SI1181713T1 - Postopek za pripravo čistega citaloprama - Google Patents

Postopek za pripravo čistega citaloprama

Info

Publication number
SI1181713T1
SI1181713T1 SI200130238T SI200130238T SI1181713T1 SI 1181713 T1 SI1181713 T1 SI 1181713T1 SI 200130238 T SI200130238 T SI 200130238T SI 200130238 T SI200130238 T SI 200130238T SI 1181713 T1 SI1181713 T1 SI 1181713T1
Authority
SI
Slovenia
Prior art keywords
preparation
pure citalopram
citalopram
pure
Prior art date
Application number
SI200130238T
Other languages
English (en)
Inventor
Marco Villa
Federico Sbrogio
Robert Dancer
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SI1181713T1 publication Critical patent/SI1181713T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200130238T 2000-12-22 2001-03-07 Postopek za pripravo čistega citaloprama SI1181713T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22
PCT/DK2001/000147 WO2001045483A2 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram
EP01913726A EP1181713B1 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram

Publications (1)

Publication Number Publication Date
SI1181713T1 true SI1181713T1 (sl) 2005-02-28

Family

ID=8159922

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130238T SI1181713T1 (sl) 2000-12-22 2001-03-07 Postopek za pripravo čistega citaloprama

Country Status (43)

