SI1912949T1 - Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze - Google Patents

Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze

Info

Publication number
SI1912949T1
SI1912949T1 SI200631175T SI200631175T SI1912949T1 SI 1912949 T1 SI1912949 T1 SI 1912949T1 SI 200631175 T SI200631175 T SI 200631175T SI 200631175 T SI200631175 T SI 200631175T SI 1912949 T1 SI1912949 T1 SI 1912949T1
Authority
SI
Slovenia
Prior art keywords
cyclohexylamin
rho
kinase inhibitors
isoquinolone derivatives
isoquinolone
Prior art date
Application number
SI200631175T
Other languages
English (en)
Slovenian (sl)
Inventor
Oliver Plettenburg
Armin Hofmeister
Dieter Kadereit
Joachim Brendel
Matthias Loehn
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SI1912949T1 publication Critical patent/SI1912949T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
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  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
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SI200631175T 2005-07-26 2006-07-20 Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze SI1912949T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05016153 2005-07-26
EP06776307A EP1912949B1 (en) 2005-07-26 2006-07-20 Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors
PCT/EP2006/007140 WO2007012422A1 (en) 2005-07-26 2006-07-20 Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors

Publications (1)

Publication Number Publication Date
SI1912949T1 true SI1912949T1 (sl) 2011-12-30

Family

ID=35115842

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631175T SI1912949T1 (sl) 2005-07-26 2006-07-20 Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze

Country Status (36)

Country Link
US (2) US8609691B2 (enExample)
EP (1) EP1912949B1 (enExample)
JP (1) JP5049970B2 (enExample)
KR (1) KR101336678B1 (enExample)
CN (1) CN101228132B (enExample)
AR (1) AR057082A1 (enExample)
AT (1) ATE521595T1 (enExample)
AU (1) AU2006274246B2 (enExample)
BR (1) BRPI0614063A2 (enExample)
CA (1) CA2615663C (enExample)
CR (1) CR9604A (enExample)
CY (1) CY1112085T1 (enExample)
DK (1) DK1912949T3 (enExample)
DO (1) DOP2006000177A (enExample)
EC (1) ECSP088136A (enExample)
ES (1) ES2372067T3 (enExample)
GT (1) GT200600327A (enExample)
HN (1) HN2008000130A (enExample)
HR (1) HRP20110839T1 (enExample)
IL (1) IL188949A (enExample)
MA (1) MA29639B1 (enExample)
MX (1) MX2008000956A (enExample)
MY (1) MY146644A (enExample)
NI (1) NI200800024A (enExample)
NO (1) NO20080965L (enExample)
NZ (1) NZ565669A (enExample)
PE (1) PE20070181A1 (enExample)
PL (1) PL1912949T3 (enExample)
PT (1) PT1912949E (enExample)
RS (1) RS52241B (enExample)
RU (1) RU2440988C2 (enExample)
SI (1) SI1912949T1 (enExample)
TN (1) TNSN08038A1 (enExample)
TW (1) TWI412521B (enExample)
WO (1) WO2007012422A1 (enExample)
ZA (1) ZA200710952B (enExample)

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ATE490243T1 (de) 2006-12-27 2010-12-15 Sanofi Aventis Cycloalkylaminsubstituierte isochinolin- und isochinolinonderivate
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ES2625266T3 (es) 2006-12-27 2017-07-19 Sanofi Derivados de isoquinolona sustituidos con cicloalquilamina
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MX2010013975A (es) 2008-06-24 2011-01-14 Sanofi Aventis Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasa.
PL2313374T3 (pl) * 2008-06-24 2014-03-31 Sanofi Sa 6-podstawione izochinoliny i izochinolinony
DK2303845T3 (da) 2008-06-24 2013-12-16 Sanofi Sa Bi- og polycyklisk substitueret isoquinolin og bi- og polycykliske substituerede isoquinolinderivater som rho-kinasehæmmere
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JP6488239B2 (ja) * 2013-01-18 2019-03-20 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン
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CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
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WO2017003723A1 (en) 2015-07-01 2017-01-05 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
EP3445750A4 (en) 2016-04-18 2019-11-27 Celgene Quanticel Research, Inc. THERAPEUTIC COMPOUNDS
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