LV12516B - FACTOR XA INHIBITORS WITH NITRATE GROUP P1 SPECIFICITY - Google Patents
FACTOR XA INHIBITORS WITH NITRATE GROUP P1 SPECIFICITY Download PDFInfo
- Publication number
- LV12516B LV12516B LVP-99-177A LV990177A LV12516B LV 12516 B LV12516 B LV 12516B LV 990177 A LV990177 A LV 990177A LV 12516 B LV12516 B LV 12516B
- Authority
- LV
- Latvia
- Prior art keywords
- phenyl
- carboxamide
- methoxyphenyl
- biphen
- pyrazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87888597A | 1997-06-19 | 1997-06-19 | |
US7669198P | 1998-02-27 | 1998-02-27 | |
PCT/US1998/012681 WO1998057937A2 (en) | 1997-06-19 | 1998-06-18 | Inhibitors of factor xa with a neutral p1 specificity group |
Publications (2)
Publication Number | Publication Date |
---|---|
LV12516A LV12516A (en) | 2000-07-20 |
LV12516B true LV12516B (en) | 2001-03-20 |
Family
ID=26758382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-99-177A LV12516B (en) | 1997-06-19 | 1999-12-16 | FACTOR XA INHIBITORS WITH NITRATE GROUP P1 SPECIFICITY |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0991625B1 (ru) |
JP (1) | JP2002507968A (ru) |
KR (1) | KR20010013977A (ru) |
AR (1) | AR015906A1 (ru) |
AT (1) | ATE296805T1 (ru) |
AU (1) | AU8150398A (ru) |
BR (1) | BR9810151A (ru) |
CA (1) | CA2290982A1 (ru) |
DE (1) | DE69830403T2 (ru) |
EA (1) | EA200000048A1 (ru) |
EE (1) | EE9900584A (ru) |
ES (1) | ES2239806T3 (ru) |
HR (1) | HRP980334A2 (ru) |
HU (1) | HUP0003906A2 (ru) |
IL (1) | IL133526A0 (ru) |
LV (1) | LV12516B (ru) |
NO (1) | NO996316L (ru) |
PL (1) | PL337831A1 (ru) |
PT (1) | PT991625E (ru) |
SI (1) | SI20208A (ru) |
SK (1) | SK174699A3 (ru) |
WO (1) | WO1998057937A2 (ru) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
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AU7687998A (en) * | 1997-05-19 | 1998-12-11 | Sugen, Inc. | Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders |
US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
CA2314401A1 (en) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
US6358960B1 (en) | 1998-02-17 | 2002-03-19 | Ono Pharmaceutical Co., Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
AU3110999A (en) | 1998-03-27 | 1999-10-18 | Du Pont Pharmaceuticals Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
WO2000006550A1 (fr) * | 1998-07-31 | 2000-02-10 | Nippon Soda Co., Ltd. | Composes phenylazole, procede de production desdits composes et medicaments pour le traitement de l'hyperlipidemie |
WO2000038683A1 (en) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
CA2360740A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
ATE241621T1 (de) | 1999-04-02 | 2003-06-15 | Bristol Myers Squibb Pharma Co | Arylsulfonyle als faktor xa inhibitoren |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
MXPA01010292A (es) | 1999-04-15 | 2002-10-23 | Squibb Bristol Myers Co | Inhibidores ciclicos de la proteina tirosina cinasa. |
CA2380727A1 (en) | 1999-07-16 | 2001-01-25 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor xa inhibitors |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6407256B1 (en) | 1999-11-03 | 2002-06-18 | Bristol Myers Squibb Co | Cyano-pyrrole, cyano-imidazole, cyano-pyrazole, and cyano-triazole compounds as factor Xa inhibitors |
EP1226123A1 (en) * | 1999-11-03 | 2002-07-31 | Du Pont Pharmaceuticals Company | Cyano compounds as factor xa inhibitors |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
WO2002000647A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
WO2002000655A1 (en) * | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors |
AU2001275857A1 (en) * | 2000-06-29 | 2002-01-14 | Bristol-Myers Squibb Pharma Company | Thrombin or factor xa inhibitors |
HUP0303901A2 (hu) | 2000-11-07 | 2004-03-01 | Bristol-Myers Squibb Co. | Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények |
US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
EP1332131A2 (en) * | 2000-11-07 | 2003-08-06 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
TWI325302B (en) | 2001-08-13 | 2010-06-01 | Du Pont | Benzoxazinone compounds |
AR036872A1 (es) | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
WO2003016300A1 (en) | 2001-08-15 | 2003-02-27 | E. I. Du Pont De Nemours And Company | Ortho-substituted aryl amides for controlling invertebrate pests |
CN100506817C (zh) | 2001-08-15 | 2009-07-01 | 纳幕尔杜邦公司 | 用于防治无脊椎害虫的邻-杂环取代的芳基酰胺类化合物 |
