ATE523493T1 - 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate - Google Patents

2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate

Info

Publication number
ATE523493T1
ATE523493T1 AT07842137T AT07842137T ATE523493T1 AT E523493 T1 ATE523493 T1 AT E523493T1 AT 07842137 T AT07842137 T AT 07842137T AT 07842137 T AT07842137 T AT 07842137T AT E523493 T1 ATE523493 T1 AT E523493T1
Authority
AT
Austria
Prior art keywords
isochinolin
oxo
acetamide derivatives
acetamide
derivatives
Prior art date
Application number
AT07842137T
Other languages
English (en)
Inventor
Jeffrey Letourneau
Jui Hsiang Chan
Patrick Jokiel
Michael Ohlmeyer
Irina Neagu
Christopher Mark Riviello
John Richard Morphy
Susan Elizabeth Napier
Koc-Kan Ho
Original Assignee
Organon Nv
Pharmacopeia Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv, Pharmacopeia Llc filed Critical Organon Nv
Application granted granted Critical
Publication of ATE523493T1 publication Critical patent/ATE523493T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT07842137T 2006-09-11 2007-09-10 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate ATE523493T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84371306P 2006-09-11 2006-09-11
PCT/US2007/077999 WO2008033757A2 (en) 2006-09-11 2007-09-10 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives

Publications (1)

Publication Number Publication Date
ATE523493T1 true ATE523493T1 (de) 2011-09-15

Family

ID=39184481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07842137T ATE523493T1 (de) 2006-09-11 2007-09-10 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate

Country Status (9)

Country Link
US (1) US7906504B2 (de)
EP (1) EP2066640B1 (de)
JP (1) JP5271909B2 (de)
CN (1) CN101528703B (de)
AR (1) AR062734A1 (de)
AT (1) ATE523493T1 (de)
CA (1) CA2663193A1 (de)
MX (1) MX2009002685A (de)
WO (1) WO2008033757A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2069315B1 (de) * 2006-09-11 2011-09-07 N.V. Organon Chinazolinon- und isochinolinon-acetamid-derivate
CN103119028B (zh) 2010-10-01 2016-05-25 大正制药株式会社 1,2,4-三唑酮衍生物
SG11201401766UA (en) 2011-10-27 2014-10-30 Taisho Pharmaceutical Co Ltd Azole derivative
AU2013241076A1 (en) * 2012-03-30 2014-10-09 Taisho Pharmaceutical Co., Ltd. Fused azole derivative
WO2017100593A1 (en) 2015-12-09 2017-06-15 Luc Therapeutics Thienopyrimidinone nmda receptor modulators and uses thereof
ES2821010T3 (es) 2015-12-09 2021-04-23 Cadent Therapeutics Inc Moduladores heteroaromáticos del receptor NMDA y usos de los mismos
JP7332472B2 (ja) 2016-12-22 2023-08-23 ノバルティス アーゲー Ｎｍｄａ受容体モジュレーターおよびその使用
JP7319369B2 (ja) 2018-08-03 2023-08-01 ノバルティス アーゲー ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2506767A1 (fr) * 1981-05-26 1982-12-03 Synthelabo Derives heterocycliques d'amidoximes, leur preparation et leur application en therapeutique
EP1324994A4 (de) * 2000-10-10 2004-06-16 Calyx Therapeutics Inc Tricyclische verbindungen und deren verwendungen
CN100503572C (zh) * 2002-06-28 2009-06-24 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
JP2008506689A (ja) * 2004-07-14 2008-03-06 リガンド・ファーマシューティカルズ・インコーポレイテッド 細胞間受容体のモジュレーター化合物および方法
TW200643015A (en) * 2005-03-11 2006-12-16 Akzo Nobel Nv 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
KR101373535B1 (ko) * 2005-07-26 2014-03-12 사노피 Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체
NZ565669A (en) * 2005-07-26 2010-05-28 Sanofi Aventis Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors

Also Published As

Publication number Publication date
JP5271909B2 (ja) 2013-08-21
CN101528703A (zh) 2009-09-09
US20080064678A1 (en) 2008-03-13
JP2010502745A (ja) 2010-01-28
CA2663193A1 (en) 2008-03-20
WO2008033757A2 (en) 2008-03-20
CN101528703B (zh) 2011-09-07
EP2066640A4 (de) 2010-12-22
MX2009002685A (es) 2009-10-13
EP2066640A2 (de) 2009-06-10
US7906504B2 (en) 2011-03-15
EP2066640B1 (de) 2011-09-07
WO2008033757A3 (en) 2008-12-11
AR062734A1 (es) 2008-11-26

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties