KR101336678B1 - Ｒｈｏ-키나제 억제제로서의 사이클로헥실아민 이소퀴놀론유도체 - Google Patents

Ｒｈｏ-키나제 억제제로서의 사이클로헥실아민 이소퀴놀론유도체 Download PDF

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KR101336678B1
KR101336678B1 KR1020087002147A KR20087002147A KR101336678B1 KR 101336678 B1 KR101336678 B1 KR 101336678B1 KR 1020087002147 A KR1020087002147 A KR 1020087002147A KR 20087002147 A KR20087002147 A KR 20087002147A KR 101336678 B1 KR101336678 B1 KR 101336678B1
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alkyl
alkylene
compound
halogen
cycloalkyl
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KR20080028970A (ko
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올리버 플레텐부르크
아르민 호프마이슈터
디터 카데라이트
요아힘 브렌델
마티아스 뢴
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사노피
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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KR1020087002147A 2005-07-26 2006-07-20 Ｒｈｏ-키나제 억제제로서의 사이클로헥실아민 이소퀴놀론유도체 Expired - Fee Related KR101336678B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05016153 2005-07-26
EP05016153.8 2005-07-26
PCT/EP2006/007140 WO2007012422A1 (en) 2005-07-26 2006-07-20 Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20080028970A KR20080028970A (ko) 2008-04-02
KR101336678B1 true KR101336678B1 (ko) 2013-12-04

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US (2) US8609691B2 (enExample)
EP (1) EP1912949B1 (enExample)
JP (1) JP5049970B2 (enExample)
KR (1) KR101336678B1 (enExample)
CN (1) CN101228132B (enExample)
AR (1) AR057082A1 (enExample)
AT (1) ATE521595T1 (enExample)
AU (1) AU2006274246B2 (enExample)
BR (1) BRPI0614063A2 (enExample)
CA (1) CA2615663C (enExample)
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MX (1) MX2008000956A (enExample)
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WO2007000240A1 (en) 2005-06-28 2007-01-04 Sanofi-Aventis Isoquinoline derivatives as inhibitors of rho-kinase
JP5049970B2 (ja) 2005-07-26 2012-10-17 サノフイ Ｒｈｏ−キナーゼ阻害剤としてのシクロヘキシルアミンイソキノロン誘導体
UA93882C2 (ru) 2005-07-26 2011-03-25 Санофи-Авентис Пиперидинил-замещенные производные изохинолона kak ингибиторы rho-киназы
US7893088B2 (en) * 2006-08-18 2011-02-22 N.V. Organon 6-substituted isoquinoline derivatives
CN101528703B (zh) * 2006-09-11 2011-09-07 欧加农股份有限公司 2-（1-氧代-1h-异喹啉-2-基）乙酰胺衍生物
NZ577980A (en) 2006-12-27 2012-01-12 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
MY150746A (en) 2006-12-27 2014-02-28 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
WO2008077552A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
KR101545533B1 (ko) 2006-12-27 2015-08-19 사노피 치환된 이소퀴놀린 및 Ｒｈｏ-키나아제 억제제로서의 이의 용도
JP5405316B2 (ja) * 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノリン誘導体
WO2008077556A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
TW200845988A (en) 2007-04-05 2008-12-01 Astrazeneca Ab New compounds and their uses 707
CA2701594C (en) * 2007-10-24 2014-02-18 Merck Sharp & Dohme Corp. Heterocycle phenyl amide t-type calcium channel antagonists
HUE026617T2 (en) 2008-06-24 2016-06-28 Sanofi Sa Substituted isoquinolines and isoquinolinones as RHO kinase inhibitors
WO2009156099A1 (en) * 2008-06-24 2009-12-30 Sanofi-Aventis 6-substituted isoquinolines and isoquinolinones
ES2434121T3 (es) * 2008-06-24 2013-12-13 Sanofi Derivados de isoquinolina e isoquinolinona bi- y policíclicos sustituidos como inhibidores de rho cinasa
JP5555236B2 (ja) * 2008-08-25 2014-07-23 アイアールエム・リミテッド・ライアビリティ・カンパニー ヘッジホッグ経路モジュレーター
AR073711A1 (es) 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
TW201443023A (zh) * 2013-01-18 2014-11-16 必治妥美雅史谷比公司 作爲ｒｏｃｋ抑制劑之酞□酮及異喹啉酮
HRP20200341T1 (hr) 2013-10-18 2020-06-12 Celgene Quanticel Research, Inc. Bromodomenski (bet) inhibitori
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FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
JP6883173B2 (ja) 2015-05-12 2021-06-09 ヘモストッド エスエー 改善された血小板産生のための薬理学的特徴およびマイクロ流体特徴の組み合わせ
HK1255034A1 (zh) 2015-07-01 2019-08-02 Crinetics Pharmaceuticals, Inc. 生长抑素调节剂及其用途
AU2017252276A1 (en) 2016-04-18 2018-11-15 Celgene Quanticel Research, Inc. Therapeutic compounds
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
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CN112839647B (zh) * 2018-06-07 2025-09-23 达萨玛治疗公司 Sarm1抑制剂
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Citations (3)

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