SI1601776T1 - Ekspresijski vektorji, ki vsebujejo mcmv ie2 promotor - Google Patents

Ekspresijski vektorji, ki vsebujejo mcmv ie2 promotor

Info

Publication number
SI1601776T1
SI1601776T1 SI200430835T SI200430835T SI1601776T1 SI 1601776 T1 SI1601776 T1 SI 1601776T1 SI 200430835 T SI200430835 T SI 200430835T SI 200430835 T SI200430835 T SI 200430835T SI 1601776 T1 SI1601776 T1 SI 1601776T1
Authority
SI
Slovenia
Prior art keywords
mcmv
promoter
expression vectors
gene
expression
Prior art date
Application number
SI200430835T
Other languages
English (en)
Slovenian (sl)
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Publication of SI1601776T1 publication Critical patent/SI1601776T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/04—Varicella-zoster virus
    • C07K14/045—Cytomegalovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200430835T 2003-03-11 2004-03-10 Ekspresijski vektorji, ki vsebujejo mcmv ie2 promotor SI1601776T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03100617 2003-03-11
EP04718972A EP1601776B1 (en) 2003-03-11 2004-03-10 Expression vectors comprising the mcmv ie2 promoter
PCT/EP2004/050280 WO2004081167A2 (en) 2003-03-11 2004-03-10 Expression vectors comprising the mcmv ie2 promoter

Publications (1)

Publication Number Publication Date
SI1601776T1 true SI1601776T1 (sl) 2008-10-31

Family

ID=32981915

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200430835T SI1601776T1 (sl) 2003-03-11 2004-03-10 Ekspresijski vektorji, ki vsebujejo mcmv ie2 promotor

Country Status (26)

Country Link
US (3) US7824907B2 (sr)
EP (1) EP1601776B1 (sr)
JP (3) JP5171033B2 (sr)
KR (1) KR101180139B1 (sr)
CN (1) CN100429315C (sr)
AT (1) ATE399872T1 (sr)
AU (1) AU2004219917B2 (sr)
BR (1) BRPI0408246A (sr)
CA (1) CA2516157C (sr)
CY (1) CY1108344T1 (sr)
DE (1) DE602004014738D1 (sr)
DK (1) DK1601776T3 (sr)
EA (1) EA010096B1 (sr)
ES (1) ES2309508T3 (sr)
HK (1) HK1085766A1 (sr)
HR (1) HRP20050705B1 (sr)
IL (1) IL170754A (sr)
MX (1) MXPA05009608A (sr)
NO (1) NO333818B1 (sr)
PL (1) PL1601776T4 (sr)
PT (1) PT1601776E (sr)
RS (1) RS50488B (sr)
SI (1) SI1601776T1 (sr)
UA (1) UA88138C2 (sr)
WO (1) WO2004081167A2 (sr)
ZA (1) ZA200506400B (sr)

Families Citing this family (41)