Country Link
US (1) US6455710B1 (sl)
EP (2) EP1181713B1 (sl)
JP (1) JP3798982B2 (sl)
KR (1) KR100439329B1 (sl)
CN (1) CN1282648C (sl)
AR (1) AR030056A1 (sl)
AT (2) ATE277920T1 (sl)
AU (2) AU2001100405B4 (sl)
BE (2) BE1013212A6 (sl)
BG (1) BG65131B1 (sl)
BR (1) BR0106272A (sl)
CA (1) CA2360303C (sl)
CH (1) CH691535A5 (sl)
CZ (1) CZ292200B6 (sl)
DE (2) DE60105926T2 (sl)
DK (1) DK1181713T3 (sl)
EA (1) EA003581B1 (sl)
ES (2) ES2228824T3 (sl)
FI (2) FI108639B (sl)
FR (1) FR2812877B1 (sl)
GB (1) GB2357763B (sl)
GR (1) GR1003874B (sl)
HK (1) HK1048812B (sl)
HR (1) HRP20020004A2 (sl)
HU (2) HU0101029D0 (sl)
IE (1) IES20010254A2 (sl)
IL (1) IL147226A (sl)
IS (1) IS2060B (sl)
IT (1) ITMI20010602A1 (sl)
MX (1) MXPA01013151A (sl)
NL (2) NL1017525C1 (sl)
NO (1) NO312462B1 (sl)
NZ (1) NZ516298A (sl)
PL (1) PL205724B1 (sl)
PT (1) PT1181713E (sl)
SE (1) SE517623C2 (sl)
SG (1) SG167655A1 (sl)
SI (1) SI1181713T1 (sl)
SK (2) SK284428B6 (sl)
TR (1) TR200201166T1 (sl)
UA (1) UA71634C2 (sl)
WO (1) WO2001045483A2 (sl)
ZA (1) ZA200110179B (sl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
SI1246812T1 (sl) 1999-12-28 2004-08-31 H. Lundbeck A/S Postopek za pripravo citaloprama
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
EA005134B1 (ru) 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NZ521201A (en) 2000-03-13 2004-02-27 H Method for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
ATE257832T1 (de) 2000-03-14 2004-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2001068632A1 (en) * 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
HUP0400095A3 (en) * 2001-03-09 2005-10-28 Ranbaxy Lab Ltd Process for the preparation of citalopram
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
NZ532478A (en) * 2001-11-08 2007-02-23 Sepracor Inc Methods for treating depression and other CNS disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
WO2004046067A2 (en) * 2002-11-15 2004-06-03 Akzo Nobel N.V. Purification/decolorization treatment for fatty nitriles
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
AU2003278409A1 (en) * 2003-10-28 2005-05-19 Krishnaji Upadhye Bhargav Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) * 1931-06-20 1935-02-19 Du Pont Separation of secondary and tertiary amines
DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
GB1143702A (sl) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4302399A (en) * 1978-09-28 1981-11-24 Dynapol Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
DE3926765A1 (de) * 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
WO1999000548A1 (en) * 1997-06-30 1999-01-07 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
PT1015416E (pt) 1997-07-08 2002-03-28 Lundbeck & Co As H Metodo para a producao de citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) * 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
HU228576B1 (en) 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
ES2170732B2 (es) 2003-09-16
ITMI20010602A1 (it) 2002-09-22
IL147226A (en) 2006-04-10
EP1181713A2 (en) 2002-02-27
BR0106272A (pt) 2004-06-15
ES2228824T3 (es) 2005-04-16
FI20011577A0 (fi) 2001-07-26
DE60105926T2 (de) 2005-11-24
BG106203A (en) 2002-08-30
PL353398A1 (en) 2003-11-17
EP1462447A3 (en) 2004-11-17
CN1366525A (zh) 2002-08-28
HK1048812A1 (en) 2003-04-17
WO2001045483A2 (en) 2001-06-28
IS5883A (is) 2001-06-20
NO20011271A (no) 2002-05-13
AU2001100405A4 (en) 2001-11-01
CN1282648C (zh) 2006-11-01
SG167655A1 (en) 2011-01-28
KR20020065345A (ko) 2002-08-13
NZ516298A (en) 2002-12-20
US20020120005A1 (en) 2002-08-29
CZ292200B6 (cs) 2003-08-13
GR1003874B (el) 2002-04-24
ES2170732A1 (es) 2002-08-01
PT1181713E (pt) 2005-02-28
HUP0102817A2 (hu) 2001-12-28
IL147226A0 (en) 2002-08-14
NO312462B1 (no) 2002-05-13
HK1048812B (zh) 2007-06-01
NL1017525C1 (nl) 2001-04-26
EA200200018A1 (ru) 2002-04-25
AR030056A1 (es) 2003-08-13
HRP20020004A2 (en) 2003-04-30
JP3798982B2 (ja) 2006-07-19
SK284428B6 (sk) 2005-04-01
AU2001100405B4 (en) 2002-03-21
NO20011271D0 (no) 2001-03-13
ATE277920T1 (de) 2004-10-15
SE0103045L (sv) 2002-06-23
UA71634C2 (uk) 2004-12-15
CH691535A5 (de) 2001-08-15
SK18482001A3 (sk) 2002-05-09
SE0103045D0 (sv) 2001-09-14
ZA200110179B (en) 2002-12-11
IES20010254A2 (en) 2002-03-06
HU0102817D0 (en) 2001-09-28
ITMI20010602A0 (it) 2001-03-22
EA003581B1 (ru) 2003-06-26
BE1013213A6 (fr) 2001-10-02
MXPA01013151A (es) 2002-08-12
SK286283B6 (sk) 2008-06-06
HU0101029D0 (en) 2001-05-28
US6455710B1 (en) 2002-09-24
AU3920101A (en) 2001-07-03
NL1018360C1 (nl) 2001-10-04
DE60105926D1 (de) 2004-11-04
JP2003517484A (ja) 2003-05-27
GB0105983D0 (en) 2001-05-02
BG65131B1 (bg) 2007-03-30
GB2357763A (en) 2001-07-04
EP1462447A2 (en) 2004-09-29
DE10112829C1 (de) 2002-07-25
EP1181713B1 (en) 2004-09-29
AT4367U1 (de) 2001-06-25
CZ2001890A3 (cs) 2002-08-14
BE1013212A6 (fr) 2001-10-02
CA2360303C (en) 2003-08-12
PL205724B1 (pl) 2010-05-31
SE517623C2 (sv) 2002-06-25
FR2812877B1 (fr) 2003-04-04
FI20010500A0 (fi) 2001-03-13
IS2060B (is) 2005-11-15
HUP0102817A3 (en) 2003-07-28
FR2812877A1 (fr) 2002-02-15
GB2357763B (en) 2002-01-16
TR200201166T1 (tr) 2002-10-21
CA2360303A1 (en) 2001-06-28
DK1181713T3 (da) 2005-01-31
KR100439329B1 (ko) 2004-07-07
FI108639B (fi) 2002-02-28
WO2001045483A3 (en) 2001-12-27

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