SI20072A - Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze - Google Patents
Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze Download PDFInfo
- Publication number
- SI20072A SI20072A SI9800241A SI9800241A SI20072A SI 20072 A SI20072 A SI 20072A SI 9800241 A SI9800241 A SI 9800241A SI 9800241 A SI9800241 A SI 9800241A SI 20072 A SI20072 A SI 20072A
- Authority
- SI
- Slovenia
- Prior art keywords
- hmg
- coa reductase
- reductase inhibitor
- process described
- phase
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 45
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 title abstract 4
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title description 2
- 238000002086 displacement chromatography Methods 0.000 claims abstract description 12
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960002965 pravastatin Drugs 0.000 claims abstract description 11
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims abstract description 11
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims abstract description 6
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims abstract description 6
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims abstract description 6
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960005370 atorvastatin Drugs 0.000 claims abstract description 6
- 229960004844 lovastatin Drugs 0.000 claims abstract description 6
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims abstract description 6
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims abstract description 6
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 claims abstract description 6
- 229960002855 simvastatin Drugs 0.000 claims abstract description 6
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims abstract description 6
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229950009116 mevastatin Drugs 0.000 claims abstract description 5
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 31
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims description 31
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- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims description 14
- 230000005526 G1 to G0 transition Effects 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000006073 displacement reaction Methods 0.000 claims description 9
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- 150000001298 alcohols Chemical class 0.000 claims description 5
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
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- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
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- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
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- VWBQYTRBTXKKOG-IYNICTALSA-M pravastatin sodium Chemical compound [Na+].C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 VWBQYTRBTXKKOG-IYNICTALSA-M 0.000 description 3
- 108010040201 Polymyxins Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N Cephalosporin C Natural products S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 102100029251 Phagocytosis-stimulating peptide Human genes 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 108010084754 Tuftsin Proteins 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-M cephalosporin C(1-) Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H]([NH3+])C([O-])=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-M 0.000 description 1
- MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
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- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 description 1