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GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
BRPI0408246A (pt) * 2003-03-11 2006-03-01 Applied Research Systems vetores de expressão que compreendem o promotor ie2 do mcmv
ES2384241T3 (es) * 2003-05-13 2012-07-02 Merck Serono Sa Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas
PT1675956E (pt) 2003-10-21 2010-11-04 Merck Serono Sa Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína
DE602004006157T2 (de) 2003-11-05 2008-01-03 Ares Trading S.A. Verfahren zur aufreinigung von il-18-bindendem protein
WO2005083058A1 (en) 2004-03-01 2005-09-09 Ares Trading S.A. Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells
EP1761552B1 (en) * 2004-06-29 2008-09-17 Ares Trading S.A. Process for the purification of il-18 binding protein
EP1819812B1 (en) * 2004-12-02 2012-05-30 Merck Serono SA The lupac bifunctional marker and its use in protein production
EP1874929A2 (en) 2005-04-22 2008-01-09 Lonza Biologics plc Mammalian expression vector comprising the mcmv promoter and first intron of hcmv major immediate early gene
JP2008539785A (ja) * 2005-05-16 2008-11-20 モルフォテック、インク． 所望の表現型を示す細胞を選択するために制御されたベクター
ATE557038T1 (de) * 2005-06-03 2012-05-15 Ares Trading Sa Herstellung von rekombinantem il-18 bindendem protein
EP1891088B1 (en) 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
AU2008340017B2 (en) * 2007-12-21 2012-04-05 Novartis Ag Organic compounds
JP2009276724A (ja) * 2008-05-19 2009-11-26 Nitto Denko Corp 光導波路装置の製造方法
JP5801207B2 (ja) 2009-02-27 2015-10-28 ノバルティス アーゲー ２種類の選択マーカーを含む発現ベクター系
JP5502406B2 (ja) * 2009-09-14 2014-05-28 ロンザ・バイオロジクス・ピーエルシー Ｃｈｏ細胞において組換えタンパク質を発現する方法
KR101038126B1 (ko) * 2010-11-30 2011-05-31 주식회사 엘지생명과학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
US9249785B2 (en) * 2012-01-31 2016-02-02 Brightsource Industries (Isreal) Ltd. Method and system for operating a solar steam system during reduced-insolation events
HUE026516T2 (en) * 2012-09-24 2016-06-28 Lonza Biologics Plc Expression vectors containing chimeric cytomegalovirus promoter and enhancer sequences
ITFI20120221A1 (it) * 2012-10-22 2014-04-23 Nuovo Pignone Srl "exhaust gas collector and gas turbine"
WO2014133468A1 (en) * 2013-02-28 2014-09-04 Agency For Science, Technology And Research Chimeric promoters for high gene expression level and stability in mammalian cells
CN103173480B (zh) * 2013-03-01 2015-06-24 上海中医药大学附属曙光医院 一种利用双荧光素酶报告基因筛选多药耐药相关microRNA的方法
CN103173481A (zh) * 2013-03-01 2013-06-26 上海中医药大学附属普陀医院 一种含有abcb1基因3′utr序列和报告基因的质粒载体及其构建方法和用途
US20160017319A1 (en) 2013-03-11 2016-01-21 Audrey Nommay Method of screening cell clones
LT3412684T (lt) 2013-07-31 2022-07-11 Novartis Ag Nauji atrankos vektoriai ir eukariotinių ląstelių šeimininkių atrankos metodai
ES2758505T3 (es) 2013-12-20 2020-05-05 Novartis Ag Células eucariotas novedosas y métodos para expresar de forma recombinante un producto de interés
KR102288857B1 (ko) 2013-12-20 2021-08-11 노파르티스 아게 신규한 진핵 세포 및 관심 생성물의 재조합 발현 방법
JP6265020B2 (ja) * 2014-04-16 2018-01-24 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
RU2710726C2 (ru) 2014-04-29 2020-01-10 Новартис Аг Новые клетки позвоночных и способы рекомбинантной экспрессии интересующего полипептида
ES2821940T3 (es) * 2014-05-19 2021-04-28 Hoffmann La Roche Procedimiento para la producción de polipéptidos
KR20160068558A (ko) 2014-12-05 2016-06-15 삼성바이오에피스 주식회사 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법
KR102511343B1 (ko) 2015-03-05 2023-03-17 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체
SI3283634T1 (sl) * 2015-04-14 2019-08-30 Janssen Vaccines & Prevention B.V. Rekombinantni adenovirus, ki izraža dva transgena z dvosmernim promotorjem
ES2823173T3 (es) 2016-01-27 2021-05-06 Just Biotherapeutics Inc Promotor híbrido y usos del mismo
CA3023322A1 (en) * 2016-05-12 2017-11-16 Janssen Vaccines & Prevention B.V. Potent and balanced bidirectional promoter
BR112018075969A2 (pt) 2016-06-20 2019-04-02 Janssen Vaccines & Prevention B.V. promotor bidirecional potente e equilibrado
KR101864581B1 (ko) * 2016-11-04 2018-07-13 국립암센터 양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도
CN110268061A (zh) 2017-02-09 2019-09-20 扬森疫苗与预防公司 用于表达异源基因的有效的短启动子
EP3692153A1 (en) 2017-10-02 2020-08-12 Astrazeneca AB Cell lines and methods for increased protein production
AU2019392554A1 (en) * 2018-12-04 2021-06-03 Catalent Pharma Solutions, Llc Vectors for protein manufacture

