LV12516B - FACTOR XA INHIBITORS WITH NITRATE GROUP P1 SPECIFICITY - Google Patents

FACTOR XA INHIBITORS WITH NITRATE GROUP P1 SPECIFICITY Download PDF

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Publication number
LV12516B
LV12516B LVP-99-177A LV990177A LV12516B LV 12516 B LV12516 B LV 12516B LV 990177 A LV990177 A LV 990177A LV 12516 B LV12516 B LV 12516B
Authority
LV
Latvia
Prior art keywords
phenyl
carboxamide
methoxyphenyl
biphen
pyrazol
Prior art date
Application number
LVP-99-177A
Other languages
English (en)
Latvian (lv)
Other versions
LV12516A (en
Inventor
Robert Anthony Galemmo Jr.
Celia Dominguez
John Matthew Fevig
Qi Han
Patrick Y. Lam
Donald Joseph-Phillip Pinto
James Russell PRUITT
Mimi Lifen QUAN
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26758382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV12516(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Publication of LV12516A publication Critical patent/LV12516A/xx
Publication of LV12516B publication Critical patent/LV12516B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LVP-99-177A 1997-06-19 1999-12-16 FACTOR XA INHIBITORS WITH NITRATE GROUP P1 SPECIFICITY LV12516B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87888597A 1997-06-19 1997-06-19
US7669198P 1998-02-27 1998-02-27
PCT/US1998/012681 WO1998057937A2 (en) 1997-06-19 1998-06-18 Inhibitors of factor xa with a neutral p1 specificity group

Publications (2)

Publication Number Publication Date
LV12516A LV12516A (en) 2000-07-20
LV12516B true LV12516B (en) 2001-03-20

Family

ID=26758382

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-177A LV12516B (en) 1997-06-19 1999-12-16 FACTOR XA INHIBITORS WITH NITRATE GROUP P1 SPECIFICITY

Country Status (22)

Country Link
EP (1) EP0991625B1 (ru)
JP (1) JP2002507968A (ru)
KR (1) KR20010013977A (ru)
AR (1) AR015906A1 (ru)
AT (1) ATE296805T1 (ru)
AU (1) AU8150398A (ru)
BR (1) BR9810151A (ru)
CA (1) CA2290982A1 (ru)
DE (1) DE69830403T2 (ru)
EA (1) EA200000048A1 (ru)
EE (1) EE9900584A (ru)
ES (1) ES2239806T3 (ru)
HR (1) HRP980334A2 (ru)
HU (1) HUP0003906A2 (ru)
IL (1) IL133526A0 (ru)
LV (1) LV12516B (ru)
NO (1) NO996316L (ru)
PL (1) PL337831A1 (ru)
PT (1) PT991625E (ru)
SI (1) SI20208A (ru)
SK (1) SK174699A3 (ru)
WO (1) WO1998057937A2 (ru)

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CN104086501B (zh) * 2014-07-23 2016-02-17 张远强 一种par-1拮抗剂、其制备方法和用途
CN104072432B (zh) * 2014-07-23 2015-12-30 张远强 含苯基取代三唑希夫碱类结构的化合物、其制备方法和用途
CN104086502B (zh) * 2014-07-23 2015-10-14 张远强 卤代四氮唑苯乙酮化合物、其制备方法和用途
CN104072431B (zh) * 2014-07-23 2015-11-18 张远强 烷氧基取代的苯基三唑希夫碱结构的化合物及用途
CN104072438B (zh) * 2014-07-23 2015-10-14 张远强 二烷氧代四氮唑苯乙酮化合物、其制备方法和用途
CN104086503B (zh) * 2014-07-23 2015-10-14 张远强 Par-1拮抗剂及其用途
CN104086498B (zh) * 2014-07-23 2015-11-18 张远强 末端取代的三唑希夫碱类结构的化合物、其制备方法和用途
CN104072436B (zh) * 2014-07-23 2015-10-14 张远强 对位取代的四氮唑苯乙酮化合物、其制备方法和用途
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CN104072437B (zh) * 2014-07-23 2015-10-14 张远强 双取代的四氮唑苯乙酮化合物、其制备方法和用途
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EP0991625A2 (en) 2000-04-12
HUP0003906A2 (hu) 2001-05-28
NO996316D0 (no) 1999-12-17
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AR015906A1 (es) 2001-05-30
HRP980334A2 (en) 1999-04-30
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NO996316L (no) 1999-12-17
WO1998057937A2 (en) 1998-12-23
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CA2290982A1 (en) 1998-12-23
ATE296805T1 (de) 2005-06-15
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LV12516A (en) 2000-07-20
EE9900584A (et) 2000-08-15
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WO1998057937A3 (en) 1999-03-18
DE69830403T2 (de) 2006-02-02

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