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- 238000004108 freeze drying Methods 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000007273 lactonization reaction Methods 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229940041153 polymyxins Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
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- 241000894007 species Species 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 description 1
- 229940035670 tuftsin Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/422—Displacement mode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800241A SI20072A (sl) | 1998-09-18 | 1998-09-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| YUP-818/00A RS49996B (sr) | 1998-09-18 | 1999-09-17 | POSTUPAK ZA DOBIJANJE INHIBITORA HMG-CoA REDUKTAZE VISOKE ČISTOĆE |
| AU55284/99A AU766630B2 (en) | 1998-09-18 | 1999-09-17 | Process for obtaining HMG-CoA reductase inhibitors of high purity |
| NZ509582A NZ509582A (en) | 1998-09-18 | 1999-09-17 | Process for obtaining HMG-CoA reductase inhibitors of high purity using displacement chromatography |
| HU0102997A HUP0102997A2 (hu) | 1998-09-18 | 1999-09-17 | Eljárás nagy tisztaságú HMG-CoA-reduktáz inhibitorok előállítására |
| HR20010045A HRP20010045B1 (en) | 1998-09-18 | 1999-09-17 | PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY |
| ROA200100289A RO121116B1 (ro) | 1998-09-18 | 1999-09-17 | Procedeu pentru obţinerea inhibitorilor reductazei hmg-coa |
| RU2001108381/04A RU2235098C2 (ru) | 1998-09-18 | 1999-09-17 | Способ получения ингибиторов hmg-coa-редуктазы с высокой степенью чистоты |
| KR1020017000044A KR100607608B1 (ko) | 1998-09-18 | 1999-09-17 | 고순도의 ＨＭＧ-ＣｏＡ 환원효소 억제제 생산방법 |
| CA002343645A CA2343645A1 (en) | 1998-09-18 | 1999-09-17 | Process for obtaining hmg-coa reductase inhibitors of high purity |
| US09/720,952 US6695969B1 (en) | 1998-09-18 | 1999-09-17 | Process for obtaining HMG-CoA reductase inhibitors of high purity |
| SK2002-2000A SK285868B6 (sk) | 1998-09-18 | 1999-09-17 | Spôsob získania vysokočistých inhibítorov HMG-CoAreduktázy |
| PCT/IB1999/001553 WO2000017182A1 (en) | 1998-09-18 | 1999-09-17 | PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY |
| CNB998110760A CN1186335C (zh) | 1998-09-18 | 1999-09-17 | 得到高纯度HMG－CoA还原酶抑制剂的方法 |
| EP99941797A EP1114040B1 (en) | 1998-09-18 | 1999-09-17 | PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY |
| IL14205699A IL142056A0 (en) | 1998-09-18 | 1999-09-17 | Process for obtaining hmg-coa reductase inhibitors of high purity |
| AT99941797T ATE284396T1 (de) | 1998-09-18 | 1999-09-17 | Verfahren zur bereitstellung von hochreinen hmg- coa reductase hemmer |
| PL345883A PL200336B1 (pl) | 1998-09-18 | 1999-09-17 | Sposób otrzymywania inhibitorów reduktazy HMG-CoA |
| DE69922519T DE69922519T2 (de) | 1998-09-18 | 1999-09-17 | Verfahren zur bereitstellung von hochreinen hmg-coa reductase hemmer |
| JP2000574092A JP3795755B2 (ja) | 1998-09-18 | 1999-09-17 | 高純度のＨＭＧ−ＣｏＡレダクターゼインヒビターを得るためのプロセス |
| SI9930754T SI1114040T1 (sr) | 1998-09-18 | 1999-09-17 | |
| IS5886A IS2149B (is) | 1998-09-18 | 2001-03-12 | Aðferð til að öðlast mjög hreina HMG-CoA redúktasatálma |
| BG105348A BG64676B1 (bg) | 1998-09-18 | 2001-03-16 | МЕТОД ЗА ПОЛУЧАВАНЕ НА HMG-CoA РЕДУКТАЗНИ ИНХИБИТОРИ С ВИСОКА ЧИСТОТА |
| IL142056A IL142056A (en) | 1998-09-18 | 2001-03-18 | Process for obtaining high-purity HMG – CoA reductase inhibitors |
| US10/698,009 US7141602B2 (en) | 1998-09-18 | 2003-10-30 | Process for obtaining HMG-CoA reductase inhibitors of high purity |