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ATE395075T1 (de) * 2000-05-05 2008-05-15 Serono Lab Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose
US7812148B2 (en) * 2001-04-05 2010-10-12 Millipore Corporation Vectors comprising CpG islands without position effect varigation and having increased expression
WO2002099070A2 (en) * 2001-06-04 2002-12-12 Corixa Corporation Compositions and methods for high-level, large-scale production of recombinant proteins
BRPI0408246A (pt) * 2003-03-11 2006-03-01 Applied Research Systems vetores de expressão que compreendem o promotor ie2 do mcmv
ES2384241T3 (es) 2003-05-13 2012-07-02 Merck Serono Sa Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas
PT1675956E (pt) 2003-10-21 2010-11-04 Merck Serono Sa Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína
DE602004006157T2 (de) 2003-11-05 2008-01-03 Ares Trading S.A. Verfahren zur aufreinigung von il-18-bindendem protein
WO2005083058A1 (en) * 2004-03-01 2005-09-09 Ares Trading S.A. Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells
EP1761552B1 (en) 2004-06-29 2008-09-17 Ares Trading S.A. Process for the purification of il-18 binding protein
EP1819812B1 (en) * 2004-12-02 2012-05-30 Merck Serono SA The lupac bifunctional marker and its use in protein production
ATE557038T1 (de) 2005-06-03 2012-05-15 Ares Trading Sa Herstellung von rekombinantem il-18 bindendem protein
EP1891088B1 (en) 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
TWI647309B (zh) * 2011-04-01 2019-01-11 中外製藥股份有限公司 重組多肽之製造方法

Also Published As

Publication number Publication date
WO2004081167A3 (en) 2004-11-04
AU2004219917B2 (en) 2008-01-31
WO2004081167A2 (en) 2004-09-23
KR20050113193A (ko) 2005-12-01
IL170754A (en) 2010-11-30
EA200501444A1 (ru) 2006-02-24
EP1601776A2 (en) 2005-12-07
ATE399872T1 (de) 2008-07-15
AU2004219917A1 (en) 2004-09-23
PL1601776T3 (pl) 2008-12-31
JP2015180222A (ja) 2015-10-15
BRPI0408246A (pt) 2006-03-01
ES2309508T3 (es) 2008-12-16
HK1085766A1 (en) 2006-09-01
KR101180139B1 (ko) 2012-09-13
NO333818B1 (no) 2013-09-23
US7824907B2 (en) 2010-11-02
JP2012235787A (ja) 2012-12-06
EA010096B1 (ru) 2008-06-30
DE602004014738D1 (de) 2008-08-14
CA2516157C (en) 2012-09-18
JP2006520589A (ja) 2006-09-14
ZA200506400B (en) 2006-12-27
PL1601776T4 (pl) 2009-05-29
DK1601776T3 (da) 2008-10-13
EP1601776B1 (en) 2008-07-02
PT1601776E (pt) 2008-09-17
US9051582B2 (en) 2015-06-09
HRP20050705A2 (en) 2005-12-31
MXPA05009608A (es) 2006-03-21
CN1759184A (zh) 2006-04-12
US20150252383A1 (en) 2015-09-10
JP5848202B2 (ja) 2016-01-27
US20110008839A1 (en) 2011-01-13
CA2516157A1 (en) 2004-09-23
NO20054642L (no) 2005-10-10
UA88138C2 (en) 2009-09-25
CN100429315C (zh) 2008-10-29
US20070258962A1 (en) 2007-11-08
RS20050687A (en) 2007-11-15
HRP20050705B1 (hr) 2013-08-31
JP5171033B2 (ja) 2013-03-27
RS50488B (sr) 2010-03-02
CY1108344T1 (el) 2014-02-12

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