KR100869002B1 (ko) | 2001-08-16 | 2008-11-17 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충 방제를 위한 치환된 안트라닐아미드 |
TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
TWI283164B (en) | 2001-09-21 | 2007-07-01 | Du Pont | Anthranilamide arthropodicide treatment |
PL204653B1 (pl) | 2001-09-21 | 2010-01-29 | Bristol Myers Squibb Co | Pochodna pirazolo [3, 4-c] pirydyny, jej zastosowanie i kompozycja farmaceutyczna |
JP2005512975A (ja) | 2001-10-25 | 2005-05-12 | アストラゼネカ アクチボラグ | 抗菌薬として有用なイソキサゾリン誘導体 |
ES2427141T3 (es) | 2002-01-22 | 2013-10-29 | E. I. Du Pont De Nemours And Company | Quinazolina(di)onas para el control de plagas de invertebrados |
EP1505966A4 (en) | 2002-05-10 | 2006-08-30 | Bristol Myers Squibb Co | 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA HEMMER |
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PL2256106T3 (pl) | 2003-07-22 | 2015-08-31 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
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CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
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CN104072434B (zh) * | 2014-07-23 | 2015-12-02 | 张远强 | 间位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
CN104086501B (zh) * | 2014-07-23 | 2016-02-17 | 张远强 | 一种par-1拮抗剂、其制备方法和用途 |
CN104072432B (zh) * | 2014-07-23 | 2015-12-30 | 张远强 | 含苯基取代三唑希夫碱类结构的化合物、其制备方法和用途 |
CN104086502B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 卤代四氮唑苯乙酮化合物、其制备方法和用途 |
CN104072431B (zh) * | 2014-07-23 | 2015-11-18 | 张远强 | 烷氧基取代的苯基三唑希夫碱结构的化合物及用途 |
CN104072438B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 二烷氧代四氮唑苯乙酮化合物、其制备方法和用途 |
CN104086503B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | Par-1拮抗剂及其用途 |
CN104086498B (zh) * | 2014-07-23 | 2015-11-18 | 张远强 | 末端取代的三唑希夫碱类结构的化合物、其制备方法和用途 |
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-
1998
- 1998-06-18 AU AU81503/98A patent/AU8150398A/en not_active Abandoned
- 1998-06-18 WO PCT/US1998/012681 patent/WO1998057937A2/en active IP Right Grant
- 1998-06-18 EP EP98931355A patent/EP0991625B1/en not_active Revoked
- 1998-06-18 JP JP50478699A patent/JP2002507968A/ja active Pending
- 1998-06-18 IL IL13352698A patent/IL133526A0/xx unknown
- 1998-06-18 BR BR9810151-0A patent/BR9810151A/pt not_active IP Right Cessation
- 1998-06-18 EE EEP199900584A patent/EE9900584A/xx unknown
- 1998-06-18 PL PL98337831A patent/PL337831A1/xx not_active Application Discontinuation
- 1998-06-18 SK SK1746-99A patent/SK174699A3/sk unknown
- 1998-06-18 HR HR60/076,691A patent/HRP980334A2/hr not_active Application Discontinuation
- 1998-06-18 DE DE69830403T patent/DE69830403T2/de not_active Expired - Lifetime
- 1998-06-18 KR KR19997012003A patent/KR20010013977A/ko not_active Application Discontinuation
- 1998-06-18 SI SI9820043A patent/SI20208A/sl not_active IP Right Cessation
- 1998-06-18 ES ES98931355T patent/ES2239806T3/es not_active Expired - Lifetime
- 1998-06-18 AT AT98931355T patent/ATE296805T1/de not_active IP Right Cessation
- 1998-06-18 CA CA002290982A patent/CA2290982A1/en not_active Abandoned
- 1998-06-18 HU HU0003906A patent/HUP0003906A2/hu unknown
- 1998-06-18 EA EA200000048A patent/EA200000048A1/ru unknown
- 1998-06-18 PT PT98931355T patent/PT991625E/pt unknown
- 1998-06-19 AR ARP980102939A patent/AR015906A1/es unknown
-
1999
- 1999-12-16 LV LVP-99-177A patent/LV12516B/en unknown
- 1999-12-17 NO NO996316A patent/NO996316L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002507968A (ja) | 2002-03-12 |
EA200000048A1 (ru) | 2000-08-28 |
SI20208A (sl) | 2000-10-31 |
IL133526A0 (en) | 2001-04-30 |
PT991625E (pt) | 2005-10-31 |
EP0991625A2 (en) | 2000-04-12 |
HUP0003906A2 (hu) | 2001-05-28 |
NO996316D0 (no) | 1999-12-17 |
SK174699A3 (en) | 2000-08-14 |
AR015906A1 (es) | 2001-05-30 |
HRP980334A2 (en) | 1999-04-30 |
EP0991625B1 (en) | 2005-06-01 |
DE69830403D1 (de) | 2005-07-07 |
NO996316L (no) | 1999-12-17 |
WO1998057937A2 (en) | 1998-12-23 |
KR20010013977A (ko) | 2001-02-26 |
AU8150398A (en) | 1999-01-04 |
CA2290982A1 (en) | 1998-12-23 |
ATE296805T1 (de) | 2005-06-15 |
ES2239806T3 (es) | 2005-10-01 |
LV12516A (en) | 2000-07-20 |
EE9900584A (et) | 2000-08-15 |
PL337831A1 (en) | 2000-09-11 |
BR9810151A (pt) | 2000-08-08 |
WO1998057937A3 (en) | 1999-03-18 |
DE69830403T2 (de) | 2006-02-02 |
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