代四氮唑苯乙酮化合物、其制备方法和用途 |
CN104072436B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 对位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
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1998
- 1998-06-18 WO PCT/US1998/012681 patent/WO1998057937A2/en active IP Right Grant
- 1998-06-18 AT AT98931355T patent/ATE296805T1/de not_active IP Right Cessation
- 1998-06-18 HU HU0003906A patent/HUP0003906A2/hu unknown
- 1998-06-18 EP EP98931355A patent/EP0991625B1/en not_active Revoked
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- 1998-06-18 JP JP50478699A patent/JP2002507968A/ja active Pending
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- 1998-06-18 PL PL98337831A patent/PL337831A1/xx not_active Application Discontinuation
- 1998-06-18 SK SK1746-99A patent/SK174699A3/sk unknown
- 1998-06-18 DE DE69830403T patent/DE69830403T2/de not_active Expired - Lifetime
- 1998-06-18 IL IL13352698A patent/IL133526A0/xx unknown
- 1998-06-18 EA EA200000048A patent/EA200000048A1/ru unknown
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- 1998-06-18 KR KR19997012003A patent/KR20010013977A/ko not_active Application Discontinuation
- 1998-06-18 SI SI9820043A patent/SI20208A/sl not_active IP Right Cessation
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AU8150398A (en) | 1999-01-04 |
HRP980334A2 (en) | 1999-04-30 |
HUP0003906A2 (hu) | 2001-05-28 |
EE9900584A (et) | 2000-08-15 |
JP2002507968A (ja) | 2002-03-12 |
EP0991625A2 (en) | 2000-04-12 |
ATE296805T1 (de) | 2005-06-15 |
BR9810151A (pt) | 2000-08-08 |
ES2239806T3 (es) | 2005-10-01 |
SK174699A3 (en) | 2000-08-14 |
IL133526A0 (en) | 2001-04-30 |
EA200000048A1 (ru) | 2000-08-28 |
DE69830403D1 (de) | 2005-07-07 |
LV12516B (en) | 2001-03-20 |
DE69830403T2 (de) | 2006-02-02 |
WO1998057937A2 (en) | 1998-12-23 |
NO996316D0 (no) | 1999-12-17 |
AR015906A1 (es) | 2001-05-30 |
NO996316L (no) | 1999-12-17 |
KR20010013977A (ko) | 2001-02-26 |
PL337831A1 (en) | 2000-09-11 |
LV12516A (en) | 2000-07-20 |
EP0991625B1 (en) | 2005-06-01 |
PT991625E (pt) | 2005-10-31 |
WO1998057937A3 (en) | 1999-03-18 |
CA2290982A1 (en) | 1998-12-23 |
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