| US11/581,637 US20070032549A1 (en) | 1998-09-18 | 2006-10-16 | Process for obtaining HMG-CoA reductase inhibitors of high purity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800241A SI20072A (sl) | 1998-09-18 | 1998-09-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI20072A true SI20072A (sl) | 2000-04-30 |
Family
ID=20432332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9800241A SI20072A (sl) | 1998-09-18 | 1998-09-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6695969B1 (sr) |
| EP (1) | EP1114040B1 (sr) |
| JP (1) | JP3795755B2 (sr) |
| KR (1) | KR100607608B1 (sr) |
| CN (1) | CN1186335C (sr) |
| AT (1) | ATE284396T1 (sr) |
| AU (1) | AU766630B2 (sr) |
| BG (1) | BG64676B1 (sr) |
| CA (1) | CA2343645A1 (sr) |
| DE (1) | DE69922519T2 (sr) |
| HR (1) | HRP20010045B1 (sr) |
| HU (1) | HUP0102997A2 (sr) |
| IL (2) | IL142056A0 (sr) |
| IS (1) | IS2149B (sr) |
| NZ (1) | NZ509582A (sr) |
| PL (1) | PL200336B1 (sr) |
| RO (1) | RO121116B1 (sr) |
| RS (1) | RS49996B (sr) |
| RU (1) | RU2235098C2 (sr) |
| SI (1) | SI20072A (sr) |
| SK (1) | SK285868B6 (sr) |
| WO (1) | WO2000017182A1 (sr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
| US7141602B2 (en) * | 1998-09-18 | 2006-11-28 | Lek Pharmaceuticals D.D. | Process for obtaining HMG-CoA reductase inhibitors of high purity |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| MXPA02005283A (es) * | 1999-11-30 | 2003-10-06 | Biogal Gyogyszergyar | Proceso para recuperar compuestos estatina de un caldo de fermentacion. |
| CZ20021998A3 (cs) * | 1999-12-14 | 2003-02-12 | Biogal Gyogyszergyar Rt. | Nové formy sodné soli pravastatinu |
| PL357533A1 (en) | 2000-03-03 | 2004-07-26 | Plus Chemicals, S.A. | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
| US20050215636A1 (en) * | 2000-10-05 | 2005-09-29 | Vilmos Keri | Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same |
| CN1468098A (zh) * | 2000-10-05 | 2004-01-14 | �ݰ¸Ƕ�ҩ������˾ | 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物 |
| US6936731B2 (en) * | 2000-10-05 | 2005-08-30 | TEVA Gyógyszergyár Részvénytársaság | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| JP3236282B1 (ja) | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| JP3463875B2 (ja) | 2001-08-06 | 2003-11-05 | 三共株式会社 | プラバスタチンを精製する方法 |
| KR100407758B1 (ko) * | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
| JP2003093045A (ja) * | 2001-09-26 | 2003-04-02 | Godo Shusei Co Ltd | 有用変換微生物 |
| KR100435078B1 (ko) * | 2002-02-08 | 2004-06-09 | 종근당바이오 주식회사 | 심바스타틴의 정제방법 |
| JP3463881B2 (ja) | 2002-08-06 | 2003-11-05 | 三共株式会社 | プラバスタチン又はその薬理上許容される塩の単離・精製方法 |
| CA2521276A1 (en) * | 2003-04-01 | 2004-10-14 | Ranbaxy Laboratories Limited | Fermentation process for the preparation of pravastatin |
| US6978908B2 (en) * | 2003-09-15 | 2005-12-27 | Gerber Products Company | Drinking vessel with adjustable handles |
| PL1641447T3 (pl) * | 2003-11-24 | 2009-04-30 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Sposób oczyszczania prawastatyny |
| ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
| KR100923939B1 (ko) * | 2004-09-28 | 2009-10-29 | 테바 파마슈티컬 인더스트리즈 리미티드 | 실질적으로 불순물을 함유하지 않는 아토르바스타틴 칼슘의형태를 제조하는 방법 |
| CN102043030A (zh) * | 2009-10-22 | 2011-05-04 | 北京万全阳光医学技术有限公司 | 一种用高效液相色谱法测定烟酸辛伐他汀缓释片有关物质的方法 |
| CN102621238A (zh) * | 2011-02-01 | 2012-08-01 | 北京北大维信生物科技有限公司 | 一种测定HMG-CoA还原酶抑制剂浓度的方法 |
| CN105985244A (zh) * | 2015-02-04 | 2016-10-05 | 北京北大维信生物科技有限公司 | 化合物、其分离方法、合成方法及用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| SU1319352A1 (ru) * | 1985-01-07 | 1995-09-10 | Ленинградский государственный университет им.А.А.Жданова | Способ очистки препарата гистона н4 из ткани тимуса |
| IT1232311B (it) * | 1989-09-04 | 1992-01-28 | Sclavo Spa | Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. |
| US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| US5407050A (en) * | 1991-03-14 | 1995-04-18 | Kabushiki Kaisha Ace Denken | Article control system |
| US5420024A (en) * | 1993-05-11 | 1995-05-30 | Merck & Co., Inc. | Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea |
| US5427686A (en) | 1994-04-05 | 1995-06-27 | Sri International | Process for separating material from mixture using displacement chromatography |
| EP0877089A1 (en) * | 1997-05-07 | 1998-11-11 | Gist-Brocades B.V. | HMG-CoA reductase inhibitor preparation process |
-
1998
- 1998-09-18 SI SI9800241A patent/SI20072A/sl not_active IP Right Cessation
-
1999
- 1999-09-17 RS YUP-818/00A patent/RS49996B/sr unknown
- 1999-09-17 IL IL14205699A patent/IL142056A0/xx active IP Right Grant
- 1999-09-17 SK SK2002-2000A patent/SK285868B6/sk not_active IP Right Cessation
- 1999-09-17 DE DE69922519T patent/DE69922519T2/de not_active Expired - Lifetime
- 1999-09-17 AU AU55284/99A patent/AU766630B2/en not_active Ceased
- 1999-09-17 NZ NZ509582A patent/NZ509582A/en not_active IP Right Cessation
- 1999-09-17 RO ROA200100289A patent/RO121116B1/ro unknown
- 1999-09-17 WO PCT/IB1999/001553 patent/WO2000017182A1/en not_active Ceased
- 1999-09-17 HR HR20010045A patent/HRP20010045B1/xx not_active IP Right Cessation
- 1999-09-17 HU HU0102997A patent/HUP0102997A2/hu unknown
- 1999-09-17 RU RU2001108381/04A patent/RU2235098C2/ru not_active IP Right Cessation
- 1999-09-17 CN CNB998110760A patent/CN1186335C/zh not_active Expired - Fee Related
- 1999-09-17 US US09/720,952 patent/US6695969B1/en not_active Expired - Fee Related
- 1999-09-17 AT AT99941797T patent/ATE284396T1/de active
- 1999-09-17 KR KR1020017000044A patent/KR100607608B1/ko not_active Expired - Fee Related
- 1999-09-17 EP EP99941797A patent/EP1114040B1/en not_active Expired - Lifetime
- 1999-09-17 JP JP2000574092A patent/JP3795755B2/ja not_active Expired - Fee Related
- 1999-09-17 CA CA002343645A patent/CA2343645A1/en not_active Abandoned
- 1999-09-17 PL PL345883A patent/PL200336B1/pl not_active IP Right Cessation
-
2001
- 2001-03-12 IS IS5886A patent/IS2149B/is unknown
- 2001-03-16 BG BG105348A patent/BG64676B1/bg unknown
- 2001-03-18 IL IL142056A patent/IL142056A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK285868B6 (sk) | 2007-10-04 |
| RU2235098C2 (ru) | 2004-08-27 |
| HRP20010045A2 (en) | 2001-12-31 |
| PL200336B1 (pl) | 2008-12-31 |
| JP2002526486A (ja) | 2002-08-20 |
| US6695969B1 (en) | 2004-02-24 |
| SK20022000A3 (sk) | 2001-08-06 |
| DE69922519D1 (de) | 2005-01-13 |
| IL142056A0 (en) | 2002-03-10 |
| BG105348A (en) | 2001-11-30 |
| DE69922519T2 (de) | 2005-12-08 |
| JP3795755B2 (ja) | 2006-07-12 |
| CA2343645A1 (en) | 2000-03-30 |
| RS49996B (sr) | 2008-09-29 |
| IL142056A (en) | 2006-08-01 |
| EP1114040B1 (en) | 2004-12-08 |
| WO2000017182A1 (en) | 2000-03-30 |
| HRP20010045B1 (en) | 2005-08-31 |
| CN1186335C (zh) | 2005-01-26 |
| RO121116B1 (ro) | 2006-12-29 |
| IS5886A (is) | 2001-03-12 |
| IS2149B (is) | 2006-10-13 |
| YU81800A (sh) | 2003-02-28 |
| CN1318063A (zh) | 2001-10-17 |
| HUP0102997A2 (hu) | 2001-12-28 |
| AU5528499A (en) | 2000-04-10 |
| NZ509582A (en) | 2003-10-31 |
| EP1114040A1 (en) | 2001-07-11 |
| BG64676B1 (bg) | 2005-11-30 |
| KR20010099584A (ko) | 2001-11-09 |
| PL345883A1 (en) | 2002-01-14 |
| KR100607608B1 (ko) | 2006-08-02 |
| AU766630B2 (en) | 2003-10-23 |
| ATE284396T1 (de) | 2004-12-15 |
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Effective date: 20081